CN107223979A - 一种山药黄精泡腾片及其制备方法 - Google Patents
一种山药黄精泡腾片及其制备方法 Download PDFInfo
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- CN107223979A CN107223979A CN201710375267.2A CN201710375267A CN107223979A CN 107223979 A CN107223979 A CN 107223979A CN 201710375267 A CN201710375267 A CN 201710375267A CN 107223979 A CN107223979 A CN 107223979A
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- sealwort
- chinese yam
- effervescent tablet
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种山药黄精泡腾片及其制备方法，其山药黄精泡腾片由以下重量份的原料和辅料制备而成，原料：山药50‑70份、黄精50‑70份、枸杞25‑35份、覆盆子8‑12份、茯苓15‑25份、砂仁8‑12份、大枣8‑12份、玉竹25‑35份、芡实8‑12份、桑椹8‑12份、甘草10‑15份；辅料：枸橼酸40‑50份、碳酸氢钠40‑50份、微粉硅胶8‑12份、双歧糖3‑6份、甘露醇300‑370份。本发明中综合使用多种药食同源的中药原料，口感佳，同时具有补肝肾、强筋骨、增强机体免疫力、安神益智、调理脾胃等多种生理活性功能的泡腾片，对于亚健康人群有很好的疗效，而且制备方法简单，可长期食用。
Description
技术领域
本发明属于食品加工技术领域，具体涉及一种山药黄精泡腾片及其制备方法。
背景技术
随着现代生活节奏的加快和环境污染加剧，很多人尤其是中老年人、久坐办公室的都市白领及学生都处于亚健康状态，亚健康的主要临床表现为疲劳、虚弱、肌肉和关节酸痛、头昏头痛、心悸胸闷、睡眠紊乱、食欲不振、易于感冒、记忆力下降、急躁易怒、反应迟钝等；而目前针对亚健康尚无明确的治疗方法和针对性药物。
泡腾是近年来发展起来的一种新的剂型，由原料和崩解剂组成，泡腾可加速崩解和溶化，提高生物利用度、改变原料本身味道，改良口感，兼顾液体制剂和固体制剂的优点，而目前市场上泡腾片仅有Vc泡腾片，补钙泡腾片、阿司匹林泡腾片等较少的几种，并没有针对亚健康人群使用的泡腾制剂。
发明内容
本发明的目的就在于为解决现有技术的不足而提供一种适用于亚健康人群，具有补肝肾、强筋骨、增强机体免疫力、安神益智、调理脾胃等功能的山药黄精泡腾片。
本发明的目的是以下述技术方案实现的：
一种山药黄精泡腾片，由以下重量份的原料和辅料制备而成：
原料：山药50-70份、黄精50-70份、枸杞25-35份、覆盆子8-12份、茯苓15-25份、砂仁8-12份、大枣8-12份、玉竹25-35份、芡实8-12份、桑椹8-12份、甘草10-15份；
辅料：枸橼酸40-50份、碳酸氢钠40-50份、微粉硅胶8-12份、双歧糖3-6份、甘露醇300-370份。
优选的，所述的山药黄精泡腾片，由以下重量份的原料和辅料制备而成：
原料：山药60份、黄精60份、枸杞30份、覆盆子10份、茯苓20份、砂仁10份、大枣10份、玉竹30份、芡实10份、桑椹10份、甘草12.5份；
辅料：枸橼酸45份、碳酸氢钠45份、微粉硅胶10份、双歧糖4.5份、甘露醇335份。
所述山药黄精泡腾片的制备方法，包括以下步骤：
（1）原料浸提浓膏制备：取上述原料加水浸提，过滤，取滤液浓缩至相对密度为1.25-1.35的浸膏，备用；
（2）酸性颗粒的制备：取全部枸橼酸、甘露醇总质量的45-55%、微粉硅胶总质量的45-55%、双歧糖总质量的45-55%混合均匀，加入浸膏总质量的45-55%，以水为润湿剂，制成软材，然后采用湿法制粒，于40-60℃条件下烘干；
（3）碱性颗粒的制备：取全部碳酸氢钠，步骤（2）剩余的甘露醇、微粉硅胶、双歧糖和浸膏，以水为润湿剂，制成软材，然后采用湿法制粒，于40-60℃条件下烘干；
（4）压片：将步骤（2）制备得到的酸性颗粒和步骤（3）制备得到的碱性颗粒混合均匀后压片。
优选的，所述山药黄精泡腾片的制备方法，步骤（1）中具体步骤为取上述原料加5-10倍质量水煮沸浸提1.5-2h，过滤，取残渣重复浸提，然后过滤，合并两次滤液，浓缩至相对密度为1.25-1.35的浸膏。
本发明中综合使用多种药食同源的中药原料，然后加入崩解剂和其它辅料制备得到一种溶解迅速，口感佳，同时具有补肝肾、强筋骨、增强机体免疫力、安神益智、调理脾胃等多种生理活性功能的泡腾片，对于亚健康人群有很好的疗效，而且制备方法简单，可长期食用，无副作用。
具体实施方式
实施例1
一种山药黄精泡腾片，由以下重量份的原料和辅料制备而成：
原料：山药50份、黄精50份、枸杞30份、覆盆子10份、茯苓20份、砂仁10份、大枣10份、玉竹30份、芡实10份、桑椹10份、甘草12.5份；
辅料：枸橼酸45份、碳酸氢钠45份、微粉硅胶10份、双歧糖4.5份、甘露醇335份。
所述山药黄精泡腾片的制备方法，包括以下步骤：
（1）原料浸提浓膏制备：取上述原料加5-10倍质量水煮沸浸提1.5-2h，过滤，取残渣重复浸提，然后过滤，合并两次滤液，浓缩至相对密度为1.25-1.35的浸膏，备用；
（2）酸性颗粒的制备：取全部枸橼酸、甘露醇总质量的45-55%、微粉硅胶总质量的45-55%、双歧糖总质量的45-55%混合均匀，加入浸膏总质量的45-55%，以水为润湿剂，制成软材，然后采用湿法制粒，于40-60℃条件下烘干；
（3）碱性颗粒的制备：取全部碳酸氢钠，步骤（2）剩余的甘露醇、微粉硅胶、双歧糖和浸膏，以水为润湿剂，制成软材，然后采用湿法制粒，于40-60℃条件下烘干；
（4）压片：将步骤（2）制备得到的酸性颗粒和步骤（3）制备得到的碱性颗粒混合均匀后压片。
原料中，山药可补脾养胃，生津益肺，补肾涩精，用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。黄精可补气养阴，健脾，润肺，益肾。用于脾胃气虚，体倦乏力，胃阴不足，口干食少，肺虚燥咳，劳嗽咳血，精血不足，腰膝酸软，须发早白，内热消渴。枸杞子可滋补肝肾，益精明目，用于虚劳精亏，腰膝酸痛，眩晕耳鸣，阳萎遗精，内热消渴，血虚萎黄，目昏不明。覆盆子可益肾固精缩尿，养肝明目，用于遗精滑精，遗尿尿频，阳痿早泄，目暗昏花。茯苓可解毒，除湿，通利关节。砂仁可化湿开胃，温脾止泻，理气。用于湿浊中阻，脘痞不饥，脾胃虚寒，呕吐泄泻。大枣可补中益气，养血安神。用于脾虚食少，乏力便溏，妇人脏躁。玉竹可养阴润燥，生津止渴，用于肺胃阴伤，燥热咳嗽，咽干口渴，内热消渴。芡实，可有益肾固精，补脾止泻，除湿止带。桑椹可滋阴补血，生津润燥，用于肝肾阴虚，眩晕耳鸣，心悸失眠，须发早白，津伤口渴，内热消渴，肠燥便秘。甘草气微，味甜而特殊，用于补中益气。
上述原料中，以山药、黄精为主料，用以补气健脾胃益肾，枸杞、甘草、大枣可增强补气效果，覆盆子、芡实可增强益肾效果，玉竹、桑椹可滋阴润燥，上述补益的药食用较多以后会导致痞满胃胀，因此配方中添加砂仁、茯苓可化湿利气，减少不良反应，使其可长期食用。而且，经过实验发现，使用砂仁比药性形同的厚朴有更好的效果；原料中的甘草、大枣、枸杞均带有甜味，可中和其他原料带来的不良口感；同时，泡腾加水崩解以后，产生大量的二氧化碳，会起到明显的矫味作用，双歧糖可进一步矫味，提升口感；山药水体液中含有较多的黏液质，甘草、大枣等原料制备得到的水提液均含有一定的糖分，储存时间长容易吸潮结块，实验发现通过添加微粉硅胶、甘露醇可防止粘结，使用枸橼酸和碳酸氢钠做崩解剂，加水以后会迅速溶解，无残留；因此，本发明制备得到的山药黄精泡腾片，速溶性好，可以掩盖中药的不良气味，提高生物利用度。
实施例2
一种山药黄精泡腾片，由以下重量份的原料和辅料制备而成：
原料：山药60份、黄精60份、枸杞30份、覆盆子10份、茯苓20份、砂仁10份、大枣10份、玉竹30份、芡实10份、桑椹10份、甘草12.5份；
辅料：枸橼酸45份、碳酸氢钠45份、微粉硅胶10份、双歧糖4.5份、甘露醇335份。
所述山药黄精泡腾片的制备方法，包括以下步骤：
（1）原料浸提浓膏制备：取上述原料加10倍质量水煮沸浸提2h，过滤，取残渣重复浸提，然后过滤，合并两次滤液，浓缩至相对密度为1.35的浸膏，备用；
（2）酸性颗粒的制备：取全部枸橼酸、甘露醇总质量的50%、微粉硅胶总质量的50%、双歧糖总质量的50%混合均匀，加入浸膏总质量的50%，以水为润湿剂，制成软材，然后采用湿法制粒，于50℃条件下烘干；
（3）碱性颗粒的制备：取全部碳酸氢钠，步骤（2）剩余的甘露醇、微粉硅胶、双歧糖和浸膏，以水为润湿剂，制成软材，然后采用湿法制粒，于50℃条件下烘干；
（4）压片：将步骤（2）制备得到的酸性颗粒和步骤（3）制备得到的碱性颗粒混合均匀后压片。
实施例3
一种山药黄精泡腾片，由以下重量份的原料和辅料制备而成：
原料：山药70份、黄精70份、枸杞30份、覆盆子10份、茯苓20份、砂仁10份、大枣10份、玉竹30份、芡实10份、桑椹10份、甘草12.5份；
辅料：枸橼酸45份、碳酸氢钠45份、微粉硅胶10份、双歧糖4.5份、甘露醇335份。制备方法同实施例 2。
比较例1
一种山药黄精泡腾片，由以下重量份的原料和辅料制备而成：
原料：山药60份、黄精60份、枸杞30份、覆盆子10份、茯苓20份、砂仁10份、大枣10份、玉竹30份、芡实10份、桑椹10份、甘草12.5份；
辅料：苹果酸45份、碳酸氢钠45份、微粉硅胶10份、双歧糖4.5份、甘露醇335份。制备方法同实施例 2。与实施例2中的配方相比较，把辅料中的枸橼酸用苹果酸替换。
比较例2
一种山药黄精泡腾片，由以下重量份的原料和辅料制备而成：
原料：山药60份、黄精60份、枸杞30份、覆盆子10份、茯苓20份、砂仁10份、大枣10份、玉竹30份、芡实10份、桑椹10份、甘草12.5份；
辅料：枸橼酸45份、碳酸氢钠45份、微粉硅胶10份、双歧糖4.5份、麦芽糊精335份。制备方法同实施例 2。与实施例2中的配方相比较，把辅料中的甘露醇用麦芽糊精替换。
比较例3
一种山药黄精泡腾片，其特征在于由以下重量份的原料和辅料制备而成：
原料：山药60份、黄精60份、枸杞30份、覆盆子10份、茯苓20份、砂仁10份、大枣10份、玉竹30份、芡实10份、桑椹10份、甘草12.5份；
辅料：枸橼酸45份、碳酸氢钠45份、PVP乙醇溶液10份、双歧糖4.5份、甘露醇335份。制备方法同实施例 2。与实施例2中的配方相比较，把辅料中的微粉硅胶用PVP乙醇溶液替换。
对每个产品做评定，具体结果见下表1。
调理亚健康状态的试验
1、抗疲劳效果试验
易疲劳是亚健康人群的典型特征之一，即使是对于正常人群，工作时间过长也会有疲劳感。本试验以容易疲惫的亚健康人群为研究对象，观察对象中男、女各 10 人，无其他严重疾病，年龄为 25-45岁，平均年龄 35岁。观察对象随机分成两组，一组10人。
第一组人群每天用温水冲服本发明实施例 2中的泡腾片3片（共30g），持续60 天。
第二组人群每天没有服用任何药物或保健品，也未食用本产品。
试验结果显示，第一组试验对象中有9人表示食用泡腾片期间工作精神充沛，无明显的疲惫感或困倦感，1人表示食用泡腾片期间工作有疲惫感。第二组试验对象中有8人表示工作期间有疲劳感和困倦感，2人表示有困倦感。
上述试验结果表明，长期饮用本发明的泡腾片具有缓解疲劳和补充体力的作用。
2、改善食欲效果试验
亚健康人群的另一个特征就是食欲不振，没有食欲就会影响情绪和健康，身体不能补充所需营养成分。长期的食欲不振会引起贫血、低血糖和营养不良等其他疾病，早期应得到足够的重视。本试验以食欲不振的亚健康人群为研究对象，观察对象中男、女各 10 人，无其他严重疾病，年龄为 25-40岁，平均年龄 32岁。观察对象随机分成两组，一组10人。
第一组人群每天用温水冲服本发明实施例 2中的泡腾片3片（共30g），持续60 天。
第二组人群每天没有服用任何药物或保健品，也未食用本产品。
试验结果显示，第一组试验对象中有8人表示食用泡腾片期间食欲明显提高，2人表示食用泡腾片期间食欲有所提高。第二组试验对象中有10人表示依然食欲不振和体力不支。
上述试验结果表明，长期饮用本发明的泡腾片具有提高食欲和补充体力的作用。
3、改善失眠效果试验
失眠是指无法入睡或无法保持睡眠状态，导致睡眠不足。又称入睡和维持睡眠障碍，为各种原因引起入睡困难、睡眠深度或频度过短、早醒及睡眠时间不足或质量差等，是现代人最常见的疾病之一。失眠往往会给患者带来极大的痛苦和心理负担，又会因为滥用失眠药物而损伤身体其他方方面面。
本试验以经常失眠的亚健康人群为研究对象，观察对象中男、女各 10 人，无其他严重疾病，年龄为 35-50岁，平均年龄 43岁。观察对象随机分成两组，一组10人。
第一组人群每天用温水冲服本发明实施例 2中的泡腾片3片，持续60 天。
第二组人群每天没有服用任何药物或保健品，也未食用本产品。
试验结果显示，第一组试验对象中有8人表示食用泡腾片期间失眠症状明显得到改善，2人表示食用泡腾片期间失眠症状有所提高。第二组试验对象中有10人表示依然失眠，工作时精神状态不佳。
上述试验结果表明，长期饮用本发明的泡腾片对改善睡眠具有一定作用。
本发明实施例4-27提供的山药黄精泡腾片原料配方见表2-5，山药黄精泡腾片辅料配方见表6-9，其制备方法与实施例2相同。
Claims (4)
1.一种山药黄精泡腾片，其特征在于由以下重量份的原料和辅料制备而成：
原料：山药50-70份、黄精50-70份、枸杞25-35份、覆盆子8-12份、茯苓15-25份、砂仁8-12份、大枣8-12份、玉竹25-35份、芡实8-12份、桑椹8-12份、甘草10-15份；
辅料：枸橼酸40-50份、碳酸氢钠40-50份、微粉硅胶8-12份、双歧糖3-6份、甘露醇300-370份。
2.如权利要求1所述的山药黄精泡腾片，其特征在于由以下重量份的原料和辅料制备而成：
原料：山药60份、黄精60份、枸杞30份、覆盆子10份、茯苓20份、砂仁10份、大枣10份、玉竹30份、芡实10份、桑椹10份、甘草12.5份；
辅料：枸橼酸45份、碳酸氢钠45份、微粉硅胶10份、双歧糖4.5份、甘露醇335份。
3.如权利要求1-2任一项所述山药黄精泡腾片的制备方法，其特征在于包括以下步骤：
（1）原料浸提浓膏制备：取上述原料加水浸提，过滤，取滤液浓缩至相对密度为1.25-1.35的浸膏，备用；
（2）酸性颗粒的制备：取全部枸橼酸、甘露醇总质量的45-55%、微粉硅胶总质量的45-55%、双歧糖总质量的45-55%混合均匀，加入浸膏总质量的45-55%，以水为润湿剂，制成软材，然后采用湿法制粒，于40-60℃条件下烘干；
（3）碱性颗粒的制备：取全部碳酸氢钠，步骤（2）剩余的甘露醇、微粉硅胶、双歧糖和浸膏，以水为润湿剂，制成软材，然后采用湿法制粒，于40-60℃条件下烘干；
（4）压片：将步骤（2）制备得到的酸性颗粒和步骤（3）制备得到的碱性颗粒混合均匀后压片。
4.如权利要求3所述山药黄精泡腾片的制备方法，其特征在于步骤（1）中具体步骤为取上述原料加5-10倍质量水煮沸浸提1.5-2h，过滤，取残渣重复浸提，然后过滤，合并两次滤液，浓缩至相对密度为1.25-1.35的浸膏。
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| CN109497550A (zh) * | 2019-01-14 | 2019-03-22 | 楚雄州百草岭药业发展有限公司 | 一种黄精组合物及其制备方法、制剂与应用 |
| CN110897070A (zh) * | 2019-11-29 | 2020-03-24 | 山西恩予健康产业有限公司 | 一种固体饮料及其制备方法 |
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| CN107714936A (zh) * | 2017-11-30 | 2018-02-23 | 江苏康缘药业股份有限公司 | 一种中药组合物及其制备方法与应用 |
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