CN107109491A - 用于治疗和诊断化学疗法抗性癌症的组合物和方法 - Google Patents

用于治疗和诊断化学疗法抗性癌症的组合物和方法 Download PDF

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CN107109491A
CN107109491A CN201580070095.7A CN201580070095A CN107109491A CN 107109491 A CN107109491 A CN 107109491A CN 201580070095 A CN201580070095 A CN 201580070095A CN 107109491 A CN107109491 A CN 107109491A
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cancer
patient
postn
chemotherapy
stromal
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Y·王
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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CN201580070095.7A 2014-12-23 2015-12-22 用于治疗和诊断化学疗法抗性癌症的组合物和方法 Pending CN107109491A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462096355P 2014-12-23 2014-12-23
US62/096,355 2014-12-23
US201562200340P 2015-08-03 2015-08-03
US62/200,340 2015-08-03
PCT/US2015/067427 WO2016106340A2 (en) 2014-12-23 2015-12-22 Compositions and methods for treating and diagnosing chemotherapy-resistant cancers

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CN107109491A true CN107109491A (zh) 2017-08-29

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Country Link
US (1) US20170253933A1 (https=)
EP (1) EP3237639A2 (https=)
JP (1) JP2018508183A (https=)
KR (1) KR20170094165A (https=)
CN (1) CN107109491A (https=)
AU (1) AU2015369624A1 (https=)
BR (1) BR112017010788A2 (https=)
CA (1) CA2968359A1 (https=)
HK (1) HK1243141A1 (https=)
IL (1) IL252361A0 (https=)
MX (1) MX2017006864A (https=)
RU (1) RU2710735C2 (https=)
SG (1) SG11201704707PA (https=)
WO (1) WO2016106340A2 (https=)

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CN110563830A (zh) * 2019-09-16 2019-12-13 中南大学湘雅医院 Anxa1衍生多肽及其应用
CN110950960A (zh) * 2019-11-26 2020-04-03 中国农业大学 基于高通量测序和杂合杂交瘤技术的小分子化合物抗体的制备方法
CN112367994A (zh) * 2018-06-27 2021-02-12 株式会社麦迪帕克特 诊断和治疗表达高水平TGF-β应答标记的癌症患者的方法
WO2021164563A1 (en) * 2020-02-20 2021-08-26 The University Of Hong Kong Pd1-based vaccination composition and methods thereof
CN114761009A (zh) * 2019-10-09 2022-07-15 G1治疗公司 具有失调的成纤维细胞生长因子受体信号转导的癌症的靶向治疗

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JP7595413B2 (ja) 2016-11-30 2024-12-06 ケース ウエスタン リザーブ ユニバーシティ １５－ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用
WO2018145080A1 (en) 2017-02-06 2018-08-09 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
JP7379355B2 (ja) * 2017-11-20 2023-11-14 トルレモ セラピューティクス アーゲー 診断方法
WO2019103456A2 (ko) * 2017-11-22 2019-05-31 울산대학교 산학협력단 Pmvk를 유효성분으로 포함하는 방사선 저항성 암 진단용 또는 방사선 치료 예후 예측용 바이오마커 조성물
KR102141997B1 (ko) 2017-11-22 2020-08-06 (주)인핸스드바이오 Pmvk를 유효성분으로 포함하는 방사선 저항성 암 진단용 또는 방사선 치료 예후 예측용 바이오마커 조성물
TWI841554B (zh) 2018-03-21 2024-05-11 丹麥商珍美寶股份有限公司 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法
US11447769B2 (en) 2018-03-27 2022-09-20 The Trustees Of The University Of Pennsylvania Modified immune cells having enhanced function and methods for screening for same
WO2019217455A1 (en) 2018-05-07 2019-11-14 Genmab A/S Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
TWI844571B (zh) * 2018-10-30 2024-06-11 丹麥商珍美寶股份有限公司 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法
WO2020092808A1 (en) * 2018-10-31 2020-05-07 Regents Of The University Of Minnesota Methods for predicting a response to bevacizumab or platinum-based chemotherapy or both in patients with ovarian cancer
CN120463721A (zh) 2018-11-21 2025-08-12 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
EP3906031A4 (en) * 2019-01-02 2022-10-05 Zhejiang Crownmab Biotech Co. Ltd. CANCER TREATMENT USING A MULTI-TARGETED KINAS INHIBITOR IN COMBINATION WITH PROTEIN KINASES BIOMARKERS
CN111440871A (zh) * 2020-04-26 2020-07-24 至本医疗科技（上海）有限公司 基因标记物在肺癌预后判断中的应用
RU2738167C1 (ru) * 2020-06-08 2020-12-09 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии" Министерства здравоохранения Российской Федерации Способ определения эффективности химиотерапии препаратами платины при раке яичников III-IV стадии
EP4302093A1 (en) * 2021-03-01 2024-01-10 Genentech, Inc. Diagnostic methods and methods of treatment of ovarian cancer
CN114230655B (zh) * 2021-03-24 2025-02-25 深圳市新靶向生物科技有限公司 一种与食道癌驱动基因突变相关的抗原肽组合及其应用
CN113174439B (zh) * 2021-03-30 2022-06-28 中国医学科学院肿瘤医院 一种基于免疫基因对评分体系在预测非小细胞肺癌患者免疫治疗效果中的应用
KR20230001587A (ko) * 2021-06-28 2023-01-05 연세대학교 산학협력단 암의 예방 또는 치료용 약학 조성물
CN113876753A (zh) * 2021-10-20 2022-01-04 复旦大学附属中山医院 重组人半乳糖凝集素1抑制剂的制药用途
WO2024054074A1 (ko) * 2022-09-07 2024-03-14 재단법인 아산사회복지재단 고형암 환자의 화학요법 내성 억제용 약학 조성물 및 이의 용도
CN117248022A (zh) * 2023-10-24 2023-12-19 郑州大学第一附属医院 双硫死亡相关基因及风险模型预测肾上腺皮质癌预后及治疗中的应用
CN119224306A (zh) * 2024-09-26 2024-12-31 上海交通大学医学院附属仁济医院 Gprc5a的新用途

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