CN102973642A - Chinese medicine composition for enhancing poultry immunity and preparation method thereof - Google Patents
Chinese medicine composition for enhancing poultry immunity and preparation method thereof Download PDFInfo
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- CN102973642A CN102973642A CN2012104384158A CN201210438415A CN102973642A CN 102973642 A CN102973642 A CN 102973642A CN 2012104384158 A CN2012104384158 A CN 2012104384158A CN 201210438415 A CN201210438415 A CN 201210438415A CN 102973642 A CN102973642 A CN 102973642A
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Abstract
The invention belongs to the field of veterinary medicines, and particularly relates to a Chinese medicine composition for enhancing poultry immunity and a preparation method thereof. The Chinese medicine composition includes by weight: 200-600 parts of seabuckthorn, 100-400 parts of astragalus mongholicus, 100-200 parts of acanthopanax root, and 100-300 parts of herba epimedii. The Chinese medicine composition of the present invention can improve the poultry immunity, and enhance antibody titer and poultry uniformity before and after vaccine immunity.
Description
Technical field
The invention belongs to field of veterinary, particularly a kind of Chinese medicine composition that strengthens poultry immunity power and preparation method thereof.
Background technology
The avian viral immunosuppressant disease is the important infectious disease of a class of puzzle aviculture, because the existence of immunosuppressive condition, very easily concurrent and other infectious disease of secondary and parasitic disease.Such as atypical newcastle disease, low pathogenicity bird flu, colibacillosis, mycoplasma, coccidiosis etc.Cause that most viruses that bird immunity suppresses have the vertical transmission characteristics, make such epidemic disease medium-term and long-term the existence be difficult to purify the chicken group, thereby have a strong impact on growth and the fertility performance of poultry, cause the tremendous economic loss to aviculture.
In order to prevent poultry infection immunity inhibition virus or to treat infection immunity inhibition virus, method commonly used is to use vaccine or biological preparation, but use these biological product in prevention the problems such as often to exist that antibody titer rising speed is slow, antibody is held time in such disease short, therapeutic effect is undesirable, nonreactive cultivation trend highlights in addition, antibiotic is severely limited because of its application of safety issue, and developing green, poultry immunity reinforcing agent product efficient, that have no drug resistance become market in urgent need.
Summary of the invention
The object of the invention is to overcome existing fowl with the deficiency of immunostimulant, for poultry remove immunosuppressant provide a kind of safety good, have no side effect, determined curative effect, the Chinese medicine composition that has no drug resistance and preparation method thereof.
The technical solution used in the present invention is as follows:
A kind of Chinese medicine composition that strengthens poultry immunity power is characterized in that, the weight portion of described compositions is composed as follows: Fructus Hippophae 200-600 part, Radix Astragali 100-400 part, Radix Et Caulis Acanthopanacis Senticosi 100-200 part and Herba Epimedii 100-300 part.
The present composition can according to but be not limited in by the following method and be prepared: take by weighing by weight dry Fructus Hippophae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii, pulverize, sieve, make granularity reach the 60-200 order, packing namely gets described Chinese medicine composition.
Described Chinese medicine adopts commercially available product to get final product, and composition principle of the present invention is as follows:
Fructus Hippophae: be rich in vitamin, contain more vitamin A former and vitamin C, E, B1, B2 and flavone, folic acid etc.The root of Fructus Hippophae, stem, leaf, flower and fruit all contain flavone compound, and important medical value is arranged, but there are very large difference in the ratio of the composition at each position, each component and content.The bioactive ingredients such as Fructus Hippophae total flavones all have in various degree regulating power to immune too many levels, humoral immunization there is obvious regulating action, also have certain anti-allergic effects, thereby clinical available its treatment panimmunity systemic immune function lowly reaches the diseases such as human body metabolic function deficiency.What the present invention adopted is the fruit of Fructus Hippophae.
The Radix Astragali: sweet in the mouth, tepor; Return spleen, lung meridian.Have tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, the effect of diuretic detumescent.Contain sucrose, glucuronic acid, flavone compound, several aminoacid etc., clinically be usually used in the diseases such as deficiency of both the splenic and pulmonary QI, sinking of QI of middle-JIAO.
Radix Et Caulis Acanthopanacis Senticosi: suffering, little hardship, temperature.Return spleen, kidney, heart channel.Have replenishing QI to invigorate the spleen, the kidney invigorating, the effect of calming the nerves, Radix Et Caulis Acanthopanacis Senticosi contains multiple glycoside, and daucosterol, Syringa oblata Lindl. phenol glycoside etc. are arranged, and contains in addition Radix Et Caulis Acanthopanacis Senticosi polysaccharide.Radix Et Caulis Acanthopanacis Senticosi can strengthen the phagocytic function of inflammatory exudation cell, also can strengthen the phagocytic function of reticuloendothelial system.
Herba Epimedii: hot, sweet, temperature; Return liver, kidney channel.Have kidney invigorating and YANG supporting, the smart strong bone of benefit dispels the wind except the effect of temperature, contains icariine, des-o-methylicariine, magnoline, plant sterol etc.Epimedium brevicornum polysaccharide can stimulate the poult Development of Immune Organs, activate the nonspecific immunity system, strengthens the function of macrophage phagocytic.
The gas of Radix Astragali spleen reinforcing lung in the side, Fructus Hippophae can enhancing body serum lysozyme and complement content, promote macrophage phagocytic function, jointly activate body nonspecific immunity system in conjunction with Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii, the Promote immunity allelotaxis removes immunosuppressant, makes a concerted effort to promote immunity of organisms.
The present invention is vulnerable to marek's disease virus according to poultry in recent years in breeding process, infectious bursal disease virus, avian leukosis virus, infections anaemia virus, the infectiousness immunosuppressant virus factors such as reticuloendotheliosis virus, various stress be (supercool, overheated, arrest, turn the group, disconnected beak, reload, immunity inoculation) factor, mycotoxin factors etc. affect and the present situation of generation immunosuppressant phenomenon, take the QI invigorating YANG invigorating as the rule for the treatment of, special interpolation Novel immune reinforcing agent Fructus Hippophae is with QI invigorating, the Chinese medicine astragalus of YANG invigorating, Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii is played invigorating the spleen and replenishing QI altogether, the merit of spleen invigorating yang invigorating.Chinese medicine composition of the present invention can promote antibody titer and poultry regularity before and after poultry immunity power and the vaccine immunity, has cheap and easy to getly, and safety coefficient height, no drug residue, the characteristics such as have no side effect.
The present invention has following advantage with respect to prior art:
Chinese medicine composition of the present invention can promote poultry immunity power, promotes vaccine immunity front and back antibody titer and poultry regularity.
The specific embodiment
Below with specific embodiment technical scheme of the present invention is described, but protection scope of the present invention is not limited to this:
Embodiment 1
Strengthen the Chinese medicine composition of poultry immunity power, the weight portion of described compositions is composed as follows: 100 parts of 200 parts of Fructus Hippophaes, 400 parts of the Radixs Astragali, 150 parts of Radix Et Caulis Acanthopanacis Senticosis and Herba Epimedii.
Preparation method is: take by weighing by weight dry Fructus Hippophae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii, pulverize, sieve, make granularity reach 80 orders, packing namely gets described Chinese medicine composition.
Embodiment 2
Strengthen the Chinese medicine composition of poultry immunity power, the weight portion of described compositions is composed as follows: 200 parts of 400 parts of Fructus Hippophaes, 200 parts of the Radixs Astragali, 100 parts of Radix Et Caulis Acanthopanacis Senticosis and Herba Epimedii.
Preparation method is: take by weighing by weight dry Fructus Hippophae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii, pulverize, sieve, make granularity reach 60 orders, packing namely gets described Chinese medicine composition.
Embodiment 3
Strengthen the Chinese medicine composition of poultry immunity power, the weight portion of described compositions is composed as follows: 300 parts of 600 parts of Fructus Hippophaes, 100 parts of the Radixs Astragali, 200 parts of Radix Et Caulis Acanthopanacis Senticosis and Herba Epimedii.
Preparation method is: take by weighing by weight dry Fructus Hippophae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii, pulverize, sieve, make granularity reach 120 orders, packing namely gets described Chinese medicine composition.
According to the ratio of 100 kilograms of per 100 gram spices, mixed feeding was used in conjunction 3-5 days when above compositions was used.
Described Chinese medicine composition can be used for the birdss such as chicken and duck goose, and the below describes take 817 broiler as laboratory animal.
Clinical trial:
1. laboratory animal: large-scale feeding of broiler field, Xinxiang, Henan, 817 broiler chicks, are divided into 5 groups, 1200 every group at random by 6000.
2. Experimental agents: the Chinese medicine composition of the enhancing poultry immunity of the embodiment of the invention 1 preparation.
(great company of universe unit produces 1000 plumages part/bottle, lot number: 20111102) to new Zhi Erlian Seedling.
3. experimental technique: with 6000 chickling, be divided at random totally 5 groups of ABCDE.
A group blank group does not give medicine, does not carry out vaccine immunity, the basal diet of feeding.
B group vaccine matched group does not give medicine, and 7 age in days head exempt from new Zhi Erlian Seedling, the basal diet of feeding.
C organizes low dose group, admixes 200 kilograms of dosage whole process of basal diet according to 100 gram Chinese medicine compositions and feeds, and 7 age in days head exempt from new Zhi Erlian Seedling.
Dosage group in the D group is admixed 100 kilograms of dosage whole process of basal diet according to 100 gram Chinese medicine compositions and is fed, and 7 age in days head exempt from new Zhi Erlian Seedling.
E organizes high dose group, admixes 50 kilograms of dosage whole process of basal diet according to 100 gram Chinese medicine compositions and feeds, and 7 age in days head exempt from new Zhi Erlian Seedling.
The new Zhi Erlian Seedling of 7 ages in days collunarium select 1 day at the moment, immunity rear 7 days, 14 days, 21 days respectively every group randomly draw venous blood collection under 60 chicken wing, detect ND_HI antibody titre (the results are shown in following table 1), every group and randomly draw in addition 10 and carry out carbon clearance test (the results are shown in following table 2).All test datas are through SPASS 13 statistical analysiss.
4. conclusion:
From table 1 result of the test statistical analysis, aspect the specific immunity lifting: the embodiment of the invention 1 product is used for the middle and high dosage group of lifting antibody titer of ND and compares vaccine matched group difference extremely significantly (P＜0.01), vaccine matched group, basic, normal, high dosage group and blank group, significant difference (P＜0.05);
From table 2 result of the test, aspect the non-specific immunity lifting, head exempted from rear 7 days, 14 days, 21 days, high dose group carbon is cleaned up relatively other group significant differences (P＜0.01) of (reflection mononuclear phagocyte phagocytic activity index) index, head exempted from rear 14 days, and the embodiment of the invention 1 is cleaned up index for the carbon that promotes the non-specific ability of body and is significantly higher than the vaccine matched group.
The above presentation of results embodiment of the invention 1 product can promote the non-specific ability of poultry, can strengthen immune effect of vaccine.
Table 1 different days is respectively organized newcastle hemagglutination inhibition test result
Table 2 different days is respectively organized carbon clearance test result
Remarks: each organizes letter, and to be all mutually difference not remarkable, and lower case is all significant difference (P＜0.05) mutually, and capitalization represents difference extremely significantly (P＜0.01).
Product of the present invention is applied to the duck goose, and conclusion is identical with chicken.
Above-described embodiment is the preferred embodiment of the present invention, but embodiments of the present invention are not restricted to the described embodiments, and the change that other any the present invention of not deviating from does all should be the substitute mode of equivalence, is included within protection scope of the present invention.
Claims (2)
1. a Chinese medicine composition that strengthens poultry immunity power is characterized in that, the weight portion of described compositions is composed as follows: Fructus Hippophae 200-600 part, Radix Astragali 100-400 part, Radix Et Caulis Acanthopanacis Senticosi 100-200 part and Herba Epimedii 100-300 part.
2. the preparation method of the Chinese medicine composition of enhancing poultry immunity power claimed in claim 1, it is characterized in that, take by weighing by weight dry Fructus Hippophae, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii, pulverize, sieve, make granularity reach the 60-200 order, packing namely gets described Chinese medicine composition.
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| CN201210438415.8A CN102973642B (en) | 2012-11-07 | 2012-11-07 | Chinese medicine composition for enhancing poultry immunity and preparation method thereof |
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| CN201210438415.8A CN102973642B (en) | 2012-11-07 | 2012-11-07 | Chinese medicine composition for enhancing poultry immunity and preparation method thereof |
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| CN102973642A true CN102973642A (en) | 2013-03-20 |
| CN102973642B CN102973642B (en) | 2014-12-31 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104489398A (en) * | 2014-12-23 | 2015-04-08 | 西安鑫诚大唐畜牧有限公司 | Additive of feed for meat chicken and preparation method of additive |
| CN104758416A (en) * | 2014-12-10 | 2015-07-08 | 北京康华远景科技股份有限公司 | Botanical drug composition capable of improving immunity of laying hens and preparation method thereof |
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| CN1185908A (en) * | 1996-12-27 | 1998-07-01 | 李江 | Functional cordyceps sinensis milk, products made from cordyceps sinensis milk and preparation thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758416A (en) * | 2014-12-10 | 2015-07-08 | 北京康华远景科技股份有限公司 | Botanical drug composition capable of improving immunity of laying hens and preparation method thereof |
| CN104758416B (en) * | 2014-12-10 | 2018-08-21 | 北京康华远景科技股份有限公司 | A kind of plant drug composition improving immunity of layer chicken |
| CN104489398A (en) * | 2014-12-23 | 2015-04-08 | 西安鑫诚大唐畜牧有限公司 | Additive of feed for meat chicken and preparation method of additive |
| CN104489398B (en) * | 2014-12-23 | 2017-09-12 | 陕西鑫诚大唐畜牧有限公司 | A kind of broiler chicken feed additive and preparation method thereof |
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| CN102973642B (en) | 2014-12-31 |
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Effective date of registration: 20190107 Address after: 451162 South side of Yugang Road, Zhengzhou Airport District, Henan Province Patentee after: Henan Mu Xiang Biotechnology Co., Ltd. Address before: 451162 Airport Five Road, Zhengzhou Airport District, Henan Province Patentee before: Henan Soar Veterinary Pharmaceutical Co., Ltd. |
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