CN103720793A - Traditional Chinese medicine composition for treating amnesia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating amnesia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating amnesia and a preparation method thereof. The composition is prepared from the following materials: cassia twig, Poria cocos, Cuscuta chinensis, astragalus, polygala tenuifolia, white atractylodes rhizome and white paeony root. The invention further provides the preparation method of the traditional Chinese medicine composition for treating the amnesia. The composition has the effects of warmly nourishing heart and spleen, reinforcing intelligence, calming the nerves, obviously improving memory and treating the amnesia.
Description
Technical field
The present invention relates to pharmaceutical sanitary field, be specifically related to a kind of forgetful Chinese medicine composition and preparation method thereof for the treatment of.
Background technology
In man memory process, be exactly that Cerebral Cortex Neuronal Cells is actively movable, the process that records and preserve, memory is relevant with the activity of brain cell on cerebral cortex.When carrying out mental activity, brain cell needs a large amount of oxygen.Although only 1.4 kilograms of people's brain weights, its oxygen consumption accounts for 1/ 5～1/4 of whole body oxygen consumption, is whole body oxygen demand maximum " rich anies influential family ", and institute's energy requirement all will be supplied with by cell.Power work is heavy or when nervous, the oxygen that it is required and nutrient all can increase exponentially, and because brain itself can not be laid in more energy, it needs other histiocytes in body that energy is supplied with it continuously, if supplement and can form brain fag not in time, brain asthenia.
At present, the health product that improve memory on market are mainly to take in various nutrient substance, and trace element, as DHA, zinc, ferrum, magnesium etc.Yet, bad if the absorption of trace element is controlled, can affect the absorption of other nutrient substance, for example, take in too much zinc, can affect the absorption of calcium, and affect the formation of skeleton.Studies have shown that, memory and attention have very large associated, and it is with single-hearted devotion to only have, and with breathless interest, information and object just can iron deep trace in cerebral cortex; Otherwise, absent minded, be not intended to note too much, can make people's hypomnesis.
The traditional Chinese medical science thinks, cloudy damage of essence void or deficient and weak YANG QI all can cause hypomnesis, when anything crops up forgetful.Therefore, treat and forgetfully from essence, start with and can obtain better effect.
Summary of the invention
The object of this invention is to provide a kind of forgetful Chinese medicine composition for the treatment of;
Another object of the present invention is to provide a kind of forgetful Chinese medicine composition preparation method for the treatment of.
The object of the invention is to realize by following technical scheme:
The Chinese medicine composition that treatment of the present invention is forgetful is to be prepared from by the raw material containing following weight portion:
Poria 15-25 part, Radix Astragali 15-25 part, Ramulus Cinnamomi 5-15 part, Semen Cuscutae 5-15 part, Radix Polygalae 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Radix Paeoniae Alba 5-15 part.
Preferably, be to be prepared from by the raw material containing following weight portion:
Poria 18-22 part, Radix Astragali 18-22 part, Ramulus Cinnamomi 8-12 part, Semen Cuscutae 8-12 part, Radix Polygalae 8-12 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Radix Paeoniae Alba 8-12 part.
More preferably, be to be prepared from by the raw material containing following weight portion:
20 parts, Poria, 20 parts of the Radixs Astragali, 10 parts of Ramulus Cinnamomi, 10 parts of Semen Cuscutae, 10 parts of Radix Polygalaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Radix Paeoniae Albas.
Below crude drug source of the present invention:
Poria: this product is On Polyporaceae Poria Poriacocos(Schw.) dry sclerotia of Wolf.More than 7～JIUYUE, excavate, after digging out, remove silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now wrinkle, the large portion of internal moisture scatter and disappear for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed to different parts cutting, and dry in the shade, be called " Cortex Sclerotii Poriae " and " Poria piece ".[nature and flavor] are sweet, light, flat.[return through] GUIXIN, lung, spleen, kidney channel.[function cures mainly] promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
The Radix Astragali: leguminous plant Radix Astagali Astragalusmembranaceus(Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalusmembranaceus(Fisch.) dry root of Bge..Spring, Qiu Erji excavate, and remove fibrous root and root head, dry.[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Ramulus Cinnamomi: (formal name used at school: Cinnamomum cassia Presl), have another name called beautiful osmanthus, Cortex cinnamomi japonici (Ramulus Cinnamomi) etc., belong to Ranales, the medium megaphanerophyte of Lauraceae.Its nature and flavor are pungent, sweet, enter liver,kidney,spleen, to cure mainly the conventional drugs for dispelling internal cold of interior cold, the effect with complement sun, promoting blood circulation, warming the spleen and stomach, normal and invigorating the liver and kidney medicine, medicine compatibility fills blood, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, with other drugs for dispelling internal cold compatibility treatment coldness and pain in the epigastrium, arthralgia due to cold lumbago, have the effect of obvious analgesia and anti-cancer and cancer-preventing.
Semen Cuscutae: this product is the dry mature seed of convolvulus cuscuta plant CuscutachinensisLam..The plant of gathering during fruit maturation autumn, dries, and lays seed, removes impurity.[nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Radix Polygalae is the dry root of milk wort Radix Polygalae and Siberia Radix Polygalae.Bitter in the mouth, pungent, temperature, GUIXIN, kidney, lung meridian, have the Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, and the function of detumescence, cures mainly the diseases such as disarmony between the heart and kidney, insomnia and dreamful sleep, forgetful palpitation with fear, staring spells, expectoration are not well, sore swollen toxin, breast swell and pain.Radix Polygalae is protected brain and nervous system is had calmness, convulsion, central blood pressure lowering, promotes muscle power and intelligence dementia; respiratory system is had to phlegm-dispelling functions; there is to stronger excitation in reproductive system uterus; human body is had to mutation, antitumor action; Diplococcus pneumoniae, gram positive bacteria, dysentery bacterium, Bacillus typhi and Bacillus tuberculosis are had to obvious inhibitory action, congested edema is had to inhibitory action.
The Rhizoma Atractylodis Macrocephalae: this product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoidz..When withered and yellow, the upper leaf of bottom leaf in winter becomes fragile, excavate, remove silt, dry or dry, then remove fibrous root.[nature and flavor] are bitter, sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, frequent fetal movement.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae PaeonialactifloraPall..Summer, Qiu Erji excavate, and clean, and remove end to end and radicula, put after removing crust or peeling after boiling in boiling water and boil, dry.[nature and flavor] are bitter, sour, are slightly cold.[return through] returns liver, spleen channel.The pain relieving of [function cures mainly] suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Be used for having a headache dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Another aspect of the present invention has been to provide the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the ethanol extraction that adopts water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:
Scheme one: get all medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
Scheme two: get all medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, add ethanol, making containing alcohol amount is 40-70%, and standing 12-24 hour filters, the extractum that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
Scheme three: get all medical materials, use 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10-1.25, obtains described active component.
The Chinese medicine composition that treatment of the present invention is forgetful, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms, as tablet, granule, capsule, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get scheme one to one of scheme three gained active component, add tablet to commonly use adjuvant, production method is prepared into tablet of the present invention routinely.
The conventional adjuvant of above-mentioned tablet comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: granule
Get scheme one to one of scheme three gained active component, add granule to commonly use adjuvant, production method is prepared into granule of the present invention routinely.
The conventional adjuvant of above-mentioned granule comprises one of diluent, wetting agent, binding agent, disintegrating agent or whole.
Method 3: capsule
Get scheme one to one of scheme three gained active component, add capsule to commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
The conventional adjuvant of above-mentioned capsule comprises one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 4: syrup
Get scheme one to one of scheme three gained active component, add syrup to commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
The conventional adjuvant of above-mentioned syrup comprises one of correctives, antiseptic, cosolvent or whole.
Method 5: mixture
Get scheme one to one of scheme three gained active component, add mixture to commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
The conventional adjuvant of above-mentioned mixture comprises one of correctives, antiseptic or whole.
Technical solution of the present invention meets the mechanism of tcm treatment according to syndrome differentiation, bases oneself upon the origin of disease, reasonable recipe science.
Provided by the inventionly a kind ofly treat forgetful Chinese medicine composition and have the following advantages:
1, the forgetful Chinese medicine composition for the treatment of provided by the invention is safe and effective, effect replenishing vital QI with drugs of warm nature heart spleen, and intelligent promoting and the mind tranquilizing, it is 82% that forgetful total effective rate is treated in clinical use.
2, Chinese medicine composition composition formula of the present invention is rationally innovated, and production cost is low, technique is simple.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.
Embodiment 1 syrup
Get Poria 20g, Radix Astragali 20g, Ramulus Cinnamomi 10g, Semen Cuscutae 10g, Radix Polygalae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 10g.By above-mentioned whole medical materials, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, and merge extractive liquid, filters the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water to stir, make syrup.
Embodiment 2 tablets
Get Poria 18g, Radix Astragali 18g, Ramulus Cinnamomi 8g, Semen Cuscutae 8g, Radix Polygalae 8g, Rhizoma Atractylodis Macrocephalae 8g, Radix Paeoniae Alba 8g.By above-mentioned whole medical materials, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid,, filters, the extractum that when filtrate concentrates 60 ℃, relative density is 1.25, add supplementary product starch, ethanol, Pulvis Talci, make tablet.
Embodiment 3 mixture
Get Poria 22g, Radix Astragali 22g, Ramulus Cinnamomi 12g, Semen Cuscutae 12g, Radix Polygalae 12g, Rhizoma Atractylodis Macrocephalae 12g, Radix Paeoniae Alba 12g.By above-mentioned whole medical materials, extracting in water 3 times, three amount of water are equivalent to respectively 12 times, 8 times, 6 times of medical material gross weight, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70 ℃, relative density is 1.20, adds ethanol, and making containing alcohol amount is 40%, standing 24 hours, filter, the extractum that when filtrate is concentrated into filtrate and is concentrated into 70 ℃, relative density is 1.10, adding purified water ad pond om is 3 times of medical material gross weight, fill, obtains mixture of the present invention.
Add mixture adjuvant sucrose, ethyl ester, water, sorbic acid to stir, make mixture.
Embodiment 4 tablets
Get Poria 15g, Radix Astragali 15g, Ramulus Cinnamomi 5g, Semen Cuscutae 5g, Radix Polygalae 5g, Rhizoma Atractylodis Macrocephalae 5g, Radix Paeoniae Alba 5g.By above-mentioned whole medical materials alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid,, filters the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.10, add supplementary product starch, ethanol, Pulvis Talci, make tablet.
Embodiment 5 capsules
Get Poria 25g, Radix Astragali 25g, Ramulus Cinnamomi 15g, Semen Cuscutae 15g, Radix Polygalae 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Alba 15g.By above-mentioned whole medical materials, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid,, filters the clear paste that when filtrate is concentrated into 70 ℃, relative density is 1.25, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, make capsule.
Embodiment 6 granules
Get Poria 25g, Radix Astragali 15g, Ramulus Cinnamomi 10g, Semen Cuscutae 12g, Radix Polygalae 12g, Rhizoma Atractylodis Macrocephalae 8g, Radix Paeoniae Alba 8g.By above-mentioned whole medical materials, extracting in water 2 times, each amount of water is equivalent to respectively 12 times, 10 times of medical material gross weight, each extraction time is respectively 3 hours, 2 hours, and merge extractive liquid, filters, filtrate is concentrated into the clear paste that at 80 ℃, relative density is 1.05, add ethanol, making containing alcohol amount is 70%, standing 12 hours, filter, the extractum that when filtrate is concentrated into 70 ℃, relative density is 1.25, adds adjuvant Icing Sugar, starch, dextrin, ethanol, makes granule.
Embodiment 7 powder
Take Poria 20g, Radix Astragali 20g, Ramulus Cinnamomi 10g, Semen Cuscutae 10g, Radix Polygalae 10g, Rhizoma Atractylodis Macrocephalae 10g, Radix Paeoniae Alba 10g.Medical material cleans, pulverizes, and crosses 80-100 mesh sieve, obtains powder of the present invention.
Embodiment 8
The granule that the embodiment of the present invention 6 is prepared, gives forgetful patient oral, and each 1 bag, every day 3 times, clinical data is as table 1:
The granule clinical data table that table 1 embodiment 6 is prepared
| Disorder class | Disease number of cases | Disease year calendar | Treatment time | Efficiently individual quantity | Total effective rate |
| Forgetful | 100 people | 2-3 | 1-6 month | 82 people | 82% |
Embodiment 9
Lee, man, 64 years old.Readme is when anything crops up forgetful, fails to carry through to the end, and companion's cardiopalmus is weak.Give the embodiment of the present invention 1 syrup, take after 7 days, the weak phenomenon of cardiopalmus alleviates, and is used in conjunction after 1 month, and forgetful symptom is clearly better.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvements it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
1. treat a forgetful Chinese medicine composition, it is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Poria 15-25 part, Radix Astragali 15-25 part, Ramulus Cinnamomi 5-15 part, Semen Cuscutae 5-15 part, Radix Polygalae 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Radix Paeoniae Alba 5-15 part.
2. the forgetful Chinese medicine composition for the treatment of as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Poria 18-22 part, Radix Astragali 18-22 part, Ramulus Cinnamomi 8-12 part, Semen Cuscutae 8-12 part, Radix Polygalae 8-12 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Radix Paeoniae Alba 8-12 part.
3. the forgetful Chinese medicine composition for the treatment of as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: 20 parts, Poria, 20 parts of the Radixs Astragali, 10 parts of Ramulus Cinnamomi, 10 parts of Semen Cuscutae, 10 parts of Radix Polygalaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Radix Paeoniae Albas.
4. the Chinese medicine composition as described in claim 1-3 any one, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get all medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
6. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get all medical materials, extracting in water 2-3 time, each amount of water is equivalent to 6-12 times of medical material gross weight, each extraction time is 1-3 hour, merge extractive liquid,, filter, the clear paste that when filtrate is concentrated into 70-80 ℃, relative density is 1.05-1.20, adds ethanol, and making containing alcohol amount is 40-70%, standing 12-24 hour, filter, the extractum that when filtrate is concentrated into 70-80 ℃, relative density is 1.10-1.25, obtains described active component.
7. Chinese medicine composition as claimed in claim 4, the active component that it is characterized in that it is prepared from by the following method: get all medical materials, with 40-80% alcohol reflux 2-3 time, the 4-10 that each ethanol consumption is medical material total amount doubly, extraction time is 1-3 hour, and merge extractive liquid, filters, the extractum that when filtrate is concentrated into 60-80 ℃, relative density is 1.10-1.25, obtains described active component.
8. treat a forgetful Chinese medicine composition, comprise acceptable carrier in Chinese medicine composition that the treatment of any one in claim 1-3 is forgetful and pharmaceuticals industry.
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| WO2002102397A1 (en) * | 2001-06-15 | 2002-12-27 | Korea Research Institute Of Chemical Technology | Use of an extract of the root of balloon-flower for preventing and treating a degenerative brain disease or for enhancing memory |
| CN101045150A (en) * | 2007-05-08 | 2007-10-03 | 葛月云 | Application of compound preparation in medical composition for tonifying-kidney, strengthening body and invigorating-brain |
| CN102178301A (en) * | 2011-04-21 | 2011-09-14 | 深圳市唤然生物科技开发有限公司 | Blueberry health care beverage and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102397A1 (en) * | 2001-06-15 | 2002-12-27 | Korea Research Institute Of Chemical Technology | Use of an extract of the root of balloon-flower for preventing and treating a degenerative brain disease or for enhancing memory |
| CN1363371A (en) * | 2002-01-11 | 2002-08-14 | 潘文光 | Multifunctional bio-active medicine for preventing and curing AIDS |
| CN101045150A (en) * | 2007-05-08 | 2007-10-03 | 葛月云 | Application of compound preparation in medical composition for tonifying-kidney, strengthening body and invigorating-brain |
| CN102178301A (en) * | 2011-04-21 | 2011-09-14 | 深圳市唤然生物科技开发有限公司 | Blueberry health care beverage and preparation method thereof |
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Application publication date: 20140416 |