AU2015370911B2 - Inhibitors of Akt kinase - Google Patents

Inhibitors of Akt kinase Download PDF

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Publication number
AU2015370911B2
AU2015370911B2 AU2015370911A AU2015370911A AU2015370911B2 AU 2015370911 B2 AU2015370911 B2 AU 2015370911B2 AU 2015370911 A AU2015370911 A AU 2015370911A AU 2015370911 A AU2015370911 A AU 2015370911A AU 2015370911 B2 AU2015370911 B2 AU 2015370911B2
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AU
Australia
Prior art keywords
trans
phenyl
amino
cyclohexyl
phenylpyridin
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AU2015370911A
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AU2015370911A1 (en
Inventor
Derek Londesbrough
Alan Naylor
Stuart Thomas Onions
Mohammed Abdul QUDDUS
Colin Peter Sambrook-Smith
Jason John Shiers
John Paul Watts
Joseph William WRIGGLESWORTH
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BerGenBio ASA
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BerGenBio ASA
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Priority claimed from GBGB1508787.7A external-priority patent/GB201508787D0/en
Priority claimed from GBGB1519919.3A external-priority patent/GB201519919D0/en
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Publication of AU2015370911A1 publication Critical patent/AU2015370911A1/en
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Publication of AU2015370911B2 publication Critical patent/AU2015370911B2/en
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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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JP2020506885A (ja) 2017-01-13 2020-03-05 江蘇恒瑞医薬股▲ふん▼有限公司 １，２，４−トリアジン−３−アミン誘導体、その製造方法、および医薬におけるその使用
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CN111171065A (zh) * 2020-02-26 2020-05-19 上海博黑生物科技有限公司 一种(4-(1-((叔丁氧基羰基)氨基)环丙基)苯基)硼酸酯的合成方法
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