CN107496346A - A kind of anti-apolexis composition and its application - Google Patents
A kind of anti-apolexis composition and its application Download PDFInfo
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- CN107496346A CN107496346A CN201710872075.2A CN201710872075A CN107496346A CN 107496346 A CN107496346 A CN 107496346A CN 201710872075 A CN201710872075 A CN 201710872075A CN 107496346 A CN107496346 A CN 107496346A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Abstract
The present invention discloses a kind of anti-apolexis composition, contains following component：Chinese rose stem cell, macadimia nut oil, Chinese anise berry extract, Herb Gynostemmae Pentaphylli extract, trehalose.The anti-apolexis composition of the present invention is prepared by five kinds of Chinese rose stem cell, macadimia nut oil, Chinese anise berry extract, Herb Gynostemmae Pentaphylli extract, trehalose components compatibilities, has excellent senile-resistant efficacy, notable to the elimination effect of free radical.The anti-apolexis composition of the present invention has no toxic side effect, and property is stable, non-stimulated to skin.
Description
Technical field
The present invention relates to a kind of composition, more particularly to a kind of anti-apolexis composition and its application.
Background technology
The skin of people is an organ for being easy to that aging is presented.With the increase at age, the aging feature of skin also with
Appearance：Wrinkle increases, cutis laxa, flavescence, and gloss, smoothness and smoothness reduce, and texture is thicker, pigmentation spots increase or
There is depigmentation spot etc..
, mainly there are endogenous factor and the aspect of extrinsic factor two the reason at present it is believed that causing skin senescence.It is interior
Source sexual factor includes：Genetic factors, i.e., because chromosome telomerisation order caused by gene genetic will change with the age
Become；Hormone shortage, i.e., caused hormonal aging due to the shortage of hormone, can make the connective tissue work(of skin as female hormone lacks
It can reduce and cause various change of skin.Extrinsic factor includes：Ever-increasing waste gas and each in pollution factor, i.e. air
Pollution caused by kind pollutant forms a large amount of free radicals, and the attack of free radical causes dead skin cell and quick aging, such as skin
Skin asphyxia, pore obstruction, skin become fragility etc.；Light aging, i.e., due to the accumulation of UVA/UVB rays, to produce some non-to skin
Often harmful influence, as dermal tissue is disorderly, make the epidermis dermis connective tissue for administering skin fine setting thinning etc..In addition, excessively
Ultraviolet light exposure be also main cause that prematurely senile symptom occurs in skin of face.
Used with the limitation of many synthesis of chemicals, " green " turns into the developing direction of 21 century cosmetics, cosmetics
Natural sex be increasingly valued by people, to the exploitation of the natural galenical in anti-aging cosmetics can be applied to
As trend.
The content of the invention
The purpose of the present invention is in order to solve the above technical problems, providing a kind of anti-apolexis composition and its application.The present invention
Composition be made up of natural plant active component, there is good senile-resistant efficacy, moderate notoxic.
To reach its purpose, the technical solution adopted in the present invention is：
A kind of anti-apolexis composition, contains following component：Chinese rose stem cell, macadimia nut oil, Chinese anise berry extract,
Herb Gynostemmae Pentaphylli extract, trehalose.
Further, in the Chinese anise berry extract general flavone weight/mass percentage composition ＞ 3.0%.
Chinese rose stem cell is present in the special tectonic of the separate living tissue of Chinese rose (Rosa chinensis), has surprising
Regeneration and self-renewal capacity.Chinese rose stem cell can also grow under refrigeration or defrosting etc. the physically or chemically stimulation of factor
Phase is cultivated without morphing, and can continue division growth, the cell growth of propagation is stable, and it is raw to show extremely strong resistance etc.
Life vigor and effective active matter composition.It is demonstrated experimentally that Chinese rose stem cell has powerful anti-oxidant and activity of fighting against senium.
The preparation method of the Chinese rose stem cell is：The newborn branch of Chinese rose is taken, surface sterilizing, xylem is peeled off, will obtain
It must be cultivated 30 days containing being organized on isolation medium for forming layer, bast, cortex and epidermis, then by the forming layer of new life
Stem cell is separated with the callus of dedifferentiation, and finally the forming layer stem cell separated is transferred on growth medium and trained
Support, obtain Chinese rose stem cell.
Queensland nut (Classification system:Macadamia ternifolia F.Muell.) alias:Macadamia, it is a kind of
Originate in the tree life nut in Australia；Macadimia nut oil (such as cold-press, hot moulding method, is surpassed by different methods by Queensland nut
Critical extraction and subcritical abstraction method) handle obtained edible oil.It is green containing substantial amounts of carrotene and leaf in macadimia nut oil
Element, dermal cell growth can be promoted, reduce the generation of wrinkle.The oiliness of macadimia nut oil is gentle, non-stimulated to skin, permeability
Well, it is excellent basis oil.
Anistree (scientific name：Illicium verum Hook.f.), be Illiciaceae, Illicium a kind of plant, and this
The Chinese anise berry extract of invention is anistree drying and ripening extract symphycarpous.Containing big in Chinese anise berry extract
The flavone compound of amount, there is remarkable result to eliminating free radical, also have and absorb UV resistance well.Chinese anise fruit
Extract can be obtained by the ultrasonic extraction of routine, and to obtain optimal extraction effect, the present invention uses 60% (V/V) second
Alcohol is 80 DEG C as Extraction solvent, Extracting temperature, and ultrasonic power is：50W, extraction time 2.0h.
Herb Gynostemmae Pentaphylli extract is cucurbitaceous plant gynostemma pentaphylla (scientific name：Gynostemma pentaphyllum(Thunb.)
Makino) the extract of herb, contain gypenoside in Herb Gynostemmae Pentaphylli extract, there is anti-aging and Green Tea Extract,
Trehalose is a kind of natural carbohydrate, is not only existed with free sugar form.The molecular weight of trehalose is small, is easy to by skin
Skin absorbs.Trehalose can enter work(that is intracellular, and then playing its unique water replacement stress factor effect and protection cell membrane
Energy, resist drying, the freezing tolerance of cell are improved, so as to improve skin accommodative ability of environment.
The present invention is using Chinese rose stem cell, macadimia nut oil, Chinese anise berry extract, Herb Gynostemmae Pentaphylli extract, trehalose
Five kinds of compositions carry out compatibility and are prepared into composition, and said composition has good senile-resistant efficacy, to the elimination effect of free radical
Significantly.
Preferably, described anti-apolexis composition contains the composition of following parts by weight：0.05~0.5 part of Chinese rose stem cell,
3~10 parts of macadimia nut oil, 3~10 parts of Chinese anise berry extract, 0.5~2.5 part of Herb Gynostemmae Pentaphylli extract, trehalose 0.5~5
Part.
Preferably, described anti-apolexis composition contains the composition of following parts by weight：0.05~0.2 part of Chinese rose stem cell,
5~8 parts of macadimia nut oil, 6~10 parts of Chinese anise berry extract, 1.5~2.5 parts of Herb Gynostemmae Pentaphylli extract, trehalose 0.5~
2.5 part.
Preferably, described anti-apolexis composition contains the composition of following parts by weight：0.1 part of Chinese rose stem cell, Australia are hard
7 parts of fruit oil, 9 parts of Chinese anise berry extract, 2 parts of Herb Gynostemmae Pentaphylli extract, 1 part of trehalose.
The anti-apolexis composition of the present invention can be used for preparing anti-aging skin care product, and the formulation of gained anti-aging skin care product is：
Solution, suspension, emulsion, paste, powdery or spray., can addition as suitably desired when preparing anti-aging skin care product
The conven-tional adjuvants used in cosmetic.
Beneficial effect：The anti-apolexis composition of the present invention is extracted by Chinese rose stem cell, macadimia nut oil, Chinese anise fruit
Five kinds of thing, Herb Gynostemmae Pentaphylli extract, trehalose components compatibilities are prepared, and have excellent senile-resistant efficacy, to the clear of free radical
Except significant effect.The anti-apolexis composition of the present invention has no toxic side effect, and property is stable, non-stimulated to skin.
Embodiment
More clearly to state technical scheme, further illustrate, but can not use with reference to specific embodiment
In limitation the present invention, this be only the present invention section Example, the present invention used in composition, in addition to Chinese rose stem cell, its
Remaining composition can be commercially available in commercially available, and composition specification is cosmetics-stage.
Embodiment 1
The present embodiment 1 provides a kind of anti-apolexis composition, is composed of the following components in parts by weight：0.1 part of Chinese rose stem cell,
7 parts of macadimia nut oil, 9 parts of Chinese anise berry extract, 2 parts of Herb Gynostemmae Pentaphylli extract, 1 part of trehalose.
Embodiment 2
The present embodiment 2 provides a kind of anti-apolexis composition, is composed of the following components in parts by weight：Chinese rose stem cell 0.05
Part, 5 parts of macadimia nut oil, 8 parts of Chinese anise berry extract, 1 part of Herb Gynostemmae Pentaphylli extract, 0.5 part of trehalose.
Embodiment 3
The present embodiment 3 provides a kind of anti-apolexis composition, is composed of the following components in parts by weight：0.2 part of Chinese rose stem cell,
8 parts of macadimia nut oil, 10 parts of Chinese anise berry extract, 2.5 parts of Herb Gynostemmae Pentaphylli extract, 5 parts of trehalose.
Embodiment 4
The present embodiment 4 provides a kind of anti-apolexis composition, is composed of the following components in parts by weight：0.5 part of Chinese rose stem cell,
3 parts of macadimia nut oil, 5 parts of Chinese anise berry extract, 0.5 part of Herb Gynostemmae Pentaphylli extract, 2.5 parts of trehalose.
Embodiment 5
The present embodiment 1 provides a kind of anti-apolexis composition, is composed of the following components in parts by weight：Chinese rose stem cell 0.25
Part, 10 parts of macadimia nut oil, 3 parts of Chinese anise berry extract, 1.5 parts of Herb Gynostemmae Pentaphylli extract, 3 parts of trehalose.
Embodiment 6
The present embodiment 1 provides a kind of anti-apolexis composition, is composed of the following components in parts by weight：0.5 part of Chinese rose stem cell,
10 parts of macadimia nut oil, 10 parts of Chinese anise berry extract, 2.5 parts of Herb Gynostemmae Pentaphylli extract, 5 parts of trehalose.
Comparative example 1：Compared with Example 1, without Chinese rose stem cell and macadimia nut oil.
Comparative example 2：Compared with Example 2, without Chinese anise berry extract and Herb Gynostemmae Pentaphylli extract.
Comparative example 3：Compared with Example 3, without trehalose and Chinese rose stem cell.
Comparative example 4：Compared with Example 4, without Chinese rose stem cell and Chinese anise berry extract.
Test example
The composition of embodiment 1~6 and comparative example 1~4 is configured to the sample solution that concentration is 2% with deionized water,
Test below.
Reagent：1,1- diphenyl -2- trinitrophenyl-hydrazines (DPPH) are provided by Sigma companies；
Absolute ethyl alcohol (AR), ferrous sulfate, H2O2, salicylic acid by Tianjin sky over the river Chemical Engineering Technology Co., Ltd provide；
UV1601 types ultraviolet specrophotometer is provided by Japanese Shimadzu Corporation.
1. remove the ability of free radical (DPPH)
The preparation of DPPH solution：8mg DPPH are weighed, 100ml volumetric flasks are transferred to after being dissolved with 50% ethanol solution
In, constant volume, shake up, obtain concentration as 2.0 × 10-4Mol/L DPPH ethanol solutions, are saved backup at 4 DEG C.
DPPH shows darkviolet at 517nm, there is strong absorption, due to the presence of free radical scavenger, makes DPPH
Lone electron pair be paired (such as formula 1), cause solution colour to shoal, the absorbance of maximum absorption wave strong point diminishes, and color
The degree that shoals and sharing electron number are into stoichiometric relationship.So it can be commented by determining the absorbance at wavelength 517nm
Sentence radicals scavenging situation.
Formula 1：AH+DPPH·→DPPH-H+A·
Accurately draw each sample solution 2.0ml respectively to be put into test tube, it is 2.0 × 10 to add concentration-4Mol/L DPPH
Ethanol solution 2.0ml, reaction 30min in dark place is placed in after shaking up, then determines its absorbance (A at 517nm1)；With
2.0mlDPPH ethanol solutions add isometric deionized water to be blank control sample, determine its absorbance at 517nm
(A0)；Isometric deionized water is added to determine its suction at 517nm as sample controls by the use of 2.0ml each sample solution respectively
Shading value (A2), to eliminate the influence of sample solution intrinsic colour.
Clearance rate is calculated as follows：
R (%)={ [A0-(A1-A2)]/A0}×100
It the results are shown in Table one：
Table one
| Sample solution | To DPPH clearance rate/% | Relative standard deviation RSD/% |
| Embodiment 1 | 90.25 | 0.5350 |
| Embodiment 2 | 85.69 | 0.4200 |
| Embodiment 3 | 89.75 | 0.4524 |
| Embodiment 4 | 86.37 | 0.7452 |
| Embodiment 5 | 88.12 | 0.5642 |
| Embodiment 6 | 89.67 | 0.6823 |
| Comparative example 1 | 60.25 | 0.5710 |
| Comparative example 2 | 61.82 | 0.7164 |
| Comparative example 3 | 58.47 | 0.5468 |
| Comparative example 4 | 42.71 | 0.6842 |
As shown in Table 1, the composition of embodiment 1~6 and comparative example 1~4 has preferable scavenging action to DPPH,
But scavenging action of the composition of the present embodiment 1~6 to DPPH is apparently higher than comparative example.Illustrate, composition of the invention into
Point：Chinese rose stem cell, macadimia nut oil, Chinese anise berry extract, Herb Gynostemmae Pentaphylli extract, trehalose have good compatibility
Property, the composition of gained has the excellent anti-oxidant ability for understanding free radical.
2. the ability of scavenging hydroxyl
25mL colorimetric cylinders 11 (10 sample cells, 1 blank tube) are taken, are separately added into 5ml1mmol/LFeSO4, 5ml
3mmol/LH2O2, 1ml sample solutions are added in sample cell, 1ml distilled water is added in blank tube, shakes up, be subsequently added into 3mmol/L
Salicylic acid shakes up, taken out after heating 15min in 37 DEG C of thermostatted water, with spectrophotometer under 510nm wavelength to scale
Determine the absorbance of each pipe.Returned to zero with 3mmol/L salicylic acids.Following formula is clearance rate SA of the sample solution to OH carboxylic free radicals
(%) calculating formula：
Clearance rate SA (%)=(A3-A4)/A3100%
In formula:A3- it is not added with the absorbance of sample；A4The absorbance of-addition sample.
It the results are shown in Table two：
Table two
| Sample solution | To OH clearance rate/% | Relative standard deviation RSD/% |
| Embodiment 1 | 79.56 | 0.3250 |
| Embodiment 2 | 74.18 | 0.1642 |
| Embodiment 3 | 80.23 | 0.3852 |
| Embodiment 4 | 75.86 | 0.4523 |
| Embodiment 5 | 79.51 | 0.2424 |
| Embodiment 6 | 79.82 | 0.4315 |
| Comparative example 1 | 59.54 | 0.1810 |
| Comparative example 2 | 52.89 | 0.2464 |
| Comparative example 3 | 56.16 | 0.2768 |
| Comparative example 4 | 4358 | 0.3142 |
As shown in Table 2, the composition of embodiment 1~6 and comparative example 1~4 has preferable scavenging action to OH, but
Scavenging action of the composition of the present embodiment 1~6 to OH is apparently higher than comparative example.Illustrate, composition components of the invention：Month
Season stem cell, macadimia nut oil, Chinese anise berry extract, Herb Gynostemmae Pentaphylli extract, trehalose there is good compatibility, gained
Composition there is the excellent anti-oxidant ability for understanding free radical.
3. skin irritation test
Test objective：Whether the sample solution breast animal skin for detecting embodiment 1~6 locally has stimulation.
Experimental animal：Regular grade healthy adult New Zealand kind white rabbit is provided by Guangxi Medical University.
Test method
Using a Skin Irritation Test method.The experiment of every part of sample solution is with 6 rabbit, and body weight 2.0kg~3.0kg is female
Male dual-purpose.The day before yesterday is tested, family's rabbit back backbone diamond wool is cut, epidermis, the left and right each about 3cm of unhairing scope can not be damaged
×3cm.0.5ml sample solutions are applied on a rabbit back side skin of unhairing, scope 2.5cm × 2.5cm, then with two layers
Gauze (2.5cm × 2.5cm) and one layer of glassine paper covering, then fixed with medical proof fabric.Opposite side skin makees blank control.Application
4h, by except 1h, 24h, 48h and 72h observation smearing position dermoreaction after covering, scored with compareing after position contrasts.Press《Change
Cosmetic hygienic practice》Middle skin wound repair standards of grading scoring, the stimulation that time point is respectively observed according to 1h, 24h, 48h and 72h are anti-
Top average is answered, the stimulus intensity by skin irritatin strength grading standard determination tested material to skin, is divided into 3 class,
It the results are shown in Table three.
Table three
Note：(skin -)：It is nonirritant；(skin+)：Subexcite；(skin ++)：Moderate stimulation.
White rabbit is sensitive compared with the mankind to irritant or corrosive material, as can be seen from Table 1, the group of embodiment 1~6
Compound is nonirritant to the skin of white rabbit, it was demonstrated that composition of the invention is gently non-stimulated to skin.
Finally it should be noted that the above embodiments are merely illustrative of the technical scheme of the present invention and are not intended to be limiting thereof.To the greatest extent
The present invention is described in detail with reference to above-described embodiment for pipe, those of ordinary skills in the art should understand that：Still
The embodiment of the present invention can be modified or equivalent substitution, and without departing from any of spirit and scope of the invention
Modification or equivalent substitution, it all should cover among scope of the presently claimed invention.
Claims (7)
1. a kind of anti-apolexis composition, it is characterised in that contain following component：Chinese rose stem cell, macadimia nut oil, Chinese anise
Berry extract, Herb Gynostemmae Pentaphylli extract, trehalose.
2. anti-apolexis composition as claimed in claim 1, it is characterised in that general flavone in the Chinese anise berry extract
Weight/mass percentage composition ＞ 3.0%.
3. anti-apolexis composition as claimed in claim 2, it is characterised in that the composition containing following parts by weight：Chinese rose is dry thin
0.05~0.5 part of born of the same parents, 3~10 parts of macadimia nut oil, 3~10 parts of Chinese anise berry extract, Herb Gynostemmae Pentaphylli extract 0.5~2.5
Part, 0.5~5 part of trehalose.
4. anti-apolexis composition as claimed in claim 3, it is characterised in that the composition containing following parts by weight：Chinese rose is dry thin
0.05~0.2 part of born of the same parents, 5~8 parts of macadimia nut oil, 6~10 parts of Chinese anise berry extract, Herb Gynostemmae Pentaphylli extract 1.5~2.5
Part, 0.5~2.5 part of trehalose.
5. anti-apolexis composition as claimed in claim 4, it is characterised in that the composition containing following parts by weight：Chinese rose is dry thin
0.1 part of born of the same parents, 7 parts of macadimia nut oil, 9 parts of Chinese anise berry extract, 2 parts of Herb Gynostemmae Pentaphylli extract, 1.0 parts of trehalose.
6. anti-apolexis composition as claimed in claim 1, it is characterised in that the preparation method of the Chinese rose stem cell is：Take
The newborn branch of Chinese rose, surface sterilizing, xylem is peeled off, being organized in containing forming layer, bast, cortex and epidermis will be obtained
Cultivate on isolation medium 30 days, then separate the forming layer stem cell of new life with the callus of dedifferentiation, will finally divide
The forming layer stem cell separated out, which is transferred on growth medium, to be cultivated, and obtains Chinese rose stem cell.
7. the anti-apolexis composition as described in any one of claim 1 to 6, it is characterised in that the anti-apolexis composition is used for
Anti-aging skin care product is prepared, the formulation of gained anti-aging skin care product is：Solution, suspension, emulsion, paste, powdery or spray.
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| CN201710872075.2A CN107496346A (en) | 2017-09-22 | 2017-09-22 | A kind of anti-apolexis composition and its application |
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| CN201710872075.2A CN107496346A (en) | 2017-09-22 | 2017-09-22 | A kind of anti-apolexis composition and its application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210121393A1 (en) * | 2018-07-26 | 2021-04-29 | Exocobio Inc. | Cosmetic composition comprising rose stem cell-derived exosome as effective ingredient |
| EP4069215A4 (en) * | 2019-12-06 | 2024-01-17 | JLABS Beauty LLC | Topical compositions containing rose oil and cannabidiol and methods of making and using the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104920227A (en) * | 2015-07-15 | 2015-09-23 | 广东融和生态农业有限公司 | Stem cell tissue culture seedling raising technique |
| CN105748343A (en) * | 2016-02-25 | 2016-07-13 | 广州市科玮生物技术有限公司 | Natural plant extract composition and application thereof in cosmetics |
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2017
- 2017-09-22 CN CN201710872075.2A patent/CN107496346A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104920227A (en) * | 2015-07-15 | 2015-09-23 | 广东融和生态农业有限公司 | Stem cell tissue culture seedling raising technique |
| CN105748343A (en) * | 2016-02-25 | 2016-07-13 | 广州市科玮生物技术有限公司 | Natural plant extract composition and application thereof in cosmetics |
Non-Patent Citations (1)
| Title |
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| 王建新等: "《化妆品植物原料大全》", 30 June 2012 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210121393A1 (en) * | 2018-07-26 | 2021-04-29 | Exocobio Inc. | Cosmetic composition comprising rose stem cell-derived exosome as effective ingredient |
| US11690797B2 (en) * | 2018-07-26 | 2023-07-04 | Exocobio Inc. | Cosmetic composition comprising rose stem cell-derived exosome as effective ingredient |
| EP4069215A4 (en) * | 2019-12-06 | 2024-01-17 | JLABS Beauty LLC | Topical compositions containing rose oil and cannabidiol and methods of making and using the same |
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