CN107106494A - 阿瑞洛莫制剂 - Google Patents
阿瑞洛莫制剂 Download PDFInfo
- Publication number
- CN107106494A CN107106494A CN201580061819.1A CN201580061819A CN107106494A CN 107106494 A CN107106494 A CN 107106494A CN 201580061819 A CN201580061819 A CN 201580061819A CN 107106494 A CN107106494 A CN 107106494A
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- Prior art keywords
- pharmaceutical preparation
- preparation according
- pyridine
- hydroxyls
- chlorination
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Abstract
Description
溶出装置 | USP 2 |
浆叶速度 | 100rpm |
溶解体积 | 1000mL |
溶出介质 | USP pH 6.8的磷酸盐缓冲液或0.1M的HCl |
溶出温度 | 37℃ |
样品体积 | 5mL |
混合物 | 乙酸纤维素(EC)/淀粉比 | 重量(mg) | 硬度(kp) |
4 | 5%w/w EC/15%w/w淀粉 | 7.91(RSD 6.95%) | 2.34(51.87%) |
5 | 10%w/w EC/20%w/w淀粉 | 8.01(RSD 3.53%) | 2.02(37.44%) |
混合物 | 乙酸纤维素(EC)/淀粉比 | 平均含量(%w/w) | 理论值% |
4 | 5%w/w EC/15%w/w淀粉 | 18.2 | 97.1 |
5 | 10%w/w EC/20%w/w淀粉 | 18.1 | 96.5 |
Claims (48)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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DKPA201470566 | 2014-09-15 | ||
DKPA201470566 | 2014-09-15 | ||
PCT/DK2015/050275 WO2016041561A1 (en) | 2014-09-15 | 2015-09-15 | Arimoclomol formulation |
Publications (2)
Publication Number | Publication Date |
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CN107106494A true CN107106494A (zh) | 2017-08-29 |
CN107106494B CN107106494B (zh) | 2021-12-21 |
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CN201580061819.1A Active CN107106494B (zh) | 2014-09-15 | 2015-09-15 | 阿瑞洛莫制剂 |
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US (2) | US10709700B2 (zh) |
EP (2) | EP3193840B1 (zh) |
JP (1) | JP6678676B2 (zh) |
KR (4) | KR20240028540A (zh) |
CN (1) | CN107106494B (zh) |
AU (1) | AU2015317447B2 (zh) |
BR (1) | BR112017004948A2 (zh) |
CA (1) | CA2961097C (zh) |
DK (1) | DK3193840T3 (zh) |
ES (1) | ES2881860T3 (zh) |
HU (1) | HUE054957T2 (zh) |
IL (1) | IL251059B (zh) |
PL (1) | PL3193840T3 (zh) |
PT (1) | PT3193840T (zh) |
RU (1) | RU2745292C2 (zh) |
WO (1) | WO2016041561A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2484371T3 (en) | 2008-06-26 | 2015-03-02 | Orphazyme Aps | The use of Hsp70 as a regulator of enzymatic activity |
US9662375B2 (en) | 2010-11-30 | 2017-05-30 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
HUE054957T2 (hu) | 2014-09-15 | 2021-10-28 | Orphazyme As | Arimoklomol készítése |
EP3442530A1 (en) | 2016-04-13 | 2019-02-20 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
EP3448382B1 (en) | 2016-04-29 | 2020-10-14 | Orphazyme A/S | Arimoclomol for treating glucocerebrosidase associated disorders |
JP2023531750A (ja) * | 2020-06-24 | 2023-07-25 | ケムファーム デンマーク アー/エス | ゴーシェ病を処置するためのアリモクロモル |
WO2022106614A1 (en) * | 2020-11-19 | 2022-05-27 | Orphazyme A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
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