CN107001375B - 6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其作为MGLUR2受体的负向别构调节剂的用途 - Google Patents

6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其作为MGLUR2受体的负向别构调节剂的用途 Download PDF

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CN107001375B
CN107001375B CN201580065918.7A CN201580065918A CN107001375B CN 107001375 B CN107001375 B CN 107001375B CN 201580065918 A CN201580065918 A CN 201580065918A CN 107001375 B CN107001375 B CN 107001375B
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CN107001375A (zh
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M.L.M.范戈
M.J.阿卡扎-瓦卡
S-A.阿龙索-德迪伊戈
A.I.德鲁卡斯奥里瓦雷斯
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Janssen Pharmaceutica NV
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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CN201580065918.7A 2014-12-03 2015-12-02 6,7-二氢吡唑并[1,5-a]吡嗪-4(5H)-酮化合物及其作为MGLUR2受体的负向别构调节剂的用途 Expired - Fee Related CN107001375B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14196082.3 2014-12-03
EP14196082 2014-12-03
PCT/EP2015/078285 WO2016087487A1 (en) 2014-12-03 2015-12-02 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

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CN107001375A CN107001375A (zh) 2017-08-01
CN107001375B true CN107001375B (zh) 2020-06-09

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US (1) US10072014B2 (enExample)
EP (1) EP3227295B1 (enExample)
JP (1) JP6689856B2 (enExample)
CN (1) CN107001375B (enExample)
AU (1) AU2015357167B2 (enExample)
CA (1) CA2967153A1 (enExample)
ES (1) ES2727379T3 (enExample)
RU (1) RU2711382C2 (enExample)
WO (1) WO2016087487A1 (enExample)

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JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
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CA2967153A1 (en) 2016-06-09
RU2017123038A (ru) 2019-01-09
RU2017123038A3 (enExample) 2019-07-17
ES2727379T3 (es) 2019-10-15
WO2016087487A1 (en) 2016-06-09
CN107001375A (zh) 2017-08-01
EP3227295B1 (en) 2019-02-20
US20170369493A1 (en) 2017-12-28
JP6689856B2 (ja) 2020-04-28
US10072014B2 (en) 2018-09-11
AU2015357167A1 (en) 2017-05-25
JP2017536399A (ja) 2017-12-07
AU2015357167B2 (en) 2020-06-25
EP3227295A1 (en) 2017-10-11

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