CN105769604A - Direct-to-corium layer smearing type hydro-lifting injection and preparation method thereof - Google Patents
Direct-to-corium layer smearing type hydro-lifting injection and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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Abstract
The invention discloses a direct-to-corium layer smearing type hydro-lifting injection and a preparation method thereof. The direct-to-corium layer smearing type hydro-lifting injection comprises the following raw materials in parts by weight: 15 to 25 parts of hyaluronic acid, 15 to 25 parts of collagen, 6 to 9 parts of 1,3-propanediol, 1 to 3 parts of L-sodium ascorbate, 1 to 3 parts of L-serine, 1 to 5 parts of a stabilizing agent, 1 to 5 parts of a sun-screening agent and 60 to 450 parts of water. The direct-to-corium layer smearing type hydro-lifting injection can preserve moisture and screen sun, gives instant hydrating, rapid penetrating, deep nourishing and long-lasting water locking to dry skin respectively, realizes three-dimensional moisture preservation, increases skin elasticity, makes the skin exquisite, smooth and lustrous, passes an anti-allergy test, has no side effect, is safe and reliable, and can be used as a mask-type skin care product for a long time.
Description
Technical field
The present invention relates to technical field of skin care, painting type water laser accunputure being specifically related to a kind of through skin corium and preparation method thereof.
Background technology
The water loss of skin is relevant with many factors, such as air-conditioning, environmental pollution, Seasonal conversion, and air humidity reduces, so together skin occur being dried, turn to be yellow, intensely dark pool, aging phenomenon and many skin problems such as lax, wrinkle.
Sodium hyaluronate, is also called hyaluronic acid, is the material of naturally occurring in tissue, and it can draw the moisture of own wt 1000 times, has surprising water suction, lock water and the effect of Water Cycle.With advancing age, sodium hyaluronate can constantly run off.Thus sodium hyaluronate becomes the most best and maximally effective natural replenishing water and preserving moisture factor.But due to cost and the reason of technology, a lot of products use most sodium hyaluronates remaining big molecule, comprise only the skin care item limited use of unimodal molecular weight sodium hyaluronate, can not play the optimal skin-care effect of sodium hyaluronate.
With advancing age, the aggravation of environmental pollution, endure the young white collar of work weight to the fullest extent and cause skin that problems occur because of reasons such as ultraviolet, dust, waste gas, computer radiation, add people beautiful is constantly pursued and to healthy demand, with whitening, moisturizing, go the beauty mask series products as primary efficacy such as wrinkle, light spot to obtain the favor of most consumers.Accordingly, we have invented the painting type water laser accunputure of a kind of through skin corium, active component can penetrate into rapidly skin corium at normal temperatures and pressures, by deposited face or be applied in skin epidermis, and the most permeable epidermis, through skin corium；Raw material is simple, definite ingredients, effect are notable, technique is simple.
Summary of the invention
For above-mentioned deficiency present in prior art, one of the technical problem to be solved is to provide the painting type water laser accunputure of a kind of through skin corium.
The two of the technical problem to be solved are to provide the preparation method of the painting type water laser accunputure of above-mentioned through skin corium.
The present invention seeks to be achieved through the following technical solutions:
A kind of painting type water laser accunputure (being properly termed as again facial treatment essence liquid) of through skin corium, it is made up of following weight parts raw material: 15-25 part sodium hyaluronate and 15-25 part collagen, 6-9 part 1,3-PD, 1-3 part L-AA sodium, 1-3 part Serine, 1-5 part stabilizer, 1-5 part sun-screening agent, 60-450 part water.
Described stabilizer is mixed by guar gum, trehalose, xylitol, and described guar gum, trehalose, the mass ratio of xylitol are (1-3): (1-3): (1-3).
Described sun-screening agent is mixed by rue leaf glycosides, polygonin, barbaloin, and described rue leaf glycosides, polygonin, the mass ratio of barbaloin are (1-3): (1-3): (1-3).
Described sodium hyaluronate is that molecular weight is at the daltonian sodium hyaluronate of 300-900.
Described collagen is that molecular weight is at the daltonian collagen of 300-900.
Present invention also offers the preparation method of the painting type water laser accunputure of above-mentioned through skin corium, comprise the following steps:
(1) the water vacuum suction that temperature is 80-100 DEG C is extremely emulsified in pot, under processing condition, add stabilizer homogeneous process；
(2) when temperature is reduced to 10-40 DEG C, in emulsification pot, addition sodium hyaluronate, collagen, 1,3-PD, L-AA sodium, Serine mix, and obtain the painting type water laser accunputure of described through skin corium.
Concrete, in the present invention:
Collagen, No. CAS: 9064-67-9.
Sodium hyaluronate, also known as hyaluronic acid, No. CAS: 9004-61-9.
L-AA sodium, No. CAS: 134-03-2.
Serine, No. CAS: 56-45-1.
Rue leaf glycosides, No. CAS: 153-18-4, its structural formula is as follows:
Polygonin, No. CAS: 27208-80-6, its structural formula is as follows:
Barbaloin, No. CAS: 1415-73-2, its structural formula is as follows:
Guar gum, No. CAS: 9000-30-0.
Trehalose, No. CAS: 99-20-7, its structural formula is as follows:
Xylitol, No. CAS: 16277-71-7.
1,3-PD, No. CAS: 504-63-2
The present invention can moisturizing sun-proof, give the instant moisturizing of dry skin, rapid osmotic, deep layer nourishing, long-acting lock water respectively, realize three-dimensional moisturizing, increase skin elasticity, make skin fine and smooth, smooth, glossy, and by anti-quick test, without any side effects, safe and reliable, can be as facial mask class skin-protection product Long-Time Service.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, it is only to presently preferred embodiments of the present invention, the present invention not does the restriction of other forms, and any those skilled in the art are changed to the Equivalent embodiments changed on an equal basis possibly also with the technology contents of the disclosure above.Every without departing from the present invention program content, any simple modification following example done according to the technical spirit of the present invention or equivalent variations, all fall within protection scope of the present invention.
Raw material introduction in embodiment:
Collagen, No. CAS: 9064-67-9, molecular weight is in 500-700 dalton.
Sodium hyaluronate, No. CAS: 9004-61-9, molecular weight is in 500-700 dalton.
Embodiment 1
Weigh each raw material (weight portion): 20 parts of sodium hyaluronates, 20 parts of collagens, 7 parts of 1,3-propane diols, 2 parts of L-AA sodium, 1.5 parts of Serines, 3 parts of stabilizers, 3 parts of sun-screening agents, 90 parts of water.
Described stabilizer is uniformly mixed is obtained by guar gum, trehalose, xylitol, and described guar gum, trehalose, the mass ratio of xylitol are 1:1:1.
Described sun-screening agent is uniformly mixed is obtained by rue leaf glycosides, polygonin, barbaloin, and described rue leaf glycosides, polygonin, the mass ratio of barbaloin are 1:1:1.
Present invention also offers the preparation method of the painting type water laser accunputure of above-mentioned through skin corium, comprise the following steps:
(1) the water vacuum suction that temperature is 90 DEG C is extremely emulsified in pot, under processing condition, add 2000 revs/min of homogeneous of stabilizer process 5min；
(2) when temperature is reduced to 35 DEG C, adding sodium hyaluronate in emulsification pot, 2000 revs/min of homogeneous process 5min；Adding collagen, 2000 revs/min of homogeneous process 5min；Adding 1,3-PD, 2000 revs/min of homogeneous process 5min；Being eventually adding L-AA sodium, Serine, 2000 revs/min of homogeneous process 5min；Being eventually adding sun-screening agent, 2000 revs/min of homogeneous process 5min；It is down to room temperature, obtains the painting type water laser accunputure of the through skin corium of embodiment 1.
Embodiment 2
By raw material proportioning and the painting type water laser accunputure of the through skin corium of method preparation of embodiment 1, differing only in: described stabilizer is uniformly mixed by guar gum, trehalose and obtains, described guar gum, the mass ratio of trehalose are 1:1.Obtain the painting type water laser accunputure of the through skin corium of embodiment 2.
Embodiment 3
By raw material proportioning and the painting type water laser accunputure of the through skin corium of method preparation of embodiment 1, differing only in: described stabilizer is uniformly mixed by guar gum, xylitol and obtains, described guar gum, the mass ratio of xylitol are 1:1.Obtain the painting type water laser accunputure of the through skin corium of embodiment 3.
Embodiment 4
By raw material proportioning and the painting type water laser accunputure of the through skin corium of method preparation of embodiment 1, differing only in: described stabilizer is uniformly mixed by trehalose, xylitol and obtains, described trehalose, the mass ratio of xylitol are 1:1.Obtain the painting type water laser accunputure of the through skin corium of embodiment 4.
Embodiment 5
By raw material proportioning and the painting type water laser accunputure of the through skin corium of method preparation of embodiment 1, differing only in: described sun-screening agent is uniformly mixed is obtained by rue leaf glycosides, polygonin, described rue leaf glycosides, the mass ratio of polygonin are 1:1.Obtain the painting type water laser accunputure of the through skin corium of embodiment 5.
Embodiment 6
By raw material proportioning and the painting type water laser accunputure of the through skin corium of method preparation of embodiment 1, differing only in: described sun-screening agent is uniformly mixed is obtained by rue leaf glycosides, barbaloin, described rue leaf glycosides, the mass ratio of barbaloin are 1:1.Obtain the painting type water laser accunputure of the through skin corium of embodiment 6.
Embodiment 7
By raw material proportioning and the painting type water laser accunputure of the through skin corium of method preparation of embodiment 1, differing only in: described sun-screening agent is uniformly mixed by polygonin, barbaloin and obtains, described polygonin, the mass ratio of barbaloin are 1:1.Obtain the painting type water laser accunputure of the through skin corium of embodiment 7.
Test case 1
The painting type water laser accunputure of the through skin corium that embodiment 1-7 prepares is carried out anti-aging test, and test index is skin elasticity and keratoderma moisture.
Skin elasticity year skin senescence and reduce, therefore skin elasticity is one of important symbol judging skin senescence, is the requisite project of efficacy detection of anti-aging cosmetics.
Experimental technique: every group selection is healthy, skin is normal, without the tested crowd of cosmetic allergic contact dermatitis history, age 20-45 year, the wherein male sex 20, women 20.Within one week, being a course for the treatment of, totally four courses for the treatment of, by facial cleansing every time before using, and each face cleaning time is identical, uses corresponding product, each group to use corresponding product 1 time every day, take 10g uniform application on the face after skin dries.
Measure: select Face and cheek as test zone, test after product 10min to be used.Use skin elasticity tester to measure skin elasticity curve, according to amount of tension and the resilience data of skin, the moisturizing of cosmetics and anti-senescence function can be estimated.
Experimental result: skin elasticity test is based on suction and stretching principle, a negative pressure is produced on the surface of tested skin, by in special for skin inspiration one test probe, skin is inhaled into the degree of depth and is recorded by a non-contact optical detection system, measurement result generally represents with an index, unit is 1, and numerical value is the biggest, illustrates that skin elasticity is the strongest.The go directly painting type water light of skin corium of the present invention is as shown in table 1 for the impact of skin elasticity.
Table 1: skin elasticity test value table
| Group | 0 week | 1 week | 2 weeks | 3 weeks | 4 weeks |
| Embodiment 1 | 0.479 | 0.557 | 0.659 | 0.696 | 0.739 |
| Embodiment 2 | 0.478 | 0.538 | 0.631 | 0.662 | 0.713 |
| Embodiment 3 | 0.480 | 0.531 | 0.627 | 0.659 | 0.702 |
| Embodiment 4 | 0.481 | 0.532 | 0.635 | 0.672 | 0.715 |
| Embodiment 5 | 0.479 | 0.535 | 0.633 | 0.676 | 0.713 |
| Embodiment 6 | 0.482 | 0.529 | 0.641 | 0.680 | 0.721 |
| Embodiment 7 | 0.501 | 0.539 | 0.636 | 0.679 | 0.709 |
Note: carry out statistical analysis more afterwards, result shows P ＜ 0.05, and difference has statistical significance.
As can be seen from Table 1, the go directly painting type water laser accunputure of skin corium of the present invention can be remarkably reinforced skin elasticity, illustrates that the go directly painting type water laser accunputure of skin corium of the present invention has good anti-aging and effects such as skin of compacting, strengthens elasticity of skin, deep layer repairs skin, makes skin dynamic.
Comparing embodiment 1 and embodiment 2-4, embodiment 1 (stabilizer employing guar gum, trehalose, xylitol compound) skin elasticity is substantially better than embodiment 2-4 (arbitrarily the two compounds for stabilizer employing guar gum, trehalose, xylitol)；Comparing embodiment 5 and embodiment 6-8, embodiment 5 (sun-screening agent employing rue leaf glycosides, polygonin, barbaloin compound) skin elasticity is substantially better than embodiment 6-8 (arbitrarily the two compounds for sun-screening agent employing rue leaf glycosides, polygonin, barbaloin).
Moisture is one of important moulding material of epiderm skin cuticula, and during skin senescence, horny layer of epidermis is thinning, and in cuticula, natural moisture preserving component content reduces, and skin hydration ability declines, and moisture of skin is lost to be increased；Meanwhile, cell shrinkage Telatrophy, occur in that histological structure and morphological change make skin engender fine wrinkles.
By the mensuration of moisture of skin can be reflected the degree of skin senescence and effect of Moisturizer to a certain extent.
Experimental technique: every group selection healthy skin, without the tested crowd of cosmetic allergic contact dermatitis history, age 20-45 year, the wherein male sex 20, women 20.Room temperature 25 DEG C ± 1 DEG C；Humidity 50% ± 5%.Cleaning face during test, and everyone face cleaning time is identical, selects Face and cheek 4cm × 4cm skin as test zone, take 0.8g uniform application on the face after skin dries.
Measure: at Face and cheek (4cm × 4cm) test zone, after product to be used, 10min tests.
(1) water content of Face and cheek skin is measured with digital skin moisture detector.Use after corresponding product after 1h, 2h, 4h, 6h, survey Face and cheek moisture content of skin, measure and average for three times.
(2) water loss amount of Face and cheek skin is measured with percutaneous moisture loss measuring instrument.Use after corresponding product after 1h, 2h, 4h, 6h, survey Face and cheek moisture of skin windage, measure and average for three times.
Experimental result: weigh the change of water content of stratum corneum by the change of keratoderma capacitance before and after test use product thus evaluate the moisture-keeping efficacy of cosmetics.The method carries out quantification to skin keratin moisture, it is possible to react the change of skin moisture content, and favorable reproducibility delicately, is one of method that current moisture-keeping cosmetics efficacy assessments is conventional.This product is as shown in table 2 on the impact of skin moisture content.
Table 2: moisture test value list position: %
Note: carry out statistical analysis more afterwards, result shows P ＜ 0.05, and difference has statistical significance
As can be seen from Table 2, the present invention goes directly, and the painting type water laser accunputure moisturizing of skin corium is effective, moisture preserving time is long, illustrate that the go directly painting type water laser accunputure of skin corium of the present invention can effectively suppress excess oil, balance skin profit, while control oil, also there is moisturizing effect, persistently moisturizing, softening skin.
Comparing embodiment 1 and embodiment 2-4, embodiment 1 (stabilizer uses guar gum, trehalose, xylitol to compound) moisture is apparently higher than embodiment 2-4 (stabilizer use guar gum, trehalose, xylitol arbitrarily the two is compounding)；Comparing embodiment 5 and embodiment 6-8, embodiment 5 (sun-screening agent uses rue leaf glycosides, polygonin, barbaloin to compound) moisture is apparently higher than embodiment 6-8 (sun-screening agent use rue leaf glycosides, polygonin, barbaloin arbitrarily the two is compounding).
Test case 2
The painting type water laser accunputure of the through skin corium that embodiment 1 and embodiment 5-7 prepare is carried out radiation proof test.
Method of testing reference patent application 201410613299.8 specification page 5 embodiment 2, [0033rd] section is to [0038] section.
The cell used is immortalization epithelial cell (Hacat cell), purchased from consonance cellular resources center, Beijing.Condition of culture is DMEM culture medium (Gibco, the U.S.), and the FBS (Hyclone, Australia) containing 10% and the antibiotic (Invitrogen, the U.S.) of the antibacterium of 1% and fungi, at 37 DEG C, CO2Concentration is the interior cultivation of incubator of 5%.
Cell set 1 group of blank group, 1 group of negative control group and and 4 groups of test groups, blank group does not the most carry out UVB (ultraviolet) process without the painting type water laser accunputure of through skin corium, without the painting type water laser accunputure of through skin corium on the culture medium of negative control group, 4 groups of test group add the painting type water laser accunputure 0.1mg of the through skin corium of embodiment 5-8 respectively.
Hacat cell is with 4 × 104Cells/ hole is inoculated in 12 orifice plates, and after cell inoculation 24h, cell sucks culture medium, adds PBS cell once, removes PBS, puts into and carry out UVB process in ultraviolet irradiation case.UVB irradiation bomb wavelength 280-320nm, crest is 312nm.It is 20mJ/cm that UVB processes Hacat cell irradiation dose2。
Hacat cell IL-1 alpha content in culture supernatant after UVB processes makes employment IL-1 α/IL-1F1DuoSet ELISA kit (R&D System, the U.S.) detect, IL-6 content detection uses humanIL-6DuoSet ELISA kit (R&D System, the U.S.) carry out, TNF-a content detection uses human TNF-aDuoSet ELISA kit (R&D System, the U.S.) carry out, the same specification of method.
The content that each group of test records is respectively divided by the content of negative control group, is multiplied by 100 parts, obtains relative amount.Result of calculation see table 3.
Table 3: the painting type water laser accunputure of through skin corium carries out radiation proof test result table
| IL-1 α (part) | IL-6 (part) | TNF-a (part) | |
| Blank group | 11.4 | 18.1 | 14.4 |
| Negative control group | 100 | 100 | 100 |
| Embodiment 5 | 48.9 | 63.1 | 58.0 |
| Embodiment 6 | 49.8 | 66.1 | 61.3 |
| Embodiment 7 | 51.3 | 65.9 | 60.9 |
| Embodiment 8 | 51.2 | 65.5 | 60.4 |
After UVR process can cause Hacat cell; cell the proinflammatory factor IL-1 α, IL-6 and TNF-a can be caused to express increase; after culture medium adds the painting type water laser accunputure of the through skin corium using embodiment of the present invention 1-7; significantly reduce the content of IL-1 α, IL-6 and TNF-a; as can be seen here; it can suppress the inflammatory reaction caused by UVB, shields epithelial cell.
Comparing embodiment 1 and embodiment 5-7, embodiment 1 (sun-screening agent uses rue leaf glycosides, polygonin, barbaloin to compound) is substantially better than embodiment 5-7 (sun-screening agent use rue leaf glycosides, polygonin, barbaloin arbitrarily the two is compounding) by UVB to the effect of the inflammatory reaction that system is caused.
Claims (4)
1. the painting type water laser accunputure of a through skin corium, it is characterised in that by following weight parts raw material group
Become: 15-25 part sodium hyaluronate and 15-25 part collagen, 6-9 part 1,3-propane diols, 1-3 part L-are anti-bad
Hematic acid sodium, 1-3 part Serine, 1-5 part stabilizer, 1-5 part sun-screening agent, 60-450 part water.
Described stabilizer is mixed by guar gum, trehalose, xylitol, described guar gum, marine alga
Sugar, the mass ratio of xylitol are (1-3): (1-3): (1-3).
Described sun-screening agent is mixed by rue leaf glycosides, polygonin, barbaloin, described rue leaf glycosides,
Polygonin, the mass ratio of barbaloin are (1-3): (1-3): (1-3).
2. the painting type water laser accunputure of through skin corium as claimed in claim 1, it is characterised in that described
Sodium hyaluronate be that molecular weight is at the daltonian sodium hyaluronate of 300-900.
3. the painting type water laser accunputure of through skin corium as claimed in claim 1, it is characterised in that described
Collagen be that molecular weight is at the daltonian collagen of 300-900.
4. the preparation side of the painting type water laser accunputure of the through skin corium as described in any one of claim 1-3
Method, it is characterised in that comprise the following steps:
(1) the water vacuum suction that temperature is 80-100 DEG C is extremely emulsified in pot, add steady under processing condition
Determine agent homogeneous to process；
(2) when temperature is reduced to 10-40 DEG C, to emulsification pot in add sodium hyaluronate, collagen, 1,3-
Propane diols, L-AA sodium, Serine mix, and obtain the painting type of described through skin corium
Water laser accunputure.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US10456343B2 (en) | 2017-01-26 | 2019-10-29 | L'oreal | Microemulsion compositions comprising polydatin and method of use |
| CN111529442A (en) * | 2020-05-08 | 2020-08-14 | 紫水晶(山西)再生医学科技有限公司 | Water light injection for medical and beauty and preparation method thereof |
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| CN105616187A (en) * | 2016-02-04 | 2016-06-01 | 上海新肌生物科技有限公司 | Smearing type intradermal injection capable of directly reaching dermis layer and preparation method thereof |
| US10456343B2 (en) | 2017-01-26 | 2019-10-29 | L'oreal | Microemulsion compositions comprising polydatin and method of use |
| CN111529442A (en) * | 2020-05-08 | 2020-08-14 | 紫水晶(山西)再生医学科技有限公司 | Water light injection for medical and beauty and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN105769604B (en) | 2018-08-21 |
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