CN107257806B - 用于治疗pvns的抗csf1r抗体 - Google Patents

用于治疗pvns的抗csf1r抗体 Download PDF

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CN107257806B
CN107257806B CN201580076553.8A CN201580076553A CN107257806B CN 107257806 B CN107257806 B CN 107257806B CN 201580076553 A CN201580076553 A CN 201580076553A CN 107257806 B CN107257806 B CN 107257806B
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antibody
seq
sequence
leu
heavy chain
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CN107257806A (zh
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R·西克尔斯基
J·汉布尔顿
N·桑卡尔
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Five Prime Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201580076553.8A 2014-12-22 2015-12-21 用于治疗pvns的抗csf1r抗体 Active CN107257806B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462095297P 2014-12-22 2014-12-22
US62/095,297 2014-12-22
US201562163251P 2015-05-18 2015-05-18
US62/163,251 2015-05-18
PCT/US2015/067012 WO2016106180A1 (en) 2014-12-22 2015-12-21 Anti-csf1r antibodies for treating pvns

Publications (2)

Publication Number Publication Date
CN107257806A CN107257806A (zh) 2017-10-17
CN107257806B true CN107257806B (zh) 2021-08-10

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US (3) US10040858B2 (enExample)
EP (1) EP3237447B1 (enExample)
JP (1) JP6797801B2 (enExample)
KR (1) KR20170096187A (enExample)
CN (1) CN107257806B (enExample)
AU (1) AU2015369854B2 (enExample)
BR (1) BR112017013111A2 (enExample)
CA (1) CA2969341C (enExample)
EA (1) EA201791421A1 (enExample)
ES (1) ES2843586T3 (enExample)
HK (1) HK1245804A1 (enExample)
IL (1) IL252716A0 (enExample)
MX (1) MX2017008218A (enExample)
SG (1) SG11201704792UA (enExample)
TW (1) TW201630937A (enExample)
WO (1) WO2016106180A1 (enExample)

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CN108948199B (zh) * 2018-07-18 2019-06-21 博奥信生物技术（南京）有限公司 抗人csf-1r单克隆抗体及其用途
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WO2024059508A2 (en) * 2022-09-12 2024-03-21 AmMax Bio, Inc. Treatment of tenosynovial giant cell tumor
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
CN118593504B (zh) * 2024-06-03 2025-03-18 北京大学第三医院（北京大学第三临床医学院） 氘可来昔替尼或其盐在制备pvns药物方面的新用途
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ES2843586T3 (es) 2021-07-19
AU2015369854A1 (en) 2017-06-15
AU2015369854B2 (en) 2021-07-01
US10040858B2 (en) 2018-08-07
KR20170096187A (ko) 2017-08-23
IL252716A0 (en) 2017-08-31
US10730949B2 (en) 2020-08-04
EP3237447A1 (en) 2017-11-01
EA201791421A1 (ru) 2017-10-31
US20190119390A1 (en) 2019-04-25
MX2017008218A (es) 2017-10-18
WO2016106180A1 (en) 2016-06-30
TW201630937A (zh) 2016-09-01
CA2969341A1 (en) 2016-06-30
CA2969341C (en) 2023-07-04
BR112017013111A2 (pt) 2018-05-15
US20160185869A1 (en) 2016-06-30
EP3237447B1 (en) 2020-12-02
JP2018501254A (ja) 2018-01-18
US20210009700A1 (en) 2021-01-14
JP6797801B2 (ja) 2020-12-09
SG11201704792UA (en) 2017-07-28
CN107257806A (zh) 2017-10-17
HK1245804A1 (zh) 2018-08-31

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