CN106998685A - 14‑元酮内酯及其制备和使用方法 - Google Patents

14‑元酮内酯及其制备和使用方法 Download PDF

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Publication number
CN106998685A
CN106998685A CN201580066344.5A CN201580066344A CN106998685A CN 106998685 A CN106998685 A CN 106998685A CN 201580066344 A CN201580066344 A CN 201580066344A CN 106998685 A CN106998685 A CN 106998685A
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alkyl
compound
hydrogen
group
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CN201580066344.5A
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English (en)
Chinese (zh)
Inventor
A.G.迈尔斯
I.B.赛普勒
Z.张
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201580066344.5A 2014-10-08 2015-10-08 14‑元酮内酯及其制备和使用方法 Pending CN106998685A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462061571P 2014-10-08 2014-10-08
US62/061,571 2014-10-08
PCT/US2015/054700 WO2016057798A1 (en) 2014-10-08 2015-10-08 14-membered ketolides and methods of their preparation and use

Publications (1)

Publication Number Publication Date
CN106998685A true CN106998685A (zh) 2017-08-01

Family

ID=55653777

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580066344.5A Pending CN106998685A (zh) 2014-10-08 2015-10-08 14‑元酮内酯及其制备和使用方法

Country Status (7)

Country Link
US (3) US10633407B2 (https=)
EP (1) EP3211997A4 (https=)
JP (1) JP2017531663A (https=)
CN (1) CN106998685A (https=)
CA (1) CA2963815A1 (https=)
HK (1) HK1242920A1 (https=)
WO (1) WO2016057798A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113646319A (zh) * 2018-11-19 2021-11-12 齐卡尼治疗股份有限公司 C11-环取代的13元大环内酯及其用途
WO2025228440A1 (zh) * 2024-04-30 2025-11-06 苏州信诺维医药科技股份有限公司 大环内酯类化合物、其制备方法及其用途

Families Citing this family (6)

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US9982005B2 (en) 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
US11673910B2 (en) 2017-04-28 2023-06-13 Zikani Therapeutics, Inc. Macrolides with modified desosamine sugars and uses thereof
ES3063764T3 (en) 2018-11-19 2026-04-20 Zikani Therapeutics Inc C10-alkylene substituted 13-membered macrolides and uses thereof
IL303173A (en) * 2023-05-23 2024-12-01 Yeda Res & Dev Active macrolide antibiotic compounds against pathogens

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US20080287376A1 (en) * 2004-07-28 2008-11-20 Mohammad Salman Ketolide Derivatives as Antibacterial Agents
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US20050090461A1 (en) * 1998-06-29 2005-04-28 Leadlay Peter F. Polyketides and their synthesis
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113646319A (zh) * 2018-11-19 2021-11-12 齐卡尼治疗股份有限公司 C11-环取代的13元大环内酯及其用途
WO2025228440A1 (zh) * 2024-04-30 2025-11-06 苏州信诺维医药科技股份有限公司 大环内酯类化合物、其制备方法及其用途

Also Published As

Publication number Publication date
EP3211997A4 (en) 2018-10-24
US20200361980A1 (en) 2020-11-19
EP3211997A1 (en) 2017-09-06
US11466046B2 (en) 2022-10-11
JP2017531663A (ja) 2017-10-26
CA2963815A1 (en) 2016-04-14
HK1242920A1 (zh) 2018-07-06
US20230109357A1 (en) 2023-04-06
US20170305953A1 (en) 2017-10-26
WO2016057798A1 (en) 2016-04-14
US10633407B2 (en) 2020-04-28

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Application publication date: 20170801