CN106490609A - 一种王枣子口含片及其生产方法 - Google Patents
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Abstract
本发明公开了一种王枣子口含片及其生产方法，由以下重量份的原料制成：王枣子提取物10‑15份，青苹果稠膏38‑45份，亳菊花提取物5‑8份，糊精15‑18份，药用淀粉15‑18份，羧甲基淀粉钠1‑2份，蔗糖1‑2份，香精钠0.3‑0.4份，硬脂酸镁4‑6份，蒸馏水适量。本发明的口含片具有一定的保健功效，可使王枣子提取物、青苹果稠膏和亳菊花提取物药效成分通过口腔粘膜直接被吸收，避免了有效成分通过消化系统的吸收产生的肝脏首过效应，提高了药效成分的利用率。
Description
技术领域
本发明涉及食品加工技术领域，特别是一种王枣子口含片及其生产方法。
背景技术
口含片指含于口腔内缓慢溶解的压制片，能对口腔及咽部产生持久的药效，用于局部的消炎、消毒等，如草珊瑚含片。含化药片或药丸治疗咽炎具有以下优点：1、直接作用在咽部。具有抑菌、杀菌、消炎、消肿、稀化粘稠分泌物、收敛、刺激粘膜分泌等作用。2、由于缓慢的含化，使药物能较长时间停留在咽部，持续发挥药效。3、对于缓解咽干、咽痛等不适感觉见效快。4、具有抑菌、杀菌、消炎、消肿、稀化粘稠分泌物、收敛、刺激粘膜分泌等作用。口含片其特点主要是通过舌下和口腔颊面粘膜吸收，具有吸收快、起效迅速，临床上主要用于治疗口腔、咽喉部疾病。
王枣子生长在安徽省宿州市北部符离、夹沟、曹村、国家森林公园皇藏峪一带山区，是野生药食两用草本植物，具有一定的消炎、解毒、抗衰、抗疲劳、护肝和胃、醒酒保健、提高自身免疫力等作用，被誉为“天然植物抗生素”。王枣子为唇形科香茶菜属植物,宿州(原宿县)医院用王枣子治疗肺脓疡疗效显著。从王枣子叶乙醇提取物的中性部份分得七种结品成分,其中王枣子甲素为无色针品，为一新的四环二菇。《宿州志》《宿县志》记载，“王枣子生长在宿县北部符离、夹沟、曹村、国家森林公园黄藏峪一带山区，是野生药食两用植物”。民间习惯用于治疗各种疮疖、毒疮、肿瘤、肺结核、肺脓疡、老慢支、肾炎、咽炎、感冒发烧、乙肝、牛皮癣和毒蛇咬伤等多种疾病。具有抗菌消炎、抗肿瘤、保肝、抗氧化、保护心血管、抑制血小板凝聚，活血化瘀、整肠健胃、止咳平喘、退烧解毒等功效，故有“是疮不是疮，三碗王枣子汤，天天喝一碗，身体保健康”的民间谚语，被民间誉为“神奇的草药”。该草药多年来一直没有得到有效的保护利用和开发，现已濒临灭绝，后经建立了种植基地，仿野生种植，保种20多年，王枣子资源得到了一定程度的保护。上海中医大学、苏州大学、上海市肺科医院、上海华山医院等单位合作对王枣子全草进行有效成份提取分离和动物体内外药理、药效、药学、毒理学、药代动力学等相关领域的临床前研究，实验证明：王枣子是治疗自身免疫性疾病的良好天然药物，可以替代西药激素类、免疫抑制剂药物和抗菌素，且无西药的毒副作用。常饮王枣子茶不仅清心爽肺，具有一定的消炎、解毒、抗衰、抗疲劳、护肝和胃、醒酒保健、提高自身免疫力等作用，尤其对感冒、发烧、口腔炎、咽炎、支气管炎、肺炎、胃炎、肠炎、肾炎、前列腺炎、妇科炎症及肿瘤、疑难杂症等效果明显。它具有清咽排毒、抑制肿瘤，舒胃健脾、健身延年，促进人体新陈代谢等独特功效。对雾霾、pm2.5、沙尘暴、汽车尾气、工业粉尘、化工污染、室内装潢的受害人群，对吸入的烟、尘、废气、毒素、细菌等具有及时清洗的作用，可以减轻毒害，是理想的原生态茶饮品。
王枣子生长在安徽省宿州市北部药食两用草本植物，具有一定的消炎、解毒、抗衰、抗疲劳、护肝和胃、醒酒保健、提高自身免疫力等作用，被誉为“天然植物抗生素”。随着人们生活水平的提高和饮食保健意识的增强，进一步开发王枣子保健品成为食品企业一大课题，王枣子口含片就是在这一大背景下开发的一种以王枣子提取物加青苹果稠膏、亳菊花提取物加工而成的保健含片。
发明内容
本发明的目的是克服现有技术的不足，提供一种王枣子口含片，具有一定的保健功效。
为了实现上述目的，本发明采用如下技术方案：
一种王枣子口含片，由以下重量份的原料制成：王枣子提取物10-15份，青苹果稠膏38-45份，亳菊花提取物5-8份，糊精15-18份，药用淀粉15-18份，羧甲基淀粉钠1-2份，蔗糖1-2份，香精钠0.3-0.4份，硬脂酸镁4-6份，蒸馏水适量。
优选地，所述的王枣子口含片，由以下重量份的原料制成：王枣子提取物12份，青苹果稠膏40份，亳菊花提取物7份，糊精16份，药用淀粉17份，羧甲基淀粉钠2份，蔗糖1份，香精钠0.3份，硬脂酸镁4.7份，蒸馏水适量。
所述王枣子提取物由以下方法制备：将王枣子清洗干净，烘干，碾碎,过80目的筛网得王枣子粉末待用；向王枣子粉末中加入8倍体积的蒸馏水，加热至液体微沸状态提取2小时，然后使用5层纱布过滤两次得到王枣子提取液，再将王枣子提取液转移至旋转蒸发仪上减压蒸馏至稠膏状，烘箱内60℃鼓风干燥后研磨成粉即得王枣子提取物。
所述亳菊花提取物由以下方法制备：将亳菊花清洗干净，烘干，碾碎,过80目的筛网得亳菊花粉末待用；向亳菊花粉末中加入8倍体积的蒸馏水，加热至液体微沸状态提取2小时，然后使用5层纱布过滤两次得到亳菊花提取液，再将亳菊花提取液转移至旋转蒸发仪上减压蒸馏至稠膏状，烘箱内60℃鼓风干燥后研磨成粉即得亳菊花提取物。
所述的青苹果稠膏由以下方法制备：将青苹果去皮后，利用果蔬破碎机将去皮的青苹果绞碎至稠膏状，置烘箱内60℃鼓风干燥后研磨成粉即得青苹果稠膏。
本发明的王枣子口含片可以按照本领域普通技术人员熟知的方法制备的，优选以下制备方法：将王枣子提取物、青苹果稠膏、亳菊花提取物研碎，使之细度达到350-400目，然后与糊精、药用淀粉、羧甲基淀粉钠、蔗糖、香精钠、硬脂酸镁混合，用水均匀润湿，将润湿后的混合物过筛并干燥，再过筛，整粒，将此混合物压片，每片重200mg，提取物成分含量为100-130mg。
本发明所述重量份可以是μg、mg、g、kg等医药领域公知的质量单位。
本发明涉及的保健型口含片的剂量以单元剂型中存在的量计算，在单元剂型中本发明涉及的王枣子提取物、青苹果稠膏和亳菊花提取物总含量为100-130mg(口含片重量为200mg)。
成人服用本发明所述保健型王枣子口含片的量，每日为600-1000mg，分6-8次服用。
王枣子，是野生药食两用草本植物，是治疗自身免疫性疾病的良好天然药物，可以替代西药激素类、免疫抑制剂药物和抗菌素，且无西药的毒副作用。常饮王枣子茶不仅清心爽肺，具有一定的消炎、解毒、抗衰、抗疲劳、护肝和胃、醒酒保健、提高自身免疫力等作用，尤其对感冒、发烧、口腔炎、咽炎、支气管炎、肺炎、胃炎、肠炎、肾炎、前列腺炎、妇科炎症及肿瘤、疑难杂症等效果明显。它具有清咽排毒、抑制肿瘤，舒胃健脾、健身延年，促进人体新陈代谢等独特功效，是理想的原生态保健药食两用药材。
青苹果，含有大量的维生素、矿物质和丰富的膳食纤维，特别是果胶等成分，除了具有一般苹果之补心益气、益胃健脾等功效外，其止泻效果尤佳，慢性腹泻、神经性结肠炎、小儿腹泻患者可经常食用。青苹果养肝解毒，对抗抑郁症，适合年轻人食用，还可促进牙齿和骨骼生长，防止牙床出血。
亳菊花，是药用菊科植物，在诸多产地所产的药用菊花中，被公认为地道药材的为亳菊、滁菊、贡菊和杭菊，据《中华大辞典》载：“白菊主产安徽亳县，称亳菊，品质最佳”，具有散风清热，平肝明日。用于风热感冒，头痛眩晕，目赤肿痛，眼目昏花。
与已有技术相比，本发明的有益效果如下：
本发明的口含片可使王枣子提取物、青苹果稠膏和亳菊花提取物药效成分通过口腔粘膜直接被吸收，避免了有效成分通过消化系统的吸收产生的肝脏首过效应，提高了药效成分的利用率。本发明的王枣子口含片具有一定的保健功效，具有散风清热、消炎解毒、醒酒、补心益气的功效，可以用于治疗感冒、口腔炎、胃炎、咽炎、腹泻、牙床出血、头痛眩晕等症状。
具体实施方式
以下结合实施例对本发明作进一步的说明，但本发明不仅限于这些实施例，在未脱离本发明宗旨的前提下，所作的任何改进均落在本发明的保护范围之内。
首先，自市场购买或按照现有技术获得：
王枣子、青苹果、亳菊花、糊精、药用淀粉、羧甲基淀粉钠、蔗糖、香精钠、硬脂酸镁、蒸馏水。
接着，通过以下方法制得王枣子提取物、亳菊花提取物和青苹果稠膏：
将王枣子清洗干净，烘干，碾碎,过80目的筛网得王枣子粉末待用；向王枣子粉末中加入8倍体积的蒸馏水，加热至液体微沸状态提取2小时，然后使用5层纱布过滤两次得到王枣子提取液，再将王枣子提取液转移至旋转蒸发仪上减压蒸馏至稠膏状，烘箱内60℃鼓风干燥后研磨成粉即得王枣子提取物。
将亳菊花清洗干净，烘干，碾碎,过80目的筛网得亳菊花粉末待用；向亳菊花粉末中加入8倍体积的蒸馏水，加热至液体微沸状态提取2小时，然后使用5层纱布过滤两次得到亳菊花提取液，再将亳菊花提取液转移至旋转蒸发仪上减压蒸馏至稠膏状，烘箱内60℃鼓风干燥后研磨成粉即得亳菊花提取物。
将青苹果去皮后，利用果蔬破碎机将去皮的青苹果绞碎至稠膏状，置烘箱内60℃鼓风干燥后研磨成粉即得青苹果稠膏。
然后，
实施例1：
一种王枣子口含片，原料配比如下：王枣子提取物10份，青苹果稠膏38份，亳菊花提取物5.7份，糊精18份，药用淀粉18份，羧甲基淀粉钠2份，蔗糖2份，香精钠0.3份，硬脂酸镁6份，蒸馏水适量。
所述的王枣子口含片的生产方法：将王枣子提取物、青苹果稠膏、亳菊花提取物研碎，使之细度达到350-400目，然后与糊精、药用淀粉、羧甲基淀粉钠、蔗糖、香精钠、硬脂酸镁混合，用适量水均匀润湿，将润湿后的混合物过筛并干燥，再过筛，整粒，将此混合物压片，每片重200mg，提取物成分含量约为107mg。
实施例2：
一种王枣子口含片，原料配比如下：王枣子提取物15份，青苹果稠膏40份，亳菊花提取物6.7份，糊精15份，药用淀粉15份，羧甲基淀粉钠2份，蔗糖2份，香精钠0.3份，硬脂酸镁4份，蒸馏水适量。
所述的王枣子口含片的生产方法，将王枣子提取物、青苹果稠膏、亳菊花提取物研碎，使之细度达到350-400目，然后与糊精、药用淀粉、羧甲基淀粉钠、蔗糖、香精钠、硬脂酸镁混合，用适量水均匀润湿，将润湿后的混合物过筛并干燥，再过筛，整粒，将此混合物压片，每片重200mg，提取物成分含量约为123mg。
实施例3：
一种王枣子口含片，原料配比如下：王枣子提取物13份，青苹果稠膏41份，亳菊花提取物7.7份，糊精15份，药用淀粉15份，羧甲基淀粉钠2份，蔗糖2份，香精钠0.3份，硬脂酸镁4份，蒸馏水适量。
所述的王枣子口含片的生产方法：将王枣子提取物、青苹果稠膏、亳菊花提取物研碎，使之细度达到350-400目，然后与糊精、药用淀粉、羧甲基淀粉钠、蔗糖、香精钠、硬脂酸镁混合，用适量水均匀润湿，将润湿后的混合物过筛并干燥，再过筛，整粒，将此混合物压片，每片重200mg，提取物成分含量为约为123mg。
Claims (6)
1.一种王枣子口含片，其特征在于：由以下重量份的原料制成：王枣子提取物10-15份，青苹果稠膏38-45份，亳菊花提取物5-8份，糊精15-18份，药用淀粉15-18份，羧甲基淀粉钠1-2份，蔗糖1-2份，香精钠0.3-0.4份，硬脂酸镁4-6份，蒸馏水适量。
2.根据权利要求1所述的王枣子口含片，其特征在于：由以下重量份的原料制成：王枣子提取物12份，青苹果稠膏40份，亳菊花提取物7份，糊精16份，药用淀粉17份，羧甲基淀粉钠2份，蔗糖1份，香精钠0.3份，硬脂酸镁4.7份，蒸馏水适量。
3.根据权利要求1所述的王枣子口含片，其特征在于：所述王枣子提取物由以下方法制备：将王枣子清洗干净，烘干，碾碎,过80目的筛网得王枣子粉末待用；向王枣子粉末中加入8倍体积的蒸馏水，加热至液体微沸状态提取2小时，然后使用5层纱布过滤两次得到王枣子提取液，再将王枣子提取液转移至旋转蒸发仪上减压蒸馏至稠膏状，烘箱内60℃鼓风干燥后研磨成粉即得王枣子提取物。
4.根据权利要求1所述的王枣子口含片，其特征在于：所述亳菊花提取物由以下方法制备：将亳菊花清洗干净，烘干，碾碎,过80目的筛网得亳菊花粉末待用；向亳菊花粉末中加入8倍体积的蒸馏水，加热至液体微沸状态提取2小时，然后使用5层纱布过滤两次得到亳菊花提取液，再将亳菊花提取液转移至旋转蒸发仪上减压蒸馏至稠膏状，烘箱内60℃鼓风干燥后研磨成粉即得亳菊花提取物。
5.根据权利要求1所述的王枣子口含片，其特征在于：所述的青苹果稠膏由以下方法制备：将青苹果去皮后，利用果蔬破碎机将去皮的青苹果绞碎至稠膏状，置烘箱内60℃鼓风干燥后研磨成粉即得青苹果稠膏。
6.根据权利要求1-5中任一项所述的王枣子口含片的生产方法，其特征在于：将王枣子提取物、青苹果稠膏、亳菊花提取物研碎，使之细度达到350-400目，然后与糊精、药用淀粉、羧甲基淀粉钠、蔗糖、香精钠、硬脂酸镁混合，用适量水均匀润湿，将润湿后的混合物过筛并干燥，再过筛，整粒，将此混合物压片，即得王枣子口含片。
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| CN111888389A (zh) * | 2020-08-28 | 2020-11-06 | 宿州绿源中医药科技有限公司 | 一种用于治疗间质性肺炎的王枣子萃取物及其制备方法 |
| BE1028983B1 (fr) * | 2020-12-31 | 2022-08-02 | Laboratoires Pharmaceutiques Trenker Farm Laboratoria Trenker | Procédé de fabrication de comprimés nus et sécables de compléments alimentaires et comprimés ainsi obtenus |
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| BE1028923B1 (fr) * | 2020-12-31 | 2022-11-21 | Laboratoires Pharmaceutiques Trenker Farm Laboratoria Trenker | Procédé de fabrication de comprimés faciles à avaler, nus de pelliculage et sécables de compléments alimentaires et comprimés ainsi obtenus |
| CN114903949A (zh) * | 2022-06-08 | 2022-08-16 | 宿州市王枣子种植专业合作社 | 一种用于治疗肺结节的王枣子提取物 |
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