CN108078832B

CN108078832B - Multi-effect composition for whitening, moisturizing, anti-wrinkle repairing and application thereof

Info

Publication number: CN108078832B
Application number: CN201711278860.1A
Authority: CN
Inventors: 孟铁钢
Original assignee: Guangzhou Q Max Cosmetics Co ltd
Current assignee: Guangzhou Q Max Cosmetics Co ltd
Priority date: 2017-12-06
Filing date: 2017-12-06
Publication date: 2021-04-13
Anticipated expiration: 2037-12-06
Also published as: CN108078832A

Abstract

The invention discloses a multi-effect composition for whitening, moisturizing and anti-wrinkle repairing and application thereof, wherein the multi-effect composition for whitening, moisturizing and anti-wrinkle repairing comprises the following components in percentage by mass: 0.1-20% of yellow slender root extract; cortex Magnolia officinalis extract 0.01-5%; 0.1 to 20 percent of carnitine; 1-70% of oat beta-glucan; the balance of solvent; the application of the multi-effect composition for whitening, moisturizing and anti-wrinkle repairing is that the multi-effect composition for whitening, moisturizing and anti-wrinkle repairing is applied to skin care products; the composition acts simultaneously in multiple directions of whitening, moisturizing, anti-wrinkling, repairing and the like, so that the skin is nursed in all directions, and the requirement of a consumer on the multifunctional effect of a skin care product can be well met.

Description

Multi-effect composition for whitening, moisturizing, anti-wrinkle repairing and application thereof

Technical Field

The invention relates to a multi-effect composition for whitening, moisturizing and anti-wrinkle repairing and application thereof, belonging to the field of cosmetics.

Background

The skin care product refers to a chemical industrial product or a fine chemical product which is applied to any part of the surface of a human body, such as skin, hair, nails, lips and teeth, by a smearing, spraying or other similar method, and is aimed at cleaning, maintaining, beautifying, modifying and changing the appearance, or correcting the odor of the human body and maintaining a good state. At present, skin care products on the market have single effect, such as single action on moisture retention, or only aiming at anti-wrinkle repair, and the other actions are whitening and spot lightening. These do not meet the consumer's needs for comprehensive skin care. In order to achieve the effects of whitening, moisturizing, resisting wrinkles and repairing, consumers can buy several skin care products with different effects at the same time, and the use is complicated.

Disclosure of Invention

In order to overcome the defects of the prior art, the first object of the present invention is to provide a multi-effect composition for skin whitening, moisturizing and anti-wrinkle repair, which simultaneously acts in multiple directions of skin whitening, moisturizing, anti-wrinkle and repair, thereby comprehensively caring skin.

The second purpose of the invention is to provide the application of the multi-effect composition for whitening, moisturizing and anti-wrinkle repairing.

The first purpose of the invention can be achieved by adopting the following technical scheme:

a multi-effect composition for whitening, moisturizing, anti-wrinkle repairing comprises the following components in percentage by mass:

further, the multi-effect composition for whitening, moisturizing and anti-wrinkle repairing consists of the following components in percentage by mass:

further, the solvent is deionized water.

The second purpose of the invention can be achieved by adopting the following technical scheme: the application of the multi-effect composition for whitening, moisturizing and anti-wrinkle repairing is provided.

Further, the multi-effect composition for whitening, moisturizing and anti-wrinkle repair is applied to skin care products.

Further, the multi-effect composition for whitening, moisturizing and anti-wrinkle repair is added into a skin care product in an amount of 0.5-10% by mass.

Further, the multi-effect composition for whitening, moisturizing and anti-wrinkle repairing is added into a skin care product in an amount of 3-8% by mass.

The extract according to the present invention refers to a solution obtained by extracting a substance from which an extract is to be obtained by soaking or mixing in a solvent. The extraction process can be carried out with the aid of suitable solvents and can be: water, ethanol, methanol, propanol, butanol, chloroform, acetone or other organic solvent, extracting by isolation, percolation, decoction, countercurrent extraction, ultrasonic extraction, microwave extraction, supercritical fluid extraction, etc., and further evaporating and concentrating to obtain extract and dried extract.

Yellow slender root extract: acting on the initial mechanism of pigmentation, reducing melanogenesis activity, reducing tone and skin spots.

Cortex Magnolia officinalis extract: the main chemical components are magnolol and honokiol, and the essential oil, alkaloid and the like are also contained, so that the skin-care product has the effects of resisting bacteria, diminishing inflammation, resisting oxidation, quickly tightening skin, smoothing wrinkles, improving skin state and the like.

Carnitine: contains beta-hydroxy acid, can promote and accelerate the exfoliation of aged keratin very gently, increase the water content of the keratin and keep the skin soft and tender.

Oat beta-glucan: the anti-aging cream has excellent anti-aging effect, and can smooth fine wrinkles, improve skin elasticity and improve skin texture; has unique linear molecular structure, and has good penetration and absorption properties; promoting the fibroblast to synthesize collagen, promoting wound healing, repairing damaged skin, and providing silky moist and smooth touch feeling to the skin.

Compared with the prior art, the invention has the beneficial effects that:

the invention comprehensively improves the skin condition from whitening, moisturizing, anti-wrinkle and repairing respectively by the cooperation of plant extracts, and has particularly obvious improvement effect on melanin deposition.

Detailed Description

The invention will be further described with reference to specific embodiments:

examples 1 to 3:

a multi-effect composition for whitening, moisturizing and anti-wrinkle repairing comprises the following components in percentage by mass as shown in table 1:

TABLE 1 compositional parameters for examples 1-3

	Example 1	Example 2	Example 3
				Extract of root of Bupleurum longiligrum	18	15	10
Cortex Magnolia officinalis extract	5	3	2
				Carnitine	15	10	8
Oat beta-glucan	55	50	30
				Deionized water	Balance of	Balance of	Balance of

Detection example 1: the effect of inhibiting melanogenesis

1. Reagents and instrumentation:

RPMI1640 medium, Gibco; b16 cells, new drug center of the university of chinese pharmacy;

BBHF-16 CO2 incubator, Shanghai Li Shen Co; TDL80-2B centrifuge, Shanghai' an pavilion scientific instruments factory; 96-well culture plates, Corning; DG5031 ELISA detector, east China tube works.

2. The test method comprises the following steps:

selecting the same generation of B16 cells in logarithmic phase, blowing and beating into single cell suspension cells after conventional pancreatin digestion treatment, counting and quantitatively inoculating in 96-well culture plates. After 24 hours, the supernatant was discarded, and a culture solution containing the components shown in Table 2 was added to each well, the components being 6% by mass in the culture solution. Then 5% by volume CO at 37 deg.C₂Culturing under saturated wet condition, adding RPMI1640 culture solution into control well, culturing for 6 days, and replacing culture solution twice. Discarding the supernatant, counting the cell density after the conventional pancreatin digestion treatment, centrifuging to obtain cell sediment, washing the cells twice by PBS, centrifuging to discard the supernatant, quantitatively adding 1N NAOH solution containing 10% DMSO by mass, carrying out water bath at 80 ℃ for 50min, and then measuring the light absorption value at 450nm of an enzyme-linked immunosorbent assay detector.

The melanin production inhibition (%) was 100 (absorbance of each component/absorbance of the control group), and the results are shown in table 2.

TABLE 2 test materials and results of melanin inhibition

As can be seen from Table 2, the effect of the combination of the extract of the root of Boerhavia diffusa and the extract of the bark of Magnolia officinalis in inhibiting melanin production is more pronounced than that of the combination of the extract of the root of Boerhavia diffusa and the extract of the bark of Magnolia officinalis alone. The compositions of examples 1-3 were superior to similar skin care products on the market in use, with the composition of example 2 being the most effective.

Detection example 2: whitening effect

The following experiments were performed on 50 healthy men and 50 healthy women: an opaque tape having six through holes of 1.5cm in diameter was attached to the upper arm of each test subject, and then the skin portion of each test subject that penetrated through the through holes was irradiated with ultraviolet rays at a dose 1.5 times the minimum erythema dose, to induce skin darkening. After UV irradiation, the compositions of Table 3 were applied to the irradiated areas, respectively, 1 application per day. After two months, the skin color was measured with a colorimeter (commercially available).

The effects of the components are judged by determining "L" values representing the lightness and darkness of the skin, which are corrected by a standard plate in the present invention, and the measurement is repeated a plurality of times in one portion to uniformly measure the pigmentation portion. The difference in skin color (Δ L) between the time point at which application of the composition was started and the time point at which application of the composition was completed was calculated according to the following formula: Δ L is the luminance L after two months from the experiment — the luminance L at the start of the experiment, and the results are shown in table 3. Wherein, when the whitening effect is evaluated by the Δ L value, a Δ L value of about 2 indicates a significant reduction in pigmentation, and if it exceeds 1.5, it indicates a whitening effect.

TABLE 3 test results of the materials to be tested and the whitening effect

As can be seen from table 3, the effect of using the combination of the root extract of negundo Chastetree, the bark extract of magnolia officinalis, oat-glucan, and carnitine is more pronounced in whitening than either alone or in combination. The compositions of examples 1-3 were used more effectively than similar skin care products on the market, while the composition of example 2 was used most effectively.

Detection example 3: moisturizing effect

The working principle is that the capacitor is used as an instrument probe, and as water is a substance with the largest dielectric constant on the skin, when the moisture content of the skin changes, the capacitance value of the skin also changes, so that the moisture content on the surface of the skin can be analyzed by measuring the capacitance value of the skin. A commonly used instrument is Corneometer CM 825. The moisture-retaining efficacy of the skin care product is evaluated by measuring the change of the water content of the stratum corneum by measuring the change of the capacitance of the stratum corneum of the skin before and after the product is used. The method quantifies the moisture content of the stratum corneum of the skin, can sensitively reflect the change of the moisture content of the skin, and has good reproducibility.

The experimental method comprises the following steps: 50 healthy men and 50 healthy women were used as test subjects, and 3X 3cm was drawn on the flexed sides of the left and right forearms of the test subjects²And (3) taking the left arm as a testing area of the moisturizing product, taking the corresponding symmetrical area of the right arm as a blank control, testing and detecting the moisture content of each test part by using a Corneo meter CM825, repeating the test for 5 times respectively to obtain an average value, and calculating the moisture content by using the following formula.

Water content ═ (test value-blank value)/blank value × 100%

The results are shown in table 4:

TABLE 4 detection results of water content in examples

Time	Example 1	Example 2	Example 3
				1h	76％	76％	76％
2h	60％	65％	53％
				4h	43％	51％	39％
6h	40％	49％	35％
				8h	39％	48％	31％

As can be seen from Table 4 above, the compositions of examples 1-3 all had excellent results in terms of moisture retention, while the composition of example 2 had the best results.

Detection example 4: anti-wrinkle effect

The experimental method comprises the following steps:

the person to be tested: 100, 50 females and 50 males, respectively;

testing parts: around the eye;

the experimental requirements are as follows:

1) the test taker must not use any skin care product before testing;

2) the test subject can not smoke and drink, lives regularly and can not be exposed to the sun;

3) no symptoms of skin allergy after the subject uses the product;

4) after the skin of the subject is cleaned every day, the composition of example 2 is lightly applied to the skin around the eyes, and gently massaged for 30 seconds in a loop until the composition is absorbed; other skin care products are not needed to be applied, and the skin care products are taken in the morning and at night;

5) each test is carried out in the same time period of each day;

6) the test is completed by an instrument, and the operation of the instrument designates one person to operate;

recording test data: tracking and photographing eyes of a subject in the process of using the product by the subject for 1.5 months;

and (4) conclusion: under the conditions of this experiment, the composition of example 2 clearly removed fine lines and increased skin firmness.

Various other changes and modifications to the above-described embodiments and concepts will become apparent to those skilled in the art from the above description, and all such changes and modifications are intended to be included within the scope of the present invention as defined in the appended claims.

Claims

1. The multi-effect composition for whitening, moisturizing, resisting wrinkles and repairing is characterized by comprising the following components in percentage by mass:

5-20% of yellow slender root extract;

1-4% of cortex magnoliae officinalis extract;

5 to 15 percent of carnitine;

10-60% of oat beta-glucan;

the balance of solvent.

2. The multi-effect composition for whitening, moisturizing and anti-wrinkle repair of claim 1, which consists of the following components in percentage by mass:

15% of yellow slender root extract;

cortex Magnolia officinalis extract 3%;

10% of carnitine;

oat beta-glucan 50%;

the balance of solvent.

3. The multi-effect composition for whitening, moisturizing and anti-wrinkle repair of claim 1, wherein the solvent is deionized water.

4. Use of the multi-effect whitening, moisturizing and anti-wrinkle repairing composition as defined in any one of claims 1-2 in the preparation of a skin care product.

5. The application of the multi-effect composition for whitening, moisturizing and anti-wrinkle repair of claim 4, wherein the multi-effect composition for whitening, moisturizing and anti-wrinkle repair is added to a skin care product in an amount of 0.5-10% by mass.

6. The application of the multi-effect composition for whitening, moisturizing and anti-wrinkle repair of claim 4, wherein the multi-effect composition for whitening, moisturizing and anti-wrinkle repair is added to a skin care product in an amount of 3-8% by mass.