CN106974854A - Skin-active repairs essence - Google Patents
Skin-active repairs essence Download PDFInfo
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- CN106974854A CN106974854A CN201710158415.5A CN201710158415A CN106974854A CN 106974854 A CN106974854 A CN 106974854A CN 201710158415 A CN201710158415 A CN 201710158415A CN 106974854 A CN106974854 A CN 106974854A
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- skin
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- essence
- extract
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- 230000008439 repair process Effects 0.000 title claims description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 102000008186 Collagen Human genes 0.000 claims abstract description 23
- 108010035532 Collagen Proteins 0.000 claims abstract description 23
- 229920001436 collagen Polymers 0.000 claims abstract description 23
- 108010022355 Fibroins Proteins 0.000 claims abstract description 22
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 20
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 20
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 20
- 229940106189 ceramide Drugs 0.000 claims abstract description 20
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 20
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 20
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 20
- 241000222355 Trametes versicolor Species 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 239000000284 extract Substances 0.000 claims description 75
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 66
- 239000007788 liquid Substances 0.000 claims description 51
- 235000013557 nattō Nutrition 0.000 claims description 40
- 241000196324 Embryophyta Species 0.000 claims description 39
- 238000000605 extraction Methods 0.000 claims description 36
- 239000000463 material Substances 0.000 claims description 31
- 238000001914 filtration Methods 0.000 claims description 25
- 238000002360 preparation method Methods 0.000 claims description 19
- 241000237858 Gastropoda Species 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 17
- 235000011187 glycerol Nutrition 0.000 claims description 9
- 244000178870 Lavandula angustifolia Species 0.000 claims description 6
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 6
- 239000001102 lavandula vera Substances 0.000 claims description 6
- 235000018219 lavender Nutrition 0.000 claims description 6
- 244000061520 Angelica archangelica Species 0.000 claims description 2
- 235000011201 Ginkgo Nutrition 0.000 claims description 2
- 244000194101 Ginkgo biloba Species 0.000 claims description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 2
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 2
- 240000000249 Morus alba Species 0.000 claims description 2
- 235000008708 Morus alba Nutrition 0.000 claims description 2
- 244000131316 Panax pseudoginseng Species 0.000 claims description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 2
- 244000046146 Pueraria lobata Species 0.000 claims description 2
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 2
- 241000220317 Rosa Species 0.000 claims description 2
- -1 Vitwas E Substances 0.000 claims description 2
- 235000008434 ginseng Nutrition 0.000 claims description 2
- 244000025254 Cannabis sativa Species 0.000 claims 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229940116269 uric acid Drugs 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 238000001035 drying Methods 0.000 abstract description 4
- 238000012423 maintenance Methods 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 230000003389 potentiating effect Effects 0.000 abstract description 2
- 230000008929 regeneration Effects 0.000 abstract description 2
- 238000011069 regeneration method Methods 0.000 abstract description 2
- 230000037307 sensitive skin Effects 0.000 abstract description 2
- 230000037394 skin elasticity Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 20
- 239000000243 solution Substances 0.000 description 16
- 239000008367 deionised water Substances 0.000 description 15
- 229910021641 deionized water Inorganic materials 0.000 description 15
- 239000004744 fabric Substances 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 11
- 229940083980 lavender extract Drugs 0.000 description 9
- 235000020723 lavender extract Nutrition 0.000 description 9
- 239000007864 aqueous solution Substances 0.000 description 8
- 239000000706 filtrate Substances 0.000 description 8
- 102000004125 Interleukin-1alpha Human genes 0.000 description 7
- 108010082786 Interleukin-1alpha Proteins 0.000 description 7
- 238000005119 centrifugation Methods 0.000 description 7
- 230000036571 hydration Effects 0.000 description 7
- 238000006703 hydration reaction Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 108090001005 Interleukin-6 Proteins 0.000 description 6
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 6
- 102100040247 Tumor necrosis factor Human genes 0.000 description 6
- 206010020649 Hyperkeratosis Diseases 0.000 description 4
- 102000004889 Interleukin-6 Human genes 0.000 description 4
- 208000001126 Keratosis Diseases 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 238000011056 performance test Methods 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 238000012827 research and development Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 241000222356 Coriolus Species 0.000 description 2
- 238000008157 ELISA kit Methods 0.000 description 2
- 241000222341 Polyporaceae Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 238000010181 skin prick test Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Essence, including following raw materials are repaired the invention discloses a kind of skin-active：Collagen, fibroin, Coriolus Versicolor P.E., ceramide, sodium hyaluronate, Vitwas E, water.Skin-active reparation essence molecule of the present invention is tiny, natural, gentle, non-stimulated, can make moisturizing moisturizing for a long time and be used, and has preferable replenishing water and preserving moisture effect to drying skin quality, sensitive skin quality etc., and can strengthen skin elasticity；Regeneration, moisturizing, light spot and maintenance four-in-one, promote skin moisturizing power and maintenance power, smooth years vestige, and potent elite can quickly allow percutaneous absorption, assign elasticity of skin and compact, present silk ripple as become clear gloss.
Description
Technical field
Essence is repaired the present invention relates to cosmetic technical field, more particularly to a kind of skin-active.
Background technology
Skin is the maximum organ of human body, and the 5-15% of gross weight percentage of liveweight, the gross area is 1.5-2% square metres, thickness
It is because of people or different because of position, it is 0.5-4 millimeters.Skin covers whole body, and it makes various in vivo organize with organ from physical, machine
Tool, invasion and attack chemically with pathogenic microorganism, skin have the barrier action of two aspects, on the one hand prevent internal water
Point, on the other hand the loss of electrolyte and other materials organizes the intrusion of extraneous harmful substance, keeps human internal environment's steady
It is fixed, important defencive function is physiologically being played, while skin also assists in the metabolic process of human body.
Modern society's air pollution is on the rise, ultraviolet radiation enhancing, and computer cell phone radiation also constantly threatens people's
Skin health.Therefore, how preferably to carry out daily skin care and have become modern's urgent problem to be solved.Existing skin care production
Product, use pure chemistry formula, are cured the symptoms, not the disease for skin aging problem mostly, it is impossible to provide comprehensive nourishing for skin,
It can not realize that skin whitening highlights effect, and dependence is strong.
People are to the eager desire of delay skin aging, the tight demand to natural cosmetics, to effecting a radical cure varied skin
The strong desire of skin disease, and the strong pursuit to cosmetics, have evoked scientific worker to natural plant function raw material
Research and development.The problems such as due to outside contamination can allow in skin produces toxin, and what the time length colour of skin will become ruthless gloomy does not have
Glossy, the use for repairing product by skin-active can also play the effect of moisturizing anti-aging.
The content of the invention
In view of the deficienciess of the prior art, the technical problems to be solved by the invention, which are to provide a kind of skin-active, repairs elite
Element.
The technical problem of the present invention, is achieved by following technical proposals：
A kind of skin-active repairs essence, including following raw materials：Collagen, fibroin, Coriolus Versicolor P.E., neural acyl
Amine, sodium hyaluronate, Vitwas E, water.
A kind of skin-active repairs essence, includes the raw material of following weight parts：15-25 parts of collagen, fibroin 10-20
Part, 3-9 parts of Coriolus Versicolor P.E., 5-15 parts of snail liquid, 5-25 parts of plant extraction liquid, 0.2-2 parts of ceramide, sodium hyaluronate 5-15
Part, 2-8 parts of Vitwas E, 15-35 parts of water.
Preferably, the preparation method of the plant extraction liquid, comprises the following steps：
(1) plant material was crushed into 2-20 mesh sieves；
(2) by the plant material after crushing 65-95% ethanol (the i.e. aqueous solution of ethanol, the volume integral of ethanol therein
Number is 65-95%) extracted, obtain extract solution；
(3) extract solution is centrifuged, filtered, concentrated, obtain medicinal extract；
(4) the medicinal extract glycerine of 5-15 times of medicinal extract weight is dissolved, filtering obtains plant extraction liquid.
Extracting method is Microwave Extraction in the step (2), and solid-liquid ratio is 1：(10-30).
Preferably, the Microwave Extraction was divided into for three stages, and first stage Extracting temperature is 90-100 DEG C, and extraction time is 5-
15min, microwave power is 250-350W, and second stage Extracting temperature is 30-40 DEG C, and extraction time is 60-90min, microwave work(
Rate is 650-750W, and phase III Extracting temperature is 90-100 DEG C, and extraction time is 5-15min, and microwave power is 250-350W.
Preferably, the plant material is in the root of Dahurain angelica, natto, ginseng, ginkgo leaf, lavender, mulberry leaf, rose, the root of kudzu vine
One or more.
It is further preferred that the plant material is natto and/or lavender.
Preferably, skin-active of the present invention, which repairs essence, also includes 2-8 parts of pen container leaf extract, and the pen container leaf is extracted
Thing preparation method is：Pen container leaf was crushed into 10 mesh sieves, is boiled and carried under the conditions of 95-100 DEG C with 10 times of weight deionized waters
10h, filtering, concentration is produced.
Preferably, the collagen is referred to number of patent application：201210187819.4 method shown in middle embodiment 1
Prepare.
Preferably, the fibroin is referred to number of patent application：201210038175.2 method shown in middle embodiment 6
Prepare.
Preferably, the Coriolus Versicolor P.E. can be prepared or is commercially available, and preparation method is：Dry rainbow conk fragment is taken to crush
10 mesh sieves are crossed, is boiled with 10 times of weight deionized waters under the conditions of 95-100 DEG C and carries 10h, are filtered, filtrate is concentrated into the 1/ of original volume
2,95% ethanol for adding 4 times of volumes of concentrate is well mixed, 3000r/min's after 25 DEG C under confined conditions standing 24h
Under the conditions of centrifuge 20min, taking precipitate is dried at normal temperatures, obtains Coriolus Versicolor P.E.；The biological skill of the kind edge in Shaanxi can also be bought
The Coriolus Versicolor P.E. that art Co., Ltd provides, outward appearance is yellowish-brown powder, and withdrawal ratio is 10:1, rule of origin is Polyporaceae
Fungi Corilus versicolor Quel. Coriolus uersicolor (L.ex Fr.) Quel drying fructification.
Preferably, the snail liquid is referred to number of patent application：201210292779.X middle embodiment part
It is prepared by method shown in the 16th section to the 19th section.
Obviously, according to specific needs, preservative, essence, whitening agent, pigment and other work(can also be added in the present invention
The raw materials such as energy property additive, play its respective action, the basic performance without influenceing the present invention.
Skin-active reparation essence molecule of the present invention is tiny, natural, gentle, non-stimulated, can make moisturizing moisturizing for a long time and be used,
There is preferable replenishing water and preserving moisture effect to drying skin quality, sensitive skin quality etc., and skin elasticity can be strengthened；Regeneration, moisturizing, light spot with
Maintenance four-in-one, promotes skin moisturizing power and maintenance power, smooths years vestige, and potent elite can quickly allow percutaneous absorption, imparting
Elasticity of skin is compacted, present silk ripple as become clear gloss.The present invention can be with radiation proof, the pollutant such as haze completely cut off in air；
Go after wrinkle, use to have and loosen the effect that epidermis expression line is slided to silk；The ultra-fine molecule of nanometer imports skin test result and absorbs anti-
Should be good.
Embodiment
Keratoderma hydration rate is a kind of method of testing of cosmetics moistening effect.Keratoderma hydration rate is tested：
Operation principle is, using capacitor as instrument probe, because water is the maximum material of dielectric constant on skin, to work as skin moisture content
When changing, the capacitance of skin also changes, it is possible to by determining skin pricktest capacitance, analyzing skin surface moisture
Content.Instrument used is Corneometer CM825.By measuring the change using keratoderma capacitance before and after product
To weigh the change of water content of stratum corneum, so as to contain come such a method of moisture-keeping efficacy for evaluating face cream to the moisture of keratoderma
Amount carries out quantification, can delicately react the change of skin moisture content, and favorable reproducibility, be that current face cream efficacy assessments are normal
One of method.
Experimental method：Side, which is bent, in candidate or so forearm marks 3 × 3cm2The square Experimental Area of size, is made with left arm
For the test zone of moisturizer, uniform smearing skin-active every square centimeter repairs essence 0.1g, and the corresponding symmetrical region of right arm is
Blank control, then the moisture with each experiment position of Corneometer CM825 test detections after 8 hours, is weighed respectively
It is multiple 5 times, draw average value.With formula (1) calculated hydration rate.
The formula (1) of hydration rate=(test value-blank value)/blank value × 100%.
Radiation proof is tested：Method of testing reference specification embodiment 2 of page 5 of patent application 201410613299.8, the
[0033] section is to [0038] section.
The cell used is immortalizes epithelial cell (Hacat cells), purchased from Beijing consonance cell resource center.Cultivate bar
Part is DMEM culture mediums (Gibco, the U.S.), antibacterium and fungi containing 10% FBS (Hyclone, Australia) and 1%
Antibiotic (Invitrogen, the U.S.), in 37 DEG C, CO2Concentration is culture in 5% incubator.
Cell sets 1 group of blank control group, 1 group of negative control group and test group, and blank control group repairs essence without skin-active
Hua Su is also handled without UVB (ultraviolet), and essence, fractions tested are repaired without skin-active on the culture medium of negative control group
Skin-active reparation essence 0.1mg prepared by each embodiment is not added.
Hacat cells are with 4 × 104Cells/ holes are inoculated in 12 orifice plates, and after cell inoculation 24h, cell sucks culture medium,
Add PBS cell once, remove PBS, be put into progress UVB processing in ultraviolet irradiation case.UVB irradiation source wavelengths 280-
320nm, crest is 312nm.UVB processing Hacat cells irradiation doses are 20mJ/cm2。
IL-1 alpha content user IL-1 α/IL-1F1DuoSet of the Hacat cells after UVB is handled in culture supernatant
ELISA kit (R＆D System, the U.S.) is detected that IL-6 content detections are tried using humanIL-6DuoSet ELISA
Agent box (R＆D System, the U.S.) is carried out, and TNF-a content detections use human TNF-aDuoSet ELISA kits (R＆D
System, the U.S.) carry out, the same specification of method.
Each group is tested to the content of the content difference measured divided by negative control group, 100 parts is multiplied by, obtains relative amount.
Blank control group test result is：14.1 parts of 16.9 parts of 12.2 parts of IL-1 α, IL-6, TNF-a；Negative control group test result
For：100 parts of 100 parts of 100 parts of IL-1 α, IL-6, TNF-a.
Raw material introduction in embodiment：
Collagen is with reference to number of patent application：It is small that 201210187819.4 method shown in middle embodiment 1 is prepared
Molecule collagen Gly-His-Lys.
Fibroin is with reference to number of patent application：201210038175.2 the silkworm that method shown in middle embodiment 6 is prepared
Silk-fibroin powder.
Coriolus Versicolor P.E. uses the Coriolus Versicolor P.E. that Shaanxi Ci Yuan Bioisystech Co., Ltd provides, and outward appearance is yellowish-brown toner
End, withdrawal ratio is 10:1, rule of origin is On Polyporaceae Corilus versicolor Quel. Coriolus uersicolor (L.ex
Fr.) Quel drying fructification.
Snail liquid is with reference to number of patent application：201210292779.X middle the 16th section to the 19th section of embodiment part
The supernatant liquid that shown method is isolated.
Pen container leaf extract preparation method is：Pen container leaf was crushed into 10 mesh sieves, with 10 times of weight of pen container leaf
Deionized water is boiled under the conditions of 95 DEG C and carries 10h, using 300 mesh filter-cloth filterings, and it is 1.30g/mL (20 to concentrate to be condensed into density
DEG C) thick paste produce.
Sodium hyaluronate is hyaluronic acid, No. CAS：9004-61-9.
Ceramide, No. CAS：100403-19-8.
Vitwas E, No. CAS：7695-91-2.
Embodiment 1-8
Skin-active repairs essence, includes the raw material of following weight parts：20 parts of collagen, 15 parts of fibroin, rainbow conk are carried
Take 5 parts of thing, 10 parts of snail liquid, 16 parts of plant extraction liquid, 0.5 part of ceramide, 10 parts of sodium hyaluronate, 5 parts of Vitwas E,
25 parts of deionized water.
The preparation method of the plant extraction liquid, comprises the following steps：
(1) plant material (type of plant material and skin-active repair essence performance and be shown in Table 1) was crushed into 10 mesh sieves；
(2) by the plant material after crushing, with 75% ethanol, (i.e. the aqueous solution of ethanol, the volume fraction of ethanol therein is
75%) extracted, obtain extract solution；
(3) extract solution is centrifuged, centrifugal speed is 4000rpm, centrifugation time is 10min, is then taken thereon
Filtrate after filtering is condensed into the medicinal extract that density is 1.20g/mL (20 DEG C) by clear liquid with 300 mesh filter-cloth filterings；
(4) the medicinal extract glycerine of 10 times of medicinal extract weight is dissolved, then with 300 mesh filter-cloth filterings, obtains plant extraction liquid.
Extracting method is Microwave Extraction in the step (2), and solid-liquid ratio is 1：20 (i.e. matter of plant material and 75% ethanol
Amount is than being 1：20).
The Microwave Extraction was divided into for three stages, and first stage Extracting temperature is 95 DEG C, and extraction time is 10min, microwave work(
Rate is 300W, and second stage Extracting temperature is 35 DEG C, and extraction time is 80min, and microwave power is 700W, and the phase III extracts temperature
Spend for 95 DEG C, extraction time is 10min, microwave power is 300W.
It is as follows that skin-active repairs essence preparation method：
(1) snail liquid, plant extraction liquid, ceramide, sodium hyaluronate, Vitwas E are well mixed, are heated to 70
℃；
(2) collagen, fibroin, Coriolus Versicolor P.E. are added in deionized water and be well mixed, be heated to 70 DEG C；
(3) material obtained by above-mentioned steps (1) and (2) is mixed, homogeneous 6 minutes at 70 DEG C in homogenizer；
(4) it is cooled to the skin-active reparation essence that room temperature can be prepared by the present invention.
Table 1：Type of plant material and skin-active repair essence the performance test results table
Found out by table 1, inventors be surprised to learn that plant material use natto or lavender when with good moisture retention energy
While possess good shielding property.
Embodiment 9
Skin-active repairs essence, includes the raw material of following weight parts：20 parts of collagen, 15 parts of fibroin, rainbow conk are carried
Take 5 parts of thing, 10 parts of snail liquid, 16 parts of natto extract, 0.5 part of ceramide, 10 parts of sodium hyaluronate, 5 parts of Vitwas E,
25 parts of deionized water.
The preparation method of the plant extraction liquid, comprises the following steps：
(1) natto was crushed into 10 mesh sieves；
(2) by the natto after crushing, with 75% ethanol, (i.e. the aqueous solution of ethanol, the volume fraction of ethanol therein is
75%) extracted, obtain extract solution；
(3) extract solution is centrifuged, centrifugal speed is 4000rpm, centrifugation time is 10min, is then taken thereon
Filtrate after filtering is condensed into the medicinal extract that density is 1.20g/mL (20 DEG C) by clear liquid with 300 mesh filter-cloth filterings；
(4) the medicinal extract glycerine of 10 times of medicinal extract weight is dissolved, then with 300 mesh filter-cloth filterings, obtains natto extract.
Extracting method is Microwave Extraction in the step (2), and solid-liquid ratio is 1：20 (i.e. mass ratioes of natto and 75% ethanol
For 1：20).
The Microwave Extraction is divided into the two-stage, and first stage Extracting temperature is 95 DEG C, and extraction time is 20min, microwave work(
Rate is 300W, and second stage Extracting temperature is 35 DEG C, and extraction time is 80min, and microwave power is 700W.
It is as follows that skin-active repairs essence preparation method：
(1) snail liquid, natto extract, ceramide, sodium hyaluronate, Vitwas E are well mixed, are heated to 70
℃；
(2) collagen, fibroin, Coriolus Versicolor P.E. are added in deionized water and be well mixed, be heated to 70 DEG C；
(3) material obtained by above-mentioned steps (1) and (2) is mixed, homogeneous 6 minutes at 70 DEG C in homogenizer；
(4) it is cooled to the skin-active reparation essence that room temperature can be prepared by the present invention.
Embodiment 10
Skin-active repairs essence, includes the raw material of following weight parts：20 parts of collagen, 15 parts of fibroin, rainbow conk are carried
Take 5 parts of thing, 10 parts of snail liquid, 16 parts of natto extract, 0.5 part of ceramide, 10 parts of sodium hyaluronate, 5 parts of Vitwas E,
25 parts of deionized water.
The preparation method of the plant extraction liquid, comprises the following steps：
(1) natto was crushed into 10 mesh sieves；
(2) by the natto after crushing, with 75% ethanol, (i.e. the aqueous solution of ethanol, the volume fraction of ethanol therein is
75%) extracted, obtain extract solution；
(3) extract solution is centrifuged, centrifugal speed is 4000rpm, centrifugation time is 10min, is then taken thereon
Filtrate after filtering is condensed into the medicinal extract that density is 1.20g/mL (20 DEG C) by clear liquid with 300 mesh filter-cloth filterings；
(4) the medicinal extract glycerine of 10 times of medicinal extract weight is dissolved, then with 300 mesh filter-cloth filterings, obtains natto extract.
Extracting method is Microwave Extraction in the step (2), and solid-liquid ratio is 1：20 (i.e. mass ratioes of natto and 75% ethanol
For 1：20).
The Microwave Extraction is divided into the two-stage, and first stage Extracting temperature is 35 DEG C, and extraction time is 80min, microwave work(
Rate is 700W, and second stage Extracting temperature is 95 DEG C, and extraction time is 20min, and microwave power is 300W.
It is as follows that skin-active repairs essence preparation method：
(1) snail liquid, natto extract, ceramide, sodium hyaluronate, Vitwas E are well mixed, are heated to 70
℃；
(2) collagen, fibroin, Coriolus Versicolor P.E. are added in deionized water and be well mixed, be heated to 70 DEG C；
(3) material obtained by above-mentioned steps (1) and (2) is mixed, homogeneous 6 minutes at 70 DEG C in homogenizer；
(4) it is cooled to the skin-active reparation essence that room temperature can be prepared by the present invention.
Embodiment 11
Skin-active repairs essence, includes the raw material of following weight parts：20 parts of collagen, 15 parts of fibroin, rainbow conk are carried
Take 5 parts of thing, 10 parts of snail liquid, 16 parts of natto extract, 0.5 part of ceramide, 10 parts of sodium hyaluronate, 5 parts of Vitwas E,
25 parts of deionized water.
The preparation method of the plant extraction liquid, comprises the following steps：
(1) natto was crushed into 10 mesh sieves；
(2) by the natto after crushing, with 75% ethanol, (i.e. the aqueous solution of ethanol, the volume fraction of ethanol therein is
75%) extracted, obtain extract solution；
(3) extract solution is centrifuged, centrifugal speed is 4000rpm, centrifugation time is 10min, is then taken thereon
Filtrate after filtering is condensed into the medicinal extract that density is 1.20g/mL (20 DEG C) by clear liquid with 300 mesh filter-cloth filterings；
(4) the medicinal extract glycerine of 10 times of medicinal extract weight is dissolved, then with 300 mesh filter-cloth filterings, obtains natto extract.
Extracting method is Microwave Extraction in the step (2), and solid-liquid ratio is 1：20 (i.e. mass ratioes of natto and 75% ethanol
For 1：20).
The Microwave Extraction is a stage, and Extracting temperature is 95 DEG C, and extraction time is 100min, and microwave power is 300W.
It is as follows that skin-active repairs essence preparation method：
(1) snail liquid, natto extract, ceramide, sodium hyaluronate, Vitwas E are well mixed, are heated to 70
℃；
(2) collagen, fibroin, Coriolus Versicolor P.E. are added in deionized water and be well mixed, be heated to 70 DEG C；
(3) material obtained by above-mentioned steps (1) and (2) is mixed, homogeneous 6 minutes at 70 DEG C in homogenizer；
(4) it is cooled to the skin-active reparation essence that room temperature can be prepared by the present invention.
Embodiment 12
Skin-active repairs essence, includes the raw material of following weight parts：20 parts of collagen, 15 parts of fibroin, rainbow conk are carried
Take 5 parts of thing, 10 parts of snail liquid, 16 parts of natto extract, 0.5 part of ceramide, 10 parts of sodium hyaluronate, 5 parts of Vitwas E,
25 parts of deionized water.
The preparation method of the plant extraction liquid, comprises the following steps：
(1) natto was crushed into 10 mesh sieves；
(2) by the natto after crushing, with 75% ethanol, (i.e. the aqueous solution of ethanol, the volume fraction of ethanol therein is
75%) extracted, obtain extract solution；
(3) extract solution is centrifuged, centrifugal speed is 4000rpm, centrifugation time is 10min, is then taken thereon
Filtrate after filtering is condensed into the medicinal extract that density is 1.20g/mL (20 DEG C) by clear liquid with 300 mesh filter-cloth filterings；
(4) the medicinal extract glycerine of 10 times of medicinal extract weight is dissolved, then with 300 mesh filter-cloth filterings, obtains natto extract.
Extracting method is Microwave Extraction in the step (2), and solid-liquid ratio is 1：20 (i.e. mass ratioes of natto and 75% ethanol
For 1：20).
The Microwave Extraction is a stage, and Extracting temperature is 35 DEG C, and extraction time is 100min, and microwave power is 700W.
It is as follows that skin-active repairs essence preparation method：
(1) snail liquid, natto extract, ceramide, sodium hyaluronate, Vitwas E are well mixed, are heated to 70
℃；
(2) collagen, fibroin, Coriolus Versicolor P.E. are added in deionized water and be well mixed, be heated to 70 DEG C；
(3) material obtained by above-mentioned steps (1) and (2) is mixed, homogeneous 6 minutes at 70 DEG C in homogenizer；
(4) it is cooled to the skin-active reparation essence that room temperature can be prepared by the present invention.
Table 2：Embodiment 9-12 skin-actives repair essence the performance test results table
| Hydration rate, % | IL-1 α (part) | IL-6 (part) | TNF-a (part) | |
| Embodiment 9 | 54 | 50.1 | 66.0 | 62.9 |
| Embodiment 10 | 61 | 50.6 | 65.2 | 63.5 |
| Embodiment 11 | 37 | 48.7 | 64.5 | 60.2 |
| Embodiment 12 | 51 | 51.4 | 66.8 | 64.3 |
Embodiment 13
It is further preferred that the plant extraction liquid is natto extract and lavender extract mass ratio (1-3)：(1-
3) mixture.
Skin-active repairs essence, includes the raw material of following weight parts：20 parts of collagen, 15 parts of fibroin, rainbow conk are carried
Take 5 parts of thing, 10 parts of snail liquid, 8 parts of natto extract, 8 parts of lavender extract, 0.5 part of ceramide, 10 parts of sodium hyaluronate, dimension
Raw 5 parts of element E acetates, 25 parts of deionized water.
The preparation method of the natto extract or lavender extract, comprises the following steps：
(1) plant material (plant material is natto or lavender) was crushed into 10 mesh sieves；
(2) by the plant material after crushing, with 75% ethanol, (i.e. the aqueous solution of ethanol, the volume fraction of ethanol therein is
75%) extracted, obtain extract solution；
(3) extract solution is centrifuged, centrifugal speed is 4000rpm, centrifugation time is 10min, is then taken thereon
Filtrate after filtering is condensed into the medicinal extract that density is 1.20g/mL (20 DEG C) by clear liquid with 300 mesh filter-cloth filterings；
(4) the medicinal extract glycerine of 10 times of medicinal extract weight is dissolved, then with 300 mesh filter-cloth filterings, obtains natto extract
Or lavender extract.
Extracting method is Microwave Extraction in the step (2), and solid-liquid ratio is 1：20 (i.e. matter of plant material and 75% ethanol
Amount is than being 1：20).
The Microwave Extraction was divided into for three stages, and first stage Extracting temperature is 95 DEG C, and extraction time is 10min, microwave work(
Rate is 300W, and second stage Extracting temperature is 35 DEG C, and extraction time is 80min, and microwave power is 700W, and the phase III extracts temperature
Spend for 95 DEG C, extraction time is 10min, microwave power is 300W.
It is as follows that skin-active repairs essence preparation method：
(1) snail liquid, natto extract, lavender extract, ceramide, sodium hyaluronate, Vitwas E are mixed
Uniformly, 70 DEG C are heated to；
(2) collagen, fibroin, Coriolus Versicolor P.E. are added in deionized water and be well mixed, be heated to 70 DEG C；
(3) material obtained by above-mentioned steps (1) and (2) is mixed, homogeneous 6 minutes at 70 DEG C in homogenizer；
(4) it is cooled to the skin-active reparation essence that room temperature can be prepared by the present invention.Skin-active repairs essence performance test knot
It is really：Hydration rate is 69%；56.8 parts of 58.2 parts of 45.1 parts of IL-1 α, IL-6, TNF-a.
Embodiment 14
Skin-active repairs essence, includes the raw material of following weight parts：20 parts of collagen, 15 parts of fibroin, pen container tree
4 parts of leaf extract, 5 parts of Coriolus Versicolor P.E., 10 parts of snail liquid, 8 parts of natto extract, 8 parts of lavender extract, ceramide
0.5 part, 10 parts of sodium hyaluronate, 5 parts of Vitwas E, 25 parts of deionized water.
The preparation method of the natto extract or lavender extract, comprises the following steps：
(1) plant material (plant material is natto or lavender) was crushed into 10 mesh sieves；
(2) by the plant material after crushing, with 75% ethanol, (i.e. the aqueous solution of ethanol, the volume fraction of ethanol therein is
75%) extracted, obtain extract solution；
(3) extract solution is centrifuged, centrifugal speed is 4000rpm, centrifugation time is 10min, is then taken thereon
Filtrate after filtering is condensed into the medicinal extract that density is 1.20g/mL (20 DEG C) by clear liquid with 300 mesh filter-cloth filterings；
(4) the medicinal extract glycerine of 10 times of medicinal extract weight is dissolved, then with 300 mesh filter-cloth filterings, obtains natto extract
Or lavender extract.
Extracting method is Microwave Extraction in the step (2), and solid-liquid ratio is 1：20 (i.e. matter of plant material and 75% ethanol
Amount is than being 1：20).
The Microwave Extraction was divided into for three stages, and first stage Extracting temperature is 95 DEG C, and extraction time is 10min, microwave work(
Rate is 300W, and second stage Extracting temperature is 35 DEG C, and extraction time is 80min, and microwave power is 700W, and the phase III extracts temperature
Spend for 95 DEG C, extraction time is 10min, microwave power is 300W.
It is as follows that skin-active repairs essence preparation method：
(1) snail liquid, natto extract, lavender extract, ceramide, sodium hyaluronate, Vitwas E are mixed
Uniformly, 70 DEG C are heated to；
(2) collagen, fibroin, Coriolus Versicolor P.E., pen container leaf extract are added in deionized water and mixes equal
It is even, it is heated to 70 DEG C；
(3) material obtained by above-mentioned steps (1) and (2) is mixed, homogeneous 6 minutes at 70 DEG C in homogenizer；
(4) it is cooled to the skin-active reparation essence that room temperature can be prepared by the present invention.Skin-active repairs essence performance test knot
It is really：Hydration rate is 71%；56.3 parts of 57.0 parts of 44.6 parts of IL-1 α, IL-6, TNF-a.
Claims (9)
1. a kind of skin-active repairs essence, it is characterised in that including following raw materials：Collagen, fibroin, rainbow conk are extracted
Thing, ceramide, sodium hyaluronate, Vitwas E, water.
2. a kind of skin-active repairs essence, it is characterised in that including following raw materials：Collagen, fibroin, rainbow conk are extracted
Thing, plant extraction liquid, ceramide, sodium hyaluronate, Vitwas E, water.
3. a kind of skin-active repairs essence, it is characterised in that the raw material including following weight parts：15-25 parts of collagen, silk
- 20 parts of protein 10,3-9 parts of Coriolus Versicolor P.E., 5-15 parts of snail liquid, 5-25 parts of plant extraction liquid, 0.2-2 parts of ceramide, glass
5-15 parts of uric acid, 2-8 parts of Vitwas E, 15-35 parts of water.
4. skin-active as claimed in claim 3 repairs essence, it is characterised in that the preparation method of the plant extraction liquid, bag
Include following steps：
(1) plant material was crushed into 2-20 mesh sieves；
(2) plant material after crushing is extracted with 65-95% ethanol, obtains extract solution；
(3) extract solution is centrifuged, filtered, concentrated, obtain medicinal extract；
(4) the medicinal extract glycerine of 5-15 times of medicinal extract weight is dissolved, filtering obtains plant extraction liquid.
5. skin-active as claimed in claim 4 repairs essence, it is characterised in that extracting method is microwave in the step (2)
Extract, solid-liquid ratio is 1：(10-30).
6. skin-active as claimed in claim 4 repairs essence, it is characterised in that the Microwave Extraction is divided into three stages, first
Stage Extracting temperature is 90-100 DEG C, and extraction time is 5-15min, and microwave power is 250-350W, second stage Extracting temperature
For 30-40 DEG C, extraction time is 60-90min, and microwave power is 650-750W, and phase III Extracting temperature is 90-100 DEG C, is carried
It is 5-15min to take the time, and microwave power is 250-350W.
7. skin-active as claimed in claim 4 repairs essence, it is characterised in that the plant material is the root of Dahurain angelica, natto, people
One or more in ginseng, ginkgo leaf, lavender, mulberry leaf, rose, the root of kudzu vine.
8. skin-active as claimed in claim 7 repairs essence, it is characterised in that the plant material is natto and/or smoked clothing
Grass.
9. skin-active as claimed in claim 8 repairs essence, it is characterised in that the skin-active, which repairs essence, also includes pen container
2-8 parts of leaf extract.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108261346A (en) * | 2018-03-01 | 2018-07-10 | 森知（上海）国际贸易有限公司 | A kind of lightening compositions and preparation method thereof |
| CN110448479A (en) * | 2019-07-26 | 2019-11-15 | 苏州市绿中缘纺织科技有限公司 | A kind of protein peptides moisture retention liquid and preparation method thereof of alkalescent water dissolution |
| CN112870127A (en) * | 2021-03-06 | 2021-06-01 | 广州中草世家化妆品有限公司 | Herbal composition rich in ginseng essence and capable of repairing sensitive skin and preparation method of herbal composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434209A (en) * | 2015-06-03 | 2016-03-30 | 马南行 | Composition for beautifying, removing wrinkles, tightening and shaping and preparation method thereof |
| CN105902441A (en) * | 2016-06-01 | 2016-08-31 | 合肥丰瑞隆生物科技有限公司 | Poria cocos mash mask and preparation method thereof |
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2017
- 2017-03-17 CN CN201710158415.5A patent/CN106974854B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434209A (en) * | 2015-06-03 | 2016-03-30 | 马南行 | Composition for beautifying, removing wrinkles, tightening and shaping and preparation method thereof |
| CN105902441A (en) * | 2016-06-01 | 2016-08-31 | 合肥丰瑞隆生物科技有限公司 | Poria cocos mash mask and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108261346A (en) * | 2018-03-01 | 2018-07-10 | 森知（上海）国际贸易有限公司 | A kind of lightening compositions and preparation method thereof |
| CN108261346B (en) * | 2018-03-01 | 2020-12-29 | 上海科颜生物科技有限公司 | Whitening composition and preparation method thereof |
| CN110448479A (en) * | 2019-07-26 | 2019-11-15 | 苏州市绿中缘纺织科技有限公司 | A kind of protein peptides moisture retention liquid and preparation method thereof of alkalescent water dissolution |
| CN112870127A (en) * | 2021-03-06 | 2021-06-01 | 广州中草世家化妆品有限公司 | Herbal composition rich in ginseng essence and capable of repairing sensitive skin and preparation method of herbal composition |
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