CN112870127A - Herbal composition rich in ginseng essence and capable of repairing sensitive skin and preparation method of herbal composition - Google Patents
Herbal composition rich in ginseng essence and capable of repairing sensitive skin and preparation method of herbal composition Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9794—Liliopsida [monocotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The application relates to the technical field of cosmetics, and particularly discloses a herbal composition rich in ginseng essence for repairing sensitive skin and a preparation method thereof. A herbal composition rich in ginseng extract for repairing sensitive skin comprising: ginseng radix extract, Rosa damascena pure dew, semen Ginkgo extract, and antibacterial agent. The preparation method comprises the following steps: adding the ginseng root extract, the rose hydrosol of Damascus, the ginkgo root extract and the antibacterial agent into a container, and uniformly stirring to obtain the herbal composition rich in ginseng essence for repairing and caring sensitive skin; the herbal composition rich in ginseng essence and used for repairing sensitive skin can be applied to skin lotion, emulsion and cream, has the effect of better repairing sensitive skin, reduces stimulation of external substances to the skin, and can be used for astringing pores to make the skin fine and smooth after being used for a long time.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to a herbal composition rich in ginseng essence for repairing sensitive skin and a preparation method thereof.
Background
The skin is the largest organ of the human body, and the tissue of the body surface that wraps the outside of the muscles is called the skin, which is composed of the epidermis, dermis and subcutaneous tissue, and contains accessory organs (sweat glands, sebaceous glands, nails, toenails) as well as blood vessels, lymphatic vessels, nerves, muscles, and the like. The skin is classified into dry skin, neutral skin, oily skin, mixed skin and sensitive skin, but the sensitive skin is problematic skin, particularly a reaction of the skin under physiological or pathological conditions, mainly occurs in facial skin, the sensitive skin is classified into congenital skin and acquired skin, the basic reason of the acquired sensitive skin is that skin cells are damaged to reduce the immunity of the skin, the stratum corneum is thinned to cause insufficient skin moisture, finally, the barrier function of the skin is reduced, the skin cannot resist the stimulation of the external world to the skin, and the skin is easy to be excited after the external stimulation, so that the phenomena of discomfort such as flushing, fever, pruritus, stabbing pain and the like are generated.
For the care of the sensitive skin, some natural and non-irritant skin care products are needed, so most manufacturers can add some plant extracts with anti-allergic and anti-inflammatory functions to care the sensitive skin, the irritation of the product to the skin is reduced, but the plant extracts can not show the effects of the plants, the effective components of the plant raw materials are often complex, so the substances extracted from the plant extracts are not as single as chemical raw materials, the plant extracts are compounded and then added into the product, the expected effect of repairing the sensitive skin cannot be achieved, the effects are probably inhibited from each other, and the effect of repairing the sensitive skin is poor.
In view of the above-mentioned related technologies, the inventors believe that the effect of repairing sensitive skin after compounding plant extracts is not good and needs to be further improved.
Disclosure of Invention
In order to increase the effect of the plant extract on repairing sensitive skin, the application provides a herbal composition for repairing sensitive skin rich in ginseng essence and a preparation method thereof.
In a first aspect, the herbal composition for repairing sensitive skin, which is rich in ginseng essence, provided by the application adopts the following technical scheme:
a herbal composition rich in ginseng essence and used for repairing sensitive skin comprises the following components in parts by mass:
0.28-0.32 parts of ginseng root extract;
0.08-0.12 part of Damascus rose hydrosol;
0.08-0.12 part of ginkgo root extract;
0.28-0.32 parts of antibacterial agent;
the antibacterial agent comprises one or more of lavender flower water, centella asiatica extract, folium artemisiae argyi extract, Ruscus aculeatus root extract and aescin.
By adopting the technical scheme, the ginseng root extract, the Damascus rose hydrosol and the ginkgo root extract are compounded, so that the effect of repairing sensitive skin is stronger, the deep water replenishing effect is realized on the skin, the immunity of the skin is enhanced, the water content of the skin is increased, the barrier function of the skin is enhanced, the stimulation of external substances to the skin is reduced, the health state of the skin is better, the skin has enough self-repairing capacity, the anti-inflammatory and bactericidal effects are obvious, the sensitive skin can be sufficiently calmed and relaxed, the external stimulation is blocked more effectively, the skin sensitivity phenomenon is reduced, pores can be contracted, and the skin is fine and smooth.
The ginseng root extract contains an ether-soluble component, has a good anti-inflammatory effect, and the ginsenoside which is a main active substance in the ginseng also has good anti-inflammatory activity; the Damascus rose hydrosol can deeply moisturize the skin, whiten and brighten the skin color, lighten spots and fine lines, condition the skin, particularly has good effects of relieving, calming and repairing sensitive skin, enhances the resistance of the skin and resists external stimulation; the inventor researches and discovers that the compounding of the ginseng root extract and the rose damascena hydrosol is easy to inhibit each other, the unexpected effect of repairing sensitive skin can not be achieved, the addition of the ginkgo root extract is obviously improved, the ginseng root extract and the rose damascena hydrosol can be blended to a greater degree, and the effect of repairing sensitive skin can reach a better state.
Through the addition of the antibacterial agent, the herbal composition has better anti-allergy and anti-inflammatory effects on the skin, has the effects of sterilizing, diminishing inflammation and inhibiting bacterial growth on the skin, and avoids the skin from being infected.
Preferably, the antibacterial agent includes at least lavender flower water.
By adopting the technical scheme, the antibacterial agent at least comprises the lavender flower water, the lavender flower water has an antibacterial effect, the lavender flower water contains special fragrance, has a calming and relieving effect, can inhibit bacterial growth, prevent acne, improve the cell regeneration capacity and improve the barrier function of skin, and the lavender flower water is compounded with the ginseng root extract, the damask rose hydrosol and the ginkgo root extract, so that the anti-allergy repair capacity of the herbal composition on the skin can be further enhanced.
Preferably, the antibacterial agent further comprises at least an extract of centella asiatica.
By adopting the technical scheme, the centella asiatica contains asiatic acid, madecassic acid, asiaticoside, asiaticbioside, madecassoside and the like, helps to promote the formation of collagen in the dermis and regenerate fibrin, and can promote the close connection between the epidermis and the dermis and inhibit the increase of fat cells by matching the lavender flower water and the centella asiatica extract, so that the effect of the herbal composition on repairing sensitive skin can be further improved.
Preferably, the antibacterial agent further comprises at least an artemisia argyi extract.
By adopting the technical scheme, the folium artemisiae argyi extract has broad-spectrum antibacterial property, the folium artemisiae argyi extract can cause bacteria death by destroying the cell membrane structure, phosphorus metabolism and protein synthesis and expression of bacteria, the antibacterial effect on skin is good by matching the folium artemisiae argyi extract, lavender flower water and the asiatic pennywort herb extract, and the effect of repairing sensitive skin by the herbal composition can be further improved.
In a second aspect, the preparation method of the herbal composition for repairing sensitive skin rich in ginseng essence provided by the application adopts the following technical scheme:
a preparation method of a herbal composition rich in ginseng essence for repairing sensitive skin comprises the steps of adding a ginseng root extract, rose hydrosol of Damascus, a ginkgo root extract and an antibacterial agent into a container, and uniformly stirring to obtain the herbal composition rich in ginseng essence for repairing sensitive skin.
By adopting the technical scheme, the raw materials are added into the container and are uniformly mixed and stirred, so that the raw materials are fully reacted, the utilization rate and the use effect of the raw materials are improved, the synergistic effect among the raw materials is properly exerted, and the effect of repairing sensitive skin by the herbal composition is improved.
In a third aspect, the present application provides an application of a herbal composition rich in ginseng essence for repairing sensitive skin, which adopts the following technical scheme:
an application of a herbal composition rich in ginseng essence for repairing sensitive skin is disclosed, wherein the composition is added into skin lotion, emulsion and cream.
By adopting the technical scheme, the herbal composition for repairing sensitive skin, which is rich in ginseng essence, can be used for skin lotion, emulsion and cream, and the effect of repairing sensitive skin of skin lotion, emulsion and cream is improved.
In a fourth aspect, the present application provides a skin moisturizer containing the herbal composition for repairing sensitive skin rich in ginseng essence, which adopts the following technical scheme:
the skin moisturizer containing the herbal composition for repairing sensitive skin rich in ginseng essence comprises the following components in parts by weight:
4-6 parts of glycerol;
2-4 parts of butanediol;
0.08-0.12 part of carbomer;
0.05-0.2 part of allantoin;
0.18 to 0.22 portion of p-hydroxyacetophenone;
0.75-1 part of chelating agent;
0.78-0.82 part of the herbal composition for repairing and caring sensitive skin, which is rich in ginseng essence;
0.11-0.13 part of arginine;
the total mass part of the skin care lotion containing the herbal composition for repairing sensitive skin rich in ginseng essence is 100 parts, and the balance is water.
By adopting the technical scheme, the specific amount of the herbal composition for repairing sensitive skin, which is rich in ginseng essence, is added into the skin moisturizer, so that the compatibility of the composition and the skin moisturizer is improved, the skin moisturizer is endowed with anti-inflammatory and anti-allergy effects, and the function of repairing sensitive skin is better achieved.
In a fifth aspect, the present application provides an emulsion containing the herbal composition for repairing sensitive skin rich in ginseng essence, which adopts the following technical scheme:
the emulsion containing the herbal composition rich in ginseng essence for repairing sensitive skin comprises the following components in parts by mass:
1.8-2.2 parts of an emulsifier;
0.8-1.2 parts of auxiliary emulsifier;
0.8-1.2 parts of cetearyl alcohol;
4.8-5.2 parts of isohexadecane;
1.8-2.2 parts of caprylic/capric triglyceride;
1.8-2.2 parts of polydimethylsiloxane;
0.4-0.6 part of squalane;
0.2-0.4 part of tocopherol acetate;
5-7 parts of glycerol;
1-3 parts of butanediol;
0.05-0.1 part of EDTA disodium;
0.18-0.22 part of carbomer;
0.05-0.2 part of allantoin;
0.14-0.16 part of xanthan gum;
0.23-0.25 part of arginine;
0.48-0.52 part of p-hydroxyacetophenone;
0.5-0.7 part of 1, 2-hexanediol;
0.78-0.82 part of the herbal composition for repairing and caring sensitive skin, which is rich in ginseng essence;
the total mass part of the emulsion containing the herbal composition rich in ginseng essence for repairing sensitive skin is 100 parts, and the balance is water.
By adopting the technical scheme, the specific amount of the herbal composition rich in ginseng essence for repairing sensitive skin is added into the skin moisturizer, so that the compatibility of the composition and the emulsion is improved, the skin moisturizer is endowed with anti-inflammatory and anti-allergy effects, and the function of repairing sensitive skin is better achieved.
In a sixth aspect, the present application provides a cream containing the herbal composition for repairing sensitive skin rich in ginseng essence, which adopts the following technical scheme:
a cream containing the herbal composition rich in ginseng essence for repairing sensitive skin comprises the following components in parts by mass:
1.8-2.2 parts of an emulsifier;
0.8-1.2 parts of auxiliary emulsifier;
0.8-1.2 parts of cetearyl alcohol;
4.8-5.2 parts of isohexadecane;
1.8-2.2 parts of caprylic/capric triglyceride;
1.8-2.2 parts of polydimethylsiloxane;
0.4-0.6 part of squalane;
0.2-0.4 part of tocopherol acetate;
5-7 parts of glycerol;
1-3 parts of butanediol;
0.05-0.1 part of EDTA disodium;
0.24-0.26 part of carbomer;
0.05-0.2 part of allantoin;
0.14-0.16 part of xanthan gum;
0.29-0.31 part of arginine;
0.48-0.52 part of p-hydroxyacetophenone;
0.5-0.7 part of 1, 2-hexanediol;
0.78-0.82 part of the herbal composition for repairing and caring sensitive skin, which is rich in ginseng essence;
the total mass portion of the cream containing the herbal composition rich in ginseng essence for repairing sensitive skin is 100 portions, and the balance is water.
By adopting the technical scheme, the specific amount of the herbal composition rich in the ginseng essence for repairing the sensitive skin is added into the skin moisturizer, so that the compatibility of the composition and cream is improved, the skin moisturizer is endowed with the anti-inflammatory and anti-allergy effects, and the function of repairing the sensitive skin is better realized.
In summary, the present application has the following beneficial effects:
1. according to the technical scheme, the ginseng root extract, the Damascus rose hydrosol and the ginkgo root extract are added into the herbal composition rich in ginseng essence for repairing sensitive skin, so that the effect of repairing sensitive skin is stronger, the immunity of skin is enhanced, the water content of skin is increased, the barrier function of skin is enhanced, the stimulation of external substances to the skin is reduced, the anti-inflammatory and bactericidal effects are obvious, the external stimulation is blocked more efficiently, the skin sensitivity phenomenon is reduced, pores can be contracted, and the skin is fine and smooth.
2. The antibacterial agent is preferably added, the antibacterial effect on the skin is good, and the effect of the herbal composition on repairing sensitive skin can be further improved by compounding the antibacterial agent with the ginseng root extract, the rosa damascena hydrolat and the ginkgo root extract.
3. According to the application, lavender flower water and folium artemisiae argyi extract are preferably added, and the lavender flower water and the folium artemisiae argyi extract are matched in a synergistic mode according to a specific proportion, so that the antibacterial and anti-inflammatory cream has a broad-spectrum antibacterial property and good anti-inflammatory property, plays a role in calming and relieving the skin, can inhibit bacterial growth, prevents acne, improves the cell regeneration capacity, improves the barrier function of the skin, and further improves the effect of repairing sensitive skin by the herbal composition.
Detailed Description
The present application will be described in further detail with reference to examples.
The information on the source of each component used in the following examples and comparative examples is shown in Table 1.
TABLE 1
Examples 1 to 7
A herbal composition rich in Ginseng radix essence for caring sensitive skin comprises Ginseng radix extract, Rosa damascena pure dew, semen Ginkgo extract, and antibacterial agent.
The antibacterial agent is one or more of Lavender flower water, herba Centellae extract, folium Artemisiae Argyi extract, Ruscus aculeatus root extract, and aescin.
A preparation method of a herbal composition rich in ginseng essence for repairing sensitive skin comprises the following steps:
weighing ginseng root extract, rose hydrosol of Damascus, ginkgo root extract, lavender flower water, centella extract, folium artemisiae argyi extract, Ruscus aculeatus root extract and aescin according to a formula, adding into a mixer, starting stirring at the stirring speed of 300r/min for 15min, and thus obtaining the herbal composition rich in ginseng essence and capable of repairing sensitive skin.
In examples 1 to 7, the amounts (in kg) of the respective raw materials are shown in Table 2.
TABLE 2
Comparative example 1
The herbal composition for repairing sensitive skin, which is rich in ginseng essence, is different from example 7 only in that:
in preparing a herbal composition for repairing sensitive skin rich in ginseng extract, the ginkgo root extract is replaced with an equal amount of water.
Comparative example 2
The herbal composition for repairing sensitive skin, which is rich in ginseng essence, is different from example 7 only in that:
when preparing the herbal composition rich in ginseng essence for repairing sensitive skin, the same amount of water is used for replacing the damascus rose hydrosol and the ginkgo root extract.
Comparative example 3
The herbal composition for repairing sensitive skin, which is rich in ginseng essence, is different from example 7 only in that:
in preparing the herbal composition for repairing sensitive skin rich in ginseng essence, equal amount of water is used for replacing ginseng root extract and ginkgo root extract.
Comparative example 4
The herbal composition for repairing sensitive skin, which is rich in ginseng essence, is different from example 7 only in that:
when preparing the herbal composition rich in ginseng essence for repairing sensitive skin, the ginseng root extract and the rosa damascena hydrosol are replaced by the same amount of water.
Application example 1
A skin care lotion added with a herbal composition rich in ginseng essence for repairing sensitive skin comprises 92.05kg of water, 4kg of glycerol, 2kg of butanediol, 0.08kg of carbomer, 0.05kg of allantoin, 0.18kg of p-hydroxyacetophenone, 0.75kg of chelating agent, 0.78kg of herbal composition rich in ginseng essence for repairing sensitive skin and 0.11kg of arginine.
In this application, the chelating agent was 0.05kg disodium EDTA complexed with 0.7kg Spectrastat PG sold by INOLEX Incorporated, a combination of 7.5% caprylhydroxamic acid and 92.5% propylene glycol based on the total weight of Spectrastat PG.
In this application example, the herbal composition for repairing sensitive skin added with ginseng essence was the composition prepared in example 1.
A preparation method of skin moisturizer added with herbal composition rich in ginseng essence for repairing sensitive skin comprises the following steps:
step 1), weighing 50kg of water, adding the water into a mixing pot, uniformly spreading carbomer on the surface of the carbomer, weighing 4kg of glycerol, 1kg of butanediol, 0.05kg of disodium EDTA and 0.05kg of allantoin after the carbomer is completely wetted, adding the materials into the mixing pot, homogenizing for 3min at a rotating speed of 3000r/min, then stirring and heating to 85 ℃, and keeping the temperature for 30 min;
step 2), cooling;
step 3), cooling to 45 ℃, weighing 0.18kg of p-hydroxyacetophenone and 0.7kg of Spectrastat PG, adding the p-hydroxyacetophenone and the Spectrastat PG into a heating pot, heating the mixture to 60 ℃ by using the residual butanediol, adding the mixture into a dosing pot after the mixture is completely dissolved, and stirring for 10min under the condition of 300 r/min;
step 4), cooling to 40 ℃, weighing 0.78kg of the repair sensitive skin herbal composition rich in ginseng essence, adding the repair sensitive skin herbal composition into a mixing pot, and stirring for 10min at the speed of 300 r/min;
and 5), weighing 0.11kg of arginine, adding into a production pot, dissolving with the residual water, adding into a mixing pot after dissolving, and stirring for 10min at the speed of 300r/min to obtain the skin care lotion added with the sensitive skin repairing herbal composition rich in ginseng essence.
Application example 2
Compared with application example 1, the differences are only that:
the skin care lotion added with the herbal composition for repairing sensitive skin rich in ginseng essence comprises 87.51kg of water, 6kg of glycerol, 4kg of butanediol, 0.12kg of carbomer, 0.2kg of allantoin, 0.22kg of p-hydroxyacetophenone, 0.1kg of chelating agent, 0.82kg of herbal composition for repairing sensitive skin rich in ginseng essence and 0.13kg of arginine.
In this application, the chelating agent was 0.1kg disodium EDTA complexed with 0.9kg Spectrastat PG sold by INOLEX Incorporated.
Application examples 3 to 8
Compared with application example 2, the difference is only that:
in the step 4), the application example 3 employs the ginseng essence-enriched repair sensitive skin herbal composition prepared in the example 2;
application example 4 used the sensitive skin-rejuvenating herbal composition prepared in example 3, enriched with ginseng essence;
application example 5 used the sensitive skin-rejuvenating herbal composition prepared in example 4, enriched with ginseng essence;
application example 6 employs the sensitive skin-repairing herbal composition rich in ginseng essence prepared in application example 5;
application example 7 employs the sensitive skin-repairing herbal composition rich in ginseng extract prepared in application example 6;
application example 8 was the ginseng extract-enriched repair sensitive skin herbal composition prepared in application example 7.
Comparative application example 1
Compared with application example 2, the difference is only that:
in step 4), the herbal composition for repairing sensitive skin, which is rich in ginseng essence, is replaced with glycerin in equal amount.
Comparative application examples 2 to 5
Compared with application example 2, the difference is only that:
in step 4), the comparative application example 2 employs the ginseng essence-enriched repair sensitive skin herbal composition prepared in comparative example 1;
comparative application example 3 used the sensitive skin-repairing herbal composition rich in ginseng extract prepared in comparative example 2;
comparative application example 4 used the sensitive skin-repairing herbal composition rich in ginseng extract prepared in comparative example 3;
comparative application example 5 the sensitive skin-repairing herbal composition rich in ginseng extract prepared in comparative example 4 was used.
Application example 9
An emulsion added with a herbal composition rich in ginseng essence for repairing and caring sensitive skin comprises 79.19kg of water, 1.8kg of emulsifier, 0.8kg of co-emulsifier, 0.8kg of cetearyl alcohol, 4.8kg of isohexadecane, 1.8kg of caprylic/capric triglyceride, 1.8kg of polydimethylsiloxane, 0.4kg of squalane, 0.2kg of tocopherol acetate, 5kg of glycerol, 1kg of butanediol, 0.05kg of EDTA disodium, 0.18kg of carbomer, 0.05kg of allantoin, 0.14kg of xanthan gum, 0.23kg of arginine, 0.48kg of p-hydroxyacetophenone, 0.5kg of 1, 2-hexanediol and 0.78kg of herbal composition rich in ginseng essence for repairing and caring sensitive skin.
In the application example, the emulsifier is Olivem1000 sold by Haoisite New Material science and technology (Suzhou) Inc., and the co-emulsifier is sold by Haoisite New Material science and technology (Suzhou) Inc
LC。
In this application example, a restorative sensitive skin herbal composition rich in ginseng extract was used with the composition prepared in example 1.
A method for preparing an emulsion containing herbal composition rich in ginseng essence for repairing sensitive skin comprises the following steps:
step 1), weighing 50kg of water, adding the water into a water phase pot, uniformly spreading 0.18kg of carbomer on the surface of the water phase pot, after the carbomer is completely wetted, weighing 5kg of glycerol, 1kg of butanediol, 0.05kg of disodium EDTA, 0.05kg of allantoin and 0.14kg of xanthan gum, adding the mixture into the water phase pot, homogenizing for 3min at the rotating speed of 3000r/min, stirring, heating to 85 ℃, and preserving heat for 30min to obtain a water phase pot material body;
step 2), weighing Olivem 10001.8 kg,
0.8kg of LC, 0.8kg of cetearyl alcohol, 4.8kg of isohexadecane, 1.8kg of caprylic/capric triglyceride, 1.8kg of polydimethylsiloxane, 0.4kg of squalane and 0.2kg of tocopherol acetate are sequentially added into an oil phase pot, stirred and heated to 80 ℃,obtaining an oil phase pot material body;
step 3), preheating a material preparing pot to 70 ℃, vacuumizing, pumping into a water phase pot material body, pumping into an oil phase pot material body, stirring and heating to 80 ℃, starting homogenizing at a rotating speed of 3000r/min, and homogenizing for 3 min;
step 4), weighing 0.23kg of arginine, dissolving with the rest water, adding into a proportioning pot, uniformly stirring, and stirring for 10min under the condition of 300 r/min;
step 5), cooling;
step 6), when the temperature is reduced to 60 ℃, weighing 0.48kg of p-hydroxyacetophenone and 0.5kg of 1, 2-hexanediol, adding into a production pot, dissolving with the residual butanediol, adding into a batching pot, and stirring for 10min under the condition of 300 r/min;
and 7), when the temperature is reduced to 45 ℃, weighing 0.78kg of the repair sensitive skin herbal composition rich in the ginseng essence, adding the repair sensitive skin herbal composition into a mixing pot, and stirring for 10min at the speed of 300r/min to obtain the repair sensitive skin herbal composition emulsion rich in the ginseng essence.
Application example 10
Compared with application example 9, the difference is only that:
a herbal composition lotion for repairing sensitive skin containing ginseng essence comprises 71.83kg of water, 10002.2 kg of Olivem,
1.2kg of LC, 1.2kg of cetearyl alcohol, 5.2kg of isohexadecane, 2.2kg of caprylic/capric triglyceride, 2.2g of polydimethylsiloxane, 0.6kg of squalane, 0.4kg of tocopherol acetate, 7kg of glycerol, 3kg of butanediol, 0.1kg of EDTA disodium, 0.22kg of carbomer, 0.2kg of allantoin, 0.16kg of xanthan gum, 0.25kg of arginine, 0.52kg of p-hydroxyacetophenone, 0.7kg of 1, 2-hexanediol and 0.82kg of a repair sensitive skin herbal composition rich in ginseng essence.
Application example 11
A cream added with a herbal composition rich in ginseng essence for repairing and caring sensitive skin comprises 79.07kg of water, 1.8kg of emulsifier, 0.8kg of co-emulsifier, 0.8kg of cetearyl alcohol, 4.8kg of isohexadecane, 1.8kg of caprylic/capric triglyceride, 1.8kg of polydimethylsiloxane, 0.4kg of squalane, 0.2kg of tocopherol acetate, 5kg of glycerol, 1kg of butanediol, 0.05kg of EDTA disodium, 0.24kg of carbomer, 0.05kg of allantoin, 0.14kg of xanthan gum, 0.29kg of arginine, 0.48kg of p-hydroxyacetophenone, 0.5kg of 1, 2-hexanediol and 0.78kg of herbal composition rich in ginseng essence for repairing and caring sensitive skin.
In the application example, the emulsifier is Olivem1000 sold by Haoisite New Material science and technology (Suzhou) Inc., and the co-emulsifier is sold by Haoisite New Material science and technology (Suzhou) Inc
LC。
In this application example, a restorative sensitive skin herbal composition rich in ginseng extract was used with the composition prepared in example 1.
A preparation method of a cream added with a herbal composition rich in ginseng essence for repairing sensitive skin comprises the following steps:
step 1), weighing 50kg of water, adding the water into a water phase pot, uniformly spreading 0.24kg of carbomer on the surface of the water phase pot, after the carbomer is completely wetted, weighing 5kg of glycerol, 1kg of butanediol, 0.05kg of disodium EDTA, 0.05kg of allantoin and 0.14kg of xanthan gum, adding the mixture into the water phase pot, homogenizing for 3 minutes at a rotating speed of 3000r/min, stirring, heating to 85 ℃, and preserving heat for 30 minutes to obtain a water phase pot material body;
step 2), weighing Olivem 10001.8 kg,
0.8kg of LC, 0.8kg of cetearyl alcohol, 4.8kg of isohexadecane, 1.8kg of caprylic/capric triglyceride, 1.8kg of polydimethylsiloxane, 0.4kg of squalane and 0.2kg of tocopherol acetate are sequentially added into an oil phase pot, stirred and heated to 80 ℃ to obtain an oil phase pot body;
step 3), preheating a material preparing pot to 70 ℃, vacuumizing, pumping into a water phase pot material body, pumping into an oil phase pot material body, stirring and heating to 80 ℃, starting homogenizing at a rotating speed of 3000r/min, and homogenizing for 3 minutes;
step 4), weighing 0.29kg of arginine, dissolving the arginine with the rest of water, adding the arginine into a proportioning pot, uniformly stirring, and stirring for 10min under the condition of 300 r/min;
step 5), cooling;
step 6), when the temperature is reduced to 60 ℃, weighing 0.48kg of p-hydroxyacetophenone and 0.5kg of 1, 2-hexanediol, adding into a production pot, dissolving with the residual butanediol, adding into a batching pot, and stirring for 10min under the condition of 300 r/min;
and 7), when the temperature is reduced to 45 ℃, weighing 0.78kg of the repair sensitive skin herbal composition rich in the ginseng essence, adding the repair sensitive skin herbal composition into a mixing pot, and stirring for 10min at the speed of 300r/min to obtain the repair sensitive skin herbal composition emulsion rich in the ginseng essence.
Application example 12
Compared with application example 11, the differences are only:
a herbal composition cream for repairing sensitive skin containing ginseng essence comprises 71.73kg of water, Olivem 10002.2 kg of water,
1.2kg of LC, 1.2kg of cetearyl alcohol, 5.2kg of isohexadecane, 2.2kg of caprylic/capric triglyceride, 2.2kg of polydimethylsiloxane, 0.6kg of squalane, 0.4kg of tocopherol acetate, 7kg of glycerol, 3kg of butanediol, 0.1kg of EDTA disodium, 0.26kg of carbomer, 0.2kg of allantoin, 0.16kg of xanthan gum, 0.31kg of arginine, 0.52kg of p-hydroxyacetophenone, 0.7kg of 1, 2-hexanediol and 0.82kg of a repair sensitive skin herbal composition rich in ginseng essence.
Experiment 1
Repairing sensitive skin effect test and pore shrinking effect test:
1. test samples: application examples 2-8 and comparative application examples 1-5 are skin lotions which are prepared by adding herbal compositions rich in ginseng essence and used for repairing sensitive skin.
2. Testing an instrument: facial image analyzer VISIA, Canfield, usa.
3. The test principle is as follows: a facial picture was taken using the facial image analyzer VISIA and the IPP image analysis software analyzed the red and pore scores of the skin.
Note: and (4) red area: can reflect the condition of capillary vessels, red blood filaments, inflammatory acne, acne rosacea, spider nevus and other problems can be detected, and blood vessels and haematochrome exist in the dermal papilla layer of the skin and are endowed with red blood cells.
Pore: the dilated pores are shaded in the presence of light, so that the pores are more visible than they are in the absence of pores.
4. Experiment design: 36 subjects with sensitive skin are selected, the subjects are divided into 12 groups, each group comprises 3 subjects, each group of subjects respectively and correspondingly use the skin moisturizers prepared in the application examples 2-8 and the comparative application examples 1-5, and the subjects clean faces in the morning and evening every day and then smear test samples on the faces. A facial image analyzer VISIA is adopted to shoot images of the back of a subject 4 weeks, 8 weeks and 20 weeks before the subject uses a test sample and analyze the images to obtain the values of a face red area and pores, the value of the red area after the subject uses the test sample is remarkably improved compared with the value before the subject uses the test sample, the effect of repairing and protecting sensitive skin of the test sample after long-term use is shown, the value of the pores after the subject uses the test sample is remarkably improved compared with the value before the subject uses the test sample, and the effect of shrinking the pores after the subject uses the test sample for a.
5. And (3) data analysis:
red color partition value: taking the average value of the test results of each group of subjects;
pore score: the test results were averaged for each group of subjects.
The assay data for experiment 1 is detailed in table 3.
TABLE 3
According to the data in table 3, the comparison of the data in the comparative application example 1 and the comparative application example 2 shows that the ginseng root extract and the rosa damascena hydrolat are added into the herbal composition for repairing and caring sensitive skin rich in ginseng essence according to a specific proportion, the red region score is relatively improved, the test sample has a certain effect of repairing and caring sensitive skin after long-term use, the pore score is not obviously changed, and the test sample has no effect of shrinking pores after long-term use.
According to the data in the table 3, the comparison application example 1 is compared with the comparison application examples 3-5 respectively, the ginseng root extract, the rose hydrosol of Damascus and the ginkgo root extract are added into the repairing sensitive skin herbal composition rich in ginseng essence, the red region score is relatively improved, the test sample has a certain effect of repairing sensitive skin after long-term use, the pore score is not changed obviously, and the test sample has no effect of shrinking pores after long-term use.
According to the data in table 3, the comparison application example 2 is compared with the comparison application examples 3 and 4 respectively, the ginseng root extract and the rosa damascena hydrolat are added into the repair sensitive skin herbal composition rich in the ginseng essence according to a specific proportion, the red region score is improved to a certain extent, the ginseng root extract and the rosa damascena hydrolat are added into the repair sensitive skin herbal composition rich in the ginseng essence, the red region score is improved to a greater extent, and the combination of the ginseng root extract and the rosa damascena hydrolat is inhibited mutually.
According to the data in table 3, the data in application example 8 is compared with the data in comparative application example 1, and the ginseng root extract, the rose damascena hydrolat and the ginkgo root extract are added into the herbal composition for repairing and caring sensitive skin rich in ginseng essence according to a specific proportion, so that the red region score is obviously improved, and the ginseng root extract, the rose damascena hydrolat and the ginkgo root extract are matched, so that the repairing and caring sensitive effect of a test sample is obviously enhanced, the pore score is obviously improved, and meanwhile, the test sample has the effect of shrinking pores after being used for a long time.
According to the data in the table 3, the data in the application example 2 and the application example 5 are compared, the lavender flower water is added into the herbal composition for repairing and caring sensitive skin rich in ginseng essence according to a specific proportion, the value of a red area is relatively increased, and the lavender flower water can enhance the effect of repairing and caring sensitive skin of a test sample to a certain extent by being matched with the ginseng root extract, the rose hydrosol of damask and the ginkgo root extract.
According to the data in table 3, comparing the data in application example 3 with the data in application example 6, the centella asiatica extract is added into the herbal composition for repairing sensitive skin rich in ginseng essence according to a specific ratio, the score of the red area is relatively increased, and the centella asiatica extract is matched with lavender flower water, so that the effect of the test sample on repairing sensitive skin can be enhanced to a certain extent.
According to the data in table 3, comparing the data in application example 4 with the data in application example 7, the folium artemisiae argyi extract is added into the herbal composition for repairing sensitive skin rich in ginseng essence according to a specific proportion, the red area score is relatively improved, and the folium artemisiae argyi extract, the centella asiatica extract and the lavender flower water are matched, so that the effect of the test sample on repairing sensitive skin can be enhanced to a certain extent.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (9)
1. A herbal composition rich in ginseng essence for repairing sensitive skin is characterized in that: the paint comprises the following components in parts by mass:
0.28-0.32 parts of ginseng root extract;
0.08-0.12 part of Damascus rose hydrosol;
0.08-0.12 part of ginkgo root extract;
0.28-0.32 parts of antibacterial agent;
the antibacterial agent comprises one or more of lavender flower water, centella asiatica extract, folium artemisiae argyi extract, Ruscus aculeatus root extract and aescin.
2. The ginseng essence-enriched restorative sensitive skin herbal composition of claim 1, wherein: the antibacterial agent at least comprises lavender flower water.
3. The ginseng essence-enriched restorative sensitive skin herbal composition of claim 2, wherein: the antibacterial agent further comprises at least centella asiatica extract.
4. The restorative sensitive skin herbal composition enriched with ginseng essence of claim 3, characterized in that: the antibacterial agent at least comprises folium Artemisiae Argyi extract.
5. A method of preparing a ginseng extract-enriched restorative sensitive skin herbal composition as claimed in any one of claims 1-4, wherein:
adding the ginseng root extract, the rose hydrosol of Damascus, the ginkgo root extract and the antibacterial agent into a container, and uniformly stirring to obtain the herbal composition rich in ginseng essence for repairing and caring sensitive skin.
6. Use of a ginseng concentrate-enriched herbal composition for soothing sensitive skin according to any one of claims 1-4, wherein: the composition is added into skin care water, lotion, and cream.
7. A lotion comprising a sensitive skin rejuvenating herbal composition as defined in any one of claims 1 to 4 enriched with ginseng essence wherein: the paint comprises the following components in parts by mass:
4-6 parts of glycerol;
2-4 parts of butanediol;
0.08-0.12 part of carbomer;
0.05-0.2 part of allantoin;
0.18 to 0.22 portion of p-hydroxyacetophenone;
0.75-1 part of chelating agent;
0.78-0.82 parts of a ginseng extract-enriched restorative sensitive skin herbal composition of any one of claims 1-4;
0.11-0.13 part of arginine;
the total mass part of the skin care lotion containing the herbal composition for repairing sensitive skin rich in ginseng essence is 100 parts, and the balance is water.
8. An emulsion comprising a sensitive skin rejuvenating herbal composition enriched with ginseng essence as defined in any one of claims 1 to 4 wherein: the paint comprises the following components in parts by mass:
1.8-2.2 parts of an emulsifier;
0.8-1.2 parts of auxiliary emulsifier;
0.8-1.2 parts of cetearyl alcohol;
4.8-5.2 parts of isohexadecane;
1.8-2.2 parts of caprylic/capric triglyceride;
1.8-2.2 parts of polydimethylsiloxane;
0.4-0.6 part of squalane;
0.2-0.4 part of tocopherol acetate;
5-7 parts of glycerol;
1-3 parts of butanediol;
0.05-0.1 part of EDTA disodium;
0.18-0.22 part of carbomer;
0.05-0.2 part of allantoin;
0.14-0.16 part of xanthan gum;
0.23-0.25 part of arginine;
0.48-0.52 part of p-hydroxyacetophenone;
0.5-0.7 part of 1, 2-hexanediol;
0.78-0.82 parts of a ginseng extract-enriched restorative sensitive skin herbal composition of any one of claims 1-4;
the total mass part of the emulsion containing the herbal composition rich in ginseng essence for repairing sensitive skin is 100 parts, and the balance is water.
9. A cream comprising a sensitive skin rejuvenating herbal composition enriched with ginseng extract as claimed in any one of claims 1 to 4 wherein: the paint comprises the following components in parts by mass:
1.8-2.2 parts of an emulsifier;
0.8-1.2 parts of auxiliary emulsifier;
0.8-1.2 parts of cetearyl alcohol;
4.8-5.2 parts of isohexadecane;
1.8-2.2 parts of caprylic/capric triglyceride;
1.8-2.2 parts of polydimethylsiloxane;
0.4-0.6 part of squalane;
0.2-0.4 part of tocopherol acetate;
5-7 parts of glycerol;
1-3 parts of butanediol;
0.05-0.1 part of EDTA disodium;
0.24-0.26 part of carbomer;
0.05-0.2 part of allantoin;
0.14-0.16 part of xanthan gum;
0.29-0.31 part of arginine;
0.48-0.52 part of p-hydroxyacetophenone;
0.5-0.7 part of 1, 2-hexanediol;
0.78-0.82 parts of a ginseng extract-enriched restorative sensitive skin herbal composition of any one of claims 1-4;
the total mass portion of the cream containing the herbal composition rich in ginseng essence for repairing sensitive skin is 100 portions, and the balance is water.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114617925A (en) * | 2022-04-01 | 2022-06-14 | 上海医妃医药科技有限公司 | Antibacterial skin care composition used after medical and beauty operations |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961276A (en) * | 2014-01-08 | 2014-08-06 | 片仔癀（上海）生物科技研发有限公司 | Anti-glycation cosmetic composition and anti-glycation cosmetics containing same |
| CN106974854A (en) * | 2017-03-17 | 2017-07-25 | 上海莱沛美贸易有限公司 | Skin-active repairs essence |
| CN112263497A (en) * | 2020-10-23 | 2021-01-26 | 上海新高姿化妆品有限公司 | Skin care product composition with effects of relieving, repairing and resisting allergy |
-
2021
- 2021-03-06 CN CN202110247944.9A patent/CN112870127B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961276A (en) * | 2014-01-08 | 2014-08-06 | 片仔癀（上海）生物科技研发有限公司 | Anti-glycation cosmetic composition and anti-glycation cosmetics containing same |
| CN106974854A (en) * | 2017-03-17 | 2017-07-25 | 上海莱沛美贸易有限公司 | Skin-active repairs essence |
| CN112263497A (en) * | 2020-10-23 | 2021-01-26 | 上海新高姿化妆品有限公司 | Skin care product composition with effects of relieving, repairing and resisting allergy |
Non-Patent Citations (3)
| Title |
|---|
| 杨嘉萌: "植物提取物在化妆品中的应用及展望", 《日用化学工业》 * |
| 谢惠英等: "几种植物提取物在化妆品中的应用现状", 《香料香精化妆品》 * |
| 谢艳君等: "化妆品中常用中草药原料研究进展", 《中国中药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114617925A (en) * | 2022-04-01 | 2022-06-14 | 上海医妃医药科技有限公司 | Antibacterial skin care composition used after medical and beauty operations |
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