CN101856387A - Chinese herbal immunopotentiator for chicken - Google Patents
Chinese herbal immunopotentiator for chicken Download PDFInfo
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- CN101856387A CN101856387A CN 201010193946 CN201010193946A CN101856387A CN 101856387 A CN101856387 A CN 101856387A CN 201010193946 CN201010193946 CN 201010193946 CN 201010193946 A CN201010193946 A CN 201010193946A CN 101856387 A CN101856387 A CN 101856387A
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Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a Chinese herbal immunopotentiator for chicken as oral liquid comprising the following raw materials in parts by weight: 4-5 parts of Echinacea purpurea, 2-4 parts of hoantchy root, 0.5-1.5 parts of rhodiola root, 1-3 parts of Dangshen and 0.5-1.5 parts of liquorice. The Chinese herbal immunopotentiator for chicken is prepared by the following steps of: crashing the raw materials, mixing, boiling with water for leaching, concentrating and encapsulating. The Chinese herbal immunopotentiator for chicken has better effects of reinforcing the disease resistance and the disease prevention of chicken and increasing immunizing power.
Description
Technical field
The present invention relates to a kind of chicken and use the Chinese herbal medicine immunostimulant.
Background technology
In recent years, ubiquity after the immunity inoculation still outbreak of epidemic of infectious disease in the poultry husbandry, and dosage strengthens and do not reach the situation of ideal treatment, and wherein one of reason is that immunologic function degression causes.Cause mycotoxin content overproof, stressors and hormonal medicaments, alkanisation Application of disinfectants etc. in the influence, feedstuff of the factor of immunologic function degression such as maternal antibody interference, malnutrition, immunosuppressive disease, and these factors are common on producing.To address this problem effectively, just necessary activating immune system, promote the macrophage picked-up, handle and transmit antigen, regulate and strengthen the T/B cell respond, increase the quantity of T/B cell and promote it to reach maturity, make chicken after vaccination, can obtain high-caliber immune response.At present, chemicals para-immunity reinforcing agent all exists the drawback that toxic and side effects, drug residue and interim medication do not reach ideal effect to some extent.Chinese herbal medicine belongs to natural, green medicine to animal and human security, have no side effect, meets international veterinary development trend.Therefore, the research of Chinese herbal medicine immunostimulant receives publicity day by day.At present, the practical effect of commercially available Chinese herbal medicine immunostimulant is unsatisfactory.
Summary of the invention
The objective of the invention is at the problems referred to above, a kind of immunity that can improve chicken is provided, strengthen chicken disease-resistant, the diseases prevention ability and use the Chinese herbal medicine immunostimulant.
Technical scheme of the present invention is: a kind of chicken is used the Chinese herbal medicine immunostimulant, and it is the oral liquid of being made by the following weight proportion raw material: Echinacea 4-5 part, Radix Astragali 2-4 part, Radix Rhodiolae 0.5-1.5 part, Radix Codonopsis 1-3 part, Radix Glycyrrhizae 0.5-1.5 part.
The preferred raw material weight proportioning of the present invention is: 4 parts of Echinaceas, 2 parts of the Radixs Astragali, 1 part of Radix Rhodiolae, 2 parts of Radix Codonopsis, 1 part in Radix Glycyrrhizae.
Each component pharmacological effect is as follows in the prescription of the present invention:
1, Echinacea effect: Echinacea contains polysaccharide, flavone, caffeinic derivant, quintessence oil, polyacetylene, alkylamine and alkaloid.Echinacea has immunostimulation, reduces inflammation, and helps body to antibacterium and virus.Relevant test shows uses the Echinacea feeding animals, can improve the quantity of the phagocytic activity and the periphery lymphocyte of neutrophil cell, the immunocompetence of effective stimulus animal body; The Echinacea root is made feed additive feed chicken, can obviously increase the experimental group body weight and reduce the infection rate of coccidiosis.
2, Radix Astragali effect: the Radix Astragali contains various trace elements such as Saponin, flavone, polysaccharide, several amino acids, folic acid and selenium, zinc, copper, has the enhancing human body immunity function, protects the liver, diuresis, blood pressure lowering, defying age, anti-hypoxia, radioprotective, anti-stress, low temperature resistant and high temperature resistant effect.Animal experiment proves, can increase the phagocytic function of reticuloendothelial system, and enhancing antibody forms, and improves E-rosettes rate, and the differentiation that promotes the T cell strengthens the cytotoxic activity of NK cell with ripe, induces the generation interferon; The inductive chicken peripheral blood B of bacteria lipopolysaccharide lymphocyte in-vitro multiplication also there is obvious facilitation; The effect of strengthening capillary resistance is arranged, the phenomenon of the increased capillary permeability that can cause antihistaminic, chloroform.The Radix Astragali has stronger antibacterial action external to dysentery bacterium, diphtheria corynebacterium, Hemolytic streptococcus, Diplococcus pneumoniae, staphylococcus aureus etc., and the cytopathy due to animal influenza virus, the adenovirus etc. is had inhibitory action.
3, Radix Rhodiolae effect: Radix Rhodiolae contains 35 kinds of trace element, 18 seed amino acids, vitamin A, D, E and activity of fighting against senium superoxides.Discover, Radix Rhodiolae has stronger regulating action to the animal central nervous system, resisting fatigue, anti-hypoxia, cold resistance, defying age, radioprotective, preventing tumor and antiinflammatory preferably, detoxifcation, the effect of raising autoimmunity are arranged, be the potential activator of body self cell, organism nervous system, blood circulation, metabolic system, hormonal system etc. are had the good whole opsonic action.
4, Radix Codonopsis effect: Radix Codonopsis mainly contains sterol, tangshenoside, Radix Codonopsis polysaccharide, codonolactone, alkaloid and 17 seed amino acids, and 14 kinds of inorganic salts such as 11 kinds of trace element such as iron content, zinc, copper, manganese, chromium, brill, aluminum and potassium, sodium, calcium, phosphorus, magnesium, have pharmacological action widely.Radix Codonopsis hydroalcoholic extract and decoct all can increase the quantity of animal erythrocyte, hemoglobin, reticulocyte, the effect of anticoagulant.Radix Codonopsis can increase the peritoneal macrophage phagocytic function, improves lymhocyte transformation rate, E-rosette forming rate, can also increase the weight of animals, effects such as slow down aging, anoxia enduring, radioprotective.
5, Radix Glycyrrhizae effect: Radix Glycyrrhizae mainly contains compositions such as glycyrrhizic acid, glycyrrhizin, 24-hydroxyl enoxolone, licoflavone, glycyrrhizin, isoliquiritigenin, Angelica Polysaccharide, has antiulcer, promotes pancreatic secretion, protects the liver, the effects such as phagocytic function of blood fat reducing, adjusting macrophage.Glycyrrhizic acid is natural antidote, can be used for body defying age, enhancing immunity, keeps water-electrolyte metabolism balance etc.; Angelica Polysaccharide has anti-adenovirus type III, herpes simplex virus I-type activity.
Prescription foundation of the present invention: this prescription strengthens disease-resistant, the diseases prevention ability of chicken with strengthening vital QI to eliminate pathogenic factors, and raising immunity is principle.Echinacea has immunostimulation in the side, reduces inflammation, and can help body to antibacterium and virus; Radix Rhodiolae has invigorating the spleen and benefiting QI, clearing away lung-heat to relieve cough, the effect of blood circulation promoting and blood stasis dispelling; The Radix Astragali, Radix Codonopsis have invigorating the spleen and replenishing QI, promote the production of body fluid and nourish blood, and strengthening vital QI to eliminate pathogenic factors is regulated body's immunity; Sweet temperature QI invigorating of Radix Glycyrrhizae and middle spleen invigorating, current twelve channels and collaterals, coordinating the actions of various ingredients in a prescription.In the side all medicines mutually and, play strengthening vital QI to eliminate pathogenic factors, invigorating the spleen and replenishing QI altogether, promote the production of body fluid nourish blood, the effect of human body immunity improving power and resistance against diseases.
The immunosuppressive disease that reasons such as that the present invention is applicable to is improper by pathogenic microorganism, drug use, malnutrition and mycotoxin cause.For oral liquid is made in convenient application in the fowl disease control.
The present invention can strengthen that chicken is disease-resistant, the diseases prevention ability, improves immunity, uses the Chinese herbal medicine immunostimulant as chicken, has good effect.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment:
1, takes by weighing raw material (prepared slices of Chinese crude drugs) respectively: Echinacea 400g, Radix Astragali 200g, Radix Rhodiolae 100g, Radix Codonopsis 200g, Radix Glycyrrhizae 100g, 1000g altogether;
2, the above-mentioned raw materials pulverize separately is become the Chinese medicine coarse powder;
3, the Radix Astragali, Radix Rhodiolae, Radix Codonopsis, Radix Glycyrrhizae four flavor Chinese medicine coarse powder are mixed, add water 7000ml and soaked 1 hour, water was opened slow fire boiling after 30 minutes, put into Echinacea, and slow fire decocted 10 minutes again; Filter; Add water 5000ml more at every turn and decoct secondary, each 20 minutes;
4, filter, merge three times filtrate, be concentrated into about 900ml, add 0.05% sodium benzoate, add water to 1000ml, stir evenly, filter as antiseptic, fill, sterilization is promptly made chicken of the present invention and is used the Chinese herbal medicine immunostimulant.
Some test situation of utilizing the present invention to carry out are as follows:
1, Chinese herbal medicine immunostimulant of the present invention is to chicken immune allelotaxis's influence
80 the 21 blue brown chickens in the healthy sea of age in days are divided into 2 groups at random, and 40 every group, 1 group is test group, according to every chicken 1.0ml/ dosage, drinks immunostimulant of the present invention every day once, continuous 21d, and 2 groups is matched group, not medication.Respectively at 7d behind the drink medicine, 14d, 21d respectively gets 10 chickens at random for every group and measures the immune organ coefficients.The result shows: test group immune organ index is significantly higher than matched group (P＜0.05); The fabricius bursa pleat is significantly greater than matched group, and the thymic lobule area is significantly higher than matched group (P＜0.05), and spleen lymphocyte quantity is significantly higher than matched group (P＜0.05).The weight and the index of immune organs such as the thymus of test group chickling, spleen and fabricius bursa obviously increase, and the allelotaxis has obvious facilitation to chicken immune.
2, Chinese herbal medicine immunostimulant of the present invention is to the influence of immunocyte quantity in the harder's glands
120 the 1 blue brown chickens in age in days sea are divided into 3 groups at random, every group 40, be divided into 0.5% medication group, 1% medication group and matched group, wherein 0.5% medication group and 1% medication group are drunk Chinese herbal medicine immunostimulant of the present invention, continuous use every day by 0.5% and 1% concentration respectively in drinking-water.And 24d, 36d, every group of harder's glands of respectively getting 10 chickens at random of 48d are made tissue slice behind the drink medicine, carry out histological observation, immuning cell number in the statistics chicken harder's glands.The result shows: immuning cell number is apparently higher than matched group in the two medication group chicken harder's glandses, immunocyte quantity will be lacked than the quantity of immunocyte in the 1% medication group in the 0.5% medication group, illustrates that the quantity of chicken harder's glands generation immunocyte is relevant with the concentration of Chinese herbal medicine immunostimulant.
3, Chinese herbal medicine immunostimulant of the present invention is to chicken leukocytes phagocytic ability and T lymphocyte dynamic effects
With 90 of the blue brown chickens in 12 ages in days sea, be divided into 3 groups at random, 30 every group, promptly test I group, test II group and matched group.The I group is added Chinese herbal medicine immunostimulant of the present invention by 1% concentration in drinking-water; The II group is added Chinese herbal medicine immunostimulant of the present invention by 0.5% concentration in drinking-water; The matched group chicken freely drinks water, and does not add any ingredient.Venous blood collection under the wing when the 22nd, 32,42,52,62 ages in days, smear, microscopy.The result shows: the effect of 1% concentration group is best, is better than 0.5% concentration group, and the matched group effect is the poorest; The Chinese herbal medicine immunostimulant can significantly improve animal body mononuclear cell, eosinophilic granulocyte's activity, improves leukocytic phagocytic activity.E-rosette result shows, 1% concentration group T-lymphocyte garland formation rate and the poor heteropole of matched group be (P＜0.01) significantly, 0.5% concentration group lymphocyte garland formation rate and matched group comparing difference be (P＜0.05) significantly, 1% concentration group and 0.5% concentration group are not remarkable at 22,32,42 age in days comparing differences, in 52,62 age in days comparing differences remarkable (P＜0.05), Chinese herbal medicine immunostimulant of the present invention can obviously increase the lymphocytic quantity of chicken T-.Wherein the highest with 1% concentration group garland formation rate, 0.5% concentration group is taken second place.
4, Chinese herbal medicine immunostimulant of the present invention is to the influence of infectious bursal disease antibody horizontal
Select 4288 of 85 age in days laying hens, the chicken of participating in the experiment is through twice infectious bursal disease agar gel diffusion test, mycoplasma gallinarum agglutination test, Pullorum Disease agglutination test, and is all negative.Chicken is divided into this Chinese herbal medicine immunostimulant test group and matched group at random, and 2144 every group, grouping and immune programme for children see Table 1.
Table 1 test grouping and immune programme for children (unit: only)
Behind each immune 10d, gather determination of serum infectious bursal disease fine jade and expand antibody titer.Each group was got 20 chickens at random and is measured the infectious bursal disease antibody titer with agar gel diffusion test after head exempted from, and the immunostimulant group is 2.2log2, and matched group is 1.2log2; Two exempt from afterwards, and immunostimulant group antibody titer is 7.6log2, and matched group is 4.4log2.Two exempt from each group of back attacks infectious bursa of Fabricius virus, and the immunostimulant group is observed through 6d, and no abnormality seen cuts open during 7d and examines also no abnormality seen, protective rate 100%; Matched group sees that indivedual chicken essence god are depressed, the quilt hair is contrary disorderly, appetite minimizing, spiritual depressed, the white medicated porridge rice water sample feces of 20% chicken performance diarrhoea, other no abnormality seen.Observe 6d, do not see death, 7d cuts open inspection and sees that 20% chicken bursa has Mild edema, in exudate is arranged, protective rate about 80%.
Show by every test, Chinese herbal medicine immunostimulant of the present invention all improves significantly to immunocyte quantity, chicken leukocytes phagocytic ability and every indexs such as T lymphocyte quantity and infectious bursal disease antibody titer in chicken immune allelotaxis, the harder's glands.
Claims (2)
1. a chicken is used the Chinese herbal medicine immunostimulant, it is characterized in that it is the oral liquid of being made by the following weight proportion raw material: Echinacea 4-5 part, Radix Astragali 2-4 part, Radix Rhodiolae 0.5-1.5 part, Radix Codonopsis 1-3 part, Radix Glycyrrhizae 0.5-1.5 part.
2. chicken according to claim 1 is used the Chinese herbal medicine immunostimulant, it is characterized in that it is the oral liquid of being made by the following weight proportion raw material: 4 parts of Echinaceas, 2 parts of the Radixs Astragali, 1 part of Radix Rhodiolae, 2 parts of Radix Codonopsis, 1 part in Radix Glycyrrhizae.
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