CN106924670A - 一种治疗食管癌的药物及其制备方法 - Google Patents
一种治疗食管癌的药物及其制备方法 Download PDFInfo
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- CN106924670A CN106924670A CN201710222151.5A CN201710222151A CN106924670A CN 106924670 A CN106924670 A CN 106924670A CN 201710222151 A CN201710222151 A CN 201710222151A CN 106924670 A CN106924670 A CN 106924670A
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Abstract
本发明公开了一种治疗食管癌的药物及其制备方法,其是由人参、三棱、莪术、薏苡仁、白花蛇舌草、灵芝、蟾皮、肿节风、海藻、丹参、天南星、半夏、甘草、半枝莲、马钱子、苦参、水丁香、瓦楞子、蜣螂按一定重量配比制备而成,本发明药物具有大补元气,固脱生津,破血行气,消积止痛,清热解毒,利水消胀,消肿散结的功能,用于治疗食管癌见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗食管癌的药物及其制备方法,属中药领域。
背景技术
食管癌是常见的消化道肿瘤,全世界每年约有30万人死于食管癌。其发病率和死亡率各国差异很大。我国是世界上食管癌高发地区之一,每年平均病死约15万人。男多于女,发病年龄多在40岁以上。食管癌典型的症状为进行性咽下困难,先是难咽干的食物,继而是半流质食物,最后水和唾液也不能咽下。由于西药治疗副作用大,因此人们对有效治疗食管癌的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗食管癌的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗食管癌的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择人参、三棱、莪术、薏苡仁、白花蛇舌草、灵芝、蟾皮、肿节风、海藻、丹参、天南星、半夏、甘草、半枝莲、马钱子、苦参、水丁香、瓦楞子、蜣螂进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗食管癌。其中选用人参是因为其性味甘微甘,温,入脾、肺经,有大补元气,固脱生津,安神的功能,治劳伤虚损,食少,倦怠,反胃吐食,大便滑泄,虚咳喘促,自汗暴脱,惊悸,健忘,眩晕头痛,阳萎,尿频,消渴,妇女崩漏,小儿慢惊及久虚不复,一切气血津液不足之症。选用三棱是因为其性味苦辛,平,入肝、脾经,有破血,行气,消积,止痛的功能,治癥瘕积聚,气血凝带,心腹疼痛,胁下胀疼,经闭,产后瘀血腹痛,跌打损伤,疮肿坚硬。选用莪术是因为其性味辛、苦、温。归肝、脾经。行气破血,消积止痛。用于癥瘕痞块,瘀血经闭,食积胀痛,跌打肿痛,早期宫颈癌。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用白花蛇舌草是因为其性味苦甘,寒,入心、肝、脾三经,有清热,利湿,解毒的功能,治肺热喘咳,扁桃体炎,咽喉炎,阑尾炎,痢疾,黄疸,盆腔炎,附件炎,痈肿疔疮,毒蛇咬伤。选用灵芝是因为其性味甘,平,归心、肺、肝、肾经,有补气安神,止咳平喘的功能,治眩晕不眠,心悸气短,虚劳咳喘。选用蟾皮是因为其性味辛,凉,微毒,有清热解毒,利水消胀的功能,治痈疽,肿毒,瘰疬,肿瘤,疳积腹胀,慢性气管炎。选用肿节风是因为其性味苦、辛,平,归心、肝经,有清热凉血,活血消斑,祛风通络,治血热紫斑、紫癜,风湿痹痛,跌打损伤。选用海藻是因为其性味苦咸,寒,入肺、脾、肾经,有软坚,消痰,利水,泄热的功能,治瘰疬,瘿瘤,积聚,水肿,脚气,睾丸肿痛。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用天南星是因为其性味苦辛,温,有毒,入肺、肝、脾经,有燥湿化痰,祛风定惊,消肿散结的功能,治中风痰壅,口眼斜,半身不遂,癫癎,惊风,破伤风,风痰眩晕,喉痹,瘰疬,痈肿,跌扑折伤,蛇虫咬伤。选用半夏是因为其性味辛,温,有毒,入脾、胃经,有燥湿化痰,降逆止呕,消痞散结的功能,治湿痰冷饮,呕吐,反胃,咳喘痰多,胸膈胀满,痰厥头痛,头晕不眠,外消痈肿。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用半枝莲是因为其性味苦,寒,有清热,解毒的功能,治咽喉肿痛,烫伤,跌打损伤,湿疮。选用马钱子是因为其性味苦,寒,有毒,有散血热,消肿,止痛的功能,治咽喉痹痛,痈疽肿毒,风痹疼痛,骨折,并治面神经麻痹,重症肌无力。选用苦参是因为其性味苦,寒,入肝、肾、大肠、小肠经,有清热,燥湿,杀虫的功能,治热毒血痢,肠风下血,黄疸,赤白带下,小儿肺炎,疳积,急性扁桃体炎,痔漏,脱肛,皮肤瘙痒,阴疮湿痒,瘰疬,烫伤。选用水丁香是因为其性味苦,凉,有利尿消肿,清热解毒的功能,治水肿,淋病,痢疾,白带,痈疽,疔疮。选用瓦楞子是因为其性味甘,咸,平,入肝、脾经,有化痰,软坚,散瘀,消积的功能,治痰积,胃痛,嘈杂,吐酸,癥瘕,瘰疬,牙疳。选用蜣螂是因为其性味咸,寒,有毒,入手、足阳明,足厥阴经, 有定惊,破瘀,通便,攻毒的功能,治惊癎,癫狂,癥瘕,噎膈反胃,腹胀便结,淋病,疳积,血痢,痔漏,疔肿,恶疮。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
人参5-15克,三棱5-15克,莪术10-14克,薏苡仁5-15克,白花蛇舌草10-14克,灵芝6-10克,蟾皮4-6克,肿节风5-15克,海藻15-25克,丹参15-25克,天南星5-15克,半夏4-8克,甘草4-8克,半枝莲45-55克,马钱子1-2克,苦参10-20克,水丁香15-25克,瓦楞子15-25克,蜣螂1-5克。
优选为:
人参10克,三棱10克,莪术12克,薏苡仁10克,白花蛇舌草12克,灵芝8克,蟾皮5克,肿节风10克,海藻20克,丹参20克,天南星10克,半夏6克,甘草6克,半枝莲50克,马钱子1.5克,苦参15克,水丁香20克,瓦楞子20克,蜣螂3克。
本发明药物的制备方法如下
一、备料
1、人参:除去芦头,切段;
2、三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
3、莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
4、薏苡仁:取原药材,除去残留皮壳、杂质;
5、白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
6、灵芝:除去杂质,洗净,润软,切厚片,干燥,筛去碎屑;
7、蟾皮:除去杂质、碎屑,剪去头爪,切成小方块;
8、肿节风:除去杂质,洗净,润透,切段,干燥;
9、海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
10、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
11、天南星:拣去杂质,洗净灰屑,晒干;
12、半夏:拣去杂质,筛去灰屑;
13、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
14、半枝莲:除去杂质,洗净,稍润,切段,干燥;
15、马钱子:取原药材,除去杂质;
16、苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
17、水丁香:秋季结果时采收;
18、瓦楞子:洗净晒干,打碎;
19、蜣螂:一般于6-8月间晚上利用灯光诱捕,沸水烫死,再用炭火烘干。
二、制备
1、将所述重量的人参、三棱、莪术、薏苡仁、白花蛇舌草、灵芝、蟾皮、肿节风、海藻、丹参、天南星、半夏、甘草、半枝莲、马钱子、苦参、水丁香、瓦楞子、蜣螂放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中人参有大补元气,固脱生津的功能为君药;三棱有破血,行气,消积,止痛的功能;蟾皮有清热解毒,利水消胀的功能,二者为臣药,三味药共同发挥大补元气,固脱生津,破血行气,消积止痛,清热解毒,利水消胀的作用,治疗食管癌效力全面,且以大补元气,破血行气,消积止痛,清热解毒为主可治本,天南星有燥湿化痰,祛风定惊,消肿散结的功能为佐药,甘草有缓急,润肺,解毒,调和诸药的功能为使药,与下余诸药是治标。
本发明药物具有大补元气,固脱生津,破血行气,消积止痛,清热解毒,利水消胀,消肿散结的功能,用于治疗食管癌,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治食管癌门诊患者共26例。
2、诊断标准
典型症状为进行性咽下困难,先是难咽干的食物,继而是半流质食物,最后水和唾液也不能咽下。常吐黏液样痰,为下咽的唾液和食管的分泌物。患者逐渐消瘦、脱水、无力。持续胸痛或背痛表示为晚期症状,癌已侵犯食管外组织。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续服用6个疗程。
4、疗效评定标准
显效:食管癌症状消失,饮食吞咽恢复正常;
好转:食管癌症状明显好转,饮食吞咽逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗食管癌患者26例,结果显效21例,显效率为80.8%,好转3例,好转率为11.5%,无效2例,总有效率为92.3%。
Claims (3)
1.一种治疗食管癌的药物,其特征在于:它是由下列重量范围内的原料药制成:
人参5-15克,三棱5-15克,莪术10-14克,薏苡仁5-15克,白花蛇舌草10-14克,灵芝6-10克,蟾皮4-6克,肿节风5-15克,海藻15-25克,丹参15-25克,天南星5-15克,半夏4-8克,甘草4-8克,半枝莲45-55克,马钱子1-2克,苦参10-20克,水丁香15-25克,瓦楞子15-25克,蜣螂1-5克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
人参10克,三棱10克,莪术12克,薏苡仁10克,白花蛇舌草12克,灵芝8克,蟾皮5克,肿节风10克,海藻20克,丹参20克,天南星10克,半夏6克,甘草6克,半枝莲50克,马钱子1.5克,苦参15克,水丁香20克,瓦楞子20克,蜣螂3克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)人参:除去芦头,切段;
(2)三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
(3)莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
(4)薏苡仁:取原药材,除去残留皮壳、杂质;
(5)白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
(6)灵芝:除去杂质,洗净,润软,切厚片,干燥,筛去碎屑;
(7)蟾皮:除去杂质、碎屑,剪去头爪,切成小方块;
(8)肿节风:除去杂质,洗净,润透,切段,干燥;
(9)海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
(10)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(11)天南星:拣去杂质,洗净灰屑,晒干;
(12)半夏:拣去杂质,筛去灰屑;
(13)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(14)半枝莲:除去杂质,洗净,稍润,切段,干燥;
(15)马钱子:取原药材,除去杂质;
(16)苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
(17)水丁香:秋季结果时采收;
(18)瓦楞子:洗净晒干,打碎;
(19)蜣螂:一般于6-8月间晚上利用灯光诱捕,沸水烫死,再用炭火烘干;
(二)制备
(1)将所述重量的人参、三棱、莪术、薏苡仁、白花蛇舌草、灵芝、蟾皮、肿节风、海藻、丹参、天南星、半夏、甘草、半枝莲、马钱子、苦参、水丁香、瓦楞子、蜣螂放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
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CN107596179A (zh) * | 2017-11-08 | 2018-01-19 | 赵红侠 | 一种治疗喉癌的药物及其制备方法 |
CN109481605A (zh) * | 2018-11-02 | 2019-03-19 | 吴保喜 | 一种以毒攻毒治疗癌症的药物及多种抗癌疗法的制备方法 |
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CN104161926A (zh) * | 2014-08-27 | 2014-11-26 | 四川金堂海纳生物医药技术研究所 | 一种治疗食管癌的内服药物及其制备方法 |
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CN104161926A (zh) * | 2014-08-27 | 2014-11-26 | 四川金堂海纳生物医药技术研究所 | 一种治疗食管癌的内服药物及其制备方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107596179A (zh) * | 2017-11-08 | 2018-01-19 | 赵红侠 | 一种治疗喉癌的药物及其制备方法 |
CN109481605A (zh) * | 2018-11-02 | 2019-03-19 | 吴保喜 | 一种以毒攻毒治疗癌症的药物及多种抗癌疗法的制备方法 |
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