CN106344838A - 一种治疗口腔溃疡的中药组合物 - Google Patents
一种治疗口腔溃疡的中药组合物 Download PDFInfo
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- CN106344838A CN106344838A CN201611005932.0A CN201611005932A CN106344838A CN 106344838 A CN106344838 A CN 106344838A CN 201611005932 A CN201611005932 A CN 201611005932A CN 106344838 A CN106344838 A CN 106344838A
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Abstract
本发明公开了一种治疗口腔溃疡的中药组合物，由以下重量份数的原料制成：金银花10‑15份，生地9‑14份，玄参5‑10份，黄连6‑11份，桑叶4‑9份，薄荷10‑15份，黄柏7‑12份，黄芪5‑10份，忍冬藤7‑12份，地骨皮5‑10份，葛根10‑15份，穿心莲6‑11份，西洋参5‑10份，连翘5‑10份，蒲公英 10‑15份，竹叶5‑10份，椿树皮 6‑11份，肉桂10‑15份，山药5‑10份，甘草15‑20份。本发明中药组合物对于口腔溃疡具有疗效确切、生物利用度高、无毒副作用且不易复发等优点。
Description
技术领域
本发明涉及中药领域，特别是一种治疗口腔溃疡的中药组合物。
背景技术
口腔溃疡是一种常见的多发病，具有口腔黏膜病的共同表征，复发性口腔溃疡、口疮是最常见的口腔溃疡，口腔溃疡可发生于任何年龄，女性患此病的比例较高，一年四季均能发生，其特点是反复发作、灼痛难忍，影响病人正常饮食，同时还能引起多种并发症。多数患者能够自愈，但是病情重者持续时间较长，且因其具有反复发作的特点，给病人带来很大的痛苦。
口腔溃疡的病因很多，部分患者发病原因同紧张、外伤、戒烟、月经、食物过敏有关。目前用于治疗复发性口腔溃疡病的药物多以抗菌消炎，抗过敏，局部麻醉止痛类药物制成，但此类治疗具有一定的副作用与依赖性，因此治疗复发性口腔溃疡的药物必须安全、有效、无毒副作用，而中药学作为我国的传统医学，具有作用强、见效快、药效持久等优点，且没有依赖性、耐药性以及毒副作用，因此选择一种中药制剂治疗口腔溃疡，对于治疗口腔溃疡具有十分重要的临床意义。
发明内容
针对现有技术存在的不足，本发明所要解决的技术问题是，提供一种对于口腔溃疡疗效确切、生物利用度高、无毒副作用且不易复发的中药组合物。
为解决上述技术问题，本发明采取的技术方案是：提供一种治疗口腔溃疡的中药组合物，由以下重量份数的原料制成：金银花10-15份，生地9-14份，玄参5-10份，黄连6-11份，桑叶4-9份，薄荷10-15份，黄柏7-12份，黄芪5-10，忍冬藤7-12份，地骨皮5-10份，葛根10-15份，穿心莲6-11份，西洋参5-10份，连翘5-10份，蒲公英 10-15份，竹叶5-10份，椿树皮6-11份，肉桂10-15份，山药5-10份，甘草15-20份。
优选地，由以下重量份数的原料制成：金银花10份，生地14份，玄参5份，黄连11份，桑叶4份，薄荷15份，黄柏7份，黄芪10份，忍冬藤7份，地骨皮10份，葛根10份，穿心莲11份，西洋参5份，连翘10份，蒲公英 10份，竹叶10份，椿树皮6份，肉桂15份，山药5份，甘草20份。
优选地，由以下重量份数的原料制成：金银花15份，生地9份，玄参10份，黄连6份，桑叶9份，薄荷10份，黄柏12份，黄芪5份，忍冬藤12份，地骨皮5份，葛根15份，穿心莲6份，西洋参10份，连翘5份，蒲公英 15份，竹叶5份，椿树皮11份，肉桂10份，山药10份，甘草15份。
优选地，由以下重量份数的原料制成：金银花13份，生地12份，玄参7份，黄连8份，桑叶6份，薄荷13份，黄柏9份，黄芪7份，忍冬藤9份，地骨皮7份，葛根12份，穿心莲8份，西洋参7份，连翘7份，蒲公英 12份，竹叶8份，椿树皮9份，肉桂13份，山药8份，甘草17份。
上述中药组合物的制备方法：包含以下步骤：
(1)对各药材进行挑拣；去掉杂质、非药用和霉变部分；按照重量份数比，称取所需的各组分原料，洗净，放入煎药器内；
(2)向煎药器内加水，浸泡半个小时，开火，用武火将煎药器内中药煎煮至沸腾，然后改用文火煎煮，煎煮总时间为 1个小时；关火，滤出药渣，收集滤液；
（3）再加入药材总重量5倍量药渣再加入饮用水，大火煮开，小火保持 30分钟，滤出药渣，收集滤液；
（4）最后合并二次滤液后，静止2小时，得到滤液，即为本发明口服药剂。
优选地，步骤 (2) 中饮用水量为药材总重量10倍量。
优选地，步骤 (3) 中饮用水量为药材总重量5倍量。
优选地，步骤 (2)和（3）中过滤为取 3—4 层纱布制成滤布进行过滤。
用法与用量：所述内服中药每日一剂，每剂可服用两次，早晚饭后服用，7天为一疗程。服药期间忌食生冷、辛辣、刺激及腐烂之物。本发明中药组合物可制备成任何一种临床上适宜的口服制剂，可以深加工成中药丸、冲剂或中药片等。
本发明中，所采用的各中草药原料药的药理作用如下：
金银花：具有清热解毒、凉散风热的功效；用于治疗痈肿疔疮、喉痹丹毒、热血毒痢，风热感冒、温病发热等症。
生地：味甘苦、性寒而入血分；具有清热凉血、养阴生津的功效；用于治疗身热口干、血热毒盛、热病伤阴、口渴多饮、肠燥便秘等症。
玄参：具有清热凉血、滋阴降火、解毒散结的功效。
黄连：大苦大寒，清热燥湿、泻火解毒之功强，为治疗中焦湿热郁结的主药，并善清心胃实火，兼清肝火，解毒能力强。
桑叶：具有疏散风热、清肺润燥、平抑肝阳、清肝明目、凉血止血的功效。
薄荷：具有疏散风热、清利头目、利咽透疹、疏肝行气的功效；可用于治疗疏风，散热，解毒，咽喉肿痛，口疮，牙痛，疮疥，瘾疹，风疹瘙痒，肝郁气滞。
黄柏：性苦，寒；归肾、膀胱经，具有清热燥湿、泻火除蒸、解毒痂疮的功效；临床用于湿热泻痢，黄疸，疮疡肿毒等疾病。
黄芪：性温，味甘；具有益卫固表、托毒生肌、利水退肿的功效；现代药理研究表明黄芪有敛疮生肌，收口之效，最适用。于口腔溃疡的治疗，黄芪可增强机体免疫功能，有促进伤口愈合的作用。
忍冬藤：甘，寒；清热解毒，疏风通络；用于温病发热，热毒血痢，痈肿疮疡，风湿热痹，关节红肿热痛。
地骨皮：具有凉血除蒸、清肺降火的功效。
葛根：具有发表解肌、升阳透疹、解热生津的功效。
穿心莲：具有清热解毒、凉血、消肿、燥湿的功效；可用于感冒发热，咽喉肿痛，口舌生疮，泄泻痢疾，热淋涩痛，痈肿疮疡等症的治疗。
西洋参：凉性，归心，肺，胃，肾经；具有补气滋阴、清火生津、清肺止咳的功效。
连翘：具有清热解毒、散结消肿的功效；治温热，丹毒，斑疹，痈疡肿具有瘰疬，小便淋闭。
蒲公英：苦甘，寒；具有清热解毒、消痈散结、消炎、凉血、利尿、利胆的功效。
竹叶：味甘、淡。归心、胃、小肠经；具有清热除烦、利尿的功效；用于热病心烦、口渴，口舌生疮，小便赤涩的功效。
椿树皮：味苦、涩、寒；具有清热燥湿、涩肠止泻、止血止带的功效；用于湿热下注，便血痔血，崩漏，疥癣湿疮。
肉桂：补元阳、暖脾胃、除积冷、通血脉；治命门火衰，肢冷脉微，亡阳虚脱，腹痛泄泻，寒疝奔豚，腰膝冷痛，经闭癥瘕，阴疽，流注，及虚阳浮越，上热下寒。
山药：甘，平。归脾、肺、肾经；具有补脾养胃、生津益肺、补肾涩精的功效；用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。
甘草：具有补脾益气、清热解毒、祛痰止咳、缓急止痛、调和诸药的功效；用于脾胃虚弱，心悸气短，四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
本发明的有益效果是：本发明提供的中药组合物具有补脾益气、清热解毒、消痈散结、益气生津、消炎等功效，且生物利用度高、具有无毒副作用、不易复发，对于治疗口腔溃疡疗效确切。
具体实施方式
本发明提供一种治疗口腔溃疡的中药组合物，由以下重量份数的原料制成：金银花10-15份，生地9-14份，玄参5-10份，黄连6-11份，桑叶4-9份，薄荷10-15份，黄柏7-12份，黄芪5-10，忍冬藤7-12份，地骨皮5-10份，葛根10-15份，穿心莲6-11份，西洋参5-10份，连翘5-10份，蒲公英 10-15份，竹叶5-10份，椿树皮 6-11份，肉桂10-15份，山药5-10份，甘草15-20份。以下通过实施例对本发明作进一步详述。
实施例1，上述中药组合物由以下重量份数的原料制成：金银花10份，生地14份，玄参5份，黄连11份，桑叶4份，薄荷15份，黄柏7份，黄芪10份，忍冬藤7份，地骨皮10份，葛根10份，穿心莲11份，西洋参5份，连翘10份，蒲公英 10份，竹叶10份，椿树皮6份，肉桂15份，山药5份，甘草20份。
上述中药组合物的制备方法：将上述中草药组合物的所有原料按配比放入煎药器具内，加入中草药原料总质量的6-10倍的水浸泡1h，然后进行煎煮，先武火煎煮，待药液沸腾后，改用文火煎煮1.5-2h停止，滤去药渣，取药汁，减压浓缩至相对密度为1.20-1.25(60℃测)，离心，取离心液，按照常规制剂方法，加入常规的辅料制成临床医学上可接受的剂型。
用法与用量：所述内服中药每日一剂，每剂可服用两次，早晚饭后服用，7天为一疗程。服药期间忌食生冷、辛辣、刺激及腐烂之物。
实施例2，上述中药组合物由以下重量份数的原料制成：金银花15份，生地9份，玄参10份，黄连6份，桑叶9份，薄荷10份，黄柏12份，黄芪5份，忍冬藤12份，地骨皮5份，葛根15份，穿心莲6份，西洋参10份，连翘5份，蒲公英 15份，竹叶5份，椿树皮 11份，肉桂10份，山药10份，甘草15份。
制备方法、用法与用量同实施例1。
实施例3，上述中药组合物由以下重量份数的原料制成：金银花13份，生地12份，玄参7份，黄连8份，桑叶6份，薄荷13份，黄柏9份，黄芪7份，忍冬藤9份，地骨皮7份，葛根12份，穿心莲8份，西洋参7份，连翘7份，蒲公英 12份，竹叶8份，椿树皮 9份，肉桂13份，山药8份，甘草17份。
制备方法、用法与用量同实施例1。
以下通过临床疗效观察试验例统计结果来进一步阐述本发明所述一种治疗痛经的中药组合物。
疗效标准：
显效：1 个疗程后口腔溃疡周围无粘膜充血或红晕状，溃疡创面消失，伴有的疼痛及伴有头痛、发热、局部淋巴结肿大等症状消失；4个月以上无复发。
有效：1 个疗程后口腔溃疡大小、数目减少，周围有红晕，感疼痛明显减轻；连续不断或每月多次延至3个月以上复发一次，且复发后症状明显减轻，自愈时间缩短为3-5天；
无效：1个 疗程后口腔溃疡周围粘膜充血或红晕状，溃疡创面没有变化，伴有的疼痛及伴有头痛、发热、局部淋巴结肿大等症状；连续不断或每月多次延至1个月以上复发一次。
各实施例选取符合上述标准的50例。选取市面上治疗口腔溃疡的西瓜霜粉剂作为对照组，病例为50例，7天后试验结果如下表1：
表1
本发明经过临床试验数据统计得出，总体效率达到93.33％，与对照组对比具有显著的疗效，可见本发明药物能够安全有效地治疗口腔溃疡。
下面结合典型病例对本发明做进一步说明。
典型病例1, 陈某，女，38 岁，口腔粘膜，出现10余个直径 5mm 的溃疡，灼热疼痛，口腔粘膜溃疡较表浅，圆形，口不渴，伴畏寒，便溏。舌淡，苔薄白，脉细弱，诊断为气血亏虚；按实施例1制备该中药组合物，每日服用一剂，早晚饭后各一次，服药期间忌食生冷、辛辣、刺激及腐烂之物，7天后口腔溃疡愈合，局部无不适感。继续服用本发明中药组合物2个疗程后，半年未见复发。
典型病例2，李某，女，22 岁，口腔内表面覆有一层淡黄色假膜，溃疡周围黏膜充血呈红晕状，伴局部淋巴结肿大、发热等症状；按实施例2制备该中药组合物，每日服用一剂，早晚饭后各一次，服用本发明中药组合物两剂后，效果明显，溃疡疼痛减轻，继续服用四剂后，治愈。继续服用本发明中药组合物1个疗程后，四个月未见复发。
典型病例3，重型口腔溃疡患者，每个月发作1-2次。口腔舌尖、齿颊、齿眼及下唇内缘均有绿豆大小圆形溃疡，呈淡黄色，表面凹陷，边缘微凸。按实施例2制备该中药组合物，每日服用一剂，早晚饭后各一次，服用本发明中药组合物三剂后，症状明显缓解，继续服用五剂后，治愈。继续服用本发明中药组合物3个疗程后，半年未见复发。
以上实施例仅为进一步说明本发明，并非对发明做出的任何限制，凡在本发明实质上内容做出的简单修改和改进均仍属于本发明技术方案的保护范围之内。
Claims (5)
1.一种治疗口腔溃疡的中药组合物，其特征在于：由以下重量份数的原料制成：金银花10-15份，生地9-14份，玄参5-10份，黄连6-11份，桑叶4-9份，薄荷10-15份，黄柏7-12份，黄芪5-10份，忍冬藤7-12份，地骨皮5-10份，葛根10-15份，穿心莲6-11份，西洋参5-10份，连翘5-10份，蒲公英 10-15份，竹叶5-10份，椿树皮 6-11份，肉桂10-15份，山药5-10份，甘草15-20份。
2.根据权利要求1所述的中药组合物，其特征在于：由以下重量份数的原料制成：金银花10份，生地14份，玄参5份，黄连11份，桑叶4份，薄荷15份，黄柏7份，黄芪10份，忍冬藤7份，地骨皮10份，葛根10份，穿心莲11份，西洋参5份，连翘10份，蒲公英 10份，竹叶10份，椿树皮6份，肉桂15份，山药5份，甘草20份。
3.根据权利要求1所述的中药组合物，其特征在于：由以下重量份数的原料制成：金银花15份，生地9份，玄参10份，黄连6份，桑叶9份，薄荷10份，黄柏12份，黄芪5份，忍冬藤12份，地骨皮5份，葛根15份，穿心莲6份，西洋参10份，连翘5份，蒲公英 15份，竹叶5份，椿树皮11份，肉桂10份，山药10份，甘草15份。
4. 根据权利要求1所述的中药组合物，其特征在于：由以下重量份数的原料制成：金银花13份，生地12份，玄参7份，黄连8份，桑叶6份，薄荷13份，黄柏9份，黄芪7份，忍冬藤9份，地骨皮7份，葛根12份，穿心莲8份，西洋参7份，连翘7份，蒲公英 12份，竹叶8份，椿树皮9份，肉桂13份，山药8份，甘草17份。
5.根据权利要求1-4中任一所述的一种缓解亚健康引起失眠多梦的中草药制剂的制备方法，其特征在于：将上述中草药组合物的所有原料按配比放入煎药器具内，加入中草药原料总质量的6-10倍的水浸泡1h，然后进行煎煮，先武火煎煮，待药液沸腾后，改用文火煎煮1.5-2h停止，滤去药渣，取药汁，减压浓缩至相对密度为1.20-1.25(60℃测)，离心，取离心液，按照常规制剂方法，加入常规的辅料制成临床医学上可接受的剂型。
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