CN109316598A - A kind of Chinese medicine, antibacterial peptide and medium-height grass medicine composite preparation and preparation method and application for preventing and treating diarrhea of pigs - Google Patents
A kind of Chinese medicine, antibacterial peptide and medium-height grass medicine composite preparation and preparation method and application for preventing and treating diarrhea of pigs Download PDFInfo
- Publication number
- CN109316598A CN109316598A CN201811226899.3A CN201811226899A CN109316598A CN 109316598 A CN109316598 A CN 109316598A CN 201811226899 A CN201811226899 A CN 201811226899A CN 109316598 A CN109316598 A CN 109316598A
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- diarrhea
- preventing
- chinese medicine
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Abstract
The present invention provides a kind of Chinese medicine for preventing and treating diarrhea of pigs, antibacterial peptide and medium-height grass medicine composite preparation and preparation method and application, it is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 50 60 parts of Radix Codonopsis, 50 60 parts of Poria cocos, 50 60 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 50 60 parts of Chinese yam, fry 50 60 parts of Semen Lablab Album, 10 20 parts of evodia rutaecarpa, 10 20 parts of roasted FRUCTUS CHEBULAE, 10 20 parts of rhizoma alismatis, 10 15 parts of red halloysite, 25 35 parts of lotus seeds, bran fries 25 35 parts of semen coicis, 15 25 parts of Gorgon fruit, 10 20 parts of fructus amomi, 25 35 parts of campanulaceae, 25 35 parts of Schisandra chinensis, 25 35 parts of dried orange peel, 25 35 parts of nutmeg, 25 35 parts of charred FRUCTUS CRATAEGI, 25 35 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 25 35 parts of melanoidin malt , 10 20 parts of endothelium corneum gigeriae galli, 15 25 parts of galanga, 25 35 parts of Radix Glycyrrhizae.Control efficiency is good, has no toxic side effect, drug residue free.
Description
Technical field
The present invention relates to herbal medicines, more particularly, to prevent and treat Chinese medicine, antibacterial peptide and the medium-height grass medicine composite preparation of diarrhea of pigs
And preparation method and application.
Background technique
Now, animal husbandry has evolved to a new height, and intensive, scale, high-quality green noresidue are
It is the main trend of modern farming development, guarantees that the high-quality no drug residue of livestock products first has to the dosage of control antibiotic, or even Du
The application of exhausted antibiotic, this is the major issue concerning contemporary people and offspring's descendants's health.But since the antibiotic forties in 19th century
Since being able to large-scale production, especially because raising scale expands the reason of bring epidemic disease risk increases, it is pre- with antibiotic
Anti- and treatment livestock and poultry has become the magic weapon in the habitual thinking and reality production of people, in animal derived bacterium resistant rate
It rises, leads to the reduction of veterinary antibacterial therapeutic effect, cultivating link dosage is forced to increase, to aggravate veterinary antibacterial poison
Side effect and residual risk of exceeding criterion, seriously threaten Safety of Livestock Products ' Quality and public health security, give human and animal's health care belt
Carry out hidden danger.Therefore, to ensure animal food safety, need to carry out grinding for animal husbandry antibiotic substitution new technology and new product
Hair.
Diarrhea of pigs is prevented and treated using antibiotic in existing livestock-raising, control efficiency is not satisfactory, and is easy to improve germ
Drug resistance, additionally, due to the medicament residue of antibiotic, present people pursue health and health volume, for excessive use antibiosis
Certain resentment is presented in the livestock and poultry meat products of element, influences the sale of livestock and poultry meat products.
Summary of the invention
To solve the above problems, the present invention provides a kind of Chinese medicine, antibacterial peptide and medium-height grass medicine composite preparation for preventing and treating diarrhea of pigs
And preparation method and application, control efficiency is good, it has no toxic side effect, drug residue free.
The object of the present invention is achieved in the following manner: it is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including by weight
The following raw material of meter, 50 60 parts of Radix Codonopsis, 50 60 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 50 60 parts of Chinese yam, fry Semen Lablab Album at 50 60 parts of Poria cocos
50 60 parts, 10 20 parts of evodia rutaecarpa, 10 20 parts of roasted FRUCTUS CHEBULAE, 10 20 parts of rhizoma alismatis, 10 15 parts of red halloysite, lotus seeds 25 35
Part, bran fry 25 35 parts of semen coicis, 15 25 parts of Gorgon fruit, 10 20 parts of fructus amomi, 25 35 parts of campanulaceae, 25 35 parts of Schisandra chinensis,
25 35 parts of dried orange peel, 25 35 parts of nutmeg, 25 35 parts of charred FRUCTUS CRATAEGI, 25 35 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 25 35 parts of melanoidin malt, in chicken
Golden 10 20 parts, 15 25 parts of galanga, 25 35 parts of Radix Glycyrrhizae.
60 parts of Radix Codonopsis, 60 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, 60 parts of Chinese yam, fries 60 parts of Semen Lablab Album, 15 parts of evodia rutaecarpa, simmers and scold 60 parts of Poria cocos
15 parts of son, 15 parts of rhizoma alismatis, 10 parts of red halloysite, 30 parts of lotus seeds, bran fry 30 parts of semen coicis, 20 parts of Gorgon fruit, 15 parts of fructus amomi, campanulaceae 30
Part, 30 parts of Schisandra chinensis, 30 parts of dried orange peel, nutmeg 30 parts, 30 parts of charred FRUCTUS CRATAEGI, 30 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 30 parts of melanoidin malt, endothelium corneum gigeriae galli 15
Part, 20 parts of galanga, 30 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 100~120 meshes, and make reaching by the medicinal powder amount of sieve
70% or more, the medicinal powder for collecting sieving is spare；(3) medicinal powder not being sieved is put into the 8-12 times of weight of medicinal powder not being sieved
In water, heating and refluxing extraction twice, 30 45 minutes every time, will merge standing by extracting solution twice；(4) by two in step (3)
Secondary extracting solution merges, and using pumping and filtering device, pressure when suction filtration is 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.03
~0.06MPa, temperature are maintained at 70~80 °C, the medicinal extract that relative density is 1.20 when being concentrated into 60~70 °C；(5) medicinal extract is made
With spray drying device spray drying, 160 °C of intake air temperature are spray-dried, 90 °C of air outlet temperature, it is spare to collect spray powder；Then
Medicinal powder after the sieving that mixing step (1) is collected, what is prepared is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:(15-20).
The weight ratio of enterobacteria peptide and Chinese medicine is 1:15.
The application method of the antibacterial peptide and medium-height grass medicine composite preparation for preventing and treating diarrhea of pigs is that pig is added in pannage
The antibacterial peptide and medium-height grass medicine composite preparation for being used to prevent and treat diarrhea of pigs of the 0.3 0.6% of feed relative.
The antibacterial peptide and medium-height grass medicine composite preparation for being used to prevent and treat diarrhea of pigs of the 0.5% of pannage weight are added in pannage.
Advantageous effects of the present invention are: the Chinese medicine provided by the present invention for preventing and treating diarrhea of pigs, with Radix Codonopsis, Rhizoma Atractylodis Macrocephalae benefit
Gas invigorating the spleen is main ingredient, with the product that the sweet desalination of Poria cocos, Semen Lablab Album, semen coicis, Chinese yam is wet, sweet puckery, the evodia rutaecarpa temperature spleen benefit of lotus seeds
Kidney, supporing yang antidiarrheal, Gorgon fruit Yishen Jianpi, dehumidifying antidiarrheal, Schisandra chinensis, myrobalan's relieving diarrhea with astringents, rhizoma alismatis control dysentery, the puckery intestines of red halloysite,
Astringing to arrest bleeding, dried orange peel qi-regulating had not only helped main ingredient invigorating the spleen, but can dampness elimination and antidiarrheal is adjuvant；It is amusing on helping transporting, leading to fructus amomi fragrance
Lower mechanism of qi, vomiting and diarrhoea can stop, and nutmeg is myristic kernel, and appetite-stimulating and indigestion-relieving, charred FRUCTUS CRATAEGI, stir-baked MASSA FERMENTATA MEDICI-NALIS, melanoidin malt, endothelium corneum gigeriae galli help
Digestion, digestion gathered food, galanga warming stomach for dispelling cold are adjutant；Campanulaceae priming enters lung with beneficial lung qi, Radix Glycyrrhizae coordinating the drug actions of a prescription, to make medicine.All medicines
It shares, gathers Energy benefit taste, digestion gathered food, the function for changing water-wet, stomach function regulating antidiarrheal altogether, and have no toxic side effect, noresidue does not increase germ
Drug resistance.
Present invention application modern biotechnology product antibacterial peptide and traditional Chinese veterinarian replenish qi to invigorate the spleen, dampness elimination, disperse accumulation, antidiarrheal
Chinese herbal medicine, which combines, is made antibacterial peptide and the use of medium-height grass medicine composite preparation, can effectively kill the bacterium for causing diarrhea of pigs, virus, be good for
Spleen QI invigorating, eliminating dampness to stop diarrhea, functions of intestines and stomach are gradually recovered, and can be enhanced human body immune function, be improved resisting stress, anti-disease ability, change
Kind production performance, improves the speed of growth, is particularly suitable for the unconspicuous case of antibiotic treatment effect, can fully demonstrate antibacterial peptide
With the advantage of traditional Chinese medicine, so that drug effect and function is more fully reached treating both manifestation and root cause of disease, be not likely to produce drug resistance, without venomous injurant
Matter residual, meet subtracting of advocating in recent years it is anti-, for anti-policy, antibiotic usage, medicament residue and drug abuse etc. can be reduced and asked
Topic improves meat quality, reaches the pure natural requirement of green food, conducive to the group guard and control of animal epidemic.
Specific embodiment
Embodiment 1:
It is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 50 60 parts of Radix Codonopsis, Poria cocos 50 60
Part, 50 60 parts of Chinese yam, fries 50 60 parts of Semen Lablab Album, 10 20 parts of evodia rutaecarpa, roasted FRUCTUS CHEBULAE 10 20 at 50 60 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran
Part, 10 20 parts of rhizoma alismatis, 10 15 parts of red halloysite, 25 35 parts of lotus seeds, bran fry 25 35 parts of semen coicis, 15 25 parts of Gorgon fruit,
10 20 parts of fructus amomi, 25 35 parts of campanulaceae, 25 35 parts of Schisandra chinensis, 25 35 parts of dried orange peel, nutmeg 25 35 parts, charred FRUCTUS CRATAEGI
25 35 parts, 25 35 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 25 35 parts of melanoidin malt, 10 20 parts of endothelium corneum gigeriae galli, 15 25 parts of galanga, Radix Glycyrrhizae 25 35
Part.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 100~120 meshes, and make reaching by the medicinal powder amount of sieve
70% or more, the medicinal powder for collecting sieving is spare；(3) medicinal powder not being sieved is put into the 8-12 times of weight of medicinal powder not being sieved
In water, heating and refluxing extraction twice, 30 45 minutes every time, will merge standing by extracting solution twice；(4) by two in step (3)
Secondary extracting solution merges, and using pumping and filtering device, pressure when suction filtration is 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.03
~0.06MPa, temperature are maintained at 70~80 °C, the medicinal extract that relative density is 1.20 when being concentrated into 60~70 °C；(5) medicinal extract is made
With spray drying device spray drying, 160 °C of intake air temperature are spray-dried, 90 °C of air outlet temperature, it is spare to collect spray powder；Then
Medicinal powder after the sieving that mixing step (1) is collected, what is prepared is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:(15-20).
The application method of the antibacterial peptide and medium-height grass medicine composite preparation for preventing and treating diarrhea of pigs is that pig is added in pannage
The antibacterial peptide and medium-height grass medicine composite preparation for being used to prevent and treat diarrhea of pigs of the 0.3 0.6% of feed relative.
Embodiment 2:
It is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 60 parts of Radix Codonopsis, 60 parts of Poria cocos, bran are fried
60 parts of Rhizoma Atractylodis Macrocephalae, fries 60 parts of Semen Lablab Album, 15 parts of evodia rutaecarpa, 15 parts of roasted FRUCTUS CHEBULAE, 15 parts of rhizoma alismatis, 10 parts of red halloysite, lotus seeds at 60 parts of Chinese yam
30 parts, bran stir-fry 30 parts of semen coicis, 20 parts of Gorgon fruit, 15 parts of fructus amomi, 30 parts of campanulaceae, 30 parts of Schisandra chinensis, 30 parts of dried orange peel, nutmeg 30
Part, 30 parts of charred FRUCTUS CRATAEGI, 30 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 30 parts of melanoidin malt, 15 parts of endothelium corneum gigeriae galli, 20 parts of galanga, 30 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 100 meshes, reached 70% by the medicinal powder amount of sieve, collect sieving
Medicinal powder it is spare；(3) medicinal powder not being sieved is put into the water for the 10 times of weight of medicinal powder not being sieved, heating and refluxing extraction two
It is secondary, 45 minutes every time, standing will be merged by extracting solution twice；(4) extracting solution twice in step (3) is merged, is set using suction filtration
Standby, pressure when suction filtration is 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.03MPa, temperature is maintained at 80 °C, concentration
The medicinal extract that relative density is 1.20 when to 60 °C；(5) medicinal extract is used into spray drying device spray drying, is spray-dried intake air temperature
160 °C, 90 °C of air outlet temperature, it is spare to collect spray powder；Then the medicinal powder after the sieving that mixing step (1) is collected, is made
That gets ready is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:15.
Embodiment 3
It is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 50 parts of Radix Codonopsis, 50 parts of Poria cocos, bran are fried
50 parts of Rhizoma Atractylodis Macrocephalae, fries 50 parts of Semen Lablab Album, 10 parts of evodia rutaecarpa, 10 parts of roasted FRUCTUS CHEBULAE, 10 parts of rhizoma alismatis, 10 parts of red halloysite, lotus seeds at 50 parts of Chinese yam
25 parts, bran stir-fry 25 parts of semen coicis, 15 parts of Gorgon fruit, 10 parts of fructus amomi, 25 parts of campanulaceae, 25 parts of Schisandra chinensis, 25 parts of dried orange peel, nutmeg 25
Part, 25 parts of charred FRUCTUS CRATAEGI, 25 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 25 parts of melanoidin malt, 10 parts of endothelium corneum gigeriae galli, 15 parts of galanga, 25 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 120 meshes, reached 82% by the medicinal powder amount of sieve, collect sieving
Medicinal powder it is spare；(3) medicinal powder not being sieved is put into the water for the 8 times of weight of medicinal powder not being sieved, heating and refluxing extraction two
It is secondary, 30 minutes every time, standing will be merged by extracting solution twice；(4) extracting solution twice in step (3) is merged, is set using suction filtration
Standby, pressure when suction filtration is 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.06MPa, temperature is maintained at 70 °C, concentration
The medicinal extract that relative density is 1.20 when to 70 °C；(5) medicinal extract is used into spray drying device spray drying, is spray-dried intake air temperature
160 °C, 90 °C of air outlet temperature, it is spare to collect spray powder；Then the medicinal powder after the sieving that mixing step (1) is collected, is made
That gets ready is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:16.
Embodiment 4
It is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 60 parts of Radix Codonopsis, 60 parts of Poria cocos, bran are fried
60 parts of Rhizoma Atractylodis Macrocephalae, fries 60 parts of Semen Lablab Album, 20 parts of evodia rutaecarpa, 20 parts of roasted FRUCTUS CHEBULAE, 20 parts of rhizoma alismatis, 15 parts of red halloysite, lotus seeds at 60 parts of Chinese yam
35 parts, bran stir-fry 35 parts of semen coicis, 25 parts of Gorgon fruit, 20 parts of fructus amomi, 35 parts of campanulaceae, 35 parts of Schisandra chinensis, 35 parts of dried orange peel, nutmeg 35
Part, 35 parts of charred FRUCTUS CRATAEGI, 35 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 35 parts of melanoidin malt, 20 parts of endothelium corneum gigeriae galli, 25 parts of galanga, 35 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 120 meshes, reached 75% by the medicinal powder amount of sieve, collect sieving
Medicinal powder it is spare；(3) medicinal powder not being sieved is put into the water for the 12 times of weight of medicinal powder not being sieved, heating and refluxing extraction two
It is secondary, 35 minutes every time, standing will be merged by extracting solution twice；(4) extracting solution twice in step (3) is merged, is set using suction filtration
Standby, pressure when suction filtration is 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.04MPa, temperature is maintained at 75 °C, concentration
The medicinal extract that relative density is 1.20 when to 65 °C；(5) medicinal extract is used into spray drying device spray drying, is spray-dried intake air temperature
160 °C, 90 °C of air outlet temperature, it is spare to collect spray powder；Then the medicinal powder after the sieving that mixing step (1) is collected, is made
That gets ready is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:20.
Embodiment 5
It is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 55 parts of Radix Codonopsis, 55 parts of Poria cocos, bran are fried
55 parts of Rhizoma Atractylodis Macrocephalae, fries 55 parts of Semen Lablab Album, 15 parts of evodia rutaecarpa, 15 parts of roasted FRUCTUS CHEBULAE, 15 parts of rhizoma alismatis, 12 parts of red halloysite, lotus seeds at 55 parts of Chinese yam
30 parts, bran stir-fry 30 parts of semen coicis, 20 parts of Gorgon fruit, 15 parts of fructus amomi, 30 parts of campanulaceae, 30 parts of Schisandra chinensis, 30 parts of dried orange peel, nutmeg 30
Part, 30 parts of charred FRUCTUS CRATAEGI, 30 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 30 parts of melanoidin malt, 15 parts of endothelium corneum gigeriae galli, 20 parts of galanga, 30 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 100 meshes, reached 88% by the medicinal powder amount of sieve, collect sieving
Medicinal powder it is spare；(3) medicinal powder not being sieved is put into the water for the 9 times of weight of medicinal powder not being sieved, heating and refluxing extraction two
It is secondary, 40 minutes every time, standing will be merged by extracting solution twice；(4) extracting solution twice in step (3) is merged, is set using suction filtration
Standby, pressure when suction filtration is 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.05MPa, temperature is maintained at 72 °C, concentration
The medicinal extract that relative density is 1.20 when to 64 °C；(5) medicinal extract is used into spray drying device spray drying, is spray-dried intake air temperature
160 °C, 90 °C of air outlet temperature, it is spare to collect spray powder；Then the medicinal powder after the sieving that mixing step (1) is collected, is made
That gets ready is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:18.
Embodiment 6
It is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 50 parts of Radix Codonopsis, 60 parts of Poria cocos, bran are fried
50 parts of Rhizoma Atractylodis Macrocephalae, fries 50 parts of Semen Lablab Album, 20 parts of evodia rutaecarpa, 10 parts of roasted FRUCTUS CHEBULAE, 20 parts of rhizoma alismatis, 10 parts of red halloysite, lotus seeds at 60 parts of Chinese yam
35 parts, bran stir-fry 25 parts of semen coicis, 25 parts of Gorgon fruit, 10 parts of fructus amomi, 35 parts of campanulaceae, 25 parts of Schisandra chinensis, 35 parts of dried orange peel, nutmeg 25
Part, 35 parts of charred FRUCTUS CRATAEGI, 25 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 35 parts of melanoidin malt, 10 parts of endothelium corneum gigeriae galli, 25 parts of galanga, 25 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 100 meshes, reached 91% by the medicinal powder amount of sieve, collect sieving
Medicinal powder it is spare；(3) medicinal powder not being sieved is put into the water for the 11 times of weight of medicinal powder not being sieved, heating and refluxing extraction two
It is secondary, 40 minutes every time, standing will be merged by extracting solution twice；(4) extracting solution twice in step (3) is merged, is set using suction filtration
Standby, pressure when suction filtration is 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.03MPa, temperature is maintained at 70 °C, concentration
The medicinal extract that relative density is 1.20 when to 68 °C；(5) medicinal extract is used into spray drying device spray drying, is spray-dried intake air temperature
160 °C, 90 °C of air outlet temperature, it is spare to collect spray powder；Then the medicinal powder after the sieving that mixing step (1) is collected, is made
That gets ready is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:17.
Embodiment 7
It is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 58 parts of Radix Codonopsis, 52 parts of Poria cocos, bran are fried
59 parts of Rhizoma Atractylodis Macrocephalae, fries 57 parts of Semen Lablab Album, 11 parts of evodia rutaecarpa, 19 parts of roasted FRUCTUS CHEBULAE, 12 parts of rhizoma alismatis, 15 parts of red halloysite, lotus seeds at 53 parts of Chinese yam
26 parts, bran stir-fry 33 parts of semen coicis, 15 parts of Gorgon fruit, 19 parts of fructus amomi, 26 parts of campanulaceae, 35 parts of Schisandra chinensis, 27 parts of dried orange peel, nutmeg 33
Part, 25 parts of charred FRUCTUS CRATAEGI, 34 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 26 parts of melanoidin malt, 10 parts of endothelium corneum gigeriae galli, 25 parts of galanga, 27 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 100 meshes, reached 93% by the medicinal powder amount of sieve, collect sieving
Medicinal powder it is spare；(3) medicinal powder not being sieved is put into the water for the 10 times of weight of medicinal powder not being sieved, heating and refluxing extraction two
It is secondary, 35 minutes every time, standing will be merged by extracting solution twice；(4) extracting solution twice in step (3) is merged, is set using suction filtration
Standby, pressure when suction filtration is 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.05MPa, temperature is maintained at 80 °C, concentration
The medicinal extract that relative density is 1.20 when to 62 °C；(5) medicinal extract is used into spray drying device spray drying, is spray-dried intake air temperature
160 °C, 90 °C of air outlet temperature, it is spare to collect spray powder；Then the medicinal powder after the sieving that mixing step (1) is collected, is made
That gets ready is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:19.
Embodiment 8
It is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 52 parts of Radix Codonopsis, 58 parts of Poria cocos, bran are fried
51 parts of Rhizoma Atractylodis Macrocephalae, fries 59 parts of Semen Lablab Album, 10 parts of evodia rutaecarpa, 11 parts of roasted FRUCTUS CHEBULAE, 20 parts of rhizoma alismatis, 11 parts of red halloysite, lotus seeds at 50 parts of Chinese yam
26 parts, bran stir-fry 35 parts of semen coicis, 15 parts of Gorgon fruit, 11 parts of fructus amomi, 35 parts of campanulaceae, 26 parts of Schisandra chinensis, 25 parts of dried orange peel, nutmeg 34
Part, 26 parts of charred FRUCTUS CRATAEGI, 26 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 34 parts of melanoidin malt, 11 parts of endothelium corneum gigeriae galli, 16 parts of galanga, 34 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 120 meshes, reached 76% by the medicinal powder amount of sieve, collect sieving
Medicinal powder it is spare；(3) medicinal powder not being sieved is put into the water for the 11 times of weight of medicinal powder not being sieved, heating and refluxing extraction two
It is secondary, 40 minutes every time, standing will be merged by extracting solution twice；(4) extracting solution twice in step (3) is merged, is set using suction filtration
Standby, pressure when suction filtration is 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.06MPa, temperature is maintained at 75 °C, concentration
The medicinal extract that relative density is 1.20 when to 67 °C；(5) medicinal extract is used into spray drying device spray drying, is spray-dried intake air temperature
160 °C, 90 °C of air outlet temperature, it is spare to collect spray powder；Then the medicinal powder after the sieving that mixing step (1) is collected, is made
That gets ready is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:16.
Embodiment 9
It is a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, including following raw material by weight, 56 parts of Radix Codonopsis, 52 parts of Poria cocos, bran are fried
59 parts of Rhizoma Atractylodis Macrocephalae, fries 50 parts of Semen Lablab Album, 13 parts of evodia rutaecarpa, 16 parts of roasted FRUCTUS CHEBULAE, 18 parts of rhizoma alismatis, 12 parts of red halloysite, lotus seeds at 50 parts of Chinese yam
33 parts, bran stir-fry 28 parts of semen coicis, 20 parts of Gorgon fruit, 11 parts of fructus amomi, 29 parts of campanulaceae, 33 parts of Schisandra chinensis, 31 parts of dried orange peel, nutmeg 29
Part, 27 parts of charred FRUCTUS CRATAEGI, 26 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 28 parts of melanoidin malt, 16 parts of endothelium corneum gigeriae galli, 21 parts of galanga, 32 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine for preventing and treating diarrhea of pigs is to include the following steps, (1) weighs original by weight ratio
Material；(2) weighed each raw material is mixed, crushes, smashes it through 120 meshes, reaching 79% by the medicinal powder amount of sieve, collecting
The medicinal powder of sieve is spare；(3) medicinal powder not being sieved is put into the water for the 9 times of weight of medicinal powder not being sieved, heating and refluxing extraction
Twice, every time 45 minutes, extracting solution twice is merged and is stood；(4) extracting solution twice in step (3) is merged, uses suction filtration
Equipment, pressure when suction filtration are 0.1MPa；Using being concentrated under reduced pressure after suction filtration, it is decompressed to 0.04Pa, temperature is maintained at 75 °C, concentration
The medicinal extract that relative density is 1.20 when to 63 °C；(5) medicinal extract is used into spray drying device spray drying, is spray-dried intake air temperature
160 °C, 90 °C of air outlet temperature, it is spare to collect spray powder；Then the medicinal powder after the sieving that mixing step (1) is collected, is made
That gets ready is used to prevent and treat the Chinese medicine of diarrhea of pigs.
A kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, including enterobacteria peptide and described for preventing
Control the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:18.
Experiment
One, pharmacological toxicity is tested
I, acute toxicity test: Application mouse carries out acute toxicity testing and shows: Mouse oral stomach-filling the embodiment of the present invention 2 is made
The standby antibacterial peptide and medium-height grass medicine composite preparation for being used to prevent and treat diarrhea of pigs, under 488.8g crude drug/kg dosage, mouse goes out after administration
Existing light activity is reduced, and is restored within 1 hour or so normal, is observed continuously after administration 7 days, none animal dead, overall health of patients, drink
It eats, take the photograph that water, urine and body weight increase are normal, the results showed that Mouse oral feeds the maximum of compound formulation of the invention
Dosage is 488.8g crude drug/kg/d (50 > 488.8g of LD crude drug/kg).The daily total amount of clinical medication of compound formulation of the invention
For O.1g crude drug/kg/d；Prompt the acute toxicity low, clinical application safety.
, long term toxicity test: select health status good SD rat 300, and half male and half female is divided into three groups, often
Group 100, and every group of male and female number is identical, respectively A group, B group and C group, A group are high dose group, and B group is middle dose group, and C group is
Low dose group.A group gives the antibacterial peptide for being used to prevent and treat diarrhea of pigs of concentration 18.0g crude drug/kg the embodiment of the present invention 2 preparation
It with medium-height grass medicine composite preparation, feeds daily once, continuous 90 days, 24 hours after the last administration, 1/2 animal is killed in each group work, and female
Male fifty-fifty, work is killed after remaining 1/2 animal continues observation 2 weeks；B group gives concentration 6.0g crude drug/kg the embodiment of the present invention 2 system
It is standby for preventing and treating the antibacterial peptide and medium-height grass medicine composite preparation of diarrhea of pigs, feed daily it is primary, continuous 90 days, after the last administration 24
Hour, 1/2 animal, and half male and half female are killed in each group work, and work is killed after remaining 1/2 animal continues observation 2 weeks；C group gives concentration 2.Og
Prepared by crude drug/kg the embodiment of the present invention 2 is used to prevent and treat the antibacterial peptide and medium-height grass medicine composite preparation of diarrhea of pigs, feeds daily
Once, continuous 90 days, 24 hours after the last administration, 1/2 animal, and half male and half female were killed in each group work, remaining 1/2 animal continues to observe
Work is killed after 2 weeks.Other conditions are identical.
During test observe animal appearance, general behavior, food-intake, changes of weight, after administration 90 days and be discontinued 2 weeks into
Row hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN,
Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the index checkings such as Histopathology.
Test result shows: compound formulation of the invention is good in high, medium and low dosage group animal general state, appearance body
The variation without exception of sign, behavioral activity, food-intake and body weight increase；Three dosage groups and control group hematological examination, blood life
Chemical examination, urine biochemical analysis are between normal range (NR), group without significant difference；Each group main organs histopathological examination is not
See after obvious exception, These parameters are discontinued 2 weeks and also has no change.The dose of this test be respectively clinical medicine dose 180,
60,20 times, raw in high, medium and low three dosage, that is, 18.0g crude drug/kg, 6.0g according to test result compound formulation of the invention
Administration in medicine/kg, 2.Og crude drug/kg continuous 90 days has no significant effect rat, extensive without specific toxicity target organ and sensitive indicator
The multiple phase is that the observations in two weeks after being discontinued also have no retardance toxic reaction, prompts the dosage of compound formulation clinical application of the invention
Safety is higher.
Two, the application influence of antibacterial peptide and medium-height grass medicine composite preparation to diarrhea of pigs obtained for preventing and treating diarrhea of pigs tries
It tests
The diagnostic criteria of diarrhea of pigs
1. clinical symptoms: sick pig has loose bowels diarrhea, body temperature increases, spirit is depressed, the cold nose of ear is cool, watery nasal discharge, chilly fear it is cold it is tired crouch,
Poor appetite or abolish, day rush down more than 10 times, arrange stench watery stools, vomiting, body height dehydration, thin, death.
2. dissect lesion: after death abdomen tympanites, intestinal wall relaxation, gastrointestinal mucosa is congested, and gastric content is full of, and intestinal contents are dilute
It is thin and gassy, mesenteric adenophyma are big, section succulence.
The obtained antibacterial peptide and medium-height grass medicine composite preparation for preventing and treating diarrhea of pigs of following the application be referred to as antibacterial peptide with
Medium-height grass medicine composite preparation, the application Chinese medicine obtained for preventing and treating diarrhea of pigs are referred to as traditional Chinese medicine formula.
(1) enterobacteria peptide and influence of the medium-height grass medicine composite preparation to Production Performance of Weaning Pigs and diarrhea are added in daily ration
Test
Using single factor test completely randomized design, the long white × Yorkshire piglet 180 of 30 ages in days of health is selected, every group 12 random
It is divided into 15 groups, experimental period 15 days.For each group in addition to daily medication is different, other conditions are identical.Each group medicining condition see the table below table 1.
Each group test result see the table below table 2.
By compareing Tables 1 and 2,1 group of test, 3 groups of test, the test 4 of feeding enterobacteria peptide and medium-height grass medicine composite preparation
Group, 5 groups of test, 7 groups of test, 9 groups of test, 11 groups of 13 groups of tests than only adding enterobacteria peptide of test and corresponding same
2 groups of the test of the traditional Chinese medicine formula of embodiment preparation, 6 groups of test, 8 groups of test, 10 groups of test, test 12 groups and colistin sulphate
14 groups of test, basal diet control group average daily gain distinguish high 40g, 47g, 20g, 13g, 38g, 27g, 33g, 33g,
66g, 86g, feedstuff-meat ratio reduces by 0.417 respectively, 0.383,0.168,0.111,0.351,0.236,0.351,0.316,0.383,
0.805.Therefore, enterobacteria peptide and influence of the medium-height grass medicine composite preparation to Production Performance of Weaning Pigs and diarrhea are substantially better than individually
Enterobacteria peptide, traditional Chinese medicine formula, 10% colistin sulphate are fed, and enterobacteria peptide made from embodiment 2 and Chinese herbal medicine are compound
Preparation effect is optimal.In traditional Chinese medicine formula group, traditional Chinese medicine formula group effect made from embodiment 2 is optimal.
(2) influence of enterobacteria peptide and medium-height grass medicine composite preparation to sow reproductive performance is added in daily ration to test
Choose 40 breeding times are close, parity is roughly the same, weight approximately, the length that is in a good state of health it is white × Yorkshire
Suprapubic arch sling is randomly divided into two groups, every group of 4 repetitions, each repetition 5.Test is divided into 2 groups, and 1 group is control group, feeding basis
Daily ration；2 groups are handled as test group, feeds enterobacteria peptide made from ten embodiment 2 of basal diet and medium-height grass medicine composite preparation
5000mg/kg, basal diet use the original daily ration in the pig farm.Sow was driven in positioning rail before on-test to raise, pre-feeding period 7d,
Test terminates from 90 d of sow gestation to weaned piglet.Enterobacteria peptide and influence of the medium-height grass medicine composite preparation to sow production performance
As a result it see the table below table 3.
Note: the female different expression differences of colleague's data shoulder marking-up are significant (P < 0.05): identical expression difference does not show potato (P > 0.
05)
(3) application case
It selects and has loose bowels piglet 160 similar in same 6 age in days weight of pig farm, every group 10 are randomly divided into 16 groups, experimental period 5
It.Medication in afternoon 1 time on May 13, since May 14 daily medication twice, until without having loose bowels piglet.Each group removes daily medication
Different outer, other conditions are identical.Each group medicining condition and therapeutic effect see the table below table 4.
By the experimental result of table 4, enterobacteria peptide has significant therapeutic effect to piglet diarrhea with medium-height grass medicine composite preparation,
And curative effect is substantially better than and enterobacteria peptide, Chinese herbal medicine, Norfloxacin, furazolidone is used alone.Enterobacteria peptide made from embodiment 2 with
Medium-height grass medicine composite preparation is optimal to the therapeutic effect of piglet diarrhea, in traditional Chinese medicine formula group, Chinese herbal medicine prescription made from embodiment 2
Agent group effect is optimal.
What has been described above is only a preferred embodiment of the present invention, it is noted that for those skilled in the art,
Without depart from that overall concept of the invention, several changes and improvements can also be made, these also should be considered as of the invention
Protection scope.
Claims (7)
1. a kind of for preventing and treating the Chinese medicine of diarrhea of pigs, it is characterised in that: including following raw material by weight, Radix Codonopsis 50 60
Part, 50 60 parts of Chinese yam, fries 50 60 parts of Semen Lablab Album, evodia rutaecarpa 10 20 at 50 60 parts of Poria cocos, 50 60 parts of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran
Part, 10 20 parts of roasted FRUCTUS CHEBULAE, 10 20 parts of rhizoma alismatis, 10 15 parts of red halloysite, 25 35 parts of lotus seeds, bran fry semen coicis 25 35
Part, 15 25 parts of Gorgon fruit, 10 20 parts of fructus amomi, 25 35 parts of campanulaceae, 25 35 parts of Schisandra chinensis, 25 35 parts of dried orange peel, nutmeg
25 35 parts, 25 35 parts of charred FRUCTUS CRATAEGI, 25 35 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 25 35 parts of melanoidin malt, 10 20 parts of endothelium corneum gigeriae galli, galanga 15
25 parts, 25 35 parts of Radix Glycyrrhizae.
2. according to claim 1 for preventing and treating the Chinese medicine of diarrhea of pigs, it is characterised in that: 60 parts of Radix Codonopsis, 60 parts of Poria cocos, bran
60 parts of rhizoma atractylodis macrocephalae, fries 60 parts of Semen Lablab Album, 15 parts of evodia rutaecarpa, 15 parts of roasted FRUCTUS CHEBULAE, 15 parts of rhizoma alismatis, 10 parts of red halloysite, lotus at 60 parts of Chinese yam
30 parts of son, bran fry 30 parts of semen coicis, 20 parts of Gorgon fruit, 15 parts of fructus amomi, 30 parts of campanulaceae, 30 parts of Schisandra chinensis, 30 parts of dried orange peel, nutmeg 30
Part, 30 parts of charred FRUCTUS CRATAEGI, 30 parts of stir-baked MASSA FERMENTATA MEDICI-NALIS, 30 parts of melanoidin malt, 15 parts of endothelium corneum gigeriae galli, 20 parts of galanga, 30 parts of Radix Glycyrrhizae.
3. it is according to claim 1 or 2 for prevent and treat diarrhea of pigs Chinese medicine preparation method, it is characterised in that: including with
Lower step, (1) weigh raw material by weight ratio；(2) weighed each raw material is mixed, crushes, smashes it through 100~120 meshes,
And make reaching 70% or more by the medicinal powder amount of sieve, the medicinal powder for collecting sieving is spare；(3) medicinal powder not being sieved is put into not
Have in the water of 8-12 times of weight of medicinal powder of sieving, heating and refluxing extraction twice, 30 45 minutes every time, extracting solution will merge twice
It stands；(4) extracting solution twice in step (3) is merged, using pumping and filtering device, pressure when suction filtration is 0.1MPa, after suction filtration
It is concentrated under reduced pressure, is decompressed to 0.03~0.06MPa, temperature is maintained at 70~80 °C, relative density when being concentrated into 60~70 °C
For 1.20 medicinal extract；(5) medicinal extract is used into spray drying device spray drying, is spray-dried 160 °C of intake air temperature, air outlet temperature
90 °C, it is spare to collect spray powder；Then the medicinal powder after the sieving that mixing step (1) is collected, what is prepared is used to prevent and treat pig
The Chinese medicine of diarrhea.
4. a kind of antibacterial peptide for preventing and treating diarrhea of pigs and medium-height grass medicine composite preparation, it is characterised in that: including enterobacteria peptide and power
Benefit require 1 or 2 described in for preventing and treating the Chinese medicine of diarrhea of pigs, the weight ratio of enterobacteria peptide and Chinese medicine is 1:(15-20).
5. according to claim 4 for preventing and treating the antibacterial peptide and medium-height grass medicine composite preparation of diarrhea of pigs, it is characterised in that: intestines
The weight ratio of bacitracin and Chinese medicine is 1:15.
6. it is according to claim 4 or 5 for preventing and treating the application method of the antibacterial peptide and medium-height grass medicine composite preparation of diarrhea of pigs,
It is characterized by: adding 0.3 0.6% antibacterial peptide and Chinese herbal medicine for being used to prevent and treat diarrhea of pigs of pannage weight in pannage
Compound formulation.
7. it is according to claim 6 for preventing and treating the application method of the antibacterial peptide and medium-height grass medicine composite preparation of diarrhea of pigs,
It is characterized in that: adding the antibacterial peptide and the compound system of Chinese herbal medicine for being used to prevent and treat diarrhea of pigs of the 0.5% of pannage weight in pannage
Agent.
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| CN110302300A (en) * | 2019-08-16 | 2019-10-08 | 咸阳职业技术学院 | A kind of herbal composite for treating pig epidemic diarrhea |
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