CN1071117C - 镇咳剂 - Google Patents

镇咳剂 Download PDF

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Publication number
CN1071117C
CN1071117C CN93119935A CN93119935A CN1071117C CN 1071117 C CN1071117 C CN 1071117C CN 93119935 A CN93119935 A CN 93119935A CN 93119935 A CN93119935 A CN 93119935A CN 1071117 C CN1071117 C CN 1071117C
Authority
CN
China
Prior art keywords
morphinan
beta
epoxy
bis
dehydrogenations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93119935A
Other languages
English (en)
Chinese (zh)
Other versions
CN1099617A (zh
Inventor
长濑博
龟井淳三
河合孝治
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of CN1099617A publication Critical patent/CN1099617A/zh
Application granted granted Critical
Publication of CN1071117C publication Critical patent/CN1071117C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Linear Motors (AREA)
  • Fats And Perfumes (AREA)
CN93119935A 1992-12-22 1993-12-22 镇咳剂 Expired - Fee Related CN1071117C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34194792 1992-12-22
JP341947/1992 1992-12-22
JP341947/92 1992-12-22

Publications (2)

Publication Number Publication Date
CN1099617A CN1099617A (zh) 1995-03-08
CN1071117C true CN1071117C (zh) 2001-09-19

Family

ID=18349997

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93119935A Expired - Fee Related CN1071117C (zh) 1992-12-22 1993-12-22 镇咳剂

Country Status (11)

Country Link
US (1) US5714483A (enExample)
EP (1) EP0636371B1 (enExample)
KR (1) KR950700065A (enExample)
CN (1) CN1071117C (enExample)
AT (1) ATE166229T1 (enExample)
AU (1) AU674379B2 (enExample)
CA (1) CA2130457A1 (enExample)
DE (1) DE69318710T2 (enExample)
NO (1) NO307496B1 (enExample)
TW (1) TW366284B (enExample)
WO (1) WO1994014445A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU712012B2 (en) * 1995-09-26 1999-10-28 Toray Industries, Inc. Indole derivatives and medical application thereof
EP0894799B1 (en) * 1997-01-16 2004-04-07 Toray Industries, Inc. Indolomorphinane derivatives and remedies/preventives for cerebral disorders
EP0998928A4 (en) * 1997-07-09 2002-10-24 Toray Industries Cough medium
KR20020012314A (ko) * 1999-07-19 2002-02-15 히라이 가쯔히꼬 빈뇨 혹은 요실금의 치료 또는 예방제
PL368612A1 (en) * 2001-08-14 2005-04-04 Biotie Therapies Corporation Method of treating alcoholism or alcohol abuse
EP1522542A1 (en) * 2002-07-11 2005-04-13 Toray Industries, Inc. Therapeutic or preventive agent for nausea/vomiting
TW200633721A (en) * 2004-12-14 2006-10-01 Shionogi & Co A pharmaceutical composition for treating constipation
CN101355943A (zh) * 2005-10-11 2009-01-28 东丽株式会社 呕气和/或呕吐治疗药
JPWO2008001859A1 (ja) * 2006-06-30 2009-11-26 学校法人北里研究所 オピオイドδ受容体アゴニスト

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
PT95069B (pt) * 1989-08-24 1997-10-31 Searle & Co Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
AU654275B2 (en) * 1991-04-30 1994-11-03 Ur Labs, Inc. Method for reducing emesis and nausea induced by the administration of an emesis-causing agent
JPH04342529A (ja) * 1991-05-21 1992-11-30 Toray Ind Inc 抗アレルギー剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists

Also Published As

Publication number Publication date
US5714483A (en) 1998-02-03
EP0636371A1 (en) 1995-02-01
DE69318710T2 (de) 1998-09-10
CA2130457A1 (en) 1994-07-07
KR950700065A (ko) 1995-01-16
EP0636371A4 (enExample) 1995-03-01
WO1994014445A1 (fr) 1994-07-07
NO943070L (no) 1994-10-21
CN1099617A (zh) 1995-03-08
DE69318710D1 (en) 1998-06-25
TW366284B (en) 1999-08-11
NO943070D0 (no) 1994-08-19
NO307496B1 (no) 2000-04-17
ATE166229T1 (de) 1998-06-15
AU5715694A (en) 1994-07-19
EP0636371B1 (en) 1998-05-20
AU674379B2 (en) 1996-12-19

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee