CN106491846A - Herbal mixture shield lung cream and preparation method thereof - Google Patents

Herbal mixture shield lung cream and preparation method thereof Download PDF

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CN106491846A
CN106491846A CN201610988632.2A CN201610988632A CN106491846A CN 106491846 A CN106491846 A CN 106491846A CN 201610988632 A CN201610988632 A CN 201610988632A CN 106491846 A CN106491846 A CN 106491846A
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radix
lung
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borneolum syntheticum
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楼晶
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Dai Yuanzheng
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Dai Yuanzheng
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Abstract

The present invention relates to Chinese medicine formula, and in particular to a kind of herbal mixture protects lung cream, for pulmonary nursing care and treatment lung conditions, such as asthma, cough etc..Herbal mixture shield lung cream (bag) of the present invention is made up of 15 parts of Folium Perillae, few 10 parts of Foeniculi, 10 parts of Radix orixae japonicae, 10 parts of Cortex Cinnamomi, 10 parts of Pericarpium Zanthoxyli, 5 parts of Herba Asari, 10 parts of Folium Artemisiae Argyi, 20 parts of Radix Et Rhizoma Nardostachyos, 1 part of Borneolum Syntheticum.It is belonging to the traditional daoyin technique principle of the traditional Chinese medical science, with reference to the rule of " inner disease outer treat ", make by the pharmaceutical properties in ointment (medicated bag), rely body temperature Spontaneous release, Chinese medicine active ingredient is made slowly to suck in vivo by relevant acupuncture point and skin pore, to reach the purpose for the treatment of.

Description

Herbal mixture shield lung cream and preparation method thereof
Technical field
The present invention relates to Chinese medicine formula, and in particular to a kind of herbal mixture protects lung cream, for pulmonary nursing care and treatment pulmonary Disease, such as asthma, cough etc..
Background technology
Asthma, ancient title dyspnea, sees《Plain Questions arteries and veins will be dispelled micro- opinion》, also known as panting, see《Opinion really hidden by beautiful machine》.Asthma is A kind of disease being characterized with rapid breathing, its morbidity are mainly related to lung, kidney.Because of the lung being the dominator of QI, the kidney being the root of QI.By The heap soil or fertilizer over and around the roots such as wind, cold, expectorant, drink, pathogenic fire is hindered in lung, and it is how true that gas loses a surname drop person;By ferritic weakness or disease vigour consume long, lung qi mistake is caused Main, failure of the kidney in receiving QI person belongs to empty more.Excess-dyspnea is controlled based on the evil removing that gets rid of illness, is controlled based on dyspnea due to deficiency taken the photograph with reinforcing and receive.Also pathogenic factor does not remove, Vigour is damaged, symptoms include simulataneous insufficiency and excessive person, when righting and eliminating evil and.Chinese traditional treatment asthma, in addition to oral medicine, also can select acupuncture, Medicine acupuncture point electrophore, or plastering therapy etc..Controlling the conventional lead method that breathes heavily is:One method is " to pinch six with handss in si 15 14 degree, also wipe such as it;Again with two handss wipe breast under several times, after chafe and two shoulders, centering pharynx Tianjin sending down the abnormal ascending QI, breathed heavily with lying prostrate which ".Two methods are " with the tight FEIYU acupoint of hand sticker, push up and press, to three or five ten times, vertebra work heat heals ".
Content of the invention
Herbal mixture shield lung cream (bag) of the present invention is belonging to the traditional daoyin technique principle of the traditional Chinese medical science, with reference to the method for " inner disease outer treat " Then, make by the pharmaceutical properties in ointment (medicated bag), rely body temperature Spontaneous release, make Chinese medicine active ingredient pass through relevant acupuncture point Slowly suck in vivo with skin pore, to reach the purpose for the treatment of.Without any damage and pair effect, it is simple and easy to do, safety And effective outer treating method.
The above-mentioned technical problem of the present invention is carried out by the following technical programs:A kind of herbal mixture protects lung cream, Its component includes:14~16 parts of Folium Perillae;Few 9~11 parts of Foeniculi;9~11 parts of Radix orixae japonicae;9~11 parts of Cortex Cinnamomi;Pericarpium Zanthoxyli 9~11 Part;4.5~5.5 parts of Herba Asari;9~11 parts of Folium Artemisiae Argyi;28~32 parts of Radix Et Rhizoma Nardostachyos;0.9~1.5 part of Borneolum Syntheticum.
Folium Perillae:Acrid in the mouth warm in nature, return lung, spleen channel.Indication:Effect expelling cold and relieving exterior syndrome of Folium Perillae;Dispersing lung-QI and dissipating phlegm;Circulation of qi promoting With in;Antiabortive;Cowfish Eriocheir sinensiss poison.Cure mainly exterior syndrome due to wind-cold;Cough with copious phlegm;Crisp distension;Nausea and vomiting;Stomachache is vomited and diarrhoea;Nausea is got along well;Pregnant Evil of being pregnent is cloudy;Food fish and crab poisoning.
Few Foeniculi:Acrid in the mouth warm in nature, returns liver,kidney,spleen, stomach.Indication:Function warming spleen and stomach for dispelling cold, appetizing of being amusing.
Cortex Cinnamomi:Acrid in the mouth, sweet, extremely hot in nature;Returns spleen, kidney, the heart, Liver Channel.Indication:Cortex Cinnamomi has mends fire supporing yang, ignites and returns The effect of original, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Pericarpium Zanthoxyli:Acrid in the mouth, warm in nature;Mild toxicity, returns spleen, lung, liver, kidney, the heart, pericardium channel.Indication:Warming middle-JIAO to relieve pain;Dehumidifying stops Rush down;Killing parasites for relieving itching.Cure mainly the coldness and pain in the epigastrium of Deficiency and coldness of spleen and stomach;Ascarid is suffered from abdominal pain;Vomiting is had loose bowels;Lung cold cough with asthma;Lung cold cough with asthma;Dental caries tooth Bitterly;Pudendal pruritus leukorrhagia;Eczema skin pruritus.
Herba Asari:Acrid in the mouth;Warm in nature;Mild toxicity, returns spleen, lung, liver, kidney, the heart, gallbladder meridian.Indication:Cold expelling wind-dispelling;Pain relieving;Warming the lung Dissipating fluid-retention;Sensible.Cure mainly exterior syndrome due to wind-cold;Headache, toothache;Rheumatic arthralgia;Phlegm retention cough with asthma;Nasal obstruction;Nasal sinusitis;Aphtha.
Folium Artemisiae Argyi:Acrid in the mouth, hardship;Warm in nature, returns spleen, liver and kidney channel.Indication:Warming the meridian for stopping bleeding;Dispersing cold for relieving pain;Removing dampness to relieve itching.Main Control haematemesis;Epistaxis;Painstaking blood;Have blood in stool;Have blood in stool;Metrorrhagia;Gestation hemorrhage;Menoxenia;Dysmenorrhea;Frequent fetal movement;Trusted subordinate's crymodynia;Let out Rush down chronic dysentery;Cramp caused by acute vomiting and diarrhea;Leukorrhagia;Eczema;Scabies;Hemorrhoid;Carbuncle and ulcer.
Radix Et Rhizoma Nardostachyos:Acrid in the mouth, sweet;Warm in nature, returns spleen, stomach.Indication:Regulating QI to relieve pain;Activating spleen and strengthening stomach.Cure mainly abdominal distention; Not national diet;Toothache;Tinea pedis.
Borneolum Syntheticum:Acrid in the mouth, sweet;Cool in nature, GUIXIN, lung meridian.Borneolum Syntheticum is dextro Borneolum Syntheticum.Indication:Inducing resuscitation of having one's ideas straightened out;Radiating stops Bitterly;Shade removing.Cure mainly apoplexy locked mouth;Calentura coma;Infantile convulsion expectorant fan;Deafness with qi stagnation;Conjunctivitiss;Sore throat;Aphtha;Carbuncle; Hemorrhoid;Enterobiasiss.
Preferably, component includes:15 parts of Folium Perillae;Few 10 parts of Foeniculi;10 parts of Radix orixae japonicae;10 parts of Cortex Cinnamomi;10 parts of Pericarpium Zanthoxyli; 5 parts of Herba Asari;10 parts of Folium Artemisiae Argyi;20 parts of Radix Et Rhizoma Nardostachyos;1 part of Borneolum Syntheticum.
In sum, the present invention is had the advantage that compared with prior art:
Herbal mixture shield lung cream (bag) of the present invention is belonging to the traditional daoyin technique principle of the traditional Chinese medical science, with reference to the method for " inner disease outer treat " Then, make by the pharmaceutical properties in ointment (medicated bag), rely body temperature Spontaneous release, make Chinese medicine active ingredient pass through relevant acupuncture point Slowly suck in vivo with skin pore, to reach the purpose for the treatment of.Without any damage and negative interaction, it is simple and easy to do, safety And effective outer treating method;This prescription is on probation through several patients, works well, is particularly suited for children and is reluctant to take medicine, and fears to beat Pin, particularly infant, are conducive to family and infant to obtain rehabilitation in the undamaged treatment of milli.Medicine external therapy, with medicine Light effect is prompt, simple and practical with the characteristics of, and understandable easy to learn, extremely suitably carry out at home.
Specific embodiment
With reference to embodiment, the present invention is further described.
Embodiment 1:
A kind of herbal mixture protects lung cream, by 15 parts of Folium Perillae, few 10 parts of Foeniculi, 10 parts of Radix orixae japonicae, 10 parts of Cortex Cinnamomi, Pericarpium Zanthoxyli 10 Part, 5 parts of Herba Asari, 10 parts of Folium Artemisiae Argyi, 20 parts of Radix Et Rhizoma Nardostachyos, 1 part of composition of Borneolum Syntheticum.
Embodiment 2:
A kind of herbal mixture protects lung cream, by 14 parts of Folium Perillae, few 11 parts of Foeniculi, 9 parts of Radix orixae japonicae, 11 parts of Cortex Cinnamomi, Pericarpium Zanthoxyli 9 Part, 5.5 parts of Herba Asari, 9 parts of Folium Artemisiae Argyi, 22 parts of Radix Et Rhizoma Nardostachyos, 0.9 part of composition of Borneolum Syntheticum.
Embodiment 3:
A kind of herbal mixture protects lung cream, by 16 parts of Folium Perillae, few 9 parts of Foeniculi, 11 parts of Radix orixae japonicae, 9 parts of Cortex Cinnamomi, Pericarpium Zanthoxyli 11 Part, 4.5 parts of Herba Asari, 11 parts of Folium Artemisiae Argyi, 18 parts of Radix Et Rhizoma Nardostachyos, 1.5 parts of compositions of Borneolum Syntheticum.
First, prescriptions functional analyses.
Folium Perillae:Acrid in the mouth warm in nature, return lung, spleen channel.
Chemical composition:Folium Perillae contains volatile oil (perilla oil) about 0.5%, 16.8%-22.6% containing perillaldehyde in oil, perilla alcohol 19.7%-23.1%, dihydroperilla alcohol 7.4%-8.5%, limonene about 2.8%, linalool 3.2%-4.6%, Mentholum 4.2%-20%, Flos Caryophylli alkene 4.6%-22.7%, separately contain elsholtziakesone, platform Ru ketone, perilla ketone, isoegomaketone, elemicine, lima bean Cool ether, dill-apiol and australene etc..Contain nopinene, menthone, eugenol and other furanone derivatives according to another report.Ye Zhong Red pigments be anthocyanidin -3- (6- is to coumaric acyl-β-D-Glucose) -5- β-D-Glucose glycoside.
Indication.Effect expelling cold and relieving exterior syndrome of Folium Perillae;Dispersing lung-QI and dissipating phlegm;Circulation of qi promoting is with;Antiabortive;Cowfish Eriocheir sinensiss poison.Cure mainly wind Cold exterior syndrome;Cough with copious phlegm;Crisp distension;Nausea and vomiting;Stomachache is vomited and diarrhoea;Nausea is got along well;Gestation is disliked cloudy;Food fish and crab poisoning.
Pharmacological action.1st, refrigeration function:With Folium Perillae leaf decoction and the preserved material 2g/kg families that typhoid fever polyvalent vaccine generates heat by oral administration Rabbit, has faint refrigeration function.
2nd, bacteriostasis:Folium Perillae can in vitro suppress aureus growth.Folium Perillae extractum is trained to 6 kinds of mycobiotic agars Foster thing minimum inhibitory concentration (MIC) is 200-1600mg/ml;Perillaldehyde in extractum plays main bacteriostasis.
3rd, blood glucose increasing effect:It is oral that perilla oil 0.35ml/kg gives rabbit;Blood glucose can be made to increase;Main component in oil After perillaldehyde makes oxime (Oxime), blood glucose increasing effect is higher compared with perilla oil.
4th, the effect to blood clotting:Folium Perillae Aqueous extracts to rabbit ear table intravenous injection, when can shorten the multiple calcium of blood clotting time, blood plasma Between and activated partial thromboplastin time, illustrate that Folium Perillae intrinsic coagulation system has facilitation, and the impact of exogenous blood coagulation system be simultaneously Unobvious.
5th, promote enterokinesia:The Perilla ketone isolated from Folium Perillae, have promotion enterokinesia effect to rat, Move enteral prods to accelerate, this is that have stimulation as Perill ketone expand about flesh to intestinal.
6th, sedation:The perillaldehyde isolated from Folium Perillae, Stigmasterol, Dill apiole have calmness Effect, can extend the length of one's sleep of the rat of phenobarbital minimizing, the wherein median effective dose=1.57mg/ of Dill apiole kg.Folium Perillae water decoction 1:2O concentration, has inhibitory action to viral ECHO11 strains.
Few Foeniculi:Acrid in the mouth warm in nature, returns liver,kidney,spleen, stomach.
Indication:Effect of Fructus Foeniculi is the warm liver of the kidney warming;Promoting the circulation of QI to relieve pain;Stomach function regulating.Cure mainly cold hernia stomachache;The testis swelling and hanging down of either of the testes; Stomach abdomen cold type of pain;Lack of appetite and vomiting;Hypochondriac pain;Lumbago due to renal deficiency;Dysmenorrhea.
Chemical composition:Contained by few Foeniculi, the composition of volatile oil is very complicated, and main component is trans-anethole, is secondly lemon Lemon alkene, fenchone, other have estragole, γ-terpinene, australene, myrcene, nopinene, Camphora, lauro lene, anisyl Acetone and the sabinene of trace, α-phellandrene, cymol, 1,8- cineole, 4- terpineol, trans-fenchol second Acid esters, anisaldehyde etc..Identified 16 kinds of fatty acid compositions in fruit fatty oil have:10- octadecenoic acids, arachidic acid, palm fibre Palmitic acid acid, behenic acid, myristic acid, stearic acid, lauric acid, 15 carbonic acid, two hendecoic acids etc..Fruit also contains stigmasterol, umbrella shape Flower lactone, by Palmic acid, arachidic acid, behenic acid and wax mixture, cupreol, Pericarpium Zanthoxyli formed by the higher alcohol more than 18 carbon Toxin, α-Amyrin, imperatorin, bergapten and India's element.
Pharmacological action.1. the effect of pair gi system:1. the impact to gastrointestinal motility:Fructus Foeniculi is compacted in body intestinal to rabbit Dynamic have facilitation.2. antiulcer action:Fructus Foeniculi 600mg/kg duodenums or oral administration, the suppression to rat gastric secretion Restriction 38.9%, is suppressed to 34.9% to Shay ulcer gastric secretions, and stress ulcer gastric secretion is suppressed to 33.8%.3. choleretic effect:Little mattress perfume (or spice) has choleretic effect, can promote bile secretion, and increase bile solid composition.
2. the effect of pair trachea:Fructus Foeniculi volatile oil has relexation to guinea pig tracheal smooth muscle, and volatile oil is dissolved in Anaesthetized guinea pig gavage given by 12% ethanol, increases can tracheal strips liquid secretion, and cut-out nervus gastrica does not produce impact, it is believed that this effect Cause not by stomach reaction.
3. the effect of pair liver:Rat is extractd to part liver, to Fructus Foeniculi volatile oil 10 days, hepatic tissue regeneration increased, liver Weight increases than matched group.
4. gonadotropic Effect:To Fructus Foeniculi acetone extractum 15 days, testis, deferential total protein content subtracted Mus great and mighty or powerful Few, the total protein of the smart wing and prostate then substantially increases, and the acidity of these organs, alkaline phosphatase activitieses reduce;Female rat is used , there is intravaginal keratinization in acetone extractum 10 days and sexual cycle promotes, and mammary gland, fallopian tube, endometrium, myometrium weight increase Plus, it is believed that Fructus Foeniculi has estrogen -like effectss.Separately have been reported that, it is believed that effective ingredient is anethole and its polymer such as dimerization Fructus Foeniculi Brain.
5. other effects:Fructus Foeniculi volatile oil, anethole have maincenter paralysis to act on to Rana nigromaculata, and frog cardiac muscle is started slightly Excitement, then causes paralysis.Neuromuscular is benumbed in curare sample, the irritability of muscle itself weakens, and is extracted by Fructus Foeniculi The poly- polysaccharide of plant has antitumor action.Volatile oil has sterilizing to make fungal spore, mycobacterium tuberculosis, staphylococcus aureuses With.
Radix orixae japonicae:Nature and flavor are pungent, return stomach, large intestine channel.
Indication:Function warming spleen and stomach for dispelling cold, appetizing of being amusing.《Compendium of Materia Medica》" warm the intestines and stomach, eliminating cold-damp regurgitation are empty to think it Swollen cold product, insidious ".《Tang materia medica》Say its " the main therapeutic method to keep the adverse QI flowing downwards, warming middle-JIAO, remove expectorant, except air-cooled in internal organs ".《Haiyao Bencao, Oversea Materia Medica》Point out that it can " go the appetite deficiency of vital energy is cold, dyspepsia does not disappear, cholera QI rising in reverse order, sudden attack of pain in the chest and abdomen, cold adverses QI rushing upwards ".
Chemical composition:Containing piperine, chavicine and volatile oil etc..Radix orixae japonicae volatile oil mainly have 3- carenes, limonene, The basic 4- benzene of nopinene, caryophyllene, 1- methoxies, a- pinenes, a- phellandrenes etc..
Pharmacological action:Energy appetite stimulator, stimulates gastric mucosa in a large number in a small amount, causes congested inflammation.
Cortex Cinnamomi:Acrid in the mouth, sweet, extremely hot in nature.Returns spleen, kidney, the heart, Liver Channel.
Indication:The effect of Cortex Cinnamomi has mends fire supporing yang, conducting fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Insufficiency of kidney-YANG; Gate of vitality's fire aversion to cold and cold limbs;Soreness of the waist and knees;Impotence and seminal emission;Dysuria or frequency;Lose heart dyspnea with rapid and short breath;The all cards of edema oliguria;Gate of vitality's fire Decline;Fiery not Gui Yuan;Floating YANG;Refusing yang;And heat in the upper and cold in the lower;Flushed complexion cold foot;Dizziness and tinnitus;Dispute is rotten broken;Spleen-kidney vacuity cold;Gastral cavity abdomen is cold Bitterly;Decreased food intake loose stool;Lumbago due to renal deficiency;Arthralgia due to cold-dampnes;Colic of cold type pain;Uterus cold infertile;Dysmenorrhea amenorrhea;Puerperal stasis of blood;Carbuncle of yin nature stream Note;Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus;Or do not hold back after bursting.
Chemical composition:Cortex cinnamomi japonici (Ramulus Cinnamomi) 1.98%-2.06% containing volatile oil, its main component are cinnamic aldehyde, account for 52.92%- 61.20%, also acetic acid cassia bark ester, ethyl cinnamate, benzyl benzoate, benzaldehyde, coumarin, β-cadinene, Rhizoma Acori Graminei alkene, Beta-elemene, protocatechuic acid, trans isomer cinnamic acid etc..
Cortex cinnamomi japonici (Ramulus Cinnamomi) also methyl containing 3'--left-handed-epicatechin, 5,3'- dimethyl-left-handed-epicatechin, 5,7,3'- trimethoxies Base-left-handed-epicatechin, 4'- methyl-Ds-cachou extract, 7,4'- dimethyl-dextrorotation-cachou extract, 5,7, the 4'- trimethyls-right side Rotation-cachou extract, left-handed-zero-β of epicatechin -3--glycoside, left-handed-epicatechin -8- β-glycoside, left-handed-table Caffein -6- β-glycoside, left-handed-epicatechin, Cortex cinnamomi japonici (Ramulus Cinnamomi) tannin A2, A3, A4, former cyanidin C1, B1, B2, B5, B7, A2, Procyanidin B2-8-C- β-D-Glucose glycoside, Procyanidin B2-6-C- β-D-Glucose glycoside, Cinnamomum zeylanicum Bl. element, Ceylon's meat Cinnamic alcohol, dehydration Cinnamomum zeylanicum Bl. element, dehydration cinnazeylanol and the new alcohol A of multiple diterpene-kind compound-Cortex Cinnamomis, B, C1, C2, C3, D1, D2, D3, D4, E, the new alcohol A of Cortex Cinnamomi, B, C1, D2, zero-β of -19--D-Glucose glycoside, the zero-β of -2--D-Glucose glycoside of D4 etc..
Pharmacological action.1. the effect of Central nervous system:1. sedation:The cinnamic aldehyde contained in Cortex Cinnamomi has to mice Significantly sedation, shows as spontaneous activity minimizing, resists excessive produced by methamphetamine (Methamphetamine) Anesthesia duration of activity, the movement disorder of rotating stick test generation and prolongation ciclobarbital soluble etc..Application mouse pressure anal spine swashs Or the method for lumbar injection acetic acid observation writhing motion proves that it has analgesic activity.2. cooling effect:To mice normal body temperature with And the artificial fever caused with typhoid fever, paratyphoid fever mixed vaccine has cooling effect.
2. hypotensive effect:Cortex Cinnamomi compound recipe is to adrenal cortex Hypertensive Rats (the formed mould of side adrenal gland of burning Type) there is hypotensive effect.
3. the effect of schistosomicide is prevented:Daily oral preserved material (unreceipted kind) 0.2ml/10g body weight (10.8g/ of mice 180ml), take altogether 15 days, the 3rd day infection schistosomicide of medication has no preventive effect, if with Realgar, Semen Arecae and Resina Ferulae with using There is certain effect.
4. the effect of pair blood:Cortex Cinnamomi is external and in vivo test, has the rat platelet aggregation for substantially suppressing ADP inductions Effect, in vitro tests shows that there is stronger anticoagulation Cortex Cinnamomi water decoction and solution and methanol part.The list extracted from Cortex Cinnamomi Body -- cinnamic acid and coumarin, anticoagulation be not obvious.In vivo test Cortex Cinnamomi water decoction without anticoagulation, does not affect rabbit fiber yet Protein dissolution activity.
5. the effect of pair digestive system:1. digestion promoting function:Oleum Cinnamomi stimulates olfactory sensation, can promote stomach function reflectingly, also can Directly there is the stimulation of mitigation to gastric mucosa, increase secretion, wriggle and strengthen, in armaticity digestion promoting function.2. intestinal tube is excited Effect:Oleum Cinnamomi is oral to rabbit, can promote bowel movement, makes intestinal tube excited.Also there is same purpose to isolated rabbit intestinal tube, is Ancients' warming the spleen and stomach, except good explanation has been made in cold long-pending saying.
6. other effects:1. stimulate the menstrual flow effect:A large amount of Oleum Cinnamomis can cause metremia, show stimulating the menstrual flow effect, this for ancient originally The fetal abortion effect that grass is said provides experimental basis.2. bactericidal action:Oleum Cinnamomi has powerful bactericidal action, to Gram’s staining The effect of positive bacteria is better than negative patient, because irritant, be seldom used as antibacterials, but external application can treat stomachache, flatulence Angor etc..3. stomach invigorating and carminative:Take orally and can make stomach invigorating and carminative.Also there is obvious fungicidal action, once application contains 1.5% The mixture treatment tinea capitis of Oleum Cinnamomi and 0.5% thymol.Cinnamic aldehyde and Fortificar can cause frog foot web film vasodilation And rabbit leukocyte increases.4. eliminating phlegm and relieving cough effect:Oleum Cinnamomi is discharged by lung after absorbing, and is diluted mucus, is assumed eliminating phlegm and relieving cough Effect.5. diuresis:Discharge from kidney and cause local excitation, show certain diuresis.6. anti-radiation effect:Natrium cinnamicum To giving one subtotal body irradiation Co 60 of mice and Canis familiaris L., the experiment of the lethal dose of gamma ray, it was demonstrated that there is anti-radiation to act on.7. anticomplementary Effect.
Pericarpium Zanthoxyli:Acrid in the mouth;Warm in nature;Mild toxicity, returns spleen, lung, liver, kidney, the heart, pericardium channel.
Indication:Warming middle-JIAO to relieve pain;Dehumidifying antidiarrheal;Killing parasites for relieving itching.Cure mainly the coldness and pain in the epigastrium of Deficiency and coldness of spleen and stomach;Ascarid is suffered from abdominal pain; Vomiting is had loose bowels;Lung cold cough with asthma;Lung cold cough with asthma;Toothache due to dental caries;Pudendal pruritus leukorrhagia;Eczema skin pruritus.
Chemical composition:In Pericarpium Zanthoxyli peel, the main component of volatile oil accounts for the 25.10% of total oil mass, 1,8- Folium eucalypti globueli (Eucalyptus globulus Labill.) for limonene Element accounts for 21.79%, and myrcene accounts for 11.99%, also containing a- and nopinene, sabinene, the p- poly- umbrellas of β-phellandrene, β-ocimene-X Florigen, a- terpinenes, perillene, linalool, 4- Oleum Pini olefin(e) acids, estragole, a- terpineol, transcaryophyllene, acetic acid Oleum Pini are liquor-saturated Ester, oxalene, neryl acetate, β-cadinene (β-, acetic acid geraniol ester, nerolidol isomer etc..Peel also contains Kokusaginine .beta.-fagarine, single leaf Folium Symplocoris Caudatae product alkali, 2 '-four acrylamide of hydroxy-n-isobutyl group [2E, 6E, 8E, 10E]-ten two carbon, Capsicum annuum L. alkali is exactly N- methyl -2- heptyl -4- quinolinones, herniarin), nonacosane.In the volatile oil of Pericarpium Zanthoxyli fruit, content is most Many is 4- terpinenols, accounts for 13.46%, and also piperitone accounts for 10.64%, and linalool accounts for 9.10%, and sabinene is accounted for 9.7%, limonene accounts for 7.30%, and o- P-cymene accounts for 7.00%, and myrcene accounts for 3.00% and a- and nopinene, a- Oleum Pinis Alcohol etc..In the volatile oil of Semen Pericarpium Zanthoxyli, main constituent is that linalool accounts for 18.5%, next to that myrcene account for 10.2% and tert-butyl benzene account for 11.8%, also sabinene, a- pinenes, limonene, 1,3,3- trimethyl -2- oxabicyclos [2.2.2] octane, terpineol are peppery Menthone, (E) -3- isopropyls -6- oxos -2-heptenic aldehyde, (E) -8- methyl -5- isopropyl -6,8- nonadiene -2- ketone.
Pharmacological action.1. the impact of pair digestive system:1. the impact to Experimental Gastric Ucler:Pericarpium Zanthoxyli water extract 5 and 10g/ Kg has notable anti-mouse water logging stress ulcer formation effect, and ether extract only suppresses tendency.2.. to Carbon Tetrachloride Induced The impact Pericarpium Zanthoxyli water extract 5.0g/kg of acute liver injury rat blood serum GPT and GOT can resist the effect that carbon tetrachloride raises GPT (P < 0.05=, and assume dose dependent, but GOT is raised without antagonism.3.. the impact to Drug diarrhea of mouse: Pericarpium Zanthoxyli ether extract 3.O and 6.0ml/kg can resist the diarrhea of mouse caused by Oleum Ricini, and effect not only occurs soon, and persistently.
2. the impact of pair experimental vein thrombosis and blood coagulation system:Using experimental caused by electricity irritation rat artery blood vessel wall Thrombus in vivo is formed, and Simultaneous Determination its impact to coagulation function.Test result indicate that:Pericarpium Zanthoxyli water extract 10-20g/kg and Obvious inhibiting effect is formed with to rat suppository under Pericarpium Zanthoxyli ether extract 0.3ml/kg dosage.Pericarpium Zanthoxyli water extract 10g/kg and ether extract There is during 0.15-0.3ml/kg dosage certain anticoagulation, water extract anticoagulation to be better than ether extract.
3. analgesic activity:The mouse writhing that Pericarpium Zanthoxyli water extract 5-10g/kg and ether extract 3.0-6.0ml/kg cause to acetic acid Reaction has obvious inhibitory action.
4. bacteriostasis:11 kinds of dermatophytosises of this product volatile oil and 4 kinds of deep fungals have certain suppression and kill to be made With.
5. anthelmintic action:Volatile oil contained by Pericarpium Zanthoxyli can make ascaris suum seriously be poisoned in the ringer solution of insulation.
6. other effects:.beta.-fagarine contained by this product has ephedrine sample to act on, but intensity is weaker.
Herba Asari:Acrid in the mouth;Warm in nature;Mild toxicity, returns spleen, lung, liver, kidney, the heart, gallbladder meridian.
Indication:Cold expelling wind-dispelling;Pain relieving;Warming the lung to resolve fluid-retention;Sensible.Cure mainly exterior syndrome due to wind-cold;Headache, toothache;Rheumatic arthralgia; Phlegm retention cough with asthma;Nasal obstruction;Nasal sinusitis;Aphtha.
Chemical composition:Herba Asari herb contains volatile oil 2.5%, and the composition in volatile oil has:A- pinenes, lauro lene, nopinene, the moon Osmanthus alkene, sabinene, limonene, 1, 8-Cineole, cymol, Y- terpinenes, terpinolene, Borneolum Syntheticum, Eucarvone, love Careless brain, 2- isopropyl -5- methyl anisoles, 3,5- dimethoxy-ps, safrole, methyleugenol, asaricin, Semen Myristicae Ether, elemicine, β-phellandrene, β-terpinene, 3,4- dimethyl -2,4,6- sarohornenes, epicamphor, isoborneol, a- terpineol, Pentadecane, β-bisabolence, 2- methoxyl group safrole, kakuol, asarone, 12 carbon tetraene acid amide chamber of N- isobutyl groups.Separately contain Higenamine manages environment.
Pharmacological action.1. the effect of pair cardiovascular system:1. effect of the Herba Asari to dog left chamber function:Herba Asari is extracted with ethanol To extractum shape, add water and be diluted to 1:2 solution (per 1ml 2g containing crude drug, abbreviation A.H).Inject in heart-lung preparation dog medium-sized vein Dog left chamber function can be strengthened.2.. effect of the Herba Asari to dog cardiogenic shock.
2. the effect of Central nervous system:1. the effect of central depressant is cooperateed with.2. the anesthesia to different genera animal Effect:.3. analgesic activity:Methyleugenol has certain analgesic activity to mice, but specificity is not high.4.. cooling effect:First Base eugenol has obvious cooling effect to rats by intraperitoneal injection 90mg/kg, 144mg/kg.
3. the impact pair Rabbit EEG activity:Herba Asari volatile oil is to rabbit brain cortex, Hippocampus, formatio reticularis mesencephali and cardiac electrical Synchronous recording, it was demonstrated that its effect to maincenter is similar to barbiturateses.
4. on microcirculatory impact:Test result indicate that, Herba Asari stops to the arteriole blood flow for slightly being caused by epinephrine Only or slow down and have retardation function, but statistical disposition is not notable.
5. antiinflammatory action:The volatile oil extracted in Herba Asari, the rat paw edema that Carrageenan causes have inhibitory action.Carefully The capillary permeability that pungent oil can also cause to antihistamine or PGE2 increases;Rat thoracic cavity can be suppressed because injecting after carrageenin The leukoplania for causing;There is inhibitory action to swollen hyperplasia of rat granuloma, and atrophy of thymus gland can be made, can also reduce normal rat kidney Vitamin C content in upper gland.
6. bacteriostasis:Preliminary in vitro test shows that Herba Asari is to Hemolytic streptococcuss, dysentery bacterium, Bacillus typhi and knot Core bacillus has some inhibitory action.Herba Asari can also completely inhibit the generation of flavacin.
7. body metabolism function is improved:The demethylcoclaurine contained in Herba Asari has adrenergic B analeptic samples Extensive physiological action, with heart tonifying, expand blood vessel, relaxing smooth muscle, strengthen lipid metabolism and rise hyperglycemia the effects such as.
8. antihistamine and the reaction of antiinflammatory state:The methyleugenol got in Herba Asari, 12 carbon four of Hakucl, N- isobutyl group Enamine and demethylcoclaurine etc., can substantially suppress the contraction of the made isolated ileum segments in guinea pigs of histamine.The water of Herba Asari or ethanol are extracted Thing can make the total Anaphylactic mediator burst size of immediate allergy reduce more than 40%.Prompting has the effect of antiallergic action.
9. the effect of pair smooth muscle:Herba Asari volatile oil to rabbit isolated uterine, intestinal tube, low concentration tension force is first increased after under Drop, amplitude increase;High concentration is then in suppression.It is in inhibitory action to Isolated Rat Uterus.
10. the impact of pair respiratory system:The intravenous injection of kakuol preserved material in rabbit, can to anti-morphine ab caused by breathing suppression System.Methyleugenol has significant relexation to guinea-pig isolated trachea.
Folium Artemisiae Argyi:Acrid in the mouth, hardship;Warm in nature, returns spleen, liver and kidney channel.
Indication:Warming the meridian for stopping bleeding;Dispersing cold for relieving pain;Removing dampness to relieve itching.Cure mainly haematemesis;Epistaxis;Painstaking blood;Have blood in stool;Have blood in stool;Collapse Leakage;Gestation hemorrhage;Menoxenia;Dysmenorrhea;Frequent fetal movement;Trusted subordinate's crymodynia;Have loose bowels chronic dysentery;Cramp caused by acute vomiting and diarrhea;Leukorrhagia;Eczema;Scabies; Hemorrhoid;Carbuncle and ulcer.
Chemical composition:Chinese mugwort contains volatile oil, is multicomponent mixture, and separated identification has:Terpinenol -4, β-Dianthus chinensis Alkene, artemisol, linalool, Camphora, Borneolum Syntheticum, cineole and phellandrene, Cadinene, thujanol) etc..
Pharmacological action.1. antibacterial action:Folium Artemisiae Argyi is in vitro to anthrax bacillus, Alpha-hemolytic streptococcus, B- Streptococcus hemolyticuss, white Larynx bacillus, bacillus pseudodiphthericus, lung diplococcoid, staphylococcus aureuses, Staphylococcus citreus, staphylococcus aureus, hay 10 kinds of gram-positive Aeromonas bacterias such as bacillus all have antibacterial action.2. antiasthmatic effect:Oleum Folium Artemisiae Argyi directly can relax guinea pig trachea put down Sliding flesh, can also resist the airway constriction phenomenon that acetylcholine, barium chloride and histamine cause;And increase Guinea pig lung perfusion flow.Chinese mugwort Leaf oil 0.5ml/kg gavages have inhibitory action to acetylcholine-Cavia porcelluss are breathed heavily in the cause of histamine mixed liquor nebulization.3. choleretic effect:Experiment As a result:Folium Artemisiae Argyi oil suspension 0.8ml/100g make normal rat bile flow increase by 91.5%, with compare before administration have extremely notable Sex differernce.4. suppress platelet aggregation:Cupreol and 5,7- dihydroxy -6 in Folium Artemisiae Argyi, 3', 4',-trimethoxy flavone, it To suppress platelet aggregation have remarkable effect.5. anastalsis:Folium Artemisiae Argyi infusion has promotion Blood coagulation to rabbit gavage. 6. the effect to gastrointestinal tract and uterus:Folium Artemisiae Argyi decoct can excited rabbit isolated uterine, produce tetanic contraction.Crude extract is to globefish Mus isolated uterine also has appreciable stimulating action.7. to Cardiovascular System:Folium Artemisiae Argyi infusion has when a large amount of to isolated frog heart Inhibitory action.8. anti-allergic effects:The anaphylactic shock guinea-pigs that ovalbumin causes are had antagonism by Oleum Folium Artemisiae Argyi 0.5ml/kg gavages Effect, it is possible to decrease mortality rate.
Radix Et Rhizoma Nardostachyos:Acrid in the mouth, sweet;Warm in nature, returns spleen, stomach.
Indication:Regulating QI to relieve pain;Activating spleen and strengthening stomach.Cure mainly abdominal distention;Not national diet;Toothache;Tinea pedis.
Chemical composition:Radix Et Rhizoma Nardostachyos root and rhizome contain multiple sesquiterpenoidss compositions, Rhizoma et radix valerianae terpene ketone, nardosinone, 1 (10- Fructus Aristolochiaes Alkene, 9- aristolene -2- ketone, 1,8,9,10- tetra- dehydrogenation aristolane -2- ketone [2] also known as jatamansone, 9- aristolenols also known as Radix Et Rhizoma Nardostachyos alcohol, 1,2,9,10- tetra- dehydrogenation aristolane [4], Radix Aristolochiae ketone [5], patchouli alcohol, β-patchoulene [6], Radix Et Rhizoma Nardostachyos are aromatic A [7], β-Fructus Canarii albi alkene [8], Radix Et Rhizoma Nardostachyos epoxide [9], nardosinone A, B [10, C [11] D, E, different nardosinone, nardosinone Glycol, Radix Et Rhizoma Nardostachyos furan [12] deoxygenate Radix Et Rhizoma Nardostachyos aromatic A [13].Radix Et Rhizoma Nardostachyos root ketone, Radix Et Rhizoma Nardostachyos root alcohol be -9 β of 1 (10)-aristolene - Alcohol, 9 β-Fructus Aristolochiae alkanol [14], 11- eudesmene -2,4 salmefamols etc..And iridoid compound Radix Et Rhizoma Nardostachyos diester [16].Also Contain Triterpenoid:Oleanolic acid [14], ursolic acid [16] and ethyl-β-D- glucopyanosides, cupreol.
Pharmacological action.1. maincenter sedation:Nardostachys chinensis Batal. has the sedation similar to Rhizoma et radix valerianae to the frog, rabbit.
2. antiarrhythmic effect:1. Radix Et Rhizoma Nardostachyos can resist the effect that sodium chloride induces rat ventricular.2. Radix Et Rhizoma Nardostachyos have right Anti- rabbit is in the arrhythmia of chloroform-epinephrine induction.3. the rat ventricular effect of antagonism barium chloride induction.4. Rhizoma et radix valerianae Ketone plays the role of anti-arrhythmia.5.. the effect to isolated rabbit atrial refractory period:Radix Et Rhizoma Nardostachyos have direct inhibitory action to cardiac muscle. 6.. to isolated rabbit atrial refractory period, damage stimulates the anesthesia Canis familiaris L. atrial flutter for causing to jatamansi perfume volatile oil, and because of Aconitum carmichjaelii Debx. Canis familiaris L. atrial fibrillation that alkali, acetylcholine cause etc. has arrhythmia to act on.
3. pair cardiovascular effect:Radix Et Rhizoma Nardostachyos injection (including volatile oil and water extract-alcohol precipitation part) 2g/kg intravenous injections, make Rabbit decreased heart rate, and the acute myocardial ischemia that pituitrin causes is resisted, mitigate the rising of T ripples.Volatilize to Canis familiaris L. intravenous injection Oily 0.1-1.0mg/kg, Sanguis Canitis drops 1.9995-3.9996kPa, as long as can last for hours;Can weaken cardiac contractile force and Accelerate heart rate, and play the role of necessarily anti-adrenal gland and expand peripheral vessel.
4. the effect of pair smooth muscle:To the forward and backward of Cavia porcelluss jet tissue amine, application jatamansi expands can bronchus ?.Alcohol extracting thing (small intestinal, large intestine, uterus, bronchus) on isolated smooth muscle organ, with antagonism histamine, 5-hydroxy tryptamine And the effect of acetylcholine;Can also the spasm that causes of antagonism barium chloride or sodium chloride, therefore still have direct effect to smooth muscle.Clinical On with controlling asthma, coughing, drop, suffering from abdominal pain etc. may be relevant with this.
5. Radix Et Rhizoma Nardostachyos injection 16.7,40,60g/kg intravenous injections, strengthens mice hypoxia-bearing capability.
6. other effects:Jatamansi volatile oil has faint antibacterial, wind dispelling and spasmolysises, to skin, mucosa without office Portion's zest.Jatamansi gives rabbit subcutaneous injection, bradykinesia, sleepy, loss of appetite of the rabbit performance to stimulation.Radix Et Rhizoma Nardostachyos alcohol extraction Thing has blood pressure lowering and antiulcer action.
Borneolum Syntheticum:Acrid in the mouth, sweet;Cool in nature, GUIXIN, lung meridian.
Indication:Inducing resuscitation of having one's ideas straightened out;Radiating pain relieving;Shade removing.Cure mainly apoplexy locked mouth;Calentura coma;Infantile convulsion expectorant fan;Gas Close deafness;Conjunctivitiss;Sore throat;Aphtha;Carbuncle;Hemorrhoid;Enterobiasiss.
Chemical composition:Borneolum Syntheticum is dextro Borneolum Syntheticum.
Pharmacological action.1. the effect of Central nervous system:Experiment shows that Borneolum Syntheticum has substantially analgesia and sedation.
2. 5% Borneolum Syntheticum of antiinflammatory action or isoborneol Emulsion apply ear and apply ear induced mice inflammatory reaction to 2% Oleum Tiglii mixture There is inhibitory action.
3. antibacterial action Borneolum Syntheticum, isoborneol and synthetic Borneolum Syntheticum to staphylococcus aureuses, beta hemolytic streptococcuss, Streptococcus viridanss, streptococcus pneumoniae and escherichia coli etc., in vitro have obvious antibacterial action
4. antifertility action:First Trimester is acted on without obvious induced labor, has notable induced labor effect to mid trimester of pregnancy and late period.
5. other effect Borneolum Syntheticum and isoborneol 200mg/kg lumbar injections can be obviously prolonged the normobaric hypoxia mouse survival time. The contraction of rat preduodenal caused by Borneolum Syntheticum energy partial agonist acetylcholine.Topical application, Borneolum Syntheticum have slight thorn to sensory nerve Swash and some pain relievings and antisepsises.
Above nine traditional Chinese medicines are taken a broad view of, the product of pungent-warm are mostly, which is slightly cold and has the work(of qi-regulating obvious.
The disease of asthma, with lung as mark, with kidney as root.The person of healing when sending out when which is not healed for many years, is also lung insufficiency of kidney-YANG, and invasion by pathogenic cold is not Fortune, phlegm retention given birth to then, on violate and form in lung.Though asthma have void, reality point, mostly deficiency in origin and mark reality, deficiency and excess is simultaneous see based on.Therefore often With affection of exogenous wind-cold, dyspepsia, middle burnt and induce.Therefore our nine tastes medicine, with warming lung for dispelling cold, dissipating fluid-retention, warming middle-JIAO and strengthening the spleen are supporing yang.Folium Perillae is Expelling cold and relieving exterior syndrome, relieving cough and asthma.Herba Asari is expelling wind and cold, warming the lung to resolve fluid-retention.And few Foeniculi, Radix orixae japonicae, Pericarpium Zanthoxyli, Radix Et Rhizoma Nardostachyos are warm activating QI Blood.Cortex Cinnamomi mends fire supporing yang, cold expelling of promoting blood circulation.Folium Artemisiae Argyi then warm activating QI blood.In nine taste medicines based on Folium Perillae, Herba Asari, Cortex Cinnamomi, few returning is equipped with Perfume, Radix orixae japonicae, Pericarpium Zanthoxyli, Radix Et Rhizoma Nardostachyos, Folium Artemisiae Argyi, Borneolum Syntheticum.Then making for closing is warmly and scattered cold, drinks to obtain Wen Eryi, and lung obtains Wen Erxuan, and spleen obtains warm And transport, kidney obtains Wen Erhua, then asthma spontaneous recovery.
2nd, herbal mixture shield lung cream (bag) treatment apoplexes involving the channels and collaterals acupuncture points on the human body principle.
Internal treatment's treatment asthma has multiple differentiation of symptoms and signs for classification of syndrome.And ointment (bag) external treatment, it is always to make to face with meridional point Bed analysis.
Example be《Class is through the figure wing》All urgency of breathing is controlled, is taken in Tiantu, circumpolar constellation template canopy, Danzhong, Rugen, Qimen, Qihai, ridge more Section seven, lower cave.
Example be《The Compendium of Acupuncture and Moxibustion》Asthma is controlled, the acupuncture points such as Yu mansion, Tiantu, Danzhong, fei shu, tsu san li, Qihai, Rugen are taken.
More than control Yu cave majority is breathed heavily in shirtfront and back.Therefore the taken treatment principle of ointment (bag) i.e. temperature solution front, back has Acupuncture point is closed, and has direct relation with meridians.
I.e. to lung meridian, relevant acupuncture point Zhongfu (main asthma, cough, stuffy sensation with restlessness, lung-wind syndrome swelling of the face, can moxibustion cave), Yunmen (homophony reason lung qi, cough with asthma, chest pain etc., can moxibustion cave).
To spleen meridian, there is the breast cave of moxibustion (main the chest stuffiness relieving profit diaphragm can), Zhourong (cures mainly fullness and distention in the chest and hypochondrium, cough and asthma can moxibustion Cave), Tianxi (cure mainly chest pain, cough.Can moxibustion cave).
The stomach channel of foot-Yang-ming, acupuncture point Wuyi, storehouse (gas of supervising the cooking, cough-relieving, resolving sputum, control cough, asthma, can moxibustion cave).
Small intestine meridian, si 15 (control asthma).
Bladder meridian, fei shu (control cough, pant, can moxibustion cave).
Hsinshu (acupoint) (control cough, pant, can moxibustion cave) ke shu (and control cough, asthma, can moxibustion cave).
Pohu (control cough, pant, can moxibustion cave) cream blind (control cough, pant, spit blood, can moxibustion cave) Shentang (control cough, Asthma, can moxibustion cave).
Various acupuncture points exemplified as above, be all integrated distribution in shirtfront, back is from relevant flow routes of the meridians.And person is Can moxibustion acupuncture point.So attach before and after ointment (bag), it is natural that its warm extensively treating is breathed heavily, and effect is also apparent from.
3rd, manufacture method.
Above nine tastes medicine, Borneolum Syntheticum appropriate amount of ethanol dissolve.Few Foeniculi, Radix orixae japonicae, Pericarpium Zanthoxyli, four taste of Cortex Cinnamomi are ground into coarse powder, Plus 7 times of ethanol room temperatures are carried 2 hours, then 60 degree of heating extraction 1 hour, extracting juice is squeezed, is stood, removed precipitation, obtain medicinal liquid standby.Purple Folium Perillae, Herba Asari, Radix Et Rhizoma Nardostachyos, Folium Artemisiae Argyi four Chinese medicine add 7 times of ethanol room temperatures to carry 1 hour, then 50 degree of heating extraction 1 hour, squeeze extracting juice, quiet Put, remove precipitation, obtain medicinal liquid standby.Upper two medicinal liquid is mixed, is stirred evenly, in 70-80 degree distillation and concentrations, 1 milliliter is obtained containing 5 grams of crude drugs Concentrated solution.Borneolum Syntheticum ethanol is mixed with above-mentioned concentrated solution, is stirred evenly.0.13 square metre of pure cotton is immersed in above-mentioned medicinal liquid, Wait to fully absorb, take out, dry Drug absorbability pieces of cloth again, be cut into the ointment table of certain specification, make ointment, or by tablet Outsourcing byssuss, make shield lung bag, theoretical according to human meridian point, make child's medicinal undergarment covering the chest and abdomen or adult medication's underwear, into People's vest etc..
This prescription is on probation through several patients, works well.Especially children are reluctant to take medicine, and fear to have an injection, particularly baby children Youngster is particularly difficult.Therefore family and infant wish to obtain rehabilitation in the undamaged treatment of milli.Medicine external therapy is light with medicine Effect is prompt, simple and practical with the characteristics of, and understandable easy to learn, extremely suitably carry out at home.Now, many national to China in the world External treatment with Chinese medicine therapy is had the greatest esteem, and this injustice is clinical needs, and the direction of future medicine development.
Specific embodiment described in text is only to the spiritual explanation for example of the present invention.The technical field of the invention Technical staff described specific embodiment can be made various modification supplement or using similar mode replacement, But the spirit without departing from the present invention surmounts scope defined in appended claims.

Claims (3)

1. a kind of herbal mixture protects lung cream, and its component includes:
14~16 parts of Folium Perillae;
Few 9~11 parts of Foeniculi;
9~11 parts of Radix orixae japonicae;
9~11 parts of Cortex Cinnamomi;
9~11 parts of Pericarpium Zanthoxyli;
4.5~5.5 parts of Herba Asari;
9~11 parts of Folium Artemisiae Argyi;
28~32 parts of Radix Et Rhizoma Nardostachyos;
0.9~1.5 part of Borneolum Syntheticum.
2. herbal mixture according to claim 1 protects lung cream, it is characterised in that component includes:
15 parts of Folium Perillae;
Few 10 parts of Foeniculi;
10 parts of Radix orixae japonicae;
10 parts of Cortex Cinnamomi;
10 parts of Pericarpium Zanthoxyli;
5 parts of Herba Asari;
10 parts of Folium Artemisiae Argyi;
20 parts of Radix Et Rhizoma Nardostachyos;
1 part of Borneolum Syntheticum.
3. a kind of herbal mixture protects the preparation method of lung cream, including Folium Perillae, few 10 parts of Foeniculi, 10 parts of Radix orixae japonicae, 10 parts of Cortex Cinnamomi, 10 parts of Pericarpium Zanthoxyli, 5 parts of Herba Asari, 10 parts of Folium Artemisiae Argyi, 20 parts of Radix Et Rhizoma Nardostachyos, 1 part of Borneolum Syntheticum, above nine tastes medicine, Borneolum Syntheticum appropriate amount of ethanol dissolve.Few time Perfume, Radix orixae japonicae, Pericarpium Zanthoxyli, four taste of Cortex Cinnamomi are ground into coarse powder, plus 7 times of ethanol room temperatures are carried 2 hours, then 60 degree of heating extraction 1 hour, pressure Extracting juice, stands, and removes precipitation, obtains that medicinal liquid is standby, and it is little that Folium Perillae, Herba Asari, Radix Et Rhizoma Nardostachyos, Folium Artemisiae Argyi four Chinese medicine add 7 times of ethanol room temperatures to carry 1 When, then 50 degree of heating extraction 1 hour, extracting juice is squeezed, is stood, removed precipitation, obtain medicinal liquid standby.Upper two medicinal liquid is mixed, is stirred evenly, In 70-80 degree distillation and concentrations, 1 milliliter of concentrated solution containing 5 grams of crude drugs is obtained, Borneolum Syntheticum ethanol is mixed with above-mentioned concentrated solution, is stirred evenly, 0.13 square metre of pure cotton is immersed in above-mentioned medicinal liquid, waits to fully absorb, taken out, dry Drug absorbability pieces of cloth again, be cut into The ointment table of certain specification, makes ointment, or by tablet outsourcing byssuss, makes shield lung bag, theoretical according to human meridian point, Make child's medicinal undergarment covering the chest and abdomen or adult medication's underwear, adult's vest etc..
CN201610988632.2A 2016-11-10 2016-11-10 Herbal mixture shield lung cream and preparation method thereof Pending CN106491846A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1069194A (en) * 1991-08-03 1993-02-24 董学武 The prescription and the processing technology of the safe and comfortable bag medicine core of child
CN1583115A (en) * 2004-05-26 2005-02-23 许旭东 External used ointment for cough and asthma and its preparation
CN104027642A (en) * 2014-06-06 2014-09-10 黄艳梅 Traditional Chinese medicine composition for protecting lung and relieving cough for infants
CN104587433A (en) * 2015-01-16 2015-05-06 山东中医药高等专科学校 Kidney tonifying and qi holding plaster for external application and using method of plaster

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1069194A (en) * 1991-08-03 1993-02-24 董学武 The prescription and the processing technology of the safe and comfortable bag medicine core of child
CN1583115A (en) * 2004-05-26 2005-02-23 许旭东 External used ointment for cough and asthma and its preparation
CN104027642A (en) * 2014-06-06 2014-09-10 黄艳梅 Traditional Chinese medicine composition for protecting lung and relieving cough for infants
CN104587433A (en) * 2015-01-16 2015-05-06 山东中医药高等专科学校 Kidney tonifying and qi holding plaster for external application and using method of plaster

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
胡献国等: "《中国膏药配方配制全书》", 30 April 2014, 辽宁科学技术出版社 *

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