CN107207472B - Akt激酶的抑制剂 - Google Patents
Akt激酶的抑制剂 Download PDFInfo
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- CN107207472B CN107207472B CN201580075417.7A CN201580075417A CN107207472B CN 107207472 B CN107207472 B CN 107207472B CN 201580075417 A CN201580075417 A CN 201580075417A CN 107207472 B CN107207472 B CN 107207472B
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- Prior art keywords
- trans
- phenyl
- amino
- cyclohexyl
- phenylpyridin
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201423087 | 2014-12-23 | ||
| GB1423087.4 | 2014-12-23 | ||
| GB1508787.7 | 2015-05-22 | ||
| GBGB1508787.7A GB201508787D0 (en) | 2014-12-23 | 2015-05-22 | Pharmaceutically active compounds |
| GBGB1519919.3A GB201519919D0 (en) | 2015-11-11 | 2015-11-11 | Pharmaceutically active compounds |
| GB1519919.3 | 2015-11-11 | ||
| PCT/EP2015/081168 WO2016102672A2 (en) | 2014-12-23 | 2015-12-23 | Pharmaceutically active compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107207472A CN107207472A (zh) | 2017-09-26 |
| CN107207472B true CN107207472B (zh) | 2020-08-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580075417.7A Expired - Fee Related CN107207472B (zh) | 2014-12-23 | 2015-12-23 | Akt激酶的抑制剂 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10336702B2 (enExample) |
| EP (1) | EP3240784A2 (enExample) |
| JP (2) | JP6787899B2 (enExample) |
| KR (1) | KR20170115042A (enExample) |
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| MX2017005462A (es) | 2014-11-05 | 2017-07-28 | Flexus Biosciences Inc | Agentes inmunorreguladores. |
| US10336702B2 (en) * | 2014-12-23 | 2019-07-02 | Bergenbio Asa | Pharmaceutically active compounds |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| JP2020506885A (ja) | 2017-01-13 | 2020-03-05 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 1,2,4−トリアジン−3−アミン誘導体、その製造方法、および医薬におけるその使用 |
| WO2019158070A1 (zh) * | 2018-02-15 | 2019-08-22 | 杭州阿诺生物医药科技有限公司 | A2a和/或a2b受体拮抗剂 |
| US20210215697A1 (en) | 2018-05-14 | 2021-07-15 | Bergenbio Asa | Serum Biomarkers |
| CN111171065A (zh) * | 2020-02-26 | 2020-05-19 | 上海博黑生物科技有限公司 | 一种(4-(1-((叔丁氧基羰基)氨基)环丙基)苯基)硼酸酯的合成方法 |
| KR20240131463A (ko) | 2020-05-05 | 2024-08-30 | 뉴베일런트, 아이엔씨. | 헤테로방향족 거대환식 에터 화학치료제 |
| CN115916196A (zh) * | 2020-05-05 | 2023-04-04 | 纽威伦特公司 | 杂芳族大环醚化学治疗剂 |
| KR102853833B1 (ko) * | 2020-12-21 | 2025-09-02 | 동우 화인켐 주식회사 | 양자점, 양자점 분산체, 광변환 경화성 조성물, 컬러필터, 광변환 적층기재 및 화상표시장치 |
| WO2025066935A1 (en) * | 2023-09-28 | 2025-04-03 | Hepaitech (Beijing) Biopharma Technology Co., Ltd. | Compounds, compositions and methods thereof |
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| CN1942465A (zh) * | 2004-04-09 | 2007-04-04 | 默克公司 | Akt活性抑制剂 |
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| US6486199B1 (en) | 2001-06-21 | 2002-11-26 | Medicines For Malaria Venture Mmv International Centre Cointrin | Spiro and dispiro 1,2,4-trioxolane antimalarials |
| US20070185152A1 (en) * | 2004-03-02 | 2007-08-09 | Smithkline Beecham Corporation | Inhibitors of akt activity |
| ES2270715B1 (es) * | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| GB0922589D0 (en) * | 2009-12-23 | 2010-02-10 | Almac Discovery Ltd | Pharmaceutical compounds |
| KR102147420B1 (ko) * | 2012-12-07 | 2020-08-25 | 베나토알엑스 파마슈티컬스, 인크. | 베타-락타마제 억제제 |
| US10336702B2 (en) * | 2014-12-23 | 2019-07-02 | Bergenbio Asa | Pharmaceutically active compounds |
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| CN107207472A (zh) | 2017-09-26 |
| US10336702B2 (en) | 2019-07-02 |
| AU2015370911A1 (en) | 2017-08-10 |
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| US20210070708A1 (en) | 2021-03-11 |
| JP6787899B2 (ja) | 2020-11-18 |
| US20180029985A1 (en) | 2018-02-01 |
| WO2016102672A2 (en) | 2016-06-30 |
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