CN101474246B - Pharmaceutical composition for enhancing immunity of fowl and coordinating with vaccine for synergy - Google Patents
Pharmaceutical composition for enhancing immunity of fowl and coordinating with vaccine for synergy Download PDFInfo
- Publication number
- CN101474246B CN101474246B CN2009100778657A CN200910077865A CN101474246B CN 101474246 B CN101474246 B CN 101474246B CN 2009100778657 A CN2009100778657 A CN 2009100778657A CN 200910077865 A CN200910077865 A CN 200910077865A CN 101474246 B CN101474246 B CN 101474246B
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- fowl
- vaccine
- antiseptic
- percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The invention discloses a pharmaceutical composition with the functions of enhancing the fowl immunity and matching vaccine to enhance the efficacy. The components and the weight percentage thereof are as follows: 0.5 to 5 percent of astragalus polyose, 0.5 to 5 percent of glycyrrhizin, 0.5 to 5 percent of icariine, 0.5 to 3 percent of propolis, 0.02 to 0.1 percent of vitamin E and addition agents. The pharmaceutical composition of the invention can obviously improve both the fowl body cellular immunity and the humoral immunity, and has favorable functions of preventing and controlling the immunosuppressive diseases of the fowl; second, the pharmaceutical composition can be matched with the vaccine to be used to improve the fowl antibody titer, thereby causing the antibodies to be comparatively uniform and to maintain a higher level and showing obvious functions of immunization and efficacy enhancement; and the pharmaceutical composition can be matched with medicines for curing the fowl newcastle disease, the bursa of fabricius, the bird flu and the like, thereby improving treatment effects, increasing the antibody guard time and reducing loss.
Description
Technical field
The present invention relates to a kind ofly can strengthen immunity of fowl and cooperate the synergic pharmaceutical composition of vaccine.
Background technology
In the prevention and control measure of aviculture all over the world, multiple virus and bacterial disease use vaccine to carry out the specificity prevention and account for consequence.Under many circumstances, be in immune deficiency state or sub-health status etc. as body and cause the most of effects of currently available vaccines, existing vaccines unsatisfactory, in fowl, often can't set up sufficient immune environment even cause immunity degradation.In addition, the immunne response of chicken group to vaccine will be directly disturbed in immunosuppressant, cause that the immunosuppressant reason is a lot, and the factor that is infectious is as newcastle, infectious bursal disease, coccidiosis etc.; Also have many non-infectious factors, as various toxin, malnutrition, stress wait, except that above factor, the serious grade of drug abuse phenomenon is the main anthropic factor that causes present immunosuppressive disease.
Immunostimulant that can the enhancing human body immunity ability has many kinds, comprises microorganism, chemicals, bioactive ingredients, cytokine etc.The seventies in 20th century, scientists finds that the polysaccharide in the Chinese medicine has immunocompetence.Since the eighties, reported that kind more than 100 has the herbal polysaccharide of multiple biologically actives such as immunomodulating, antiviral, infection, adjusting hemopoietic function, antitumor, blood sugar lowering, blood fat reducing, antioxidation and slow down aging.On various at polysaccharide, most important pharmacological action is its immunomodulating, facilitation to organism.Some polysaccharide is used in the practice of clinical, Production of Livestock and Poultry widely, as astragalus polysaccharides be used as antiviral, medicament for immunity enhancement uses.It is multipath, too many levels, many target spots that herbal polysaccharide is regulated immunity of organism, as promoting immune cell propagation and differentiation, secretes various lymphokines, regulates the balance of a neural endocrine one immunomodulating network (NIM) etc.Herbal polysaccharide energy human body immunity improving surveillance, comprise erythrocyte, natural killer cell, macrophage, killer T cell, T cell, the activated killer cell of lymphokine, interleukin and other cytokines etc., many polysaccharide have been brought into play irreplaceable effect with its better curative effect as the wide spectrum immunomodulator in treatment, the multiple disease of prevention.
At present for Chinese medicine ingredients such as astragalus polysaccharidess at some report of effect aspect the human body immunity improving power, all can stimulate lymphopoiesis as Chinese medicine ingredients such as astragalus polysaccharides, epimedium brevicornum polysaccharide, propolis polysaccharide, and the effect of enhancing immunity (Chu Yuefeng etc. Agricultural University Of Nanjing's journal; 2004 (1), 100-103).The glycyrrhizin that extracts from Radix Glycyrrhizae has inhibitory action to multiple virus, and can also enhancing human body immunity power etc., improve the growth performance of broiler chicken, in feedstuff, add glycyrrhizin and can improve the broiler chicken daily gain, the reduction feedstuff-meat ratio (Chang Yaping etc. CHINA JOURNAL OF CHINESE MATERIA MEDICA, 1989; 14:44-46).Lentinan and astragalus polysaccharides to the generation of fowl myeloblastosis and development all have the obvious suppression effect (Qu Qihuan etc. HEILONGJIANG ANIMAL SCIENCE AND VETERINARY MEDICINE .1998 (4): 1-3).Chinnah etc. share Aloe polysaccharide and newcastle disease, bursa fabricic, infectious bronchitis trigeminy vaccine, find that Aloe polysaccharide can significantly improve the titre of newcastle disease antibody, bursal antibody retention time significant prolongation.
Summary of the invention
The purpose of this invention is to provide and a kind ofly can strengthen immunity of fowl and cooperate the synergic pharmaceutical composition of vaccine, this pharmaceutical composition is effective, and raw material sources make things convenient for, have no drug resistance, do not have incompatibility,, noresidue nontoxic to body.
Another purpose of the present invention provides the preparation method of aforementioned pharmaceutical compositions.
Realize that technical scheme of the present invention is:
The present invention is a kind of to be strengthened immunity of fowl and cooperate the synergic pharmaceutical composition of vaccine, and its composition and percentage by weight thereof are:
Astragalus polysaccharides 0.5～5%
Glycyrrhizin 0.5～5%
Icariine 0.5～5%
Propolis 0.5～3%
Vitamin E 0.02～0.1%
The auxiliary agent surplus.
The composition of the auxiliary agent described in the aforementioned pharmaceutical compositions and percentage by weight thereof are: solvent 1～50%, and solubilizing agent 0.5～15%, antiseptic 0.05～3%, water are surplus.
Solvent described in the aforementioned pharmaceutical compositions is meant one or more in ethanol, methanol, isopropyl alcohol, acetone, espeleton, propylene glycol, PEG200, PEG400, PEG600 or the glycerol equal solvent.
Solubilizing agent described in the aforementioned pharmaceutical compositions be meant Tween 80, sorbester p17, OP-10, EL-10,1702,600 or bulking agent such as 700# in one or more.
Antiseptic described in the aforementioned pharmaceutical compositions is meant one or more in the antiseptic such as benzoic acid, sodium benzoate, sorbic acid or ethyl hydroxybenzoate.
The preferred distilled water of water described in the aforementioned pharmaceutical compositions.
The preparation method of aforementioned pharmaceutical compositions comprises the steps:
(1) proportionally astragalus polysaccharides, glycyrrhizin, icariine, propolis, vitamin E are mixed with solubilizing agent, add solvent again, get original liquid;
(2) antiseptic is added distilled water, get antiseptic liquid;
(3) under stirring antiseptic liquid is added in the original liquid of preparation, mix and stir, use the distilled water standardize solution, 100 ℃ of flowing steam sterilizations promptly got the present invention in 30 minutes.
Astragalus polysaccharides described in the aforementioned pharmaceutical compositions, glycyrrhizin, icariine, propolis, vitamin E etc. all can be bought from the market, as astragalus polysaccharides can be from Sichuan with safe plant chemical industry limit company buy, glycyrrhizin can be bought from Xi'an Fu Jie pharmaceutcal corporation, Ltd, icariine can be bought from Shaanxi Sen Fu Bioisystech Co., Ltd, propolis can natural Cera Flava company limited be bought from orchard, Dongguang, Hebei province, vitamin E can be bought from Zhejiang Medicine Co etc.
Pharmaceutical composition of the present invention can add to fowl and uses by drinking-water or feedstuff.As can be with present composition water by 1: 250-500 doubly dilutes the back and drinks for fowl.
Advantage of the present invention and beneficial effect:
(1), the present invention all is significantly increased immunity of fowl body cell and humoral immunity level, and the immunosuppressive disease of control fowl is had better effect;
(2), the present invention cooperates vaccine to use to improve the fowl antibody titer, antibody comparatively evenly and keep higher level, immunopotentiation is obvious;
(3), the present invention can be used for the matching medication of fowl newcastle, fabricius bursa, bird flu etc., improves therapeutic effect, prolongs the antibody guard time, reduce the loss;
(4), the present invention can be used for the prevention of the fowl diseases sudden, that harm is serious;
(5), raw material of the present invention is natural product, has no drug resistance, do not have incompatibility,, noresidue nontoxic to body.
The specific embodiment
In order more to be expressly understood the present invention, the present invention is described in further detail by the following examples, but the invention is not restricted to these embodiment.
Embodiment 1～4 preparation of drug combination of the present invention
Comprise the steps:
(1) proportionally (see Table 1) astragalus polysaccharides (limitting company with safe plant chemical industry available from Sichuan), glycyrrhizin (available from Xi'an Fu Jie pharmaceutcal corporation, Ltd), icariine (available from Shaanxi Sen Fu Bioisystech Co., Ltd), propolis (available from the natural Cera Flava company limited in orchard, Dongguang, Hebei province), vitamin E (available from Zhejiang Medicine Co) are mixed with 0.5% Tween 80, add 5% ethanol again and make dissolving, get original liquid;
(2) taking ethylparaben 0.5g is dissolved in the distilled water, gets impregnating fluid;
(3) under stirring, the antiseptic liquid of step (2) is added in the original liquid of step (1), mix and stir, be settled to 1000ml with distilled water, the packing potting, 100 ℃ of flowing steam sterilizations 30 minutes are promptly.
Each Chinese medicine component schedule of proportion in table 1 pharmaceutical composition of the present invention
| Astragalus polysaccharides (%) | Glycyrrhizin (%) | Icariine (%) | Propolis (%) | Vitamin E (%) | |
| Embodiment 1 | 5 | 1 | 5 | 1 | 0.1 |
| Embodiment 2 | 5 | 5 | 3 | 1 | 0.1 |
| Embodiment 3 | 3 | 3 | 5 | 1 | 0.2 |
| Embodiment 4 | 5 | 1 | 5 | 0.5 | 0.1 |
Embodiment 5 pharmaceutical compositions of the present invention strengthen chicken immunity of organisms and vaccine synergism test:
1 materials and methods
1.1 material
1.1.1 experimental animal
Non-immune health meat chicken 500 plumages of mixing, available from certain chicken house of Langfang, isolated rearing is to required age in days.
1.1.2 vaccine
Bird flu, newcastle reorganization bigeminal live vaccine (rL-H5 strain) are available from biotechnology development company of Harbin dimension section; Bursa of fabricius vaccine B87 is available from China Bioisystech Co., Ltd.
1.1.3 main agents
Bird flu H5 hypotype HI antigen and newcastle antigen are available from biotechnology development company of Harbin dimension section; Fabricius bursa antigen is available from great Bioisystech Co., Ltd of universe unit.
1.2 method
1.2.1 test chicken grouping and processing: get assorted chicken 500 plumages of non-immune health meat and be divided into 5 groups at random, every group 100 plumage, 7 ages in days bird flu, Newcastle disease attenuated Seedling eye dripping collunarium; 21 ages in days carry out two and exempt from; 14 ages in days fabricius bursa B87 point mouth, 28 ages in days carry out two and exempt from.5 test group are respectively 1～4 group of the embodiment of the invention and blank group, feed by 1: 500 part by weight drinking-water, and each 3 days whole day amount drinking-water is fed before and after the immunity, and the normal drinking-water of matched group is fed.
1.2.2 the mensuration of newcastle disease and avian influenza antibody titre: after first immunisation the 7th, 14,21,28 day, get 10 chickens respectively at random for every group, venous blood collection 1mL under the wing, after waiting to separate out serum, separation of serum, measure newcastle disease and avian influenza antibody titre with micromethod, the result is with the geometric average value representation of log2.1.2.3 the mensuration of chicken bursal antibody titre: after first immunisation the 7th, 14,21,28 day, get 10 chickens respectively at random for every group, venous blood collection 1mL under the wing, after waiting to separate out serum, separation of serum is measured the antibody titer of infectious bursal disease with fine jade expansion method.
1.2.4 the exponential calculating of immune organ: before delivering for sale day, randomly draw 10 chicken blood-letting and cause death for every group, take by weighing body weight, win spleen, fabricius bursa, take by weighing weight in wet base, calculating immune organ index.
Immune organ index=(immune organ weight/body weight) * 100 wherein
Utricule ratio=(fabricius bursa weight/body weight) * 100
Spleen body ratio=(spleen weight/body weight) * 100
1.3 date processing
Analyze with SPSS 11.5 softwares, data represent that with Mean ± SD significance analysis adopts variance analysis and multiple comparisons.
2 results
2.1 influence to valence of vaccine antibody
Table 2 pharmaceutical composition of the present invention influences result of the test to what newcastle epidemic disease antibody was tired
| Group | D7 | D14 | D21 | D28 |
| 1 group of embodiment | 4.2±0.23 | 5.4±0.12 | 6.8±0.25 | 8.5±0.18 |
| 2 groups of embodiment | 4.2±0.20 | 5.6±0.20 | 7.0±0.14 | 8.4±0.22 |
| 3 groups of embodiment | 4.0±0.31 | 5.2±0.27 | 6.8±0.21 | 8.2±0.33 |
| 4 groups of embodiment | 4.1±0.25 | 5.0±0.30 | 6.9±0.26 | 8.0±0.32 |
| Matched group | 3.6±0.28 | 4.7±0.29 | 6.2±0.21 | 7.1±0.33 |
1～4 group of result's (seeing Table 2) embodiment tires and matched group difference extremely significantly (p＜0.01) at the 7th, 14,28 days newcastle epidemic disease antibodies.
Table 3 pharmaceutical composition of the present invention influences result of the test to what avian influenza antibody was tired
| The test group | D7 | D14 | D21 | D28 |
| 1 group of embodiment | 4.3±0.25 | 6.3±0.42 | 7.7±0.24 | 8.6±0.25 |
| 2 groups of embodiment | 4.2±0.30 | 6.0±0.29 | 7.6±0.32 | 8.6±0.37 |
| 3 groups of embodiment | 4.0±0.27 | 6.3±0.56 | 7.6±0.18 | 8.8±0.23 |
| 4 groups of embodiment | 3.8±0.42 | 5.9±0.32 | 7.3±0.40 | 8.7±0.35 |
| Matched group | 3.7±0.29 | 5.6±0.17 | 6.8±0.12 | 7.3±0.19 |
Result's (seeing Table 3) embodiment 1-4 organizes the 7th, 14, and 21,28 days avian influenza antibodies are tired and matched group difference extremely significantly (p＜0.01).
Table 4 pharmaceutical composition of the present invention influences result of the test to what bursal antibody was tired
| Group | D7 | D14 | D21 | D28 |
| 1 group of embodiment | 4.6±0.15 | 6.8±0.21 | 7.5±0.27 | 8.3±0.15 |
| 2 groups of embodiment | 4.6±0.32 | 6.7±0.24 | 6.9±0.26 | 8.1±0.30 |
| 3 groups of embodiment | 4.7±0.14 | 6.5±0.37 | 7.3±0.15 | 7.9±0.35 |
| 4 groups of embodiment | 4.7±0.25 | 6.3±0.29 | 7.3±0.19 | 8.2±0.17 |
| Matched group | 3.5±0.28 | 4.8±0.45 | 6.1±0.36 | 7.3±0.28 |
Interpretation of result (seeing Table 4) embodiment 1-4 organizes the 7th, 14, and 21,28 days bursal antibodies are tired and matched group difference extremely significantly (p＜0.01).
2.2 influence to the weightening finish of immune organ exponential sum
The exponential measurement result of table 5 immune organ
| Processed group | Method refers to (%) | Spleen refers to (%) | Body weight |
| 1 group of embodiment | 0.38±0.48 | 0.17±0.32 | 1.08±0.05 |
| 2 groups of embodiment | 0.37±0.21 | 0.18±0.13 | 1.06±0.36 |
| 3 groups of embodiment | 0.37±0.31 | 0.18±0.18 | 1.05±0.35 |
| 4 groups of embodiment | 0.33±0.38 | 0.16±0.30 | 1.07±0.25 |
| Matched group | 0.18±0.48 | 0.16±0.19 | 1.02±0.37 |
Result's (seeing Table 5) compares with matched group, and 1～4 group of spleen index error of embodiment heteropole is (p＜0.01) significantly, and method refers to and body weight index significant difference (p＜0.05).
The above results shows that pharmaceutical composition of the present invention cooperates vaccine to use and can improve the fowl antibody titer, and antibody produces early and comparatively evenly and to keep the higher level time long, immunopotentiation is obvious; Immunity of fowl body cell and humoral immunity level all are significantly increased, the immunosuppressive disease of preventing and treating fowl is had better effect; The matching medication that can be used for fowl newcastle, bird flu, bursa of fabricius vaccine improves therapeutic effect, prolongs the antibody guard time, reduces the loss.
Claims (7)
1. one kind can strengthen immunity of fowl and cooperate the synergic pharmaceutical composition of vaccine, it is characterized in that its composition and percentage by weight thereof are:
Astragalus polysaccharides 0.5～5%
Glycyrrhizin 0.5～5%
Icariine 0.5～5%
Propolis 0.5～3%
Vitamin E 0.02～0.1%
The auxiliary agent surplus.
2. according to the described pharmaceutical composition of claim 1, it is characterized in that its composition and percentage by weight thereof are:
Astragalus polysaccharides 5%
Glycyrrhizin 1%
Icariine 5%
Propolis 1%
Vitamin E 0.1%
The auxiliary agent surplus.
3. according to claim 1 or 2 described pharmaceutical compositions, it is characterized in that the composition of described auxiliary agent and percentage by weight thereof are: solvent 1～50%, solubilizing agent 0.5～15%, antiseptic 0.05～3%, water are surplus; Described solvent be meant ethanol, methanol, isopropyl alcohol, acetone, espeleton, propylene glycol, PEG200, PEG400, PEG600 or glycerol one or more.
4. according to the described pharmaceutical composition of claim 3, it is characterized in that described solubilizing agent is meant one or more of Tween 80, sorbester p17, OP-10 or EL-10.
5. according to the described pharmaceutical composition of claim 4, it is characterized in that described antiseptic is meant one or more of benzoic acid, sodium benzoate, sorbic acid or ethyl hydroxybenzoate.
6. according to the described pharmaceutical composition of claim 5, it is characterized in that described water is distilled water.
7. the described preparation of drug combination method of claim 3 comprises the steps:
(1) proportionally astragalus polysaccharides, glycyrrhizin, icariine, propolis, vitamin E are mixed with solubilizing agent, add solvent again, get original liquid;
(2) antiseptic is added entry, get antiseptic liquid;
(3) under stirring antiseptic liquid is added in the original liquid of preparation, mix and stir, use the distilled water standardize solution, 100 ℃ of flowing steam sterilizations got final product in 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100778657A CN101474246B (en) | 2009-01-23 | 2009-01-23 | Pharmaceutical composition for enhancing immunity of fowl and coordinating with vaccine for synergy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100778657A CN101474246B (en) | 2009-01-23 | 2009-01-23 | Pharmaceutical composition for enhancing immunity of fowl and coordinating with vaccine for synergy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101474246A CN101474246A (en) | 2009-07-08 |
| CN101474246B true CN101474246B (en) | 2011-07-27 |
Family
ID=40835084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100778657A Active CN101474246B (en) | 2009-01-23 | 2009-01-23 | Pharmaceutical composition for enhancing immunity of fowl and coordinating with vaccine for synergy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101474246B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103721070A (en) * | 2013-10-24 | 2014-04-16 | 青岛华仁技术孵化器有限公司 | Drug for treating Newcastle disease |
| CN104815334B (en) * | 2015-04-17 | 2017-09-26 | 四川省华派生物制药有限公司 | Transmissible gastroenteritis of swine, epidemic diarrhea bigeminal live vaccine dilution |
| CN106377758A (en) * | 2016-08-30 | 2017-02-08 | 林州中农颖泰生物肽有限公司 | Cecropin antibacterial peptide spraying agent and preparation method thereof |
| CN108452022A (en) * | 2017-06-28 | 2018-08-28 | 禹州市合同泰药业有限公司 | A kind of veterinary drug of enhancing immunity of poultry |
| CN107647134A (en) * | 2017-09-27 | 2018-02-02 | 芦山县科龙农牧科技有限责任公司 | A kind of additive for resisting swine fever |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1513346A (en) * | 2003-04-23 | 2004-07-21 | 新疆天康畜牧生物技术股份有限公司 | Feed additive made of herbal medicine compound concentrate, and its prepn. method |
-
2009
- 2009-01-23 CN CN2009100778657A patent/CN101474246B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1513346A (en) * | 2003-04-23 | 2004-07-21 | 新疆天康畜牧生物技术股份有限公司 | Feed additive made of herbal medicine compound concentrate, and its prepn. method |
Non-Patent Citations (1)
| Title |
|---|
| 杨晓农等.家禽常用抗病毒中药及其应用的研究进展.《江西畜牧兽医杂志》.2007,(第2期),第8页第1栏倒数第6行-第2栏倒数第11行. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101474246A (en) | 2009-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Rao et al. | Effect of Achyranthes aspera on the immunity and survival of Labeo rohita infected with Aeromonas hydrophila | |
| Hoseinifar et al. | Can dietary jujube (Ziziphus jujuba Mill.) fruit extract alter cutaneous mucosal immunity, immune related genes expression in skin and growth performance of common carp (Cyprinus carpio)? | |
| Mahdavi et al. | Effect of Aloe vera extract on growth parameters of common carp (Cyprinus carpio) | |
| Talpur | Mentha piperita (Peppermint) as feed additive enhanced growth performance, survival, immune response and disease resistance of Asian seabass, Lates calcarifer (Bloch) against Vibrio harveyi infection | |
| Babak et al. | A review on effects of Aloe vera as a feed additive in broiler chicken diets | |
| Guo et al. | Immunoactive, medicinal properties of mushroom and herb polysaccharides and their potential use in chicken diets | |
| Wei et al. | Effects of Taishan Pinus massoniana pollen polysaccharide on immune response of rabbit haemorrhagic disease tissue inactivated vaccine and on production performance of Rex rabbits | |
| CN101474246B (en) | Pharmaceutical composition for enhancing immunity of fowl and coordinating with vaccine for synergy | |
| Ghalamkari et al. | Investigation the effects using different levels of Mentha pulegium L.(pennyroyal) in comparison with an antibiotic growth promoter on performance, carcass traits and immune responses in broiler chickens | |
| Guz et al. | Effect of Echinacea purpurea on growth and survival of guppy (Poecilia reticulata) challenged with Aeromonas bestiarum | |
| CN1927281A (en) | Chinese herbal medicine slow release agent for preventing and treating rabbit and chicken coccidiosis and preparing method thereof | |
| CN104208673A (en) | Poultry antivirus composition, freeze-dried powder, preparation method and applications of the composition | |
| CN103768594A (en) | Traditional Chinese medicine mulberry polysaccharide and eucommia polysaccharide immunopotentiator and application thereof | |
| CN103860715A (en) | Compound traditional Chinese medicine extract for preventing poultry coccidiosis and application of extract | |
| CN104322931A (en) | Feed additive specially used in laying duck breeding | |
| Tukmechi et al. | The effects of short-and long-term diet supplementation with Iranian propolis on the growth and immunity in rainbow trout (Oncorhynchus mykiss) | |
| Teymouri Zadeh et al. | The effects of Thymus vulgaris L., Echinacea purpurea (L.) Moench., Allium sativum L. extracts and virginiamycin antibiotic on intestinal microflora population and immune system in broilers | |
| CN102885927A (en) | Traditional Chinese medicine composition for treating pullorum disease and preparation method thereof | |
| Yılmaz et al. | The effects of the fig (Ficus carica) extract and onion (Allium capa) extract addition to Cyprinus carpio feeds in different amount on the growth performance | |
| CN102973642B (en) | Chinese medicine composition for enhancing poultry immunity and preparation method thereof | |
| CN104208683B (en) | The pharmaceutical composition of a kind of anti-duck viral disease, lyophilized powder, preparation method and application | |
| CN112089801A (en) | Composition for enhancing immunity and preparation method thereof | |
| Chekav et al. | Effects of dietary Persian hogweed (Heracleum persicum) powder on growth performance, hematological and immune indices, and resistance against Yersinia ruckeri in rainbow trout (Oncorhynchus mykiss) | |
| CN107319171A (en) | It is a kind of to strengthen the Chinese herb feed additive of chicken immunity | |
| Awaad et al. | The effect of a combination of β (1-3) D-glucan and Propionibacterium granulosum on productive performance and immune modulation of immunocompromised and non-immunocompromised broiler chickens. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HU NAN AGRICULTURAL UNIVERSITY ANIMAL PHARMACEUTIC Effective date: 20120409 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20120409 Address after: 100085 Beijing city Haidian District Third Street No. 9 Jiahua building D block 803 Co-patentee after: Hunan Agricultural University Animal Pharmaceutical Co., Ltd. Patentee after: Beijing Vicaren Biological Technology Co., Ltd. Address before: 100085 Beijing city Haidian District Third Street No. 9 Jiahua building D block 803 Patentee before: Beijing Vicaren Biological Technology Co., Ltd. |
|
| ASS | Succession or assignment of patent right |
Owner name: HU NAN AGRICULTURAL UNIVERSITY ANIMAL PHARMACEUTIC Free format text: FORMER OWNER: BEIJING VICAREN BIOLOGICAL TECHNOLOGY CO., LTD. Effective date: 20120516 Free format text: FORMER OWNER: HU NAN AGRICULTURAL UNIVERSITY ANIMAL PHARMACEUTICAL CO., LTD. Effective date: 20120516 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100085 HAIDIAN, BEIJING TO: 410329 CHANGSHA, HUNAN PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20120516 Address after: 410329 Hunan biomedical park in Liuyang Zhiyuan Road No. 9 Patentee after: Hunan Agricultural University Animal Pharmaceutical Co., Ltd. Address before: 100085 Beijing city Haidian District Third Street No. 9 Jiahua building D block 803 Co-patentee before: Hunan Agricultural University Animal Pharmaceutical Co., Ltd. Patentee before: Beijing Vicaren Biological Technology Co., Ltd. |