CN106490383A - A kind of autumn laying-hen compound feed - Google Patents

Abstract

The invention discloses a kind of autumn laying-hen compound feed, wherein, including following raw material：12 parts of 50 60 parts of Semen Maydiss, 10 15 parts of soybean meal, 5 10 parts of Semen arachidis hypogaeae cake, 46 parts of wheat-middlings, 14 parts of vegetable oil, 46 parts of stone powder, 1 1.5 parts of calcium hydrogen phosphate, 0.1 0.5 parts of Sal and Chinese herbal medicine additive；And disclose preparation method.The invention has the beneficial effects as follows：The feedstuff of the present invention, special for laying hen, it is possible to increase the vital functionss of laying hen, autumn multiple disease is reduced, and keeps and promote the growth of laying hen, it is ensured that egg production.

Description

A kind of autumn laying-hen compound feed

Technical field

The present invention relates to laying-hen compound feed, more particularly to a kind of autumn laying-hen compound feed.

Background technology

Through hot summer, autumn air temperature declines therewith, and the cultivation of laying hen also faces some problems, due to Autumn Climate Dry, multiple pathogenic environmentals can be caused.

The commonly encountered diseases of autumn laying hen have the diseases such as white comb, bacterial diarrhea, infective rhinitises, bronchitis.Frequently-occurring disease The generation of disease, greatly reduces raising production capacity, causes certain economic loss to plant.

Autumn laying hen disease control principle：1st, strengthen feeding and management.2nd, epidemic preventive awareness is improved, prevents epidemic disease incoming.3rd, it is eager to excel Change sterilization, cause of disease is eliminated in bud.4th, to require according to " five differ process ", strict dispose die of illness laying hen and its product Product.5th, immunization is carried out.6th, preventive usage and symptomatic treatment.

The raising layer regular incidence disease in autumn how is preferably reduced and prevented, the feeding function of autumn raising layer is improved, is The problem to be solved in the present invention.

Content of the invention

In order to solve the above problems, the invention provides a kind of autumn laying-hen compound feed.

In order to achieve the above object, the invention provides a kind of autumn laying-hen compound feed, wherein, including following original Material：Semen Maydiss 50-60 parts, soybean meal 10-15 parts, Semen arachidis hypogaeae cake 5-10 parts, wheat-middlings 4-6 parts, vegetable oil 1-4 parts, stone powder 4-6 parts, Calcium hydrogen phosphate 1-1.5 parts, Sal 0.1-0.5 parts and Chinese herbal medicine additive 1-2 parts.

Wherein, the Chinese herbal medicine additive includes following component：Sirikaya, bullock's-heart, Digenea simplex (Wnlf.) C. Ag., Fructus Gleditsiae microcarpae, Herba Artemisiae Annuae, Herba Bidentis Bipinnatae, Herba Thesii Longifolii, Caulis Mahoniae, Fructus Aurantii Immaturus, Herba Portulacae, Flos Caryophylli, Herba Euphorbiae Humifusae, Herba hyperici elodeoidis, Radix Puerariae, Radix Rhodomyrti, Celastrus orbiculatus Thunb., brave tail Orchid, Cortex Syringae, Herba galinsogae parviflorae, Fructus Litchi, Corm Eleocharitiss, stick grass, Rhizoma Curcumae Longae and Lemmaphyllum microphullum Presl.

Wherein, the Chinese herbal medicine additive includes the composition of following parts by weight：Sirikaya 5-10 parts, bullock's-heart 4-8 parts, Digenea simplex (Wnlf.) C. Ag. 10-14 parts, Fructus Gleditsiae microcarpae 5-9 parts, Herba Artemisiae Annuae 7-12 parts, Herba Bidentis Bipinnatae 6-12 parts, Herba Thesii Longifolii 10-15 parts, Caulis Mahoniae 6-12 Harvest in part, Fructus Aurantii Immaturus 4-7 parts, Herba Portulacae 4-7 parts, Flos Caryophylli 10-15 parts, Herba Euphorbiae Humifusae 4-8 parts, Herba hyperici elodeoidis 10-14 parts, Radix Puerariae 5-9 parts, mountain Root 3-6 parts, Celastrus orbiculatus Thunb. 10-15 parts, Folium Sansevieriae Trifasclatae 4-7 parts, Cortex Syringae 3-6 parts, Herba galinsogae parviflorae 7-13 parts, Fructus Litchi 6-9 parts, Corm Eleocharitiss 4-8 Part, stick grass 5-10 parts, Rhizoma Curcumae Longae 3-6 parts and Lemmaphyllum microphullum Presl 3-6 parts.

Wherein, the Chinese herbal medicine additive includes the composition of following parts by weight：8 parts of Sirikaya, 6 parts of bullock's-heart, extra large people Grass 12 parts, 7 parts of Fructus Gleditsiae microcarpae, 9 parts of Herba Artemisiae Annuae, 8 parts of Herba Bidentis Bipinnatae, 12 parts of Herba Thesii Longifolii, 8 parts of Caulis Mahoniae, 5 parts of Fructus Aurantii Immaturus, 6 parts of Herba Portulacae, 12 parts of Flos Caryophylli, 6 parts of Herba Euphorbiae Humifusae, 12 parts of Herba hyperici elodeoidis, 7 parts of Radix Puerariae, 5 parts of Radix Rhodomyrti, 12 parts of Celastrus orbiculatus Thunb., 6 parts of Folium Sansevieriae Trifasclatae, Cortex Syringae 5 5 parts of part, 9 parts of Herba galinsogae parviflorae, 8 parts of Fructus Litchi, 6 parts of Corm Eleocharitiss, 8 parts of stick grass, 5 parts of Rhizoma Curcumae Longae and Lemmaphyllum microphullum Presl.

Wherein, its method of Chinese herbal medicine additive is：The components in certain proportion is mixed, powder is ground into；Powder will be obtained Add in cold water and soak 6 hours～12 hours, to be cooked by slow fire, decocting time is 3 hours～5 hours, decoction liquor is filtered, is obtained The first filtrate is obtained, the quality of the water for being added is 2～4 times of the powder quality for obtaining；The filtering residue for filtering acquisition is added again In cold water, to be cooked by slow fire 2 hours～4 hours, filter and obtain the second filtrate, the quality of the water for being added is the powder matter for obtaining 2～4 times of amount；The first filtrate for obtaining and the mixing of second filtrate of acquisition, concentrating under reduced pressure are removed water, dry, pulverize into powder End, granularity are 80～120 mesh, i.e. Chinese herbal medicine additive.

Wherein, feed producing method is：The corn and soybean dregs of rice and Semen arachidis hypogaeae cake are added to pulverizer to be crushed, are crushed Granule is 60-80 mesh, sieves；Each raw material after by process is added to after carrying out physical agitation 2-3 hour in blender and is raised Material.

The pharmacology of each taste composition is as follows：

Fruit of the Sirikaya for annonaceae plant Sirikaya.Sweet in the mouth；Cold in nature.Tonifying the spleen and stomach；Heat-clearing and toxic substances removing；Parasite killing.Main malignant boil swells Bitterly；Intestinal parasitic diseases.

Fruit of the bullock's-heart for annonaceae plant Annona reticulata.Bitter in the mouth；Sweet；Cold in nature.Return through large intestine channel.Heat clearing away stops Dysentery；Anthelmintic.Main pyrotoxic dysentery dysentery；Intestinal parasitical diseases.

Frond of the Digenea simplex (Wnlf.) C. Ag. for Rhodomelaceae plant Digenea simplex (Wnlf.) C. Ag..3～August is harvested.Nature and flavor are cool；Salty；Flat.Return through large intestine channel. Drive ascarid.Main ascariasis

Fruit of the Fructus Gleditsiae microcarpae for leguminous plant Fructus Gleditsiae microcarpae.Nature and flavor are bitter；Cold.Return through spleen；Stomach.Anthelmintic；Removing toxic substances and promoting subsidence of swelling.Main carbuncle Cellulitis toxic swelling；Intestinal parasitic diseases.

Dry aerial parts of the Herba Artemisiae Annuae for feverfew Herba Artemisiae annuae.Tap when autumn spends in full bloom, remove old stem, dry in the shade.Property Taste bitter, acrid, cold.Return liver, gallbladder meridian.Clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria.Generate heat for pathogenic summer-heat, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency labor Heat, malaria cold and heat, jaundice due to damp-heat.

Herb of the Herba Bidentis Bipinnatae for feverfew bidens pilosa.Sweet in the mouth；Slight bitter；Cool in nature.Heat clearing away；Removing toxic substances；Dampness removing；Spleen invigorating. Main influenza；Laryngopharynx swelling and pain；Icterohepatitis；Heat-damp in summer is vomited and diarrhoea；Enteritis；Dysentery；Acute appendicitis；Infantile malnutrition；Blood deficiency general edema with yellowish skin；Hemorrhoid； Snake bite and insect sting.

Herba Thesii Longifolii comes into leaves for sandalwood plants the herb of Herba Thesii or Western Regions Herba Thesii.Summer, autumn collection, dry.Nature and flavor are pungent Hardship, cool.Expelling wind and clearing away heat, spasmolytic.Cure cold, heatstroke, infantile pneumonia, cough, infantile convulsion.

Caulis Mahoniae is Berberidaceae plant Mahonia bealei (Fort.) Carr., the stem of mahonia fortuneiFedde or peel of stem.Nature and flavor are bitter；Cold in nature.Return Through large intestine；Kidney；Lung meridian.Heat clearing away；Dampness；Removing toxic substances.Main cough due to lung-heat；Jaundice；Have loose bowels；Dysentery；Conjunctival congestion and swelling pain；Skin infection；Eczema；Scald Wound.

Fructus Aurantii Immaturus is that rutaceae Citrus aurantium Linn. and its variety or Fructus Citri sinensiss dry young fruit.Nature and flavor are bitter, pungent, sour, temperature.Return Spleen, stomach.Dispelling the stagnated QI removing food stagnancy, resolving sputum dissipate painful abdominal mass.For internal stagnation, feeling of fullness distending pain, weight after rush down dysentery, constipation, expectorant stagnant gas hinder breast Numbness, blocked-up chest；Gastroptosis, proctoptosis, uterine prolapse.

Herba Portulacae is portulacaceous plant Herba Portulacae, with all herbal medicine.Nature and flavor acid, trembles with fear.Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.With In bacillary dysentery, acute gastroenteritiss, acute appendicitiss, mastitis, bleeding hemorrhoidss, leucorrhea；Furuncle swelling toxin is controlled in external, eczema, Herpes zoster.

Flos Caryophylli:Nature and flavor are pungent, temperature.Returns spleen, stomach, lung, kidney channel.Warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultuss are vomitted Tell, lack of appetite and vomiting, trusted subordinate's crymodynia, impotence due to deficiency of the kidney.

Herba Euphorbiae Humifusae is that euphorbia plant Radix seu Caulis Parthenocissi tricuspidatae or Herba Euphorbiae supinae dry herb.Summer, the harvesting of two season of autumn, remove impurity, dry. Nature and flavor are pungent, put down.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.For dysentery, have loose bowels, hemoptysis, hematuria are had blood in stool, metrorrhagia, skin ulcer Furuncle carbuncle.

Herba hyperici elodeoidis are Hypericaceae Herba hyperici elodeoidis, with all herbal medicine.Nature and flavor are bitter, put down.Heat-clearing and toxic substances removing, restores menstrual flow and invigorates blood circulation.Cure mainly mouth Chamber is scorching, infantile whitish aphthae, infantile pneumonia, infantile dyspepsia, mastitis, chronic dysentery of suffering from diarrhoea, dysmenorrhea.Impetigo, poisonous snake are controlled in external Bite.

Radix Puerariae is the tuber of legume pueraria lobata or Radix Puerariae rattan.Nature and flavor are sweet；Pungent；Flat.Return through spleen；Stomach；Lung；Bladder warp.Solution Flesh is brought down a fever；Deliver and examine；Promoting the production of body fluid to quench thirst；Shengyang Zhixie.Main fever caused by exogenous pathogens；Rigidity pain on the head and nape；Measles from the beginning of；Rash goes out not smooth；Epidemic febrile disease Thirsty；Diabetes；Have loose bowels；Dysentery；Hypertension；Coronary heart disease

Radix Rhodomyrti is myrtaceous of myrtle.Acrid in the mouth；Sweet；Mild-natured.Regulating QI to relieve pain；Dampness removing antidiarrheal；Passive stasis of blood hemostasis； Kidney tonifying blood-nourishing.Main epigastric pain；Dyspepsia；Vomiting and diarrhoea dysentery；The epoch-making subcutaneous ulcer of hypochondriac pain；Abdominal mass；Mass in the abdomen；Metrorrhagia；Impairment caused by overstrain bleeding；Fall Injure bitterly；Rheumatic arthralgia；Blood deficiency is weak；Lumbago due to renal deficiency；Knee joint is soft；Frequent micturition；Nebulousurine；Edema；Hernia；Carbuncle scrofula；Hemorrhoid；Tang Huo Wound.

Rattan of the Celastrus orbiculatus Thunb. for Celastraceae plant Celastrus orbiculatus Thunb..Nature and flavor are bitter；Pungent；Tepor.Return through liver；Bladder warp.Expelling wind and removing dampness； Inducing menstruation to relieve menalgia；Promoting blood circulation and detoxication.Main rheumatic arthritis；Numb limbs and tense tendons, paralysis；Headache；Toothache；Hernia；Dysmenorrhea；Amenorrhea；Children shy Wind；Osteopatia sprain；Dysentery；Acute filthy disease；Herpes zoster

Leaf of the Folium Sansevieriae Trifasclatae for Agavaceae plant Folium Sansevieriae Trifasclatae.Can adopt at any time.Nature and flavor《Luchuan book on Chinese herbal medicine》：" cool in nature, sour in the mouth." heat clearing away solution Poison.Cure cold, bronchitis, traumatic injury, skin infection.

Cortex Syringae is Oleaceae genus syringa syringa reticulata var mandshurica, is used as medicine with trunk and branch.Whole year can adopt, with October to next March in year fells preferably, is cut into segment, and using fresh herb is dried.Nature and flavor are bitter, are slightly cold.Lung heat clearing away, sputum eliminating, relieving cough and asthma.For coughing, a gas Guan Yan, bronchial asthma.

Herba galinsogae parviflorae is Compositae Herba galinsogae parviflorae, with all herbal medicine.Nature and flavor are light, put down.Hemostasis, antiinflammatory.Cure mainly tonsillitiss, throat Inflammation, acute icterohepatitises；Wound hemorrhage is controlled in external.

Fructus Litchi is Sapindaceae Fructus Litchi platymiscium Fructus Litchi, with root, aril（Sarcocarp）And core is used as medicine.Summer autumn harvest collection, dries. Nature and flavor sweet acid, temperature.Return through《Beautiful Chinese catalpa medicine is slack》:" enter spleen of Foot-Taiyin, liver channel of foot-Jueyin." promote the production of body fluid, beneficial blood, qi-regulating, pain relieving.Control tired Yearningly, singultuss, stomachache, scrofula, furuncle are swollen, toothache, traumatic hemorrhage.

Corm Eleocharitiss：Nature and flavor are sweet, tremble with fear.Enter lung, stomach.Heat clearing away, resolving sputum, removing food stagnancy.Control angry disease to quench one's thirst, jaundice, pyretic stranguria, mass in the abdomen, mesh Red, chew larynx and swell and ache, wart.

Dried root of the stick grass for the short and small Radix Ginseng of pinkwort.Nature and flavor are sweet；Bitter；Tepor.Tonifying the lung；Spleen invigorating；Yin nourishing Promote the production of body fluid.Main cough due to deficiency of the lung；Spleen eating less；Cardiopalmus spontaneous perspiration；Tired out weak；Xerostomia.

Dry rhizome of the Rhizoma Curcumae Longae for zingiberaceous plant Rhizoma Curcumae Longae.Excavate when winter stem and leaf is withered, clean, boil or steam to the saturating heart, shine Dry, remove fibrous root.Nature and flavor are pungent, bitter, temperature.Returns spleen, Liver Channel.Blood-breaking, inducing menstruation to relieve menalgia.Twinge for chest side of body, amenorrhea, abdominal mass, Rheumatism takes on arm pain, tumbling and swelling.

Lemmaphyllum microphullum Presl is the herb or whole herb with root that Plants of Polypodiaceae lies prostrate stone Herba pteridii latiusculi.Summer, autumn harvesting.Nature and flavor are pungent, cool.Lung heat clearing stops Cough, removing pathogenic heat from blood and toxic substance from the body.Lung abscess is controlled, hemoptysis is spitted blood, epistaxis, hematuria, carbuncle, mange, traumatic injury, acute toothache.

The invention has the beneficial effects as follows：The feedstuff of the present invention, special for autumn raising layer, it is possible to increase the life of laying hen Function, reduces autumn multiple disease, and keeps and promote the growth of laying hen, it is ensured that egg production.

Specific embodiment

It is further illustrated by detailed description below.

1 Chinese herbal medicine additive I of embodiment

Composition：Sirikaya 5g, bullock's-heart 4g, Digenea simplex (Wnlf.) C. Ag. 10g, Fructus Gleditsiae microcarpae 5g, Herba Artemisiae Annuae 7g, Herba Bidentis Bipinnatae 6g, Herba Thesii Longifolii 10g, work( Labor wood 6g, Fructus Aurantii Immaturus 4g, Herba Portulacae 4g, Flos Caryophylli 10g, Herba Euphorbiae Humifusae 4g, Herba hyperici elodeoidis 10g, Radix Puerariae 5g, Radix Rhodomyrti 3g, Celastrus orbiculatus Thunb. 10g, Folium Sansevieriae Trifasclatae 4g, Cortex Syringae 3g, Herba galinsogae parviflorae 7g, Fructus Litchi 6g, Corm Eleocharitiss 4g, stick grass 5g, Rhizoma Curcumae Longae 3g and Lemmaphyllum microphullum Presl 3g.

Preparation method：The components in certain proportion is mixed, powder is ground into；Powder will be obtained adds immersion 6 in cold water little When, to be cooked by slow fire, decocting time is 2 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water for being added is to obtain 2 times of the powder quality for obtaining；The filtering residue for filtering acquisition is added in cold water again, to be cooked by slow fire 2 hours, is filtered and is obtained second Filtrate, the quality of the water for being added are 2 times of the powder quality for obtaining；The first filtrate for obtaining and the second filtrate for obtaining are mixed Close, concentrating under reduced pressure removes water, dry, pulverize into powder, granularity is 80 mesh, obtains final product Chinese herbal medicine additive I.

2 Chinese herbal medicine additive II of embodiment

Composition：Sirikaya 10g, bullock's-heart 8g, Digenea simplex (Wnlf.) C. Ag. 14g, Fructus Gleditsiae microcarpae 9g, Herba Artemisiae Annuae 12g, Herba Bidentis Bipinnatae 12g, Herba Thesii Longifolii 15g, Caulis Mahoniae 12g, Fructus Aurantii Immaturus 7g, Herba Portulacae 7g, Flos Caryophylli 15g, Herba Euphorbiae Humifusae 8g, Herba hyperici elodeoidis 14g, Radix Puerariae 9g, Radix Rhodomyrti 6g, Celastrus orbiculatus Thunb. 15g, Folium Sansevieriae Trifasclatae 7g, Cortex Syringae 6g, Herba galinsogae parviflorae 13g, Fructus Litchi 9g, Corm Eleocharitiss 8g, stick grass 10g, Rhizoma Curcumae Longae 6g and Lemmaphyllum microphullum Presl 6g.

Preparation method：The components in certain proportion is mixed, powder is ground into；Powder will be obtained adds immersion 8 in cold water little When, to be cooked by slow fire, decocting time is 3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water for being added is to obtain 3 times of the powder quality for obtaining；The filtering residue for filtering acquisition is added in cold water again, to be cooked by slow fire 3 hours, is filtered and is obtained second Filtrate, the quality of the water for being added are 2 times of the powder quality for obtaining；The first filtrate for obtaining and the second filtrate for obtaining are mixed Close, concentrating under reduced pressure removes water, dry, pulverize into powder, granularity is 90 mesh, obtains final product Chinese herbal medicine additive II.

3 Chinese herbal medicine additive III of embodiment

Composition：Sirikaya 8g, bullock's-heart 6g, Digenea simplex (Wnlf.) C. Ag. 12g, Fructus Gleditsiae microcarpae 7g, Herba Artemisiae Annuae 9g, Herba Bidentis Bipinnatae 8g, Herba Thesii Longifolii 12g, work( Labor wood 8g, Fructus Aurantii Immaturus 5g, Herba Portulacae 6g, Flos Caryophylli 12g, Herba Euphorbiae Humifusae 6g, Herba hyperici elodeoidis 12g, Radix Puerariae 7g, Radix Rhodomyrti 5g, Celastrus orbiculatus Thunb. 12g, Folium Sansevieriae Trifasclatae 6g, Cortex Syringae 5g, Herba galinsogae parviflorae 9g, Fructus Litchi 8g, Corm Eleocharitiss 6g, stick grass 8g, Rhizoma Curcumae Longae 5g and Lemmaphyllum microphullum Presl 5g.

Preparation method：The components in certain proportion is mixed, powder is ground into；Powder will be obtained adds immersion 8 in cold water little When, to be cooked by slow fire, decocting time is 3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water for being added is to obtain 2 times of the powder quality for obtaining；The filtering residue for filtering acquisition is added in cold water again, to be cooked by slow fire 2 hours, is filtered and is obtained second Filtrate, the quality of the water for being added are 2 times of the powder quality for obtaining；The first filtrate for obtaining and the second filtrate for obtaining are mixed Close, concentrating under reduced pressure removes water, dry, pulverize into powder, granularity is 100 mesh, obtains final product Chinese herbal medicine additive III.

The safety testing of Chinese herbal medicine additive

First, acute toxicity test

1 test method

1.1 animal subject：Cleaning grade ICR mices, about 20 grams per only, male and female half and half.

1.2 test medicine：The Chinese herbal medicine additive I of the embodiment of the present invention 1.

The half maximum tolerance determination of the Chinese herbal medicine additive I of 1.3 embodiment of the present invention 1：40 mices are pressed body weight Equilibrium is divided into two groups, 20 per group, male and female half and half, sub-cage rearing.Experiment prospective adaptation is observed 1 week, after fasting 16 hours, with Concentration of ordinary dissolution (the 2g mL of Chinese herbal medicine additive agent I^-1) gavage, per 4 hours gavages once, single oral gavage capacity is every 0.5mL, even Continue and gavage three times, it is every 1.5mL to gavage total capacity, dosage is always gavaged for 150g kg body weight^-1, matched group gavage equivalent steaming Distilled water.Animal instant and toxicity, death condition in 14 days after observation administration.The behavioral activity of observation mice, spiritual shape State, hair color gloss, drinking-water of ingesting, Excreta situation, nose, eye, oral cavity whether there is situations such as abnormal secretion and death, continuous sight Examine 14 days.The pathological changes of internal organs such as all mices, the observation heart, liver, spleen, lung, kidney, brain were put to death in the 14th day and took tissue rapidly As for fixed in 4% neutral Liquor Formaldehyde, the inspection of conventional H .E. is carried out for making histopathologic slide.Record administration before with And after administration the 7th day and the 14th day mice body weight.

1.4 Histomorphologicals and analysis

Preliminary observation organizational structure, is analyzed under an optical microscope.Contrast test group and the organizational structure of matched group, find Test group mice organs are organized, particularly the damage of the liver and renal tissue of metabolism burden weight.

1.5 data statisticss and analysis

Body weight unit is gram (g), and experimental result data is expressed as mean+SD, using SPSS (17.0) statistical software In student t check groups between carry out comparing between group, P<0.05 is judged to significant difference, P<0.01 be judged to poor Heteropole is notable.

2 results and analysis

2.1 median lethal dose(LD 50) measurement results

After the administration of test group mouse stomach, drinking-water, skin, by hair, spirit, behavior, mouth and nose discharge of eye, Excreta (feces) etc. All right, feeding is had increased slightly with autonomic activitieses, and remaining project and control group mice are without being clearly distinguished from.Search for food within 3rd day Amount is returned with autonomic activitieses and drops to level before administration, without being clearly distinguished from compared with control group mice.Without little in 7 days of observation period Mus are dead, therefore Chinese herbal medicine additive I does not have the median lethal dose(LD 50) to mice and minimum lethal dose, therefore determine mice to Chinese herbal medicine The maximum tolerated dose of additive I.

2.2 maximum tolerance determination results

After the administration of test group mouse stomach, do not occur closing one's eyes, sleeping volt, the bad phenomenon such as restless.

The maximum tolerated dose multiple of mice is calculated as follows：

The daily maximum tolerated dose of Mus：2g ml × 0.5ml 0.02kg body weight^-1× 3 days^-1=150g kg body weight^-1

The current status of 2.3 experimental periods

After the administration of test group mouse stomach, there are not the bad phenomenon such as volt of closing one's eyes, crouch.Compared with matched group, test group mice is certainly Main activity increases, and feeding also increased, and feces are in pitchy.Within the observation period, test group mice without cry abnormal, tremble, Convulsions, movement disorder, sialorrhea, shed tears, rhinorrhea, dyspnea, heart beating exception, diarrhoea, constipation, the phenomenon such as intestinal tympaniteses occur, Mice fur gloss, after administration, in 14 days, there is not death in mice.The feeding of test group mice, drinking-water belong to normal.Additionally, examination A group mouse skin, good by hair, mental status, behavior, eyelid, eyeball, breathing, mouth and nose discharge of eye, Excreta situation is tested, With matched group without being clearly distinguished from.

2.4 body weight change

Mice had in body weight at 7 days, 14 days be given before Cmax and extremely large amount of Chinese herbal medicine additive I and after administration Micro difference.Concrete condition see the table below 1.

Impact (n=20) (units of the 1 medicine I of table to Mouse Weight：Gram)

Group	0th day	7th day	14th day
				Matched group	20.1±1.34	24.65±1.35	26.87±1.43
Test group	20.1±1.53	25.23±1.43	31.12±1.56

As shown in Table 1, the body weight increase situation of test group is increased slightly, and shows that Chinese herbal medicine additive I has rush to the body weight of mice Enter effect.

2.5 system postmortems and histopathologic examination's result

, without obvious substantially pathological changes, histopathologic examination also shows no obvious abnormalities for the anatomic observation heart, liver, spleen, lung, kidney, brain.

This result of the test shows, gavages medicine I aqueous solutions up to 150g kg body weight 3 times in ICR mices 12 hours^-1(quite In human body recommended dose 0.5g kg^-1300 times) when without obvious toxicity, point out Chinese herbal medicine additive I peroral administration Safe-dosaging limits are wider.It is generally believed that according to the weight, 1 day maximum dosage-feeding of mice is equivalent to the clinical consumption per day of adult More than 100 times is exactly safer.The above results show that Chinese herbal medicine additive I gavages mice with maximum dosage-feeding and do not produce Acute toxicity.

2nd, subacute toxicity test

2.1 test method

2.1.1 animal subject：SD rats, about 200 grams per only, male and female half and half.

2.1.2 test medicine：The Chinese herbal medicine additive II of the embodiment of the present invention 2

2.1.3 Chinese herbal medicine additive II subchronic toxicities test：By 80 healthy cleaning grade SD rats in constant temperature laboratory (temperature Degree：24 ± 1 DEG C, humidity：50 ± 10%) adapt to 7 days.Male and female half and half, are randomly divided into 4 groups by body weight equilibrium, i.e., Chinese herbal medicine adds Plus the high, medium and low dosage groups of agent II and matched group, 20 per group, rat free water.High dose group gives Chinese herbal medicine additive II 150g kg body weight^-1(equivalent to adult's effective dose 0.5g kg body weight^-1300 times), middle dose group gives Chinese herbal medicine Additive II 100g kg body weight^-1(equivalent to adult's effective dose 0.5g kg body weight^-1200 times), low dose group is given Chinese herbal medicine additive II 50g kg-1 are given (equivalent to adult's effective dose 0.5g kg body weight^-1100 times), matched group is given Give isometric(al) distilled water.Administration volume is 100 g of 0.75mL^-1Body weight, once a day, successive administration 7 days changes pad daily Material, drinking-water and diet, are weighed once daily, adjust dosage according to body weight change.

Continue observation 28 days after drug withdrawal, record feed intake and body weight weekly.Fasting 12 hours after off-test, neck collection of breaking Blood, closes in heparin sodium anticoagulant blood-collecting pipe, carries out hematological examination.The blood for collecting is used 1500rpm, 10 minutes points Blood biochemical analysis inspection is carried out from serum.After obduction, the main organs such as the systems inspection heart, liver, spleen, lung, kidney, are gathered afterwards The tissue of the internal organs such as the heart, liver, spleen, lung, kidney makes pathological section, carries out pathological examination after dyeing using H.E..

2.1.4 hematology's blood routine examination

Carry out hematology's routine blood indexes inspection, including hemoglobin (HGB), erythrocyte (RBC), MCV (MCV), Average hemoglobin content (MCH), packed cell volume (HCT), average hemoglobin content (MCH), the averagely blood red egg of erythrocyte White concentration (MCHC), Red cell distribution width (RDW), reticulocyte (RETIC), total white blood cellses (WBC), neutral grain Cell (NEU), lymphocyte (LYM), mononuclear cell (MONO), eosinophilic granulocyte (EOS), basophilic granulocyte (BASO), The inspection of 16 projects such as mean platelet volume (MPV) and MPW (PDW).

2.1.5 blood biochemical analysis inspection

Blood biochemical analysis index checking, including glutamate pyruvate transaminase (ALT), glutamic oxaloacetic transaminase, GOT (AST), blood urea nitrogen (BUN) and flesh The inspection of the indexs such as acid anhydride (CREA).

2.1.6 Histomorphological and analysis

Preliminary observation organizational structure, is analyzed under an optical microscope.Contrast test group and the organizational structure of matched group, find Test group mice organs are organized, particularly the damage of the liver and renal tissue of metabolism burden weight.

2.1.7 data statisticss and analysis

Body weight unit is gram (g), and experimental result data is expressed as mean+SD, using SPSS (20.0) statistical software In one factor analysis of variance (One-Way ANOVA) model carry out group difference significance test, P<0.05 be judged to poor Different notable, P<0.01 is judged to that difference is extremely notable.

2.2 results and analysis

2.2.1 the current status of experimental period

Rats in test groups occurs the bad phenomenon such as volt of closing one's eyes, crouch after gastric infusion, not.In 7 days administration phases, with matched group Compare, rats in test groups does not occur that cry is abnormal, trembles, faints from fear, movement disorder, sialorrhea, shed tears, rhinorrhea, dyspnea, The phenomenons such as heart beating exception, diarrhoea, constipation, intestinal tympaniteses, rat fur light are soft and smooth, in 7 days of administration and the observation period 28 In it, there is not the death caused because of drug toxicity in rat.The feeding of administration group rat, drinking-water belong to normal.Additionally, administration group Rat within 28 day observation period, skin, by hair, mental status, behavior, eyelid, eyeball, breathing, mouth and nose discharge of eye, excretion Principle condition is also normal, and nothing is clearly distinguished from compared with matched group.

2.2.2 body weight change

In experimental period, each administration group rat (female, male) body weight and matched group are than more significant no difference of science of statistics.That is, 7 After it medication, 28 days conventinal breedings, between administration each group, same sex rat body weight there was no significant difference (P> 0.05).Tool Body result see the table below.(table 2)

Impact (n=10) of the 2 Chinese herbal medicine additive II gavages of table to female, male rat body weight

As shown in Table 2, same sex rat has slightly difference in body weight within the experimental period between each group.Show long-term taking Chinese herbal medicine After additive II, as the increase of dosage, the body weight increase of rat are slightly fast, show that this Chinese herbal medicine additive has increasing to rat body weight Plus facilitation.

2.2.3 hematology's blood routine examination result

Hematology results show that the Chinese herbal medicine additive II gavages of various dose are aobvious to rat items hematological indices nothing Writing affects.That is, after the medication at 7 days, 28 days conventinal breedings, every hematological indices of each group rat have no significantly Sex differernce (P> 0.05).Concrete outcome see the table below.(table 3)

Measure project	Unit	High dose group	Middle dose group	Low dose group	Matched group
						Red blood cell count(RBC)（RBC）	M/uL	8.2±0.23	8.1±0.2	8.05±0.23	7.96±0.34
Packed cell volume (HCT)	%	45.7±1.3	45.5±1.3	45.2±1.32	44.9±1.4
						Hemoglobin (HGB)	g/dl	15.8±1.2	15.4±1.23	15.2±1.25	14.7±1.33
MCV (MCV)	Fl	54.1±2.02	53.6±2.02	53.2±2.2	53.2±2.3
						Average hemoglobin content（MCH）	Pg	19.1±0.32	18.6±0.35	18.4±0.45	19.2±0.5
Mean corpuscular hemoglobin（MCHC）	g/dL	35.5±2.4	35.4±2.15	35.1±2.4	34.5±2.2
						Erythrocyte is evenly distributed density（RDW）	%	21.5±1.35	21.2±1.3	21.5±1.2	21.2±1.23
Reticulocyte（RETIC）	K/uL	376.5±45.1	382.3±45.4	386.4±45.5	394.5±45
						Total white blood cellses（WBC）	K/uL	15.3±1.2	14.4±1.4	13.9±1.6	13.8±1.4
Neutrophilic granulocyte（NEU）	K/uL	1.74±1.2	1.71±1.4	1.64±1.23	1.56±1.23
						Lymphocyte（LYM）	K/uL	11.5±2.32	11.2±2.32	10.8±2.2	10.6±2.1
Mononuclear cell（MONO）	K/uL	0.58±0.23	0.63±0.22	0.62±0.22	0.53±0.34
						Eosinophilic granulocyte（EOS）	K/uL	0.43±0.26	0.42±0.21	0.42±0.12	0.31±0.34
Basophilic granulocyte（BASO）	K/uL	0.01±0.01	0.01±0.01	0.01±0.01	0.01±0.01
						Mean platelet volume (MPV)	FL	6.61±0.12	6.51±0.2	6.45±0.2	6.41±0.14
MPW（PDW）	fL	7.2±0.25	6.7±0.35	6.2±0.34	5.6±0.45

As shown in Table 3, rat is within the experimental period, without particularly significant sex differernce in every blood routine project between each group.This Individual result shows, after long-term taking Chinese herbal medicine additive II, medicine will not cause obvious hematology to affect on rat.

2.4.4 blood biochemical analysis inspection result blood biochemical analysis testing result shows, various dose Chinese herbal medicine additive II Solution gavage is to (P that do not make significant difference such as the glutamate pyruvate transaminase of rat, blood urea nitrogen, glutamic oxaloacetic transaminase, GOT and creatinines> 0.05).

Impact (n=20) of the 4 Chinese herbal medicine additive II gavages of table to rat blood biochemical indexes

Measure project	Unit	High dose group	Middle dose group	Low dose group	Matched group
						Glutamate pyruvate transaminase（ALT）	U/L	50.5±6.1	48.2±6.3	46.5±6.2	45.6±6.2
Glutamic oxaloacetic transaminase, GOT（AST）	U/L	101.5±15.3	99.8±15.2	99.5±15.3	101.5±15.1
						Blood urea nitrogen（BUN）	mmol/L	6.43±0.61	6.65±0.64	7.3±0.52	7.2±0.35
Creatinine（CREA）	mmol/L	29.7±3.2	30.5±3.5	315±3.2	34.4±2.67

As shown in Table 4, rat is within the experimental period, between each group in every blood biochemical analysis project without significant difference therefore, After prolonged administration of drugs II, medicine will not cause obvious blood biochemical analysis to affect on rat.

2.4.5 system postmortem and histopathologic examination's result

Postmortem has no, the internal organs inherent structure such as the various dose drug treating group rat heart, liver, spleen, lung and kidney Clearly, without pathological change.

3 summarize

This result of study shows, gavage within continuous 7 days various dose Chinese herbal medicine additive II aqueous solutions to rat spirit, behavior, Activity, hair color, Excreta etc. do not have undesirable effect, and drug withdrawal also had no that rat has obvious behavioristicss, body surface in 28 days Feature and Excreta exception.

In 28 days of withdrawal observation phase, with there are no significant between sex each group rat weight differences, hematology and blood Biochemical indicator also no abnormality seen.Additionally, in blood biochemistry detection, rat urea nitrogen levels, middle and high dosage group are not had with matched group Significant difference.Due to glutamate pyruvate transaminase index in the rat blood urea nitrogen index of the middle and high dosage group of gavage, routine blood test, gavage is high The rat gpt level of the Chinese herbal medicine additive II groups of dosage, without significant difference and normal compared with matched group Within the scope of, show that the Chinese herbal medicine additive II of maximum concentration of ordinary dissolution does not have toxic and side effects to liver, show any dosage Chinese herbal medicine additive II is to kidney without toxicity.Histopathology testing result shows oral various dose Chinese herbal medicine additive II aqueous solutions do not cause substantially damage to main organs such as the heart, liver, spleen, lung, kidneys.

Therefore, Chinese herbal medicine additive II oral administrations will not cause subchronic injury or subchronic toxicity to animal.

Comprehensive, the Chinese herbal medicine additive that the present invention adds does not have acute toxicity, and not there is inferior toxicity and long-term poison yet Property.

4 feedstuff I of embodiment

Composition：Semen Maydiss 50g, soybean meal 10g, Semen arachidis hypogaeae cake 5g, wheat-middlings 4g, vegetable oil 1g, stone powder 4g, calcium hydrogen phosphate 1g, Sal 0.5g and Chinese herbal medicine additive 1g.The traditional Chinese medicinal additive I that Chinese herbal medicine additive is obtained using the embodiment of the present invention 1.

Prepare：The corn and soybean dregs of rice and Semen arachidis hypogaeae cake are added to pulverizer to be crushed, pulverized particles are 60 mesh, sieve； Each raw material after by process is added in blender and carries out physical agitation and obtain feedstuff I after 2 hours.

One chicken farm of Dezhou, cultivation have 1000 laying hens, part of in August, 2015,250 laying hens following epidemic situation occur：Egg Production of Laying Hens Rate averagely declines 10% or so.All diseased chickens most distinct feature is that anemia, and cockscomb is pale without color.The visible corpse of cut open inspection diseased chicken Become thin, blood is thin, whole-body muscle is pale.Liver, splenomegaly, surface have petechia, have the white tuberosity that foxtail millet grain is big on liver.Digestion Road is congested, and there is blood and slime in abdominal cavity.There is the petechial hemorrhage of needle point size on kidney hemorrhagic disease, lower limb flesh and chest muscle.Morbidity is anxious, does not slightly note at ordinary times Meaning, finds the diseased chicken of tired contracting or dead chicken at corner wall when chicken is fed, and serious chicken can bring up bloody sputum or after death bicker is bled.Send out Sick day age is more at 15-35 days or so.Through being diagnosed as white comb.Existing 50 sick laying hens are dead.

Process：By remaining 200 ill sick laying hen isolation, and cleaning sterilizing is carried out to whole plant, while to supporting Laying hen is grown using feedstuff I feedings.

Through feeding 1 week, 200 sick laying hens had 194 diseases to fully recover, and 6 return to normal vital sign, and lay eggs Before amount recovers disease.

Through feeding 4 weeks, plant did not occur the epidemic situation of white comb again, and the egg production of whole plant increases by a year-on-year basis about 12%.

5 Feed II of embodiment

Composition：Semen Maydiss 60g, soybean meal 15g, Semen arachidis hypogaeae cake 10g, wheat-middlings 6g, vegetable oil 4g, stone powder 6g, calcium hydrogen phosphate 1.5g, food Salt 0.5g and Chinese herbal medicine additive 2g.The traditional Chinese medicinal additive II that Chinese herbal medicine additive is obtained using the embodiment of the present invention 2.

Prepare：The corn and soybean dregs of rice and Semen arachidis hypogaeae cake are added to pulverizer to be crushed, pulverized particles are 70 mesh, sieve； Each raw material after by process is added in blender and carries out physical agitation and obtain Feed II after 2 hours.

One chicken farm of Binzhou, cultivation have 1000 laying hens, part of in September, 2015 to have part laying hen diarrhoea phenomenon occur, take laying hen solution Often have when abdominal cavity is opened when cuing open a kind of pungent smelling as of rotten fish.Through being diagnosed as bacterial diarrhea.There are 50 laying hens not lay eggs, and There are 120 laying hens symptom of diarrhea and physiological function deterioration occur.

Process：By ill 170 sick laying hen isolation, and cleaning sterilizing is carried out to whole plant, while to plant Laying hen uses Feed II feeding.

Through feeding 1 week, 170 sick laying hen symptoms disappeared, and recover normal vital signs, and before egg production recovers disease.

Through feeding 4 weeks, plant did not occur the epidemic situation of bacterial diarrhea again, and the egg production of whole plant increases on year-on-year basis It is about 13%.

6 Feed II I of embodiment

Composition：Semen Maydiss 55g, soybean meal 12g, Semen arachidis hypogaeae cake 7g, wheat-middlings 5g, vegetable oil 3g, stone powder 5g, calcium hydrogen phosphate 1g, Sal 0.5g and Chinese herbal medicine additive 2g.The traditional Chinese medicinal additive III that Chinese herbal medicine additive is obtained using the embodiment of the present invention 3.

Prepare：The corn and soybean dregs of rice and Semen arachidis hypogaeae cake are added to pulverizer to be crushed, pulverized particles are 70 mesh, sieve； Each raw material after by process is added in blender and carries out physical agitation and obtain Feed II I after 2 hours.

One chicken farm of Liaocheng, cultivation have 3000 laying hens, part of in September, 2015,250 laying hens following symptom occur：Performance is slight Dyspnea, cough, tracheal rale, have " snore " sound.Lassitude, subtract food, draw yellow loose stool, symptom is not bery serious, has Only a few is dead.Fall ill the 2nd day to lay eggs and begin to decline, drop to minimum point within 1～2 week, some laying rate of laying hen can drop to half, And soft egg and abnormal-shape egg is produced, Ovum Gallus domesticus album is thinning, and Ovum Gallus domesticus album is separated with egg yolk, and the incubation rate of hatching egg also reduces.Through being diagnosed as chicken gas Guan Yan.Feeding effect is badly influenced.

Process：By ill 250 sick laying hen isolation, and cleaning sterilizing is carried out to whole plant, while to plant Laying hen uses Feed II I feeding.

Through feeding 1 week, 250 sick laying hens had 242 diseases to fully recover, and egg production is back to normal.8 return to normal life Sign is ordered, and egg production is returned to normal.

Through feeding 4 weeks, plant did not occur the symptom of chicken bronchitis again, and the egg production of whole plant increases on year-on-year basis It is about 14%.

Test

Test period：In September, 2014-October, the time of 4 weeks

Test site：Six directions branch raising layer field

Subjects：1200 close laying hens of body weight are tested, and body weight is in 1kg or so.

Select, with a batch of 40 week old bird inlay 1200, to be randomly divided into 4 groups, per group of 300 laying hens, preliminary trial period Afterwards, under the conditions of each group egg production difference is inapparent, each test group of random arrangement, test layer breeding in closing hen house in, Upper and lower three layers of staged cage, free water, feeding three times daily, artificial lighting 16h feed three kinds of different process processing respectively Feedstuff, immune programme for children and other daily management modes are routinely carried out by plant.

During test, egg is picked up daily twice, count egg number every time, weigh total egg size, calculated according to egg number and egg size Go out single egg size.Laying rate is calculated according to chicken number and egg number；Daily feed supply amount and surpluses are recorded, feed consumption is calculated Amount, off-test calculate feedstuff-egg ratio.During test, observation chicken is mined massively food and health status etc., and records death and superseded chicken feelings Condition.

Result of the test

The data such as the feed intake of whole experimental period laying hen, egg size, laying rate are calculated, 1 is shown in Table.

Impact of the 5 three productions technique of table to production performance

Project	Matched group	Feedstuff I groups	Feed II group	Feed II I group
					Laying hen dies of illness number	32	7	6	8
Average feed intake（G/ pcs/day）	105.21	102.12	101.78	101.67
					Average egg production	83.5%±0.32	92.6%±0.35	91.3%±0.28	91.9%±0.36
Average egg weight（G/ piece）	58.43	61.23	61.16	62.45
					Soft egg rate	3.6%	0.28%	0.23%	0.25%

As shown in Table 5, the raising situation of three of the invention feedstuff groups is compared with being better than matched group.Laying hen dies of illness to count and has declined, and puts down Laying rate increases, and average egg weight has growth.Soft egg rate decreases.

The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and Within principle, any modification, equivalent substitution and improvements that is made etc. should be included within the scope of the present invention.

Claims (6)

1. a kind of autumn laying-hen compound feed, it is characterised in that including following raw material：Semen Maydiss 50-60 parts, soybean meal 10-15 Part, Semen arachidis hypogaeae cake 5-10 parts, wheat-middlings 4-6 parts, vegetable oil 1-4 parts, stone powder 4-6 parts, calcium hydrogen phosphate 1-1.5 parts, Sal 0.1-0.5 Part and Chinese herbal medicine additive 1-2 parts.

2. autumn laying-hen compound feed according to claim 1, it is characterised in that the Chinese herbal medicine additive include with Lower composition：Sirikaya, bullock's-heart, Digenea simplex (Wnlf.) C. Ag., Fructus Gleditsiae microcarpae, Herba Artemisiae Annuae, Herba Bidentis Bipinnatae, Herba Thesii Longifolii, Caulis Mahoniae, Fructus Aurantii Immaturus, Herba Portulacae, fourth Perfume, Herba Euphorbiae Humifusae, Herba hyperici elodeoidis, Radix Puerariae, Radix Rhodomyrti, Celastrus orbiculatus Thunb., Folium Sansevieriae Trifasclatae, Cortex Syringae, Herba galinsogae parviflorae, Fructus Litchi, Corm Eleocharitiss, stick grass, Rhizoma Zingiberis Recens Yellow and Lemmaphyllum microphullum Presl.

3. autumn laying-hen compound feed according to claim 1 and 2, it is characterised in that the Chinese herbal medicine additive bag Include the composition of following parts by weight：Sirikaya 5-10 parts, bullock's-heart 4-8 parts, Digenea simplex (Wnlf.) C. Ag. 10-14 parts, Fructus Gleditsiae microcarpae 5-9 parts, green grass or young crops Artemisia 7-12 parts, Herba Bidentis Bipinnatae 6-12 parts, Herba Thesii Longifolii 10-15 parts, Caulis Mahoniae 6-12 parts, Fructus Aurantii Immaturus 4-7 parts, Herba Portulacae 4-7 parts, Flos Caryophylli 10-15 parts, Herba Euphorbiae Humifusae 4-8 parts, Herba hyperici elodeoidis 10-14 parts, Radix Puerariae 5-9 parts, Radix Rhodomyrti 3-6 parts, Celastrus orbiculatus Thunb. 10-15 parts, Folium Sansevieriae Trifasclatae 4-7 parts, Cortex Syringae 3-6 parts, Herba galinsogae parviflorae 7-13 parts, Fructus Litchi 6-9 parts, Corm Eleocharitiss 4-8 parts, stick grass 5-10 parts, Rhizoma Curcumae Longae 3-6 parts and spiral shell Operculum grass 3-6 parts.

4. the autumn laying-hen compound feed according to claim 1 or 2 or 3, it is characterised in that the Chinese herbal medicine additive Composition including following parts by weight：8 parts of Sirikaya, 6 parts of bullock's-heart, 12 parts of Digenea simplex (Wnlf.) C. Ag., 7 parts of Fructus Gleditsiae microcarpae, 9 parts of Herba Artemisiae Annuae, blind Intestinal grass 8 parts, 12 parts of Herba Thesii Longifolii, 8 parts of Caulis Mahoniae, 5 parts of Fructus Aurantii Immaturus, 6 parts of Herba Portulacae, 12 parts of Flos Caryophylli, 6 parts of Herba Euphorbiae Humifusae, 12 parts of Herba hyperici elodeoidis, 7 parts of Radix Puerariae, 5 parts of Radix Rhodomyrti, 12 parts of Celastrus orbiculatus Thunb., 6 parts of Folium Sansevieriae Trifasclatae, 5 parts of Cortex Syringae, 9 parts of Herba galinsogae parviflorae, 8 parts of Fructus Litchi, 6 parts of Corm Eleocharitiss, rod 5 parts of 8 parts of rod grass, 5 parts of Rhizoma Curcumae Longae and Lemmaphyllum microphullum Presl.

5. the autumn laying-hen compound feed according to claim 1-4, it is characterised in that the Chinese herbal medicine additive its side Method is：The components in certain proportion is mixed, powder is ground into；Powder will be obtained and added in cold water and be soaked 6 hours～12 hours, with It is cooked by slow fire, decocting time is 3 hours～5 hours, and decoction liquor is filtered, obtains the first filtrate, the quality of the water for being added is 2～4 times of the powder quality of acquisition；The filtering residue for filtering acquisition is added in cold water again, to be cooked by slow fire 2 hours～4 hours, Filter and obtain the second filtrate, the quality of the water for being added is 2～4 times of the powder quality for obtaining；By obtain the first filtrate and The the second filtrate mixing for obtaining, concentrating under reduced pressure remove water, dry, pulverize into powder, and granularity adds for 80～120 mesh, i.e. Chinese herbal medicine Plus agent.

6. the autumn laying-hen compound feed according to claim 1-5, it is characterised in that feed producing method is：By jade Rice, soybean meal and Semen arachidis hypogaeae cake are added to pulverizer and are crushed, and pulverized particles are 60-80 mesh, sieve；Each original after by process Material is added to after carrying out physical agitation 2-3 hour in blender and obtains feedstuff.