CN1363371A - Multifunctional bio-active medicine for preventing and curing AIDS - Google Patents
Multifunctional bio-active medicine for preventing and curing AIDS Download PDFInfo
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- CN1363371A CN1363371A CN 02100252 CN02100252A CN1363371A CN 1363371 A CN1363371 A CN 1363371A CN 02100252 CN02100252 CN 02100252 CN 02100252 A CN02100252 A CN 02100252A CN 1363371 A CN1363371 A CN 1363371A
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Abstract
A multifunctional bio-activator for preventing and treating AIDS is prepared from 11 Chinese-medicinal materials including patrinia herb seed, notoginseng, Antelope's horn, pilose antler, etc; general extract of gingko leaf, SOD, CAT, GSHPx, etc. Its advantages include high suppression action to HIV, and no by-effect.
Description
1, technical field
The present invention relates to a kind of pharmaceutical preparation, particularly a kind of multifunctional bio-active agent that is exclusively used in aids prevention and treatment.
2, background technology
Since the first acquired immune deficiency syndrome (AIDS) is reported by the U.S. in 1981, existing at present this disease of country's generation more than 150.According to World Health Organization's statistics, the new the infected in the whole world reached 5,800,000 in 1998, dead patient 2,500,000 people.Add up the infected 3,340 ten thousand people then.
Acquired immune deficiency syndrome (AIDS) is that human immunodeficiency virus (HIV) is caused, and being badly damaged with cellular immune function is the chronic of principal character and highly fatal general infectious disease.This disease trafficability characteristic contact transmission, mother and baby's vertical transmission and body fluid communication show as a series of serious opportunistic infection and malignant tumor clinically.At present, the whole world does not still have specific medicine, so be considered to a kind of incurable disease.
Western medicine (chemicals) treatment aspect, the inverase that has been employed roughly is divided three classes: (1), efabirenz.(2), non-nucleoside reverse transcriptase inhibitor.(3), protease inhibitor.In recent years, the someone proposes " HAART ".Several different anti-HIV associatings and treatment by turns can improve the curative effect of HIV, and be consistent with Combination chemotherapy thinking in the treatment of cancer.But present following difficult point at present: the injury of (1), human body: all medicines all present this side effect, can suppress bone marrow hematogenesis as AZT, anemia, neutrophilic granulocyte minimizing and platelet occur and lower.And mitochondrial myopathy, drug fever, erythra and hepatic injury can take place.DDI and DDC can cause pancreatitis, peripheral neuritis, abdominal cavity and stomatitis.Be subjected at human body can't resisting and get rid of under the state of HIV injury, increased the weight of the clinical marquis of levying of this class side effect.(2), drug resistance: nearly all medicine all presents drug resistance, also easily causes the HIV sudden change, and the on duty by turns and use in conjunction of several drugs has just delayed chemical sproof appearance.According to up-to-date report, mid-December calendar year 2001, in the infectious disease meeting that Chicago,U.S is held, Ritchie mambo scholar announces, with machine testing 2,000 U.S. HIV patients' that receiving treatment blood sample, but found that 2/3rds are belonged to detection level by the viral load that contains in selective examination person's the blood.The Ritchie is graceful to be thought, U.S. HIV patient's viral Drug resistance ratio is so high amazing.Columbia Univ USA's doctor's Hamann is said: " it is extremely urgent that new medicine is developed in the new discovery explanation ".
Present domestic research with the Chinese herb prevention acquired immune deficiency syndrome (AIDS) still is in the stage of theory study and design demonstration, and the experience of actual clinical treatment is few, but has demonstrated the Chinese medicine control to improving patient's whole body situation and symptom, improves the immunologic function of human body, makes CD
4 +The T cell number increases, and certain curative effect is arranged.Some Chinese medicines such as trichosanthin, Herba Violae, glycyrrhizin have inhibitory action to HIV, and have no drug resistance.Radix Ginseng, Radix Angelicae Sinensis, Fructus Ligustri Lucidi etc. can improve immunologic function.But the problem that treatment by Chinese herbs exists is: lack the support of modern medical knowledge, because it is too traditional formed too conservative, hinder in-depth research and strengthened curative effect, some in addition Chinese medicine workers must sort out earlier when the research modern disease, when looking into ancient books and not having acquired immune deficiency syndrome (AIDS) and discuss, it is classified as " pestilence ", " chronic consumptive disease " category of traditional Chinese medical science appellation, deficiency of qi and blood.The internal and external reasons reciprocal causation, infect with the passing of time injure the bottom of heart ".Therefore, determine the rule of treatment: set upright in early days and eliminating evil and usefulness, middle and advanced stage is to set upright.The reason that is not the above-mentioned argumentation and the traditional Chinese medical science is disagreed, but this conservative traditional established practice sticks to, and has ignored scientist's known to HIV, is difficult to knowledge also to make the valuable effectiveness of Chinese medicine be difficult to be strengthened under the support of modern medical theory to knowing this conversion.In addition, distinguish that the disease general plan is difficult to the Chinese medicine commercialization: the most representative is that acquired immune deficiency syndrome (AIDS) four type treatment sides are divided into lung-stomach yin deficiency type, the deficient type of taste, spleen kidney two thanks to type, intenseness of heat expectorant illiteracy type.And all there is the rule of treatment with the disease plus-minus.Above scheme belongs to the marrow that Chinese medicine is suited the medicine to the illness at present.But this general plan be unable to do without clinicist's pulse-taking, just can't become the typing commercially available medicine and allow a large amount of patients be benefited.
The HIV vaccine medicine of the U.S. is still needed the several years just clinical, and anti-HIV vaccine may bring dawn to the control of acquired immune deficiency syndrome (AIDS) after coming out.But think that according to situation about grasping at present it also will face some difficult points: the price that (1), certificate were reported now is too expensive, does not have the meaning of whole people's prevention.(2), HIV stimulates a little less than its effect extremely of antibody that produces.(3) even solved the weak effect problem of vaccine, the reparation of still unresolved patient's immunodeficiency.
3, summary of the invention
The objective of the invention is to, propose a kind of safe and harmlessly, can effectively suppress HIV virus, rebuild and recover disrupted cellular immunization system, thereby reach the purpose of prevention and treatment AIDS, to promote the well-being of mankind.
In order to realize purpose of the present invention, adopted following technical scheme: a kind of multifunctional bio-active agent that is exclusively used in AIDS prevention and treatment, it is made of following component:
A component: Patrinia scabiosaefolia Fisch grass seed 10-15g, Radix Notoginseng powder 5-9g, Cornu Saigae Tataricae 1-2.5g, Cornu Cervi Pantotrichum 0.5-2g, VB
10.5-2mg, Herb Gynostemmae Pentaphylli powder 0.75g; Ginkgo biloba leaf total extract 6-10mg, SMI, SEI is 5.1g (be Semen Astragali Complanati extract, respectively be about 50%) altogether, Radix Ginseng 4-10g, Radix Panacis Quinquefolii 3-5g, Fructus Schisandrae Chinensis 2-6g, Fructus Phyllanthi (Tibetan medicine) 3-9g, Herba Violae 15-30g, Herba Artemisiae Scopariae 10-20g, close Flos Lonicerae 6-15g, Rhizoma Dioscoreae 15-30g, Rhizoma Chuanxiong 3-9g, Fructus Crataegi 8-12g, Radix Salviae Miltiorrhizae 2-4g, Rhizoma Polygonati Odorati 5-10g, Retinervus Luffae Fructus 8-9g, Herba Cynomorii 4-8g, Concha Ostreae 10-30g, Fructus Hippophae (Tibetan medicine) 3-8g, Radix Ophiopogonis 10-16g, Aloe 1.5-4.5g, Fructus Choerospondiatis (mongolian medicine) 2-2.5g, Radix Rhodiolae (mongolian medicine) 3-9g, Rhizoma Coptidis 1.5-4g, Radix Arnebiae (Radix Lithospermi) 4.5-8g, Radix Polygalae 6-12g, Cortex Moutan 6-12g, Radix Hedysari 10g, Ramulus Cinnamomi 3-8g;
B component: lentinan 25-50mg, grifolan 25-50mg, Ganoderma spore powder 0.2-0.5mg, Ganoderma mycelium (dry weight) 25-75mg, Ganderma lucidum pompon (dry weight) 25-50mg, Cordyceps polysaccharide 200-500mg, falmmulin 10-30mg, Agaricus blazei Murrill submerged fermentation liquid 50ml;
C component: SOD 3000-5000IU, CAT 2000-3000IU, GSHP
X2000-3000IU, Se, Cu, Zn, cysteine, tea polyphenols a little;
D component: Spica Prunellae 9-15g, Radix Paeoniae Rubra 6-15g, Rhizoma Polygoni Cuspidati 10-15g, Radix Paeoniae Alba 6-12g, Rhizoma Atractylodis Macrocephalae 6-10g, Rhizoma Polygonati 12-15g, Semen Cuscutae 6-10g, Herba Epimedii 5-9g, Radix Et Caulis Acanthopanacis Senticosi 15-25g, Radix Angelicae Sinensis 5-15g, Herba Cistanches 10-15g, Poria 10-15g, Radix Astragali 15-30g.
In order to realize purpose of the present invention better, adopted following technical scheme:
Scheme one,
The A component also comprises: Angelica Polysaccharide 0.5mg, Calculus Bovis bile salts 100mg, Herba Houttuyniae 15g, Rhizoma Panacis Majoris 10g, Radix Trichosanthis 10g, Radix Codonopsis 15g, catechu 1.4g, Fructus Arctii 10g, Rhizoma Bolbostematis 4.5g, Fructus Ligustri Lucidi 8g, Radix Astragali 15g, Fructus Lycii 15g) after the winter wind dish chromosome doubling, artificial culture is got the aquatic foods 20ml that squeezes the juice of its 1-4 leaf in bottom); The B component also comprises: Cordyceps AaBb fungus ball dry product 0.3g, and diameter is less than 0.3cm; The D component also comprises: Radix Glycyrrhizae 8g, Radix Achyranthis Bidentatae 5g.
Scheme two
The A component also comprises: catechin 150 μ g, trichosanthin (trichosanthin that the 5g Radix Trichosanthis is extracted), glycoside that Fructus Arctii extracts and the 6.3 μ g of glycoside unit, Radix Glycyrrhizae extract 1.5 μ g, Calculus Bovis bile salts 100mg, Tubeimuside I 15 μ g, Radix Trichosanthis 10g, Rhizoma Panacis Majoris 15g, Herba Houttuyniae 20g, Fructus Ligustri Lucidi 10g, Radix Et Caulis Acanthopanacis Senticosi 20g, Fructus Hippophae (Tibetan medicine) 6g, Radix Ophiopogonis 15g, Aloe 2.5g, Fructus Choerospondiatis (mongolian medicine) 2g, Radix Rhodiolae (mongolian medicine) 6g, Rhizoma Coptidis 2.5g, Radix Arnebiae (Radix Lithospermi) 6g, Radix Polygalae 8g, Radix Polygoni Multiflori Preparata 15g, Cortex Moutan 8g, Fructus Lycii 20g, Radix Codonopsis 20g, Radix Hedysari 10g, Ramulus Cinnamomi 3g;
The B component also comprises: Cordyceps AaBb fungus ball dry product 0.4g;
The C component also comprises: monkey mushroom polysaccharide 10 μ g;
The D component also comprises: Radix Achyranthis Bidentatae 6g.
Scheme three,
The A component also comprises: catechin 180 μ g, trichosanthin (simple protein that does not contain sugar and phosphate group that the 15g Radix Trichosanthis is extracted, molecular weight 24000, isoelectric point, IP 9.4), glycoside that Fructus Arctii extracts and the 13 μ g of glycoside unit, Angelica Polysaccharide 0.5mg, Radix Glycyrrhizae extract 2.5mg, Tubeimuside I 20 μ g, the Radix Tripterygii Wilfordii good fortune is decided 0.3mg (tripterfordin), Herba Houttuyniae 25g, Radix Achyranthis Bidentatae 8g, Rhizoma Panacis Majoris 20g;
The B component also comprises: Cordyceps sporophore 0.15g, Cordyceps AaBb Stroma precursor 0.2g, Pleurotus ferulae Lanzi fermentation liquid 25ml;
The C component also comprises: ginseng royal jelly 5ml, monkey mushroom polysaccharide 0.25mg;
The D component also comprises: Fructus Ligustri Lucidi 12g, 15g, Radix Polygoni Multiflori Preparata 20g, Radix Codonopsis 30g.
The present invention has following characteristics: (one), employing Chinese medicine HIV suppress usefulness substituted chemistry medicine, have avoided the side effect injury of chemicals.Be to improve herbal medicine efficacy, the research of (1) modern Chinese medicine can have been analysed the effective ingredient known need not former medicine; (2), the performance kinds of traditional Chinese medicines synergism, the present invention be used for inhibitor have 10 surplus kind; (3), some mongolian medicines and Tibetan medicine have been used in interpolation.(2), the present invention used other Chinese medicines of removing the crude drug side effect, with the collaborative and antagonism that utilizes the Chinese medicine compound compatibility to form, and protects the liver sharp kidney from the overall situation of human body.(3), used some antineoplastic components, mainly be to suppress TNFa.(4), set up a normal complement system and could guarantee the quick and lasting of immunne response as immune support system.Complement system of the present invention derives from Chinese medicine and multiple mycoproteins such as Radix Ginseng, Radix Codonopsis, the Radix Astragali.(5), Chinese medicine of the present invention and biotic component stress to improve body constitution, enhance immunity, both take into account.The normal person is also had no side effect, can prevent, have social widely operability in the doubtful scope of dying, easily dye.
4, the specific embodiment
Embodiment one, be applicable to asymptomatic HIV carriers
AI:1, Angelica Polysaccharide 0.5mg.
2, Patrinia scabiosaefolia Fisch grass seed 10g.In this amount, be extracted as oleanolic acid, the latter two mixing for standby use of helexin.
3, Calculus Bovis bile salts 100mg.The sodium deoxycholate that should contain 60% sodium cholate and 40%.All from Calculus Bovis.
4, ginkgo biloba leaf total extract 6mg.
5, SMI, SEI are total to 5.1g and are Semen Astragali Complanati extract, respectively are about 50%.
6, Herb Gynostemmae Pentaphylli powder 0.5g
7、VB
1 0.5mg
8, Radix Notoginseng powder 5g
9, Cornu Saigae Tataricae 1g powdery (200 order)
10, Cornu Cervi Pantotrichum 0.5g powdery (200 order)
Above-mentioned 10 mix homogeneously are standby.
AII: Radix Ginseng 4g, Herba Houttuyniae 15g, Rhizoma Panacis Majoris 10g, Radix Panacis Quinquefolii 3g, Radix Trichosanthis 10g, Radix Codonopsis 15g, catechu 1.4g.Said medicine is added more than the water 250ml, 85 ℃ to 95 ℃ 30 minutes, evaporate into surplus liquid 200ml, standby.
AIII: Fructus Schisandrae Chinensis 2g, 45 ℃ of water carry that to be about 15ml standby.
AIV: Radix Glycyrrhizae 8g, Spica Prunellae 9g, Radix Paeoniae Rubra 6g, Rhizoma Polygoni Cuspidati 10g, Radix Achyranthis Bidentatae 5g, Radix Paeoniae Alba 6g Rhizoma Atractylodis Macrocephalae 6g, Rhizoma Polygonati 12g, Semen Cuscutae 6g, Herba Epimedii 5g, Radix Et Caulis Acanthopanacis Senticosi 15g, Radix Angelicae Sinensis 5g, Herba Cistanches 10g, Poria 10g, Radix Astragali 15g.Stating medicine 128 restrains by the concentrated granulars of making 12.8 grams at 1: 10 totally.
AV: Fructus Arctii 10g, Rhizoma Bolbostematis 4.5g, Fructus Phyllanthi (Tibetan medicine) 3g, Herba Violae 15g, Herba Artemisiae Scopariae 10g, close Flos Lonicerae 6g, Rhizoma Dioscoreae 15g, Fructus Ligustri Lucidi 8g, Rhizoma Chuanxiong 3g, Fructus Crataegi 8g, Radix Salviae Miltiorrhizae 2g, Rhizoma Polygonati Odorati 5g, Radix Astragali 15g, Radix Hedysari 10g, Ramulus Cinnamomi 5g, Herba Cynomorii 4g, Retinervus Luffae Fructus 8g, Concha Ostreae 10g, Fructus Hippophae (Tibetan medicine) 3g, Radix Ophiopogonis 10g, Aloe 1.5g, Fructus Choerospondiatis (mongolian medicine) 2g, Radix Rhodiolae (mongolian medicine) 3g, Rhizoma Coptidis 1.5g, Radix Arnebiae (Radix Lithospermi) 4.5g, Radix Polygalae 6g, Radix Polygoni Multiflori Preparata 10g, Cortex Moutan 6g, Fructus Lycii 15g.More than the decocting of usefulness＞800ml is concentrated into 200ml, and is standby.
AVI: lentinan 25ma, under the situation of submerged fermentation liquid mycelium weight in wet base＜5%, the spissated dry product of ultralow temperature, natural moisture＜8%.Grifolan 25mg is the same, Ganoderma spore powder 0.2ma, Ganoderma mycelium dry weight 25ma, Ganderma lucidum pompon dry weight 25mg, Cordyceps AaBb fungus ball dry product 0.3g.Diameter is less than 0.3cm, Cordyceps polysaccharides body 0.2g, falmmulin 0.02g, Agaricus blazei Murrill submerged fermentation liquid 50ml.Above-mentioned substance is dissolved in the 50ml fermentation liquid, below 85 ℃, deactivation in 15 minutes.
AVII:SOD 3000IU, CAT 2000IU, GSHP
X2000IU, Se 10 μ g, Cu10 μ g, Zn 10 μ g, cysteine 15 μ g, tea polyphenols 30mg (behind molecular modification, with 1: the fruit juice 100ml of 25PP standard is a carrier, seals after microwave treatment).
AVIII: after winter wind dish chromosome doubling, it is standby that artificial culture is got the aquatic foods 20ml that squeezes the juice of its 1-4 leaf in bottom.
Composite and using method:
1, with AI, AII, AIII, AV, AVIII mixing through microwave sterilizating, the final liquid that forms about 435ml.
2, under aseptic condition with AVI, AVII and 1. liquid phase is molten, shake mixing in airtight.
3, the patient takes above-mentioned preparation and AIV granule the same period.
Embodiment two, be applicable to the AIDS syndrome of being correlated with.
BI:1, catechin 150 μ g.
2, trichosanthin 5g, the simple protein that does not contain sugar and phosphate group that Radix Trichosanthis extracted,
Molecular weight 24000, isoelectric point, IP 9.4.
3, the glycoside of Fructus Arctii extraction and the 6.3 μ g of glycoside unit.
4, Radix Glycyrrhizae extract 1.5 μ g.
5, contained oleanolic acid, the Caulis Hederae Sinensis of Patrinia scabiosaefolia Fisch grass seed 12g
6, Calculus Bovis bile salts 100mg.(embodiment one is seen in definition)
7, Tubeimuside I 15 μ g
8、VB
1 0.5mg
9, Radix Notoginseng powder 7g
10, ginkgo biloba leaf total extract 8mg
11, SMI, SEI are total to 5.1g, are Semen Astragali Complanati extract, respectively are about 50%.
12, Herb Gynostemmae Pentaphylli powder 0.75g
13, Cornu Saigae Tataricae 2g powdery (200 order)
14,, Cornu Cervi Pantotrichum 1.2g powdery (200 order)
To go up the thing mixing, standby.
BII: Spica Prunellae 12g, Radix Paeoniae Rubra 10g, Rhizoma Polygoni Cuspidati 12g, Radix Achyranthis Bidentatae 6g, Radix Paeoniae Alba 8g, Rhizoma Atractylodis Macrocephalae 8g, Rhizoma Polygonati 12g, Semen Cuscutae 8g, Herba Epimedii 6g, Radix Et Caulis Acanthopanacis Senticosi 20g, Radix Angelicae Sinensis 10g, Herba Cistanches 15g, Poria 10g, Radix Astragali 20g.With said medicine by the concentrated granulars of making 16.1 grams at 1: 10.
BIII: Radix Ginseng 6g, Radix Panacis Quinquefolii 4g, Radix Trichosanthis 10g, Rhizoma Panacis Majoris 15g adds water 50ml, 90 ℃ 20 minutes, be concentrated into 25ml, standby.
BIV: Herba Houttuyniae 20g, Fructus Schisandrae Chinensis 4g adds water 50ml, 45-60 ℃ 40 minutes, be concentrated into 25ml, standby.
BV: Fructus Phyllanthi (Tibetan medicine) 6g, Herba Violae 20g, Herba Artemisiae Scopariae 20g, close Flos Lonicerae 12g, Rhizoma Dioscoreae 20g, Fructus Ligustri Lucidi 10g, Rhizoma Chuanxiong 6g, Fructus Crataegi 10g, Radix Salviae Miltiorrhizae 3g, Rhizoma Polygonati Odorati 8g, Retinervus Luffae Fructus 8g, Herba Cynomorii 6g, Concha Ostreae 20g, Radix Et Caulis Acanthopanacis Senticosi 20g, Fructus Hippophae (Tibetan medicine) 6g, Radix Ophiopogonis 15g, Aloe 2.5g, Fructus Choerospondiatis (mongolian medicine) 2g, Radix Rhodiolae (mongolian medicine) 6g, Rhizoma Coptidis 2.5g, Radix Arnebiae (Radix Lithospermi) 6g, Radix Polygalae 8g, Radix Polygoni Multiflori Preparata 15g, Cortex Moutan 8g, Fructus Lycii 20g, Radix Codonopsis 20g, Radix Hedysari 10g, Ramulus Cinnamomi 3g.More than be total to 293g, add water 1000ml, be concentrated into 250ml.
BVI: lentinan 50mg, submerged fermentation liquid mycelium weight in wet base is greater than under 5/1000ths the situation, the spissated dry product of ultralow temperature, natural moisture is greater than 8/1000ths.Grifolan 50mg (defining the same), Ganoderma spore powder 0.5mg, Ganoderma mycelium dry weight 50mg, Ganderma lucidum pompon dry weight 50mg, Cordyceps AaBb fungus ball dry product 0.4g (diameter is less than 0.3cm), Cordyceps polysaccharides body 0.4g, falmmulin 0.03g, Agaricus blazei Murrill submerged fermentation liquid 65ml.Above-mentioned substance is dissolved in the 65ml fermentation liquid, below 85 ℃, deactivation in 15 minutes.
BVII:SOD 4000IU, CAT 3000IU, GSHP
X2000IU, Se 15 μ g, Cu15 μ g, Zn 15 μ g, cysteine 10 μ g, tea polyphenols 15mg, monkey mushroom polysaccharide 10 μ g.More than be dissolved in 50ml also in the original fruit juice, after microwave treatment, seal, need stored under refrigeration summer.
BVIII: the aquatic foods of 1-4 the leaf in the winter wind dish bottom 30ml that squeezes the juice is standby.
Composite and using method:
1, with BI, BIII, BIV, BV, BVII mixing, through microwave sterilizating.
2, under aseptic condition that BVI, BVIII and 1 liquid phase is molten, shake mixing in airtight.
3, the patient takes above-mentioned preparation and BII granule the same period.
Embodiment three, be applicable to typical AIDS
CI:1, catechin 180 μ g.
2, trichosanthin (simple protein that does not contain sugar and phosphate group that the 15g Radix Trichosanthis is extracted, molecular weight 24000, isoelectric point, IP 9.4).
3, the glycoside of Fructus Arctii extraction and the 13 μ g of glycoside unit.
4, Angelica Polysaccharide 0.5mg.
5, Radix Glycyrrhizae extract 2.5mg.
6, contained oleanolic acid, the Caulis Hederae Sinensis of Patrinia scabiosaefolia Fisch grass seed 15g.
7, Tubeimuside I 20 μ g.
8, the Radix Tripterygii Wilfordii good fortune is decided 0.3mg (tripterfordin).
9, SMI, SEI are total to 5.1g.
10, ginkgo biloba leaf total extract 8mg.
11, Cornu Saigae Tataricae 2.5g powdery (200 order).
12, Cornu Cervi Pantotrichum 2g powdery (200 order).
13、VB
1 2mg。
14, Radix Notoginseng powder 9g.
15, Herb Gynostemmae Pentaphylli powder 1g.
To go up the thing mixing, standby.
CII: Herba Houttuyniae 25g, Fructus Schisandrae Chinensis 6g adds water 50ml, and 60-80 ℃ of lixiviate is standby.
CIII: Radix Ginseng 10g, Radix Panacis Quinquefolii 5g.Water 30ml, 90 ℃ take about 20ml, standby.
CIV: Spica Prunellae 15g, Radix Paeoniae Rubra 15g, Rhizoma Polygoni Cuspidati 15g, Fructus Ligustri Lucidi 12g, Radix Achyranthis Bidentatae 6g, Radix Paeoniae Alba 12g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Polygonati 15g, Semen Cuscutae 10g, Herba Epimedii 9g, Radix Et Caulis Acanthopanacis Senticosi 25g, Radix Angelicae Sinensis 15g, Herba Cistanches 15g, Radix Polygoni Multiflori Preparata 20g, Poria 15g, Radix Astragali 30g, Radix Codonopsis 30g.With said medicine by the concentrated granulars of making 26.3 grams at 1: 10.
CV: Fructus Phyllanthi (Tibetan medicine) 9g, Herba Violae 30g, Herba Artemisiae Scopariae 20g, close Flos Lonicerae 15g, Rhizoma Dioscoreae 30g, Rhizoma Chuanxiong 9g, Fructus Crataegi 12g, Radix Achyranthis Bidentatae 8 g, Radix Salviae Miltiorrhizae 4g, Rhizoma Polygonati Odorati 10g, Retinervus Luffae Fructus 9g, Herba Cynomorii 8g, Concha Ostreae 30g, Fructus Hippophae (Tibetan medicine) 8g, Radix Ophiopogonis 16g, Aloe 4.5g, Fructus Choerospondiatis (mongolian medicine) 2g, Radix Rhodiolae (mongolian medicine) 9g, Rhizoma Coptidis 4g, Radix Arnebiae (Radix Lithospermi) 8g, Radix Polygalae 12g, Cortex Moutan 12g, Rhizoma Panacis Majoris 20g, Radix Hedysari 10g, Ramulus Cinnamomi 8g.Add water 1000ml, be concentrated into 350ml.
CVI: lentinan 50mg, submerged fermentation liquid mycelium weight in wet base is greater than under 5/1000ths the situation, the spissated dry product of ultralow temperature, natural moisture is greater than 8/1000ths.Grifolan 50mg (defining the same), Ganoderma spore powder 0.5mg, Ganoderma mycelium dry weight 75mg, Ganderma lucidum pompon dry weight 50mg, Cordyceps polysaccharide 0.5g.Cordyceps mycelium 0.25g.Cordyceps sporophore 0.15g.Cordyceps AaBb Stroma precursor 0.2g.Falmmulin 0.01g.Agaricus blazei Murrill submerged fermentation liquid 75ml.Pleurotus ferulae Lanzi fermentation liquid 25ml.Above-mentioned substance is dissolved in the 100ml fermentation liquid,, left standstill about 10 ℃ 48 hours through 80-85 ℃ of deactivation.
CVII:SOD 5000IU, CAT 3000IU, GSHP
X3000IU, Se 12 μ g, Cu12 μ g, Zn 12 μ g, cysteine 15 μ g, tea polyphenols 30mg, ginseng royal jelly 5ml, monkey mushroom polysaccharide 0.25mg.Behind molecular modification, be dissolved in 25% go back in the original fruit juice, after microwave treatment, seal.
Composite and using method:
1, with CI, CII, CIII, CV, CVII mixing, through microwave sterilizating.
2, under aseptic condition that CVI and 1 liquid phase is molten, shake mixing in airtight.
3, the patient takes above-mentioned preparation and CIV granule the same period.
Claims (4)
1, a kind of multifunctional bio-active agent that is exclusively used in AIDS prevention and treatment, it is characterized in that: it is made of following component:
A component: Patrinia scabiosaefolia Fisch grass seed 10-15g, Radix Notoginseng powder 5-9g, Cornu Saigae Tataricae 1-2.5g, Cornu Cervi Pantotrichum 0.5-2g, VB
10.5-2mg, Herb Gynostemmae Pentaphylli powder 0.75g; Ginkgo biloba leaf total extract 6-10mg, SMI, SEI is 5.1g (be Semen Astragali Complanati extract, respectively be about 50%) altogether, Radix Ginseng 4-10g, Radix Panacis Quinquefolii 3-5g, Fructus Schisandrae Chinensis 2-6g, Fructus Phyllanthi (Tibetan medicine) 3-9g, Herba Violae 15-30g, Herba Artemisiae Scopariae 10-20g, close Flos Lonicerae 6-15g, Rhizoma Dioscoreae 15-30g, Rhizoma Chuanxiong 3-9g, Fructus Crataegi 8-12g, Radix Salviae Miltiorrhizae 2-4g, Rhizoma Polygonati Odorati 5-10g, Retinervus Luffae Fructus 8-9g, Herba Cynomorii 4-8g, Concha Ostreae 10-30g, Fructus Hippophae (Tibetan medicine) 3-8g, Radix Ophiopogonis 10-16g, Aloe 1.5-4.5g, Fructus Choerospondiatis (mongolian medicine) 2-2.5g, Radix Rhodiolae (mongolian medicine) 3-9g, Rhizoma Coptidis 1.5-4g, Radix Arnebiae (Radix Lithospermi) 4.5-8g, Radix Polygalae 6-12g, Cortex Moutan 6-12g, Radix Hedysari 10g, Ramulus Cinnamomi 3-8g;
B component: lentinan 25-50mg, grifolan 25-50mg, Ganoderma spore powder 0.2-0.5mg, Ganoderma mycelium (dry weight) 25-75mg, Ganderma lucidum pompon (dry weight) 25-50mg, Cordyceps polysaccharide 200-500mg, falmmulin 10-30mg, Agaricus blazei Murrill submerged fermentation liquid 50ml;
The C component: SOD 3000-5000IU, CAT 2000-3000IU, GSHPX2000-3000IU, Se, Cu, Zn, cysteine, tea polyphenols a little;
D component: Spica Prunellae 9-15g, Radix Paeoniae Rubra 6-15g, Rhizoma Polygoni Cuspidati 10-15g, Radix Paeoniae Alba 6-12g, Rhizoma Atractylodis Macrocephalae 6-10g, Rhizoma Polygonati 12-15g, Semen Cuscutae 6-10g, Herba Epimedii 5-9g, Radix Et Caulis Acanthopanacis Senticosi 15-25g, Radix Angelicae Sinensis 5-15g, Herba Cistanches 10-15g, Poria 10-15g, Radix Astragali 15-30g.
2, the multifunctional bio-active agent that is exclusively used in AIDS prevention and treatment according to claim 1 is characterized in that:
The A component also comprises: Angelica Polysaccharide 0.5mg, Calculus Bovis bile salts 100mg, Herba Houttuyniae 15g, Rhizoma Panacis Majoris 10g, Radix Trichosanthis 10g, Radix Codonopsis 15g, catechu 1.4g, Fructus Arctii 10g, Rhizoma Bolbostematis 4.5g, Fructus Ligustri Lucidi 8g, Radix Astragali 15g, Fructus Lycii 15g) after the winter wind dish chromosome doubling, artificial culture is got the aquatic foods 20ml that squeezes the juice of its 1-4 leaf in bottom);
The B component also comprises: Cordyceps AaBb fungus ball dry product 0.3g, and diameter is less than 0.3cm;
The D component also comprises: Radix Glycyrrhizae 8g, Radix Achyranthis Bidentatae 5g.
3, the multifunctional bio-active agent that is exclusively used in AIDS prevention and treatment according to claim 1 is characterized in that:
The A component also comprises: catechin 150 μ g, trichosanthin (trichosanthin that the 5g Radix Trichosanthis is extracted), glycoside and first 6.3 μ g that Fructus Arctii extracts, Radix Glycyrrhizae extract 1.5 μ g, Calculus Bovis bile salts 100mg, Tubeimuside I 15 μ g, Radix Trichosanthis 10g, Rhizoma Panacis Majoris 15g, Herba Houttuyniae 20g, Fructus Ligustri Lucidi 10g, Radix Et Caulis Acanthopanacis Senticosi 20g, Fructus Hippophae (Tibetan medicine) 6g, Radix Ophiopogonis 15g, Aloe 2.5g, Fructus Choerospondiatis (mongolian medicine) 2g, Radix Rhodiolae (mongolian medicine) 6g, Rhizoma Coptidis 2.5g, Radix Arnebiae (Radix Lithospermi) 6g, Radix Polygalae 8g, Radix Polygoni Multiflori Preparata 15g, Cortex Moutan 8g, Fructus Lycii 20g, Radix Codonopsis 20g, Radix Hedysari 10g, Ramulus Cinnamomi 3g;
The B component also comprises: Cordyceps AaBb fungus ball dry product 0.4g;
The C component also comprises: monkey mushroom polysaccharide 10 μ g;
The D component also comprises: Radix Achyranthis Bidentatae 6g.
4, the multifunctional bio-active agent that is exclusively used in AIDS prevention and treatment according to claim 1 is characterized in that:
The A component also comprises: catechin 180 μ g, the trichosanthin, (simple protein that does not contain sugar and phosphate group that the 15g Radix Trichosanthis is extracted, molecular weight 24000, isoelectric point, IP 9.4), glycoside that Fructus Arctii extracts and the 13 μ g of glycoside unit, Angelica Polysaccharide 0.5mg, Radix Glycyrrhizae extract 2.5mg, Tubeimuside I 20 μ g, the Radix Tripterygii Wilfordii good fortune is decided 0.3mg (tripterfordin), Herba Houttuyniae 25g, Radix Achyranthis Bidentatae 8g, Rhizoma Panacis Majoris 20g;
The B component also comprises: Cordyceps sporophore 0.15g, Cordyceps AaBb Stroma precursor 0.2g, Pleurotus ferulae Lanzi fermentation liquid 25ml;
The C component also comprises: ginseng royal jelly 5ml, monkey mushroom polysaccharide 0.25mg;
The D component also comprises: Fructus Ligustri Lucidi 12g, Radix Polygoni Multiflori Preparata 20g, Radix Codonopsis 30g.
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| CN 02100252 CN1363371A (en) | 2002-01-11 | 2002-01-11 | Multifunctional bio-active medicine for preventing and curing AIDS |
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| CN 02100252 CN1363371A (en) | 2002-01-11 | 2002-01-11 | Multifunctional bio-active medicine for preventing and curing AIDS |
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