RU2017108238A - Олигонуклеотиды-приманки для лечения боли - Google Patents
Олигонуклеотиды-приманки для лечения боли Download PDFInfo
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- RU2017108238A RU2017108238A RU2017108238A RU2017108238A RU2017108238A RU 2017108238 A RU2017108238 A RU 2017108238A RU 2017108238 A RU2017108238 A RU 2017108238A RU 2017108238 A RU2017108238 A RU 2017108238A RU 2017108238 A RU2017108238 A RU 2017108238A
- Authority
- RU
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- Prior art keywords
- bait
- transcription factor
- oligonucleotide
- seq
- factor binding
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title claims 27
- 208000002193 Pain Diseases 0.000 title claims 9
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 108091023040 Transcription factor Proteins 0.000 claims 24
- 102000040945 Transcription factor Human genes 0.000 claims 24
- 238000000034 method Methods 0.000 claims 14
- 101001139112 Homo sapiens Krueppel-like factor 9 Proteins 0.000 claims 12
- 102100020684 Krueppel-like factor 9 Human genes 0.000 claims 12
- 101001046599 Homo sapiens Krueppel-like factor 15 Proteins 0.000 claims 8
- 101001139126 Homo sapiens Krueppel-like factor 6 Proteins 0.000 claims 8
- 102100022328 Krueppel-like factor 15 Human genes 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 8
- 238000002965 ELISA Methods 0.000 claims 5
- 102100020679 Krueppel-like factor 6 Human genes 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 101001046587 Homo sapiens Krueppel-like factor 1 Proteins 0.000 claims 3
- 101001006892 Homo sapiens Krueppel-like factor 10 Proteins 0.000 claims 3
- 101001006895 Homo sapiens Krueppel-like factor 11 Proteins 0.000 claims 3
- 101001006886 Homo sapiens Krueppel-like factor 12 Proteins 0.000 claims 3
- 101001046564 Homo sapiens Krueppel-like factor 13 Proteins 0.000 claims 3
- 101001046596 Homo sapiens Krueppel-like factor 14 Proteins 0.000 claims 3
- 101001046593 Homo sapiens Krueppel-like factor 16 Proteins 0.000 claims 3
- 101001046589 Homo sapiens Krueppel-like factor 17 Proteins 0.000 claims 3
- 101001139146 Homo sapiens Krueppel-like factor 2 Proteins 0.000 claims 3
- 101001139136 Homo sapiens Krueppel-like factor 3 Proteins 0.000 claims 3
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 claims 3
- 101001139130 Homo sapiens Krueppel-like factor 5 Proteins 0.000 claims 3
- 101001139115 Homo sapiens Krueppel-like factor 8 Proteins 0.000 claims 3
- 101000868883 Homo sapiens Transcription factor Sp6 Proteins 0.000 claims 3
- 102100022248 Krueppel-like factor 1 Human genes 0.000 claims 3
- 102100027798 Krueppel-like factor 10 Human genes 0.000 claims 3
- 102100027797 Krueppel-like factor 11 Human genes 0.000 claims 3
- 102100027792 Krueppel-like factor 12 Human genes 0.000 claims 3
- 102100022254 Krueppel-like factor 13 Human genes 0.000 claims 3
- 102100022329 Krueppel-like factor 14 Human genes 0.000 claims 3
- 102100022324 Krueppel-like factor 16 Human genes 0.000 claims 3
- 102100022249 Krueppel-like factor 17 Human genes 0.000 claims 3
- 102100020675 Krueppel-like factor 2 Human genes 0.000 claims 3
- 102100020678 Krueppel-like factor 3 Human genes 0.000 claims 3
- 102100020677 Krueppel-like factor 4 Human genes 0.000 claims 3
- 102100020680 Krueppel-like factor 5 Human genes 0.000 claims 3
- 102100020691 Krueppel-like factor 8 Human genes 0.000 claims 3
- 230000008055 nociceptive signaling Effects 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 238000012286 ELISA Assay Methods 0.000 claims 1
- 101001139117 Homo sapiens Krueppel-like factor 7 Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102100020692 Krueppel-like factor 7 Human genes 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000012289 standard assay Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 210000001835 viscera Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462037996P | 2014-08-15 | 2014-08-15 | |
| US62/037,996 | 2014-08-15 | ||
| PCT/US2015/045268 WO2016025829A1 (en) | 2014-08-15 | 2015-08-14 | Oligonucleotide decoys for the treatment of pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2017108238A true RU2017108238A (ru) | 2018-09-17 |
| RU2017108238A3 RU2017108238A3 (https=) | 2019-09-18 |
Family
ID=55304669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017108238A RU2017108238A (ru) | 2014-08-15 | 2015-08-14 | Олигонуклеотиды-приманки для лечения боли |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10287583B2 (https=) |
| EP (2) | EP3626822A1 (https=) |
| JP (2) | JP6705807B2 (https=) |
| CN (1) | CN106661578B (https=) |
| AU (1) | AU2015301491A1 (https=) |
| BR (1) | BR112017002629A2 (https=) |
| CA (1) | CA2957250A1 (https=) |
| ES (1) | ES2750689T3 (https=) |
| PT (1) | PT3180434T (https=) |
| RU (1) | RU2017108238A (https=) |
| WO (1) | WO2016025829A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2723672C (en) | 2007-05-11 | 2019-09-03 | Adynxx, Inc. | Gene expression and pain |
| EP3511022A1 (en) | 2012-05-10 | 2019-07-17 | Adynxx, Inc. | Formulations for the delivery of active ingredients |
| JP6705807B2 (ja) | 2014-08-15 | 2020-06-03 | エーダイニクス インコーポレイテッド | 疼痛を治療するためのオリゴヌクレオチドデコイ |
| FR3029450B1 (fr) * | 2014-12-03 | 2017-11-03 | Pole De Plasturgie De Lest | Dispositif de moulage pour la fabrication de pieces en materiau composite a partir de resine polymere liquide par injection haute pression. |
| KR20210135482A (ko) * | 2018-12-24 | 2021-11-15 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 키메라 디코이를 이용한 척추 질환의 치료 |
| WO2022036140A2 (en) * | 2020-08-13 | 2022-02-17 | Nevada Research & Innovation Corporation | Klf11 sirna for treatment of diabetes and obesity |
| US20250011787A1 (en) | 2021-10-21 | 2025-01-09 | The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glads | Retroelement-generated transcription factor decoys |
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| US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
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| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| KR100225087B1 (ko) | 1990-03-23 | 1999-10-15 | 한스 발터라벤 | 피타아제의 식물내 발현 |
| US5272056A (en) | 1991-01-03 | 1993-12-21 | The Research Foundation Of State University Of New York | Modification of DNA and oligonucleotides using metal complexes of polyaza ligands |
| US5683985A (en) | 1991-04-18 | 1997-11-04 | The Salk Institute For Biological Studies | Oligonucleotide decoys and methods relating thereto |
| FR2675803B1 (fr) | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
| WO1993001286A2 (en) | 1991-06-28 | 1993-01-21 | Massachusetts Institute Of Technology | Localized oligonucleotide therapy |
| WO1995004064A1 (en) | 1993-07-29 | 1995-02-09 | The Regents Of The University Of California | Polynucleotide decoys that ihnibit mhc-ii expression and uses thereof |
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-
2015
- 2015-08-14 JP JP2017508487A patent/JP6705807B2/ja not_active Expired - Fee Related
- 2015-08-14 BR BR112017002629-5A patent/BR112017002629A2/pt not_active Application Discontinuation
- 2015-08-14 AU AU2015301491A patent/AU2015301491A1/en not_active Abandoned
- 2015-08-14 US US15/504,191 patent/US10287583B2/en not_active Expired - Fee Related
- 2015-08-14 PT PT158320838T patent/PT3180434T/pt unknown
- 2015-08-14 EP EP19186119.4A patent/EP3626822A1/en not_active Withdrawn
- 2015-08-14 ES ES15832083T patent/ES2750689T3/es active Active
- 2015-08-14 WO PCT/US2015/045268 patent/WO2016025829A1/en not_active Ceased
- 2015-08-14 RU RU2017108238A patent/RU2017108238A/ru not_active Application Discontinuation
- 2015-08-14 CN CN201580042835.6A patent/CN106661578B/zh not_active Expired - Fee Related
- 2015-08-14 EP EP15832083.8A patent/EP3180434B1/en not_active Not-in-force
- 2015-08-14 CA CA2957250A patent/CA2957250A1/en not_active Abandoned
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2019
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2020
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|---|---|
| US10683502B2 (en) | 2020-06-16 |
| JP6705807B2 (ja) | 2020-06-03 |
| CN106661578A (zh) | 2017-05-10 |
| JP2020141688A (ja) | 2020-09-10 |
| EP3626822A1 (en) | 2020-03-25 |
| CN106661578B (zh) | 2020-08-04 |
| US20190276825A1 (en) | 2019-09-12 |
| US10287583B2 (en) | 2019-05-14 |
| US20170247694A1 (en) | 2017-08-31 |
| RU2017108238A3 (https=) | 2019-09-18 |
| BR112017002629A2 (pt) | 2018-02-20 |
| ES2750689T3 (es) | 2020-03-26 |
| EP3180434A4 (en) | 2018-04-04 |
| WO2016025829A1 (en) | 2016-02-18 |
| PT3180434T (pt) | 2019-10-29 |
| JP2017529834A (ja) | 2017-10-12 |
| AU2015301491A1 (en) | 2017-02-02 |
| EP3180434A1 (en) | 2017-06-21 |
| EP3180434B1 (en) | 2019-07-17 |
| CA2957250A1 (en) | 2016-02-18 |
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