CN107001221B - 用于制备曲前列尼尔的方法 - Google Patents

用于制备曲前列尼尔的方法 Download PDF

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CN107001221B
CN107001221B CN201580066416.6A CN201580066416A CN107001221B CN 107001221 B CN107001221 B CN 107001221B CN 201580066416 A CN201580066416 A CN 201580066416A CN 107001221 B CN107001221 B CN 107001221B
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formula
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CN107001221A (zh
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I·尤哈斯
I·浩特巴基
T·阿尔特萨奇
I·拉斯洛菲
A·纳吉尼伯尔克
I·罗苏姆博斯基
G·豪沃希
Z·卡多斯
P·波兹德兰托斯
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Ouyiping Hungary Co ltd
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Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
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CN201580066416.6A 2014-10-08 2015-09-28 用于制备曲前列尼尔的方法 Active CN107001221B (zh)

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HUP1400475 2014-10-08
HU1400475A HU231186B1 (hu) 2014-10-08 2014-10-08 Új eljárás treprostinil és sói előállítására
PCT/HU2015/000065 WO2016055819A1 (en) 2014-10-08 2015-09-28 Process for the preparation of treprostinil

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CN107001221B true CN107001221B (zh) 2021-05-25

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US (3) US10322990B2 (https=)
EP (1) EP3204349A1 (https=)
JP (2) JP6820255B2 (https=)
KR (2) KR102841902B1 (https=)
CN (2) CN107001221B (https=)
AU (1) AU2015329740B2 (https=)
CA (1) CA2963844C (https=)
HU (2) HU231186B1 (https=)
IL (1) IL251613B (https=)
MX (1) MX384201B (https=)
RU (1) RU2709200C2 (https=)
SG (1) SG11201702790YA (https=)
TW (2) TWI761299B (https=)
WO (1) WO2016055819A1 (https=)

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US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
ES2909890T3 (es) 2016-01-27 2022-05-10 Emcure Pharmaceuticals Ltd Proceso de preparación de derivados de prostaciclina
KR101830693B1 (ko) * 2016-04-28 2018-02-21 연성정밀화학(주) 트레프로스티닐의 제조방법 및 이를 위한 중간체
JP7220650B2 (ja) 2016-09-26 2023-02-10 ユナイテッド セラピューティクス コーポレイション トレプロスチニルプロドラッグ
HU231296B1 (hu) * 2018-03-09 2022-09-28 Chinoin Zrt Eljárás treprostinil-dietanol-amin só B polimorf formájának előállítására
KR102084044B1 (ko) * 2018-12-24 2020-03-03 주식회사 세미부스터 인산용액 중의 실리콘 농도 분석방법
CN112313202A (zh) * 2019-05-21 2021-02-02 江苏众强药业有限公司 曲前列尼尔钠盐新晶型及制备方法
EP4017588A1 (en) 2019-08-23 2022-06-29 United Therapeutics Corporation Treprostinil prodrugs
US10781160B1 (en) * 2019-10-04 2020-09-22 Chirogate International Inc. Hexadecyl Treprostinil crystals and methods for preparation thereof
US11339110B2 (en) * 2019-12-19 2022-05-24 Chirogate International Inc. Efficient crystallization process for preparing ultrapure Treprostinil and crystal prepared therefrom
JP2023523557A (ja) 2020-04-17 2023-06-06 ユナイテッド セラピューティクス コーポレイション 間質性肺疾患の治療における使用のためのトレプロスチニル
IL298591A (en) 2020-06-09 2023-01-01 United Therapeutics Corp Pomeryl dictopiperidine prodrugs of treprostinil
US11447440B2 (en) * 2020-10-29 2022-09-20 Chirogate International Inc. Treprostinil monohydrate crystals and methods for preparation thereof
KR20250133451A (ko) 2020-12-14 2025-09-05 유나이티드 쎄러퓨틱스 코포레이션 트레프로스티닐 프로드러그로 질환을 치료하는 방법
JP2024510930A (ja) 2021-03-03 2024-03-12 ユナイテッド セラピューティクス コーポレイション トレプロスチニル及びそのプロドラッグの乾燥粉末組成物、及び、さらに（ｅ）－３，６－ビス［４－（ｎ－カルボニル－２－プロペニル）アミドブチル］－２，５－ジケトピペラジン（ｆｄｋｐ）を含む乾燥粉末組成物
WO2023154705A1 (en) 2022-02-08 2023-08-17 United Therapeutics Corporation Treprostinil iloprost combination therapy
EP4652151A1 (en) 2023-01-19 2025-11-26 United Therapeutics Corporation Treprostinil analogs
US20250197338A1 (en) 2023-11-09 2025-06-19 United Therapeutics Corporation Syntheses of compounds useful for producing treprostinil

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