EP1218030A4 - Methods and compositions for the treatment and prevention of graft rejection using heat shock proteins - Google Patents

Methods and compositions for the treatment and prevention of graft rejection using heat shock proteins

Info

Publication number
EP1218030A4
EP1218030A4 EP00961701A EP00961701A EP1218030A4 EP 1218030 A4 EP1218030 A4 EP 1218030A4 EP 00961701 A EP00961701 A EP 00961701A EP 00961701 A EP00961701 A EP 00961701A EP 1218030 A4 EP1218030 A4 EP 1218030A4
Authority
EP
European Patent Office
Prior art keywords
prevention
compositions
treatment
methods
heat shock
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00961701A
Other languages
German (de)
French (fr)
Other versions
EP1218030A1 (en
Inventor
Pramod K Srivastava
Rajiv Y Chandawarkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fordham University
Original Assignee
Fordham University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fordham University filed Critical Fordham University
Publication of EP1218030A1 publication Critical patent/EP1218030A1/en
Publication of EP1218030A4 publication Critical patent/EP1218030A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6043—Heat shock proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP00961701A 1999-09-10 2000-09-08 Methods and compositions for the treatment and prevention of graft rejection using heat shock proteins Withdrawn EP1218030A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39365299A 1999-09-10 1999-09-10
US393652 1999-09-10
PCT/US2000/024711 WO2001017554A1 (en) 1999-09-10 2000-09-08 Methods and compositions for the treatment and prevention of graft rejection using heat shock proteins

Publications (2)

Publication Number Publication Date
EP1218030A1 EP1218030A1 (en) 2002-07-03
EP1218030A4 true EP1218030A4 (en) 2004-09-15

Family

ID=23555669

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00961701A Withdrawn EP1218030A4 (en) 1999-09-10 2000-09-08 Methods and compositions for the treatment and prevention of graft rejection using heat shock proteins

Country Status (4)

Country Link
EP (1) EP1218030A4 (en)
AU (1) AU7361900A (en)
CA (1) CA2383213A1 (en)
WO (1) WO2001017554A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1196772A2 (en) 1999-07-08 2002-04-17 Stressgen Biotechnologies Corporation Induction of a th1-like response in vitro
DK1296711T3 (en) 2000-06-26 2006-08-28 Stressgen Biotechnologies Corp HPV-E7 for the treatment of human papillomavirus
WO2002062959A2 (en) 2001-02-05 2002-08-15 Stressgen Biotechnologies Corp. Hepatitis b virus treatment
ES2433915T3 (en) 2002-05-21 2013-12-13 Irun R. Cohen DNA vaccines encoding heat shock proteins
AU2002952492A0 (en) 2002-11-06 2002-11-21 Cbio Limited Chaperonin 10 immunosuppression
US7745578B2 (en) * 2003-07-07 2010-06-29 The General Hospital Corporation Fugetactic proteins, compositions and methods of use
EP2397852B1 (en) 2006-03-14 2013-12-04 Oregon Health and Science University Methods for detecting a mycobacterium tuberculosis infection
EP2125868B1 (en) 2007-02-28 2015-06-10 The Govt. Of U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services Brachyury polypeptides and methods for use
HUE025852T2 (en) 2008-06-26 2016-04-28 Orphazyme Aps Use of Hsp70 as a regulator of enzymatic activity
WO2010099472A2 (en) 2009-02-27 2010-09-02 The U.S.A. Of America, As Represented By The Secretary, Department Of Health And Human Services Spanx-b polypeptides and their use
CN102462841A (en) * 2010-11-09 2012-05-23 中国科学院微生物研究所 Method for promoting immunological activity of gp96 protein and application thereof
RU2013125923A (en) 2010-11-30 2015-01-10 Орфазиме Апс METHODS FOR INCREASING THE EXTRACELLULAR ACTIVITY OF HSP70
ES2752190T3 (en) 2012-09-14 2020-04-03 Us Health Brachyury protein, adenoviral vectors encoding Brachyury protein and their use
BR102014002362A8 (en) 2014-01-30 2018-04-17 Uniao Brasileira De Educacao E Assistencia Mantenedora Da Puc Rs method of immunomodulation and / or preservation of ex vivo organs, compositions, process and uses
PL3193840T3 (en) 2014-09-15 2021-12-06 Orphazyme A/S Arimoclomol formulation
CN108289940B (en) 2015-08-03 2023-01-13 美国卫生和人力服务部 BRACHYURY deletion mutant, non-yeast vector for coding BRACHYURY deletion mutant and application thereof
EP3442530A1 (en) 2016-04-13 2019-02-20 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
RS61291B1 (en) 2016-04-29 2021-02-26 Orphazyme As Arimoclomol for treating glucocerebrosidase associated disorders
MX2023005954A (en) 2020-11-19 2023-09-04 Zevra Denmark As Processes for preparing arimoclomol citrate and intermediates thereof.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891653A (en) * 1995-12-29 1999-04-06 Attfield; Derrick Cecil Method of suppressing graft rejection by means of stress proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891653A (en) * 1995-12-29 1999-04-06 Attfield; Derrick Cecil Method of suppressing graft rejection by means of stress proteins

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DUQUESNOY R J ET AL: "Evidence for heat shock protein immunity in a rat cardiac allograft model of chronic rejection", TRANSPLANTATION 15 JAN 1999 UNITED STATES, vol. 67, no. 1, 15 January 1999 (1999-01-15), pages 156 - 164, XP008032921, ISSN: 0041-1337 *
QIAN J ET AL: "Expression of stress proteins and lymphocyte reactivity in heterotopic cardiac allografts undergoing cellular rejection", TRANSPLANT IMMUNOLOGY 1995 UNITED KINGDOM, vol. 3, no. 2, 1995, pages 114 - 123, XP002288908, ISSN: 0966-3274 *
RIZZO MONICA ET AL: "Increased expression of HDJ-2 (heat shock protein 40) and heat shock protein 70 in biopsy specimens of transplanted human lungs", JOURNAL OF HEART AND LUNG TRANSPLANTATION, vol. 17, no. 3, March 1998 (1998-03-01), pages 241 - 249, XP008032559, ISSN: 1053-2498 *
See also references of WO0117554A1 *

Also Published As

Publication number Publication date
WO2001017554A1 (en) 2001-03-15
AU7361900A (en) 2001-04-10
CA2383213A1 (en) 2001-03-15
WO2001017554A9 (en) 2002-09-26
EP1218030A1 (en) 2002-07-03

Similar Documents

Publication Publication Date Title
EP1218030A4 (en) Methods and compositions for the treatment and prevention of graft rejection using heat shock proteins
ZA989461B (en) Methods and compositions for the treatment of autoimmune disease using heat shock proteins
PT1231887E (en) Method and composition for the treatment of scars
KR100510795B1 (en) Compositions and Methods for the Treatment of Tumor
HU9802721D0 (en) Method and composition for the treatment and prevention of hyperuricemia
AU3632600A (en) Compositions and methods for the treatment of immune related diseases
HU0002963D0 (en) Methods and compositions for treating diseases and conditions of the eye field of invention
HUP0302718A3 (en) Methods and compositions for the treatment of diseases of the eye
AU9395998A (en) Compositions and methods for the treatment of immune related diseases
IL141426A0 (en) Compositions and methods for the treatment of tumor
IL143212A0 (en) Compositions and methods for the treatment of tumor
IL130968A0 (en) Pharmaceutical composition useful for the treatment of tinnitus and hearing loss
AU3434601A (en) Compositions and methods for the treatment of immune related diseases
EP1472273A4 (en) Compositions and methods for the treatment of immune related diseases
AU6786898A (en) Methods and compositions for the diagnosis and treatment of neuropsychiatric di sorders
IL141551A0 (en) Compositions and methods for the treatment of immune related diseases
EP0981357A4 (en) Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
EP1163340A4 (en) Compositions and methods for the modification of gene expression
IL120005A (en) Pharmaceutical compositions for the treatment of the eye
AU8580598A (en) Methods and compositions for the diagnosis and treatment of neuropsychiatric di sorders
AU6786798A (en) Methods and compositions for the diagnosis and treatment of neuropsychiatric di sorders
EP0979234A4 (en) Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders
HUP0300043A3 (en) Method and composition for the treatment of pain
GB9612990D0 (en) Compositions and methods for the treatment of chronic infections
AU3902600A (en) Compositions and methods for the treatment of immune related diseases

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020409

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 39/00 B

Ipc: 7A 61K 39/385 A

Ipc: 7A 61K 45/00 B

Ipc: 7A 01N 37/18 B

Ipc: 7C 07K 1/00 B

Ipc: 7C 07K 2/00 B

A4 Supplementary search report drawn up and despatched

Effective date: 20040729

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060928