CN104686806A - Compound feed additive for enhancing broiler chicken immunity - Google Patents
Compound feed additive for enhancing broiler chicken immunity Download PDFInfo
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- CN104686806A CN104686806A CN201510130882.8A CN201510130882A CN104686806A CN 104686806 A CN104686806 A CN 104686806A CN 201510130882 A CN201510130882 A CN 201510130882A CN 104686806 A CN104686806 A CN 104686806A
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Abstract
The invention provides a compound feed additive for enhancing broiler chicken immunity. The compound feed additive is prepared by 28-50 parts of rhodiola glucoside, 15-27 parts of hydrochloric acid berbamine, 9-22 parts of pueraria root extract, 7-20 parts of schisanhenol and 6-16 parts of eupolyphaga powder. The compound feed additive can effectively promote growth of broiler chicken immune organs, obviously improve the level of immune globulin IgG in serum, the lymphocyte transformation rate and the leukocyte phagocytic ability, increase the number of T-lymphocytes and enhance the body liquid and the cellular immune function of broiler chickens, and therefore the incidence rate of diseases and the use frequency of antibiotic and other medicine are reduced, and direct economic and social benefits are achieved.
Description
Technical field:
The present invention relates to poultry cultural technique field, specifically relate to a kind of composite feed additive strengthening immunity of meat chickens.
Background technology:
Body's immunity state is the important indicator of reflection animal health condition, and the power of immunologic function directly affects animal health level.In the broiler production process of modern intensive, broiler chicken is inevitably subject to the impact of various environmental stress factor, its immunologic function is usually in and suppresses or low state, produce various disease.People generally use the chemical synthetic drugs such as antibiotic to prevent and treat its disease in broiler production for this reason, and result then causes the reduction that harmful bacteria produces drug resistance and broiler chicken autoimmunity, and causes chicken drug residue, and harm humans is healthy then.Therefore, improving immunity of meat chickens is maintain broiler chicken normally to raise and resist disease and reduce the effective means of antibiotic etc use.
Summary of the invention:
The object of the present invention is to provide a kind of composite feed additive strengthening immunity of meat chickens, it can not only promote that the Immune Organs of Body of broiler chicken is grown, body humoral and cellular immune response function and oxidation resistance can also be improved, strengthen the immune level of body, thus improve the general level of the health and the efficiency of feed utilization of broiler chicken, promote growth of meat chicken.
Above-mentioned object is realized by following technical scheme:
Strengthen a composite feed additive for immunity of meat chickens, described composite feed additive is prepared from by weight by following component:
Rhodioside 28 ~ 50 parts
Berbamine hydrochloride 15 ~ 27 parts
Kudzu root extract 9 ~ 22 parts
Schisanhenol 7 ~ 20 parts
Eupolyph aga sinesis Walker 6 ~ 16 parts.
Further scheme, described composite feed additive is prepared from by weight by following component: rhodioside 50 parts, Berbamine hydrochloride 15 parts, kudzu root extract 22 parts, schisanhenol 7 parts, Eupolyph aga sinesis Walker 6 parts.
Further scheme, the 0.15-0.35% of daily ration quality based on the addition of described composite feed additive.
Described Eupolyph aga sinesis Walker refers to crosses gained after 40 mesh sieves by female ground bettle adult after pulverizer is pulverized.
In the present invention, composite feed additive preparation method is: take each component according to parts by weight, mixes again, obtain this composite feed additive after first commercial ground bettle being crossed 40 mesh sieves after pulverizer is pulverized with other component.
Composite feed additive the present invention prepared adds feeding in chicken feed to by the 0.15-0.35% of basal diet quality, obviously can promote that the Immune Organs of Body of broiler chicken is grown, body humoral and cellular immune response function and oxidation resistance can also be improved, strengthen the immune level of body, thus improve the general level of the health and the efficiency of feed utilization of broiler chicken, promote growth of meat chicken.
In composite feed additive of the present invention: rhodioside is a kind of compound extracted from the dry root and rhizome or dry herb of crassulaceae plants rhodiola kirilowii Regel; have and strengthen immunity; scavenging free radicals; pre-preventing tumor, delays senility, antifatigue; anti anoxia; radiation proof, bidirectional modulation nervous centralis, the effects such as restoration and protection body.
Berbamine hydrochloride system, from the bisbenzylisoquinoline alkaloid of Berberidaceae plant extract, has effects such as promoting leucocyte hyperplasia, the activity strengthening NK and macrophage function, scavenging free radicals, anti-inflammatory, antitumor, hypotensive, anti-myocardial anoxia ischemic.
The root of kudzu vine is the dry root of pulse family perennial defoliation liana elegant jessamine or sweet kudzu and edible Pueraria lobota, for cold-pungent and diaphoretic drugs, nature and flavor are sweet, pungent, cool, return spleen, stomach warp, there is relieving muscles to expel heat, promote the production of body fluid, effect of the positive antidiarrheal of promoting eruption, liter, belong to medicine-food two-purpose kind, main effective active matter is isoflavonoid, has the effects such as anti-oxidant, hypotensive, reducing blood lipid, reduction cholesterol concentration.And kudzu root extract is mainly derived from the dry root of legume pueraria lobata, in powdery, its active ingredient is isoflavones, is also contained in Dai, daidzin, Puerarin, Puerarin-7-xyloside etc.They can activate the phagocytic function of peritoneal macrophage, regulate the secretion of the Macrophage Cell factor, stimulate intestinal secretion type immunoglobulin (Ig) SIgA secretion, promote intestinal immunity, scavenging activated oxygen, strengthen organism oxidation resistance.
Schisanhenol a kind ofly from multiple Schisandraceae Plant, is separated the Lignanoids compounds obtained, ultra-oxygen anion free radical and Both peroxyl radical in purged body can be participated in directly, thus stop active oxygen to somatic damage, play adjustment organism metabolism, strengthen the function of immunity of organisms.
Ground bettle, having another name called ground beetle, soil unit etc., is Insecta Blattaria ground Trionychidae or light Lian section insect.Ground bettle female insect is a kind of traditional Chinese medicine, cold in nature, taste is salty, has loose blood stasis, the hard knot that disappears, separates effects such as solidifyingly invigorating blood circulation, reunion of bone, swelling and pain relieving, lactogenesis are stimulated the menstrual flow.Ground bettle is containing alkaloid, amino acid, protein, organic acid, phenols, carbohydrate, grease, steroidal, cumarin, terpene lactone and various trace elements, it is by improving animal blood serum hemolytic antibody titre, promote splenocyte antibody tormation, increase spleen and the weight of thymus gland immune organ and the phagocytic function of macrophage and red-cell immune adherence, present immunological enhancement.
So beneficial effect of the present invention:
1, composite feed additive of the present invention, effectively can promote the growth of broiler chicken immune organ, significantly improve the level of Immunoglobulin in Serum IgG, significantly improve T-lymphocyte number and lymphocyte transformation rate and leukocytes phagocytic ability, strengthen the humoral and cellular immune response function of broiler chicken, thus reduce the incidence of disease and reduce the use of antibiotic etc, there is direct economic and social benefit.
2, in broiler chicken basal diet, add the composite feed additive of the present invention accounting for quality 0.15%-0.35%, then just can significantly improve the activity of superoxide dismutase in serum of broilers (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), in obvious reduction serum, MDA (MDA) content, strengthens the oxidation resistance of its body.
3, the abundant raw material source that this composite feed additive is used, production method is simple, and product is easy to use, has green, environmental protection, ecology, stable, quality controllable feature.
Detailed description of the invention:
Embodiment 1:
Rhodioside 50 parts, Berbamine hydrochloride 15 parts, kudzu root extract 22 parts, schisanhenol 7 parts, Eupolyph aga sinesis Walker 6 parts are mixed, composite feed additive is made after mixing, then add in broiler chicken basal diet in 0.15% ratio accounting for basal diet quality, search for food for it.
Embodiment 2:
Rhodioside 43 parts, Berbamine hydrochloride 20 parts, kudzu root extract 15 parts, schisanhenol 12 parts, Eupolyph aga sinesis Walker 10 parts are mixed, mix and make composite feed additive, then add in broiler chicken basal diet in 0.20% ratio accounting for basal diet quality, search for food for it.
Embodiment 3:
Rhodioside 35 parts, Berbamine hydrochloride 25 parts, kudzu root extract 13 parts, schisanhenol 15 parts, Eupolyph aga sinesis Walker 12 parts are mixed, mix and make composite feed additive, then add in broiler chicken basal diet in 0.25% ratio accounting for basal diet quality, search for food for it.
Embodiment 4:
Rhodioside 31 parts, Berbamine hydrochloride 26 parts, kudzu root extract 11 parts, schisanhenol 18 parts, Eupolyph aga sinesis Walker 14 parts are mixed, mix and make composite feed additive, then add in broiler chicken basal diet in 0.30% ratio accounting for basal diet quality, search for food for it.
Embodiment 5:
Rhodioside 28 parts, Berbamine hydrochloride 27 parts, kudzu root extract 9 parts, schisanhenol 20 parts, Eupolyph aga sinesis Walker 16 parts are mixed, mix and make composite feed additive, then add in broiler chicken basal diet in 0.35% ratio accounting for basal diet quality, search for food for it.
Embodiment 6: contrast test:
By 1 aa broiler chicken 240 at random points 2 groups be test group and control group, often group establishes 6 repetition, in each repetition 20, and broiler weight difference between each repetition is not remarkable.
Control group fed basal diet, what test group was fed is in basal diet, add the composite feed additive accounting for embodiment 1 in the present invention of its quality 0.15%.
All broiler chicken participating in test adopt indoor three-layer stereo to raise in cages, and epidemic disaster and illumination adopt natural conditions and is aided with artificial condition, free choice feeding and drinking-water, and disease prevention and cure are carried out according to a conventional method.
42 days experimental periods, respectively at the 06:00 in early morning (stopping before this to raise 12 hours) of 21,42 ages in days, get 12 at random in often organizing, each repetition 2 (male and female half and half), Culling heart blood after weighing.Adopt heparin anti-coagulating for measuring lymphocyte transformation test, phagocytic activity of leukocytes detects, T-lymphocyte number; Non-anticoagulation, for separating of serum, measures IgG, IgA, IgM content and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activity and MDA (MDA) content in serum.Wherein serum IgG, IgA, IgM assay adopt immunoturbidimetry.Lymphocyte transformation test adopts tetramethyl tetrazolium bromide (MTT) colorimetric method.Phagocytic activity of leukocytes measures to adopt and in anticoagulation, adds a certain amount of india ink, smear, dyeing, microscopy after 37 DEG C of incubation 10min, counts 200 leucocytes, calculates and engulf the leukocytic percentage of ink particles.T TLC measures and adopts acid-α-naphthalene acetate esterase enzyme (ANAE) decoration method.In serum, SOD, GSH-Px, CAT activity and MDA assay are by the kit description operation bought.
Then chicken peels off thymus gland, the bursa of farbricius after butchering immediately, and weighs after rejecting fat, Computation immunity shoot formation, Immune Organs Index=immune organ weight/body weight × 100%.
Detailed result of the test is as shown in following table 1,2,3,4:
Table 1 is on the impact (%) of broiler chicken Immune Organs Index
Note: in the same column of identical age in days, adjacent letters and non-adjacent letter represent P<0.05 and P<0.01 respectively; Lower same.
Known by table 1, composite feed additive has no significant effect growing of the broiler chicken bursa of farbricius, but significantly improve 21,42 Day-old Broiler Chickens thymus indexs (P<0.05), illustrate and add the developmental state that composite feed additive of the present invention obviously can send its immune organ in broiler fodder.
Table 2 is on the impact (g/L) of IgG, IgA, IgM content in serum of broilers
As can be seen from Table 2, composite feed additive has no significant effect (P>0.05) IgG, IgA, IgM content in 21 Day-old Broiler Chickens serum, but in serum, globulin has the trend of rising.During 42 age in days, composite feed additive significantly can raise IgG content in serum of broilers (P<0.05), illustrates that composite feed additive of the present invention has the effect improving Humoral Immunity in Broiler function.
Table 3 affects broiler chicken cellular immune function
As shown in Table 3, add composite feed additive of the present invention in basal diet, it is increased significantly effect (P<0.05) to the T-lymphocyte transformation rate of broiler chicken.In addition, 42 Day-old Broiler Chickens leukocytes phagocytic rates are had to significant rising effect (P<0.05), can improve T-lymphocyte number (P<0.01) in serum of broilers significantly in pole at 21,42 ages in days, illustrates that composite feed additive of the present invention has the effect improving broiler chicken cellular immune function.
Table 4 is on the impact of SOD, GSH-Px, CAT activity and MDA content in serum of broilers
Known by table 4, composite immune reinforcing agent is added in basal feed, compared with control group, in test group 21,42 ages in days serum of broilers in SOD, GSH-Px, CAT activity all significantly improve (P<0.01 or P<0.05), MDA content significantly reduces (P<0.05), illustrates that composite feed additive of the present invention can improve the oxidation resistance of broiler chicken.
The above is only preferred embodiment of the present invention, not does any pro forma restriction to technical scheme of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all still belong to claimed scope of the present invention in the scope of technical scheme of the present invention.
Claims (4)
1. strengthen a composite feed additive for immunity of meat chickens, it is characterized in that: described composite feed additive is prepared from by weight by following component:
Rhodioside 28 ~ 50 parts,
Berbamine hydrochloride 15 ~ 27 parts,
Kudzu root extract 9 ~ 22 parts,
Schisanhenol 7 ~ 20 parts,
Eupolyph aga sinesis Walker 6 ~ 16 parts.
2. a kind of composite feed additive strengthening immunity of meat chickens according to claim 1, is characterized in that: described composite feed additive is prepared from by weight by following component: rhodioside 50 parts, Berbamine hydrochloride 15 parts, kudzu root extract 22 parts, schisanhenol 7 parts, Eupolyph aga sinesis Walker 6 parts.
3. a kind of composite feed additive strengthening immunity of meat chickens according to claim 1 and 2, is characterized in that: the 0.15-0.35% of daily ration quality based on the addition of described composite feed additive.
4. a kind of composite feed additive strengthening immunity of meat chickens according to claim 1 and 2, is characterized in that: described Eupolyph aga sinesis Walker refers to crosses gained after 40 mesh sieves by female ground bettle adult after pulverizer is pulverized.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105076860A (en) * | 2015-09-10 | 2015-11-25 | 马美军 | Compound feed for chickens and production method thereof |
| CN105624111A (en) * | 2016-03-31 | 2016-06-01 | 赵慧慧 | Culture reagent for culturing and amplifying DC-CIK cells with high proliferation force and high cytotoxic activity |
| CN105734012A (en) * | 2016-03-31 | 2016-07-06 | 赵玲玲 | Culture kit for maintaining totipotency of mesenchymal stem cells |
| CN107509684A (en) * | 2016-06-17 | 2017-12-26 | 石家庄以岭药业股份有限公司 | A kind of Soil unit chicken and its cultural method and feeding material |
| CN109430565A (en) * | 2018-09-26 | 2019-03-08 | 安徽科技学院 | A kind of composite feed additive improving meat quality of table poultry |
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Patent Citations (5)
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| CN101491292A (en) * | 2008-01-23 | 2009-07-29 | 北京因科瑞斯医药科技有限公司 | Natural feed additive and preparation method thereof |
| CN101856387A (en) * | 2010-06-03 | 2010-10-13 | 河北科技师范学院 | Chinese herbal immunopotentiator for chicken |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105076860A (en) * | 2015-09-10 | 2015-11-25 | 马美军 | Compound feed for chickens and production method thereof |
| CN105624111A (en) * | 2016-03-31 | 2016-06-01 | 赵慧慧 | Culture reagent for culturing and amplifying DC-CIK cells with high proliferation force and high cytotoxic activity |
| CN105734012A (en) * | 2016-03-31 | 2016-07-06 | 赵玲玲 | Culture kit for maintaining totipotency of mesenchymal stem cells |
| CN107509684A (en) * | 2016-06-17 | 2017-12-26 | 石家庄以岭药业股份有限公司 | A kind of Soil unit chicken and its cultural method and feeding material |
| CN109430565A (en) * | 2018-09-26 | 2019-03-08 | 安徽科技学院 | A kind of composite feed additive improving meat quality of table poultry |
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