CN107109470B - 用于诊断胃癌的miRNA生物标志物 - Google Patents

用于诊断胃癌的miRNA生物标志物 Download PDF

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CN107109470B
CN107109470B CN201580054452.0A CN201580054452A CN107109470B CN 107109470 B CN107109470 B CN 107109470B CN 201580054452 A CN201580054452 A CN 201580054452A CN 107109470 B CN107109470 B CN 107109470B
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mirnas
hsa
gastric cancer
mirna
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CN107109470A (zh
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朱兴奋
周砺寒
邹瑞阳
杨启源
苏博欣
朱峰
杨维平
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NAT UNIVERSITY HOSPITAL SINGAP
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National University of Singapore
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CN201580054452.0A 2014-08-07 2015-08-11 用于诊断胃癌的miRNA生物标志物 Active CN107109470B (zh)

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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4137586B1 (en) * 2014-08-07 2026-04-22 Agency for Science, Technology and Research Microrna biomarker for the diagnosis of gastric cancer
WO2016182511A1 (en) * 2015-05-08 2016-11-17 Agency For Science, Technology And Research Method for diagnosis and prognosis of chronic heart failure
CN106636334B (zh) * 2016-10-09 2020-07-03 山东大学 microRNA标志物组及其在制备检测胃癌淋巴结转移试剂盒中的应用
JP6280997B1 (ja) * 2016-10-31 2018-02-14 株式会社Preferred Networks 疾患の罹患判定装置、疾患の罹患判定方法、疾患の特徴抽出装置及び疾患の特徴抽出方法
CN106755377B (zh) * 2016-12-12 2021-05-25 浙江省中医院 一种胃癌血清学检测鉴定试剂盒及方法
EP3601564A4 (en) * 2017-03-23 2021-03-31 Quadrant Biosciences Inc. PROCESS FOR DIAGNOSING OR MONITORING CONDITIONS CHARACTERIZED BY ABNORMAL TEMPORAL VARIATIONS, PROCESS FOR NORMALIZING EPIGENETIC DATA TO COMPENSATE FOR TEMPORAL VARIATIONS
CL2017002289A1 (es) 2017-09-08 2019-08-16 Univ Pontificia Catolica Chile Método no invasivo de diagnóstico temprano de cáncer gástrico, usando como biomarcador los niveles de metilación de la secuencia de adn del promotor del microrna -335-5p
CN107723366B (zh) * 2017-09-11 2019-10-01 朱伟 一种与贲门癌辅助诊断相关的血清miRNA标志物及其应用
CN107746880B (zh) * 2017-11-01 2018-12-14 健生生物技术有限公司 一种基于RT-qPCR法检测胃癌的试剂盒及其制备方法和应用
CN108611414A (zh) * 2018-04-26 2018-10-02 北京工业大学 新的靶向肿瘤微环境与肺癌干细胞相互作用的miRNA的检测及应用
CN108743617A (zh) * 2018-05-03 2018-11-06 武汉科技大学 miR-15a-5p在提高CAR-T细胞抗肿瘤能力中的应用
CN112534053A (zh) * 2018-06-21 2021-03-19 公立大学法人名古屋市立大学 胃癌生物标志物及其用途
KR102089559B1 (ko) * 2018-08-31 2020-03-16 차의과학대학교 산학협력단 난소의 fsh에 대한 반응성의 진단 또는 예측용 바이오마커 및 이의 용도
TW202018727A (zh) 2018-11-09 2020-05-16 財團法人工業技術研究院 整體式學習預測方法與系統
SG11202106638UA (en) * 2018-12-19 2021-07-29 Agency Science Tech & Res Method of diagnosing gastric cancers using micrornas
WO2020132494A2 (en) * 2018-12-21 2020-06-25 Baylor Research Institute Methods for prognosing, diagnosing, and treating gastric cancer
CN110066870B (zh) * 2019-04-12 2021-12-14 江苏省人民医院(南京医科大学第一附属医院) hsa-miR-382-5p在制备诊断视网膜变性疾病的试剂盒中的应用
CN117683885A (zh) * 2019-04-30 2024-03-12 觅瑞实验室私人有限公司 一种检测胃癌的miRNA标志物组合及试剂盒
EP4008793A4 (en) 2019-08-02 2023-04-12 Kabushiki Kaisha Toshiba ANALYTICAL METHOD AND KIT
KR102288359B1 (ko) * 2019-12-06 2021-08-10 주식회사 레피겐엠디 면역력 감소에 의한 질병의 발병 위험 예측용 다중 유전자 마커 및 이를 이용한 질병의 발병 위험 예측 방법
CN111471764B (zh) * 2019-12-27 2023-09-15 陈锦飞 一种用于筛查或辅助诊断胃癌的生物标志物组合及其试剂盒和应用
JP7511823B2 (ja) * 2020-01-24 2024-07-08 株式会社The IT Lab miRNAの発現レベルをがんの確定診断の前のスクリーニングの指標として用いるがんの診断を補助する方法
CN111471683B (zh) * 2020-04-15 2021-09-07 湖南省科域生物医药科技有限公司 miR-93-5p作为诊断和治疗胃癌标志物的应用
KR102489708B1 (ko) * 2020-09-14 2023-01-18 서울대학교산학협력단 GDF11 유전자의 발현을 조절하는 PCBP2와 microRNA를 함유하는 조성물
CN112226514B (zh) * 2020-11-23 2021-08-03 苏州京脉生物科技有限公司 用于早期胃癌检测的标志物组合、试剂盒及其应用
CN112941185B (zh) * 2021-03-26 2023-06-23 杭州医学院 miR-29a作为标志物在制备恶性间皮瘤检测试剂盒中的应用
CN113151477B (zh) * 2021-05-08 2022-04-15 武汉大学中南医院 用于检测肠癌的miRNA标记物及其应用
CN113186285B (zh) * 2021-05-10 2022-05-24 深圳市展行生物有限公司 一种辅助诊断胃癌的方法及其使用的miRNA组合
CN113913516B (zh) * 2021-05-26 2023-08-29 东莞市松山湖中心医院(东莞市石龙人民医院、东莞市第三人民医院、东莞市心血管病研究所) hsa_circ_0006470作为靶点在制备miR-27b-3p的调节剂的应用
JP7406059B1 (ja) 2022-10-20 2023-12-27 防衛装備庁長官 急性ストレス評価用データの生成方法
WO2024229279A2 (en) * 2023-05-02 2024-11-07 Dana-Farber Cancer Institute, Inc. Use of circulating microrna profiles for identification of brca1 or brca2 mutations
CN118547069B (zh) * 2024-05-14 2025-08-22 北京热景生物技术股份有限公司 一种基于细胞外囊泡miRNA的胃癌诊断标志物及其应用
WO2025245056A1 (en) * 2024-05-20 2025-11-27 City Of Hope Gastric cancer rna biomarkers and uses thereof
CN119082291A (zh) * 2024-09-24 2024-12-06 中国人民解放军总医院第二医学中心 用于诊断评估心肌衰老的miRNA标志物、试剂盒及其应用
CN119580829A (zh) * 2024-11-25 2025-03-07 苏州大学 一种早期胃癌检测的标志物识别方法及诊断模型构建方法
CN119351558A (zh) * 2024-12-10 2025-01-24 西藏自治区人民政府驻成都办事处医院 一种检测胃癌的标志物、检测试剂盒及药物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102007223A (zh) * 2008-02-28 2011-04-06 俄亥俄州立大学研究基金会 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物
WO2012010584A1 (en) * 2010-07-20 2012-01-26 Febit Holding Gmbh Complex mirna sets as novel biomarkers for gastric cancer
CN103773761A (zh) * 2014-01-14 2014-05-07 南京医科大学 检测胃癌的血清/血浆微小rna标志物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013245505B2 (en) * 2006-01-05 2016-06-23 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
EP2487258B1 (en) * 2006-01-05 2014-10-01 The Ohio State University Research Foundation MicroRNA-based methods for the diagnosis of colon, pancreas and stomach cancer
WO2009147656A1 (en) 2008-06-01 2009-12-10 Rosetta Genomics Ltd. Compositions and methods for prognosis of gastric cancer
CN101988059B (zh) 2009-07-30 2014-04-02 江苏命码生物科技有限公司 胃癌检测标记物及其检测试剂盒和生物芯片
US9939442B2 (en) 2011-09-08 2018-04-10 The Regents Of The University Of California Salivary biomarkers for gastric cancer detection
JP2013085542A (ja) * 2011-10-21 2013-05-13 Sysmex Corp 胃癌の検出方法、胃癌の血液マーカーおよびその使用
GB201317887D0 (en) * 2013-10-09 2013-11-20 Reneuron Ltd Product
CN103937888B (zh) * 2014-04-14 2016-08-17 上海交通大学 鉴别胃癌的血浆microRNA标志物的筛选与应用
EP4137586B1 (en) * 2014-08-07 2026-04-22 Agency for Science, Technology and Research Microrna biomarker for the diagnosis of gastric cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102007223A (zh) * 2008-02-28 2011-04-06 俄亥俄州立大学研究基金会 用于胃癌的诊断、预后和治疗的基于微rna的方法和组合物
WO2012010584A1 (en) * 2010-07-20 2012-01-26 Febit Holding Gmbh Complex mirna sets as novel biomarkers for gastric cancer
CN103773761A (zh) * 2014-01-14 2014-05-07 南京医科大学 检测胃癌的血清/血浆微小rna标志物及其应用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis;Liu R等;《Eur J Cancer》;20110331;第47卷(第5期);第784-791页 *
A two-microRNA signature as a potential biomarker for early gastric cancer;Zheng G等;《Oncol Lett》;20140331;第7卷(第3期);第679-684页 *
MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin;Liu T等;《Cancer Lett》;20090118;第273卷(第2期);第233-242页 *
Validation of circulating miRNA biomarkers for predicting lymph node metastasis in gastric cancer;Kim SY等;《J Mol Diagn》;20130625;第15卷(第5期);第661-669页 *
血清miRNA作为胃癌早期诊断标记物的初步研究;国芳等;《胃肠病学》;20140425;第19卷(第4期);第198-202页 *

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KR102604163B1 (ko) 2023-11-20
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