CN106661578B - 用于疼痛治疗的寡核苷酸诱饵 - Google Patents

用于疼痛治疗的寡核苷酸诱饵 Download PDF

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Publication number
CN106661578B
CN106661578B CN201580042835.6A CN201580042835A CN106661578B CN 106661578 B CN106661578 B CN 106661578B CN 201580042835 A CN201580042835 A CN 201580042835A CN 106661578 B CN106661578 B CN 106661578B
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China
Prior art keywords
oligonucleotide
pain
transcription factor
klf
binding
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Expired - Fee Related
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Chinese (zh)
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CN106661578A (zh
Inventor
J·马梅特
R·奥尔
D·曼宁
S·哈里斯
W·马丁
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Adynxx Inc
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Adynxx Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580042835.6A 2014-08-15 2015-08-14 用于疼痛治疗的寡核苷酸诱饵 Expired - Fee Related CN106661578B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462037996P 2014-08-15 2014-08-15
US62/037,996 2014-08-15
PCT/US2015/045268 WO2016025829A1 (en) 2014-08-15 2015-08-14 Oligonucleotide decoys for the treatment of pain

Publications (2)

Publication Number Publication Date
CN106661578A CN106661578A (zh) 2017-05-10
CN106661578B true CN106661578B (zh) 2020-08-04

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CN201580042835.6A Expired - Fee Related CN106661578B (zh) 2014-08-15 2015-08-14 用于疼痛治疗的寡核苷酸诱饵

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Country Link
US (2) US10287583B2 (https=)
EP (2) EP3626822A1 (https=)
JP (2) JP6705807B2 (https=)
CN (1) CN106661578B (https=)
AU (1) AU2015301491A1 (https=)
BR (1) BR112017002629A2 (https=)
CA (1) CA2957250A1 (https=)
ES (1) ES2750689T3 (https=)
PT (1) PT3180434T (https=)
RU (1) RU2017108238A (https=)
WO (1) WO2016025829A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2723672C (en) 2007-05-11 2019-09-03 Adynxx, Inc. Gene expression and pain
EP3511022A1 (en) 2012-05-10 2019-07-17 Adynxx, Inc. Formulations for the delivery of active ingredients
JP6705807B2 (ja) 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
FR3029450B1 (fr) * 2014-12-03 2017-11-03 Pole De Plasturgie De Lest Dispositif de moulage pour la fabrication de pieces en materiau composite a partir de resine polymere liquide par injection haute pression.
KR20210135482A (ko) * 2018-12-24 2021-11-15 더 리전츠 오브 더 유니버시티 오브 캘리포니아 키메라 디코이를 이용한 척추 질환의 치료
WO2022036140A2 (en) * 2020-08-13 2022-02-17 Nevada Research & Innovation Corporation Klf11 sirna for treatment of diabetes and obesity
US20250011787A1 (en) 2021-10-21 2025-01-09 The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads Retroelement-generated transcription factor decoys

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WO2013170086A2 (en) * 2012-05-10 2013-11-14 Adynxx, Inc. Formulations for the delivery of active ingredients
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Publication number Publication date
US10683502B2 (en) 2020-06-16
JP6705807B2 (ja) 2020-06-03
CN106661578A (zh) 2017-05-10
JP2020141688A (ja) 2020-09-10
EP3626822A1 (en) 2020-03-25
US20190276825A1 (en) 2019-09-12
US10287583B2 (en) 2019-05-14
US20170247694A1 (en) 2017-08-31
RU2017108238A3 (https=) 2019-09-18
BR112017002629A2 (pt) 2018-02-20
ES2750689T3 (es) 2020-03-26
EP3180434A4 (en) 2018-04-04
WO2016025829A1 (en) 2016-02-18
PT3180434T (pt) 2019-10-29
RU2017108238A (ru) 2018-09-17
JP2017529834A (ja) 2017-10-12
AU2015301491A1 (en) 2017-02-02
EP3180434A1 (en) 2017-06-21
EP3180434B1 (en) 2019-07-17
CA2957250A1 (en) 2016-02-18

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