CN107108614B - 作为布罗莫结构域抑制剂的取代的吡咯并吡啶 - Google Patents

作为布罗莫结构域抑制剂的取代的吡咯并吡啶 Download PDF

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Publication number
CN107108614B
CN107108614B CN201580072518.9A CN201580072518A CN107108614B CN 107108614 B CN107108614 B CN 107108614B CN 201580072518 A CN201580072518 A CN 201580072518A CN 107108614 B CN107108614 B CN 107108614B
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China
Prior art keywords
methyl
pyridin
pyrrolo
phenyl
cancer
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Expired - Fee Related
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CN201580072518.9A
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Chinese (zh)
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CN107108614A (zh
Inventor
B·K·阿尔布雷克特
S·F·贝隆
D·J·伯迪克
A·科特
T·克劳福德
L·A·戴金
M·C·休伊特
V·萧魏徐
Y·勒布朗
S·R·马格努森
C·G·纳斯维斯查克
F·A·罗梅罗
Y·唐
A·M·泰勒
S·王
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Genentech Inc
Constellation Pharmaceuticals Inc
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Genentech Inc
Constellation Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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  • Biomedical Technology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
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  • Hematology (AREA)
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  • AIDS & HIV (AREA)
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CN201580072518.9A 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的取代的吡咯并吡啶 Expired - Fee Related CN107108614B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077707P 2014-11-10 2014-11-10
US62/077,707 2014-11-10
PCT/US2015/060007 WO2016077380A1 (en) 2014-11-10 2015-11-10 Substituted pyrrolopyridines as inhibitors of bromodomain

Publications (2)

Publication Number Publication Date
CN107108614A CN107108614A (zh) 2017-08-29
CN107108614B true CN107108614B (zh) 2021-06-01

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US (1) US10150767B2 (https=)
EP (1) EP3218374B1 (https=)
JP (1) JP6669745B2 (https=)
CN (1) CN107108614B (https=)
MA (1) MA40940A (https=)
WO (1) WO2016077380A1 (https=)

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WO2016077375A1 (en) 2014-11-10 2016-05-19 Genentech, Inc. Bromodomain inhibitors and uses thereof
EP3250571B1 (en) 2015-01-29 2022-11-30 Genentech, Inc. Therapeutic compounds and uses thereof
EP3265453B1 (en) * 2015-03-05 2022-06-29 Boehringer Ingelheim International GmbH New pyridinones and isoquinolinones as inhibitors of the bromodomain brd9
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
CA3018802A1 (en) 2016-04-15 2017-10-19 Abbvie Inc. Bromodomain inhibitors
EP3445357B1 (en) 2016-04-22 2021-05-26 Dana-Farber Cancer Institute, Inc. Bifunctional molecules for degradation of egfr and methods of use
TW201825490A (zh) * 2017-01-11 2018-07-16 大陸商江蘇豪森藥業集團有限公司 吡咯並［２，３－ｃ］吡啶類衍生物、其製備方法及其在醫藥上的應用
ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
WO2018188047A1 (en) * 2017-04-14 2018-10-18 Abbvie Inc. Bromodomain inhibitors
CN108976278B (zh) * 2017-06-05 2021-04-06 海创药业股份有限公司 一种嵌合分子及其制备和应用
WO2019120234A2 (zh) * 2017-12-20 2019-06-27 贝达药业股份有限公司 作为溴结构域蛋白质抑制剂的化合物和组合物
US20210261539A1 (en) * 2018-02-06 2021-08-26 Shanghai Haihe Pharmaceutical Co., Ltd. Compound having bet inhibitory activity and preparation method and use therefor
CN108465108B (zh) * 2018-03-12 2020-07-07 上海宇玫博生物科技有限公司 一种预防或治疗脑胶质瘤的特异性基因靶点
US10442799B1 (en) 2018-04-07 2019-10-15 Fuqiang Ruan Heterocyclic compounds and uses thereof
WO2020007322A1 (zh) * 2018-07-04 2020-01-09 清华大学 一种靶向降解bet蛋白的化合物及其应用
CN110776508B (zh) * 2018-07-27 2021-07-16 海创药业股份有限公司 一种brd4抑制剂及其制备方法和用途
CN110818609A (zh) * 2018-08-11 2020-02-21 中国药科大学 3-乙酰基吲哚类brpf1抑制剂的制备方法及其用途
EP3841115A4 (en) * 2018-08-20 2022-08-24 University of Georgia Research Foundation, Inc. COMPOSITIONS AND METHODS TO INCREASE STAINING OF WHITE FAT TISSUE
CN109125729A (zh) * 2018-09-06 2019-01-04 苏州吉玛基因股份有限公司 与非小细胞肺癌诊疗相关的基因BRD9及其siRNAs和应用
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US11171132B2 (en) * 2019-10-03 2021-11-09 Globalfoundries U.S. Inc. Bi-directional breakdown silicon controlled rectifiers
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