CN106588804A - 一种作为类法尼醇 x 受体(fxr)的化合物的制备方法 - Google Patents
一种作为类法尼醇 x 受体(fxr)的化合物的制备方法 Download PDFInfo
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- CN106588804A CN106588804A CN201611131748.0A CN201611131748A CN106588804A CN 106588804 A CN106588804 A CN 106588804A CN 201611131748 A CN201611131748 A CN 201611131748A CN 106588804 A CN106588804 A CN 106588804A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10220027B2 (en) | 2011-07-13 | 2019-03-05 | Gilead Sciences, Inc. | FXR (NR1H4) binding and activity modulating compounds |
US10329286B2 (en) | 2016-06-13 | 2019-06-25 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US10421730B2 (en) | 2016-06-13 | 2019-09-24 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US10450306B2 (en) | 2016-10-04 | 2019-10-22 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as FXR agonists and methods of use thereof |
US10597391B2 (en) | 2016-10-26 | 2020-03-24 | Enanta Pharmaceuticals, Inc. | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof |
US10689391B2 (en) | 2017-12-12 | 2020-06-23 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as FXR agonists and methods of use thereof |
US10829486B2 (en) | 2018-02-14 | 2020-11-10 | Enanta Pharmacueticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
CN112083113A (zh) * | 2020-07-09 | 2020-12-15 | 苏州旭辉检测有限公司 | 一种螺环化合物的生物样品分析方法 |
US11225473B2 (en) | 2019-01-15 | 2022-01-18 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US11524005B2 (en) | 2019-02-19 | 2022-12-13 | Gilead Sciences, Inc. | Solid forms of FXR agonists |
US11555032B2 (en) | 2019-05-13 | 2023-01-17 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
US11833150B2 (en) | 2017-03-28 | 2023-12-05 | Gilead Sciences, Inc. | Methods of treating liver disease |
US11958879B2 (en) | 2015-03-31 | 2024-04-16 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011020615A1 (en) * | 2009-08-19 | 2011-02-24 | Phenex Pharmaceuticals Ag | Novel fxr (nr1h4 ) binding and activity modulating compounds |
WO2013007387A1 (en) * | 2011-07-13 | 2013-01-17 | Phenex Pharmaceuticals Ag | Novel fxr (nr1h4) binding and activity modulating compounds |
WO2016096116A1 (en) * | 2014-12-17 | 2016-06-23 | Gilead Sciences, Inc. | Novel fxr (nr1h4) modulating compounds |
-
2016
- 2016-12-09 CN CN201611131748.0A patent/CN106588804B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011020615A1 (en) * | 2009-08-19 | 2011-02-24 | Phenex Pharmaceuticals Ag | Novel fxr (nr1h4 ) binding and activity modulating compounds |
WO2013007387A1 (en) * | 2011-07-13 | 2013-01-17 | Phenex Pharmaceuticals Ag | Novel fxr (nr1h4) binding and activity modulating compounds |
WO2016096116A1 (en) * | 2014-12-17 | 2016-06-23 | Gilead Sciences, Inc. | Novel fxr (nr1h4) modulating compounds |
Non-Patent Citations (1)
Title |
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CHONGMIN ZHONG 等: "Enantioselective Synthesis of trans-Aryl- and -Heteroaryl-Substituted Cyclopropylboronates by Copper(I)-Catalyzed Reactions of Allylic Phosphates with a Diboron Derivative", 《J. AM. CHEM. SOC.》 * |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10485795B2 (en) | 2011-07-13 | 2019-11-26 | Gilead Sciences, Inc. | FXR (NR1H4) binding and activity modulating compounds |
US10220027B2 (en) | 2011-07-13 | 2019-03-05 | Gilead Sciences, Inc. | FXR (NR1H4) binding and activity modulating compounds |
US11958879B2 (en) | 2015-03-31 | 2024-04-16 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
US10329286B2 (en) | 2016-06-13 | 2019-06-25 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US10421730B2 (en) | 2016-06-13 | 2019-09-24 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US10774054B2 (en) | 2016-06-13 | 2020-09-15 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US11739065B2 (en) | 2016-06-13 | 2023-08-29 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US11247986B2 (en) | 2016-06-13 | 2022-02-15 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US10981881B2 (en) | 2016-06-13 | 2021-04-20 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US11034684B2 (en) | 2016-10-04 | 2021-06-15 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as FXR agonists and methods of use thereof |
US10450306B2 (en) | 2016-10-04 | 2019-10-22 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as FXR agonists and methods of use thereof |
US10597391B2 (en) | 2016-10-26 | 2020-03-24 | Enanta Pharmaceuticals, Inc. | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof |
US11833150B2 (en) | 2017-03-28 | 2023-12-05 | Gilead Sciences, Inc. | Methods of treating liver disease |
US10689391B2 (en) | 2017-12-12 | 2020-06-23 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as FXR agonists and methods of use thereof |
US10829486B2 (en) | 2018-02-14 | 2020-11-10 | Enanta Pharmacueticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
US11225473B2 (en) | 2019-01-15 | 2022-01-18 | Gilead Sciences, Inc. | FXR (NR1H4) modulating compounds |
US11524005B2 (en) | 2019-02-19 | 2022-12-13 | Gilead Sciences, Inc. | Solid forms of FXR agonists |
US11555032B2 (en) | 2019-05-13 | 2023-01-17 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
CN112083113B (zh) * | 2020-07-09 | 2021-06-15 | 苏州旭辉检测有限公司 | 一种螺环化合物的生物样品分析方法 |
CN112083113A (zh) * | 2020-07-09 | 2020-12-15 | 苏州旭辉检测有限公司 | 一种螺环化合物的生物样品分析方法 |
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Denomination of invention: Preparation method of compound serving as farnesoid X receptor (FXR) Effective date of registration: 20190711 Granted publication date: 20181109 Pledgee: Pudong Shanghai technology financing Company limited by guarantee Pledgor: All create (Shanghai) Pharmaceutical Technology Co., Ltd Registration number: 2019310000039 |
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Date of cancellation: 20200728 Granted publication date: 20181109 Pledgee: Pudong Shanghai technology financing Company limited by guarantee Pledgor: DUCHUANG (SHANGHAI) MEDICINE TECHNOLOGY Co.,Ltd. Registration number: 2019310000039 |
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Address after: 201318 room 402-a, building 1, 1199 landi Road, Zhoupu Town, Pudong New Area, Shanghai Patentee after: Du Chuang (Shanghai) Medical Technology Co.,Ltd. Address before: 201318 room 402-a, building 1, 1199 landi Road, Zhoupu Town, Pudong New Area, Shanghai Patentee before: DUCHUANG (SHANGHAI) MEDICINE TECHNOLOGY Co.,Ltd. |
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