CN106511782A - 茯苓天麻含片 - Google Patents
茯苓天麻含片 Download PDFInfo
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Abstract
茯苓天麻含片，包括以下质量份的原料：茯苓：100~160份、莲心：50~60份、天麻：30~40份、灵芝：15~30份、薄荷：50~75份、乳糖：8~15份、精炼蜂蜜：10~20份，其制备时，先将薄荷进行薄荷油提取，并融入无水乙醇中，同时将灵芝和天麻进行超微粉碎，并通过50%乙醇进行回流提取并浓缩成浸膏；而薄荷渣与茯苓、莲心合并并进行两次煎煮，分别进行固液分离后合并两次的煎液，过滤浓缩成清膏，合并清膏与浸膏，一并加入乳糖以及精炼蜂蜜后调整含水量，经过造粒机造粒后干燥、整形、压片即得成品含片。本发明具有强身、健脑、增智、抗疲劳、抗衰老及增强机体免疫的功效。
Description
技术领域
本发明涉及口服中药制剂领域，具体涉及一种健脑、抗晕、宁神的茯苓天麻含片。
背景技术
茯苓，别名云苓、茯灵、松茯苓、松薯等，是寄生在松树根部的多孔菌科植物，是一种珍贵的药食两用菌，自古以来就是药食同源的保健食品，一直受到人们的关注，富含茯苓多糖等多种功效成分，具有健脾胃、利水消肿、降血脂、调节机体免疫、抗衰老、抗肿瘤、抗突变等功能；古人称茯苓为“四时神药”，因为它功效非常广泛，不分四季，将它与各种药物配伍，不管寒、温、风、湿诸疾，都能发挥其独特功效。
灵芝又称林中灵、琼珍，是多孔菌科真菌灵芝的子实体，自古以来都被认为一种珍贵的药食两用菌。其主含氨基酸、多肽、蛋白质、真菌溶菌酶，以及糖类（还原糖和多糖）、麦角甾醇、三萜类、香豆精甙、挥发油、硬脂酸、苯甲酸、生物碱、维生素B2及C等；孢子还含甘露醇、海藻糖，具有补气安神、止咳平喘、延年益寿的功效。经过大量临床研究，灵芝对神经衰弱、高脂血症、冠心病心绞痛、心律失常、克山病、高原不适症、肝炎、出血热、消化不良、气管炎等各有不同程度的疗效。
天麻为兰科多年生食菌草本植物，其块茎入药，主要成份包括天麻素以及各种维生素矿物质和氨基酸等。对神经衰弱、偏头痛、血管性头痛、神经性头痛、眩晕、老年痴呆、高血压、口眼歪斜、肢体麻木、小儿惊厥、癫痫、脑外伤综合症和抑郁性神经症等有显著疗效，同时，天麻还可增强神经的分辨力，保持神经的健康。
目前，对于上述组分的药物的应用主要是以简单的散剂为主，需要经过人体机体的消化后方能被吸收，使得其这些制剂生物利用率相对较低，使用不方便，起效慢，而若采用传统水提法制备口服液制剂，其提取率仅为25%~32%，根本达不到工业生产的需要，造成了物料的严重浪费。
发明内容
本发明所解决的技术问题在于提供一种茯苓天麻含片，以解决上述技术背景中的缺陷。
本发明所解决的技术问题采用以下技术方案来实现：
茯苓天麻含片，包括以下质量份的原料：
茯苓：100~160份、莲心：50~60份、天麻：30~40份、灵芝：15~30份、薄荷：10~15份、乳糖：8~15份、精炼蜂蜜：10~20份。
其优选质量份为：茯苓：120份、莲心：58份、天麻：36份、灵芝：24份、薄荷：68份、乳糖：12份、精炼蜂蜜：15份。
其具体制备方法如下：
1）按上述质量份取薄荷提取薄荷油，将提取的薄荷油按每100g薄荷5~8ml的比例溶于无水乙醇中，同时将天麻炮制、烘干，然后取炮制好的天麻与灵芝一同通过胶体磨进行超微粉碎，过200~300目筛，再加50%乙醇，然后合并两组乙醇并进行回流提取，提取回收乙醇并浓缩成浸膏。
2）将提取过薄荷油的薄荷渣与茯苓、莲心合并，按每500g药物总质量加入5000~6000ml的比例加水，然后大火煮沸后转小火煎煮2~3h，进行固液分离，然后再加入2000~3000ml水，大火煮沸后转小火煎煮1~2h，进行固液分离后合并两次的煎液，过滤，滤液浓缩至密度为1.05～1.25的清膏。
3）将步骤1中制得的浸膏加入清膏中，同时加入乳糖以及精炼蜂蜜，并以精炼蜂蜜作赋形剂，将混合料含水量控制在10%以内，制成软材，将上述软材用颗粒摇摆机过筛制成湿颗粒；
4）将上述湿颗粒用恒温箱热风干燥，将含水量控制在3%以下，再将干燥后的颗粒再通过40目~60目颗粒摇摆机整粒，按每百份质量份料加0.3~0.5份的量加入硬脂酸镁进行拌合后干燥压片成型即得成品。
作为上述步骤的进一步改进：
所述薄荷油采用水蒸气蒸馏法提取。
所述步骤2）中煎液过滤时用180～200目滤布进行过滤。
所述步骤3）中进行颗粒摇摆机过筛制粒时，其颗粒粒径控制在2mm内。
所述步骤4）中进行干燥操作时，恒温箱温度控制在50℃~60℃之间，干燥时间控制为6~8小时。
有益效果：本发明茯苓天麻含片，通过在茯苓中添加天麻进行调和补充，配合灵芝中的多种有效物质可有效提高人体免疫力、具有强身、健脑、增智、抗疲劳、抗衰老及增强机体免疫的功效。
具体实施方式
为了使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施例，进一步阐述本发明。
实施例一：
在该实施例中包括以下组分的原料：
茯苓：100g、莲心：52g、天麻：34g、灵芝：18g、薄荷：66g、乳糖：10g、精炼蜂蜜：18g。
制备时，先按上述质量份取薄荷提取薄荷油，将提取的薄荷油溶与7ml的无水乙醇中，同时将天麻炮制、烘干，并与灵芝一同送入胶体磨中进行超微粉碎，并过200目筛，将过筛的灵芝与天麻加入50%的乙醇中，并将无水乙醇与50%的乙醇混合，并进行回流提取并将进行回收乙醇操作后的液体浓缩成浸膏。然后将提取过薄荷油的薄荷渣与茯苓、莲心合并，与2600ml水一并加入容器中加热，大火煮沸后转小火煎煮150min，进行固液分离后，液渣部分中再加入1300ml水，大火煮沸后转小火煎煮90min，进行固液分离后合并两次的煎液，用200目滤布进行过滤，然后浓缩至密度为1.25的清膏。
将清膏与浸膏合并，同时加入乳糖以及精炼蜂蜜搅拌均匀，调整混合料中含水量，并将其控制在8%，制成软材，将上述软材用颗粒摇摆机过筛制粒，大颗粒粒径≤2mm，制成湿颗粒后用恒温箱热风干燥，温度控制在58℃，时间6小时，干燥后，检测综合含水量为2.6%，再将干燥后的颗粒再通过60目颗粒摇摆机整粒，按每百份质量份料加0.4份的量加入硬脂酸镁进行拌合后干燥压片成型即得成品。
实施例二：
在该实施例中包括以下组分的原料：
茯苓：120g、莲心：58g、天麻：36g、灵芝：24g、薄荷：68g、乳糖：12g、精炼蜂蜜：15g。
制备时，先按上述质量份取薄荷提取薄荷油，将提取的薄荷油溶与7ml的无水乙醇中，同时将天麻炮制、烘干，并与灵芝一同送入胶体磨中进行超微粉碎，并过300目筛，将过筛的灵芝与天麻加入50%的乙醇中，并将无水乙醇与50%的乙醇混合，并进行回流提取并将进行回收乙醇操作后的液体浓缩成浸膏。然后将提取过薄荷油的薄荷渣与茯苓、莲心合并，与2700ml水一并加入容器中加热，大火煮沸后转小火煎煮170min，进行固液分离后，液渣部分中再加入1300ml水，大火煮沸后转小火煎煮100min，进行固液分离后合并两次的煎液，用200目滤布进行过滤，然后浓缩至密度为1.10的清膏。
将清膏与浸膏合并，同时加入乳糖以及精炼蜂蜜搅拌均匀，调整混合料中含水量，并将其控制在7%，制成软材，将上述软材用颗粒摇摆机过筛制粒，大颗粒粒径≤2mm，制成湿颗粒后用恒温箱热风干燥，温度控制在60℃，时间7小时，干燥后，检测综合含水量为2.5%，再将干燥后的颗粒再通过50目颗粒摇摆机整粒，按每百份质量份料加0.4份的量加入硬脂酸镁进行拌合后干燥压片成型即得成品。
以上显示和描述了本发明的基本原理、主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (7)
1.茯苓天麻含片，其特征在于，包括以下质量份的原料：茯苓：100~160份、莲心：50~60份、天麻：30~40份、灵芝：15~30份、薄荷：50~75份、乳糖：8~15份、精炼蜂蜜：10~20份。
2.根据权利要求1所述的茯苓天麻含片，其特征在于，包括以下质量份的原料：茯苓：120份、莲心：58份、天麻：36份、灵芝：24份、薄荷：68份、乳糖：12份、精炼蜂蜜：15份。
3.一种茯苓天麻含片的制备方法，其特征在于，采用权利要求1或2中所述的各组分的原料制备茯苓天麻含片，其具体制备方法如下：
1）按上述质量份取薄荷提取薄荷油，将提取的薄荷油按每100g薄荷5~8ml的比例溶于无水乙醇中，同时将天麻炮制、烘干，然后取炮制好的天麻与灵芝一同通过胶体磨进行超微粉碎，过200~300目筛，再加50%乙醇，然后合并两组乙醇并进行回流提取，提取回收乙醇并浓缩成浸膏；
2）将提取过薄荷油的薄荷渣与茯苓、莲心合并，按每500g药物总质量加入5000~6000ml的比例加水，然后大火煮沸后转小火煎煮2~3h，进行固液分离，然后再加入2000~3000ml水，大火煮沸后转小火煎煮1~2h，进行固液分离后合并两次的煎液，过滤，滤液浓缩至密度为1.05～1.25的清膏；
3）将步骤1中制得的浸膏加入清膏中，同时加入乳糖以及精炼蜂蜜，并以精炼蜂蜜作赋形剂，将混合料含水量控制在10%以内，制成软材，将上述软材用颗粒摇摆机过筛制成湿颗粒；
4）将上述湿颗粒用恒温箱热风干燥，将含水量控制在3%以下，再将干燥后的颗粒再通过40目~60目颗粒摇摆机整粒，按每百份质量份料加0.3~0.5份的量加入硬脂酸镁进行拌合后干燥压片成型即得成品。
4.根据权利要求3所述的制备方法，其特征在于，所述步骤1）中的薄荷油采用水蒸气蒸馏法提取。
5.根据权利要求3所述的制备方法，其特征在于，所述步骤2）中煎液过滤时用180～200目滤布进行过滤。
6.根据权利要求3所述的制备方法，其特征在于，所述步骤3）中进行颗粒摇摆机过筛制粒时，其颗粒粒径控制在2mm内。
7.根据权利要求3所述的制备方法，其特征在于，所述步骤4）中进行干燥操作时，恒温箱温度控制在50℃~60℃之间，干燥时间控制为6~8小时。
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| CN113546135A (zh) * | 2021-08-09 | 2021-10-26 | 生命之花(北京)健康管理有限公司 | 一种提神醒脑组合物及其制备方法 |
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