CN106831792A - 一种PARP抑制剂Rucaparib中间体的制备方法 - Google Patents
一种PARP抑制剂Rucaparib中间体的制备方法 Download PDFInfo
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- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108752353A (zh) * | 2018-04-28 | 2018-11-06 | 程春晓 | 抗卵巢癌药物Rucaparib关键中间体1408282-26-7的制备方法 |
CN109180687A (zh) * | 2018-08-31 | 2019-01-11 | 山东轩德医药科技有限公司 | 一种瑞卡帕步中间体的制备方法 |
CN110229162A (zh) * | 2018-03-05 | 2019-09-13 | 新发药业有限公司 | 一种瑞卡帕布的简便制备方法 |
CN114516877A (zh) * | 2020-11-20 | 2022-05-20 | 烟台弘邦医药科技有限公司 | 一种瑞卡帕布中间体的制备方法 |
Citations (2)
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CN104513258A (zh) * | 2013-09-26 | 2015-04-15 | 广东东阳光药业有限公司 | 取代脲衍生物及其在药物中的应用 |
CN106008530A (zh) * | 2016-07-24 | 2016-10-12 | 石家庄久正生物科技有限公司 | 一种抗卵巢癌药物Rucaparib关键中间体的制备方法 |
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- 2017-01-25 CN CN201710055964.XA patent/CN106831792B/zh active Active
Patent Citations (2)
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CN104513258A (zh) * | 2013-09-26 | 2015-04-15 | 广东东阳光药业有限公司 | 取代脲衍生物及其在药物中的应用 |
CN106008530A (zh) * | 2016-07-24 | 2016-10-12 | 石家庄久正生物科技有限公司 | 一种抗卵巢癌药物Rucaparib关键中间体的制备方法 |
Non-Patent Citations (5)
Title |
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ADAM T.GILLMORE ET AL.: "Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 * |
ANDRE F.P.BIAJOLI ET AL.: "Recent Progress in the Use of Pd-Catalyzed C-C Cross-Coupling Reactions in the Synthesis of Pharmaceutical Compounds", 《J.BRAZ.CHEM.SOC.》 * |
HUI LI ET AL.: "Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity:design,synthesis and biological evaluation", 《BIOORGANIC & MEDICINAL CHEMISTRY》 * |
耿元硕等: "聚腺苷二磷酸核糖聚合酶抑制剂Rucaparib的合成研究", 《精细化工中间体》 * |
郑礼胜等: "聚腺苷二磷酸核糖聚合酶抑制剂rucaparib", 《现代药物与临床》 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110229162A (zh) * | 2018-03-05 | 2019-09-13 | 新发药业有限公司 | 一种瑞卡帕布的简便制备方法 |
CN110229162B (zh) * | 2018-03-05 | 2020-08-11 | 新发药业有限公司 | 一种瑞卡帕布的简便制备方法 |
CN108752353A (zh) * | 2018-04-28 | 2018-11-06 | 程春晓 | 抗卵巢癌药物Rucaparib关键中间体1408282-26-7的制备方法 |
CN108752353B (zh) * | 2018-04-28 | 2020-05-08 | 程春晓 | 抗卵巢癌药物Rucaparib关键中间体1408282‐26‐7的制备方法 |
CN109180687A (zh) * | 2018-08-31 | 2019-01-11 | 山东轩德医药科技有限公司 | 一种瑞卡帕步中间体的制备方法 |
CN114516877A (zh) * | 2020-11-20 | 2022-05-20 | 烟台弘邦医药科技有限公司 | 一种瑞卡帕布中间体的制备方法 |
CN114516877B (zh) * | 2020-11-20 | 2023-10-27 | 烟台弘邦医药科技有限公司 | 一种瑞卡帕布中间体的制备方法 |
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Inventor after: Li Mianli Inventor after: Dong Yan Inventor before: Chen Linghao |
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Effective date of registration: 20190103 Address after: 256603 Affiliated Hospital of Binzhou Medical College, 661 Second Yellow River Road, Binzhou City, Shandong Province Applicant after: Li Mianli Address before: 266520 1 residential 1708, Changjiang East Road, Huangdao District, Qingdao, Shandong, 1708 Applicant before: Chen Da bio tech ltd, Qingdao |
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Effective date of registration: 20201022 Address after: No.76 Minfeng South Road, Nanfeng Town, Zhangjiagang City, Suzhou City, Jiangsu Province Patentee after: ZHANGJIAGANG DONGDA INDUSTRIAL TECHNOLOGY Research Institute Address before: 256603 Affiliated Hospital of Binzhou Medical College, two road, Shandong, Binzhou, the Yellow River 661, China Patentee before: Li Mianli |
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