CN103721051B - A kind of anti HIV-1 virus, the dispersible tablets of Chinese medicine improving immunity and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of anti HIV-1 virus, improve dispersible tablets of Chinese medicine of immunity and preparation method thereof, it is made up of the raw material of following weight portion: Fructus Lycii 10-15, Fructus Schisandrae Chinensis 5-10, Fructus Canarii 12-16, Calendula officinalis 15-20, Radix Achyranthis Bidentatae 10-15, Herba Lobeliae Chinensis 5-10, Cortex Eucommiae 10-15, Herba Hyperici Japonici 5-10, Radix Scrophulariae 10-15, Radix Polygoni Multiflori 5-10, Penthorum chinense 11-17, Radix Ilicis Pernyi 10-15, Poria 12-18, Radix Codonopsis 16-22, Rhizoma Atractylodis Macrocephalae 10-15, Hance Brandisia Herb 18-24, Carapax et Plastrum Testudinis 10-15, Radix Salviae Miltiorrhizae 5-10, Radix Astragali 10-15, Radix Paeoniae Rubra 12-18, Folium Ginseng 10-15, Gecko 5-10, Pheretima 10-15, Radix Dipsaci 5-10, Rhizoma Polygonati 10-15, Radix Puerariae 5-10, Radix Ophiopogonis 10-15, Herb Gynostemmae Pentaphylli 5-10, Rhizoma Dioscoreae 10-15, Folium paulowniae 5-10, Bulbus Lilii 10-15, Ganoderma 12-16, Radix Trichosanthis 5-10, cod-liver oil 4-7.Dispersible tablets of Chinese medicine of the present invention has significant inhibitory action to HIV virus, and improves immunity of organisms, improves patient clinical symptom, improves life in patients, extends HIV person's life.

Description

A kind of anti HIV-1 virus, the dispersible tablets of Chinese medicine improving immunity and preparation method thereof

Technical field

The present invention relates to the dispersible tablets of Chinese medicine relating to a kind of anti HIV-1 virus, improve immunity, belong to the field of Chinese medicines.

Background technology

Acquired immune deficiency syndrome (AIDS), i.e. acquired immune deficiency syndrome (AIDS), English name AcquiredImmuneDeficiencySyndrome, AIDS.Be the mankind because cause immunodeficiency, concurrent a series of opportunistic infection and tumor after infecting HIV (human immunodeficiency virus) (HumanImmunodeficiencyVirus, HIV), severe patient can cause dead syndrome.Western medicine due to treatment acquired immune deficiency syndrome (AIDS) is expensive and toxic and side effects large, therefore finds anti HIV-1 virus, and the Chinese medicine improving immunity of organisms becomes study hotspot.

Summary of the invention

In order to overcome the deficiencies in the prior art, the object of the present invention is to provide a kind of anti HIV-1 virus, improving the dispersible tablets of Chinese medicine of immunity, improving patient clinical symptom, improve life in patients, extend patient vitals.

For achieving the above object, the present invention adopts following technical scheme:

A kind of anti HIV-1 virus, improve the dispersible tablets of Chinese medicine of immunity, be made up of the raw material of following weight portion: Fructus Lycii 10-15, Fructus Schisandrae Chinensis 5-10, Fructus Canarii 12-16, Calendula officinalis 15-20, Radix Achyranthis Bidentatae 10-15, Herba Lobeliae Chinensis 5-10, Cortex Eucommiae 10-15, Herba Hyperici Japonici 5-10, Radix Scrophulariae 10-15, Radix Polygoni Multiflori 5-10, Penthorum chinense 11-17, Radix Ilicis Pernyi 10-15, Poria 12-18, Radix Codonopsis 16-22, Rhizoma Atractylodis Macrocephalae 10-15, Hance Brandisia Herb 18-24, Carapax et Plastrum Testudinis 10-15, Radix Salviae Miltiorrhizae 5-10, Radix Astragali 10-15, Radix Paeoniae Rubra 12-18, Folium Ginseng 10-15, Gecko 5-10, Pheretima 10-15, Radix Dipsaci 5-10, Rhizoma Polygonati 10-15, Radix Puerariae 5-10, Radix Ophiopogonis 10-15, Herb Gynostemmae Pentaphylli 5-10, Rhizoma Dioscoreae 10-15, Folium paulowniae 5-10, Bulbus Lilii 10-15, Ganoderma 12-16, Radix Trichosanthis 5-10, cod-liver oil 4-7.

Preferably, a kind of anti HIV-1 virus, improve the dispersible tablets of Chinese medicine of immunity, be made up of the raw material of following weight portion: Fructus Lycii 15, Fructus Schisandrae Chinensis 10, Fructus Canarii 14, Calendula officinalis 18, Radix Achyranthis Bidentatae 10, Herba Lobeliae Chinensis 8, the Cortex Eucommiae 12, Herba Hyperici Japonici 8, Radix Scrophulariae 15, Radix Polygoni Multiflori 8, Penthorum chinense 14, Radix Ilicis Pernyi 12, Poria 16, Radix Codonopsis 18, the Rhizoma Atractylodis Macrocephalae 12, Hance Brandisia Herb 22, Carapax et Plastrum Testudinis 12, Radix Salviae Miltiorrhizae 8, the Radix Astragali 105, Radix Paeoniae Rubra 16, Folium Ginseng 15, Gecko 8, Pheretima 12, Radix Dipsaci 8, Rhizoma Polygonati 15, Radix Puerariae 8, Radix Ophiopogonis 10, Herb Gynostemmae Pentaphylli 8, Rhizoma Dioscoreae 10, Folium paulowniae 10, Bulbus Lilii 15, Ganoderma 14, Radix Trichosanthis 8, cod-liver oil 5.

A preparation method for the dispersible tablets of Chinese medicine of anti HIV-1 virus, raising immunity, comprises the following steps:

(1) get Radix Scrophulariae, Poria, Radix Puerariae, Ganoderma, Rhizoma Dioscoreae, Rhizoma Polygonati and Radix Astragali mix homogeneously, be ground into fine powder, sieve for subsequent use;

(2) get Fructus Lycii, Fructus Schisandrae Chinensis, Radix Achyranthis Bidentatae, Herba Lobeliae Chinensis, Herba Hyperici Japonici, Radix Polygoni Multiflori, Penthorum chinense, Radix Ilicis Pernyi, Radix Codonopsis, Carapax et Plastrum Testudinis, Gecko, Pheretima and Herb Gynostemmae Pentaphylli and mix mix homogeneously, decoct with water secondary, first time adds 4-8 times of water gaging, second time adds 3-6 times of water gaging, each decoction 1-3 hour, filters, merging filtrate, be concentrated into appropriate, adding 75% ethanol makes alcohol content be 50-60%, leaves standstill 24-36 hour, filters, filtrate is concentrated into the thick paste that relative density is 1.31-1.34, for subsequent use;

(3) Fructus Canarii, Calendula officinalis, the Cortex Eucommiae, the Rhizoma Atractylodis Macrocephalae, Hance Brandisia Herb, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Folium Ginseng, Radix Dipsaci, Radix Ophiopogonis, Folium paulowniae, Bulbus Lilii mix homogeneously is got, add the water of 5-10 times amount, reflux 1-2h,, distillation, after collecting first distillate, redistillation 0.5-1h, merge distillate, extract volatile oil, for subsequent use;

(4) add volatile oil, Radix Trichosanthis, cod-liver oil and appropriate dextrin that the obtained fine powder of step (1), step (3) are obtained in the thick paste that step (2) is obtained, mix homogeneously, granulates, and dry, tabletting, coating, gets product.

Usage and consumption: oral, a 3-5 sheet, 2-3 time on the one.

Beneficial effect of the present invention:

The all medicines of the present invention share have protect the liver, the kidney invigorating, enrich blood, QI invigorating, YANG invigorating, antiviral, improve immunity, profit joint, nourishing the lung to arrest cough, heat-clearing and toxic substances removing, invigorating the spleen and regulating the stomach, keep fit the multiple actions such as strong bone, to HIV virus, there is significant inhibitory action, and improve immunity of organisms, improve patient clinical symptom, improve life in patients, extend HIV person's life.

Detailed description of the invention

A dispersible tablets of Chinese medicine for anti HIV-1 virus, raising immunity, is made up of the raw material of following weight (g): Radix Codonopsis 15, Fructus Rosae Laevigatae 8, Semen Raphani 16, Caulis Cucurbitae 14, Herba Houttuyniae 22, Folium Kaki 12, Radix Polygalae 8, Herba Pogostemonis 12, Herba Menthae 8, Radix Glycyrrhizae 10, Folium Perillae 8, Flos Farfarae 15, Radix Asteris 11, Radix Peucedani 10, tilia europaea 10, Bulbus Fritillariae Cirrhosae 16, Fructus Psoraleae 13, Fructus Momordicae 12, Radix ziziphi mauritianae 8, Radix Platycodonis 14, Poria 11, Semen Sterculiae Lychnophorae 12, Herb Gynostemmae Pentaphylli 8.

A preparation method for the dispersible tablets of Chinese medicine of anti HIV-1 virus, raising immunity, comprises the following steps:

(1) get Radix Scrophulariae, Poria, Radix Puerariae, Ganoderma, Rhizoma Dioscoreae, Rhizoma Polygonati and Radix Astragali mix homogeneously, be ground into fine powder, sieve for subsequent use;

(2) get Fructus Lycii, Fructus Schisandrae Chinensis, Radix Achyranthis Bidentatae, Herba Lobeliae Chinensis, Herba Hyperici Japonici, Radix Polygoni Multiflori, Penthorum chinense, Radix Ilicis Pernyi, Radix Codonopsis, Carapax et Plastrum Testudinis, Gecko, Pheretima and Herb Gynostemmae Pentaphylli and mix mix homogeneously, decoct with water secondary, first time adds 6 times of water gagings, second time adds 4 times of water gagings, each decoction 2 hours, filters, merging filtrate, be concentrated into appropriate, adding 75% ethanol makes alcohol content be 60%, leaves standstill 36 hours, filters, filtrate is concentrated into the thick paste that relative density is 1.32, for subsequent use;

(3) get Fructus Canarii, Calendula officinalis, the Cortex Eucommiae, the Rhizoma Atractylodis Macrocephalae, Hance Brandisia Herb, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Folium Ginseng, Radix Dipsaci, Radix Ophiopogonis, Folium paulowniae, Bulbus Lilii mix homogeneously, add the water of 8 times amount, reflux 1.5h, distillation, after collecting first distillate, redistillation 1h, merge distillate, extract volatile oil, for subsequent use;

(4) add volatile oil, Radix Trichosanthis, cod-liver oil and appropriate dextrin that the obtained fine powder of step (1), step (3) are obtained in the thick paste that step (2) is obtained, mix homogeneously, granulates, and dry, tabletting, coating, gets product.

Usage and consumption: be decocted in water for oral dose, every day 1 dose, point 2-3 clothes.

Dispersible tablets of Chinese medicine of the present invention is to the systematic treating of acquired immune deficiency syndrome (AIDS), have accumulated a large amount of clinical datas, up to the present, the case having more complete case history to record is nearly thousand examples, control in AIDS in Chinese medicine examination and gained most valuable experience, wherein most patients has all adhered to the Chinese medicine of long term, and some patients adheres to that Chinese traditional treatment reaches more than 10 years, existing as follows to the more complete 729 routine brief summaries of record:

Case is the patient starting with Chinese traditional treatment in August ,-2011 January calendar year 2001, is the case that hospital is confirmed by clinical and laboratory.All cases carries out ELISA all before the treatment and checks that HIV antibody is for positive, and some cases is repeatedly checked or diagnosed further through WB and PCR.Male 267 example in 729 routine patients, women 462 example, minimum is 7 years old, is 64 years old to the maximum.In 729 routine patients, belong to silent HIV person 155 example during first visit, symptomatic HIV person 450 example, AIDS person 124 example, 523 examples of being infected with malaria before treatment or in treatment, tuberculosis 54 example, merges anemia 45 example, hypertension 11 example.The Ureteral Calculus time is less than 1 year person 300 example, 1-3 person 208 example, 3-5 person 131 example, more than 5 years person 90 examples.

The symptom that degree is different has been there is in 729 routine patients when first visit, its cardinal symptom comprises: weak 158 examples (62.8%), 233 examples of coughing (45.7%), erythra 313 example (42.9%), 312 examples of generating heat (42.8%), large 173 examples (23.7%) of lymph node, 128 examples of suffering from diarrhoea (17.5%), chest pain 96 example (13.2%), skin is itched 42 examples (5.7%), herpes zoster 42 example (5.7%), 37 examples of having a headache (5.1%), spontaneous perspiration or night sweat person 37 example (5.1%), indigestion and loss of appetite 35 examples (4.8%), aphtha 27 example (3.7%), 22 examples of becoming thin (3.0%), arthralgia 14 example (1.9%), other are as numb limbs and tense tendons, pudendal pruritus 6 example, cardiopalmus 5 example, skin infection furuncle and phyma 4 example, stomachache 4 example, pharyngalgia 3 example, menoxenia 2 example, backache, lumbago, skelalgia, facial paralysis, distending pain of the breast.Patient mainly with weak, cough, erythra, heating, lymphadenectasis, diarrhoea etc. for cardinal symptom is gone to a doctor, to take after dispersible tablets of Chinese medicine of the present invention patient's above-mentioned symptom be improved significantly, immunity of organisms significantly improves.

T lymphocyte subset group changes: patient's immune state time medical: have 722 routine patients to measure its CD4 and count, minimum is 0, be up to 1240, average out to 254.52 ± 157.10cell/ml, 666 examples have carried out CD4/CD8 ratio measuring, it is minimum is 0, is up to 2.33, average out to: 0.37 ± 0.29.Wherein 542 examples have carried out more than twice immunologic function check, are respectively 262.03 ± 187.81 before treatment, and last check CD4 is counted as 258.31 ± 217.76, and observed mean time is 18.65 ± 21.32 months.Ratio calculation before and after having had 507 examples to carry out, is: 0.392 ± 0.292 first, and last check is 0.337 ± 0.315.

The relation of table 1CD4 classification and curative effect

As can be seen from Table 1, dispersible tablets of Chinese medicine of the present invention has the effect significantly improving immunologic function, and especially CD4 counting is in reduced levels (<200) HIV sufferers, thus improves patient clinical symptom, improve life in patients, extend HIV person's life.

Claims (2)

1. an anti HIV-1 virus, improve the dispersible tablets of Chinese medicine of immunity, it is characterized in that, be made up of the raw material of following weight portion: Fructus Lycii 10-15, Fructus Schisandrae Chinensis 5-10, Fructus Canarii 12-16, Calendula officinalis 15-20, Radix Achyranthis Bidentatae 10-15, Herba Lobeliae Chinensis 5-10, Cortex Eucommiae 10-15, Herba Hyperici Japonici 5-10, Radix Scrophulariae 10-15, Radix Polygoni Multiflori 5-10, Penthorum chinense 11-17, Radix Ilicis Pernyi 10-15, Poria 12-18, Radix Codonopsis 16-22, Rhizoma Atractylodis Macrocephalae 10-15, Hance Brandisia Herb 18-24, Carapax et Plastrum Testudinis 10-15, Radix Salviae Miltiorrhizae 5-10, Radix Astragali 10-15, Radix Paeoniae Rubra 12-18, Folium Ginseng 10-15, Gecko 5-10, Pheretima 10-15, Radix Dipsaci 5-10, Rhizoma Polygonati 10-15, Radix Puerariae 5-10, Radix Ophiopogonis 10-15, Herb Gynostemmae Pentaphylli 5-10, Rhizoma Dioscoreae 10-15, Folium paulowniae 5-10, Bulbus Lilii 10-15, Ganoderma 12-16, Radix Trichosanthis 5-10, cod-liver oil 4-7.

2. a preparation method for the dispersible tablets of Chinese medicine of anti HIV-1 virus as claimed in claim 1, raising immunity, is characterized in that comprising the following steps:

(1) get Radix Scrophulariae, Poria, Radix Puerariae, Ganoderma, Rhizoma Dioscoreae, Rhizoma Polygonati and Radix Astragali mix homogeneously, be ground into fine powder, sieve for subsequent use;

(2) get Fructus Lycii, Fructus Schisandrae Chinensis, Radix Achyranthis Bidentatae, Herba Lobeliae Chinensis, Herba Hyperici Japonici, Radix Polygoni Multiflori, Penthorum chinense, Radix Ilicis Pernyi, Radix Codonopsis, Carapax et Plastrum Testudinis, Gecko, Pheretima and Herb Gynostemmae Pentaphylli mix homogeneously, decoct with water secondary, first time adds 4-8 times of water gaging, second time adds 3-6 times of water gaging, each decoction 1-3 hour, filters, merging filtrate, be concentrated into appropriate, adding 75% ethanol makes alcohol content be 50-60%, leaves standstill 24-36 hour, filters, filtrate is concentrated into the thick paste that relative density is 1.31-1.34, for subsequent use;

(3) Fructus Canarii, Calendula officinalis, the Cortex Eucommiae, the Rhizoma Atractylodis Macrocephalae, Hance Brandisia Herb, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Folium Ginseng, Radix Dipsaci, Radix Ophiopogonis, Folium paulowniae, Bulbus Lilii mix homogeneously is got, add the water of 5-10 times amount, reflux 1-2h,, distillation, after collecting first distillate, redistillation 0.5-1h, merge distillate, extract volatile oil, for subsequent use;

(4) add volatile oil, Radix Trichosanthis, cod-liver oil and appropriate dextrin that the obtained fine powder of step (1), step (3) are obtained in the thick paste that step (2) is obtained, mix homogeneously, granulates, and dry, tabletting, coating, gets product.