CN106659683A

CN106659683A - 包封修饰的环糊精复合物的脂质体组合物及其应用

包封修饰的环糊精复合物的脂质体组合物及其应用 Download PDF

Info

Publication number: CN106659683A
Authority: CN; China
Prior art keywords: cyclodextrin; liposome; liposomes; therapeutic agent; liposome composition
Prior art date: 2014-01-14
Legal status : Pending

Application number

CN201580013845.7A

Other languages

English (en)

Chinese (zh)

Inventor

B.沃格斯泰恩

K.W.金兹勒

S.周

S.苏

Current Assignee

Johns Hopkins University

Original Assignee

Johns Hopkins University

Priority date

2014-01-14

Filing date

2015-01-14

Publication date

2017-05-10

2015-01-14 Application filed by Johns Hopkins University filed Critical Johns Hopkins University

2017-05-10 Publication of CN106659683A publication Critical patent/CN106659683A/zh

Status Pending legal-status Critical Current

Links

239000002502 liposome Substances 0.000 title claims abstract description 316
239000000203 mixture Substances 0.000 title claims abstract description 127
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title claims description 91
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125000000524 functional group Chemical group 0.000 claims abstract description 18
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WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 22
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