CN106399163B - 一种抗衰老益生菌制剂及制备方法 - Google Patents
一种抗衰老益生菌制剂及制备方法 Download PDFInfo
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- CN106399163B CN106399163B CN201610809684.9A CN201610809684A CN106399163B CN 106399163 B CN106399163 B CN 106399163B CN 201610809684 A CN201610809684 A CN 201610809684A CN 106399163 B CN106399163 B CN 106399163B
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2400/00—Lactic or propionic acid bacteria
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- A23V2400/169—Plantarum
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/533—Longum
Abstract
Description
Claims (4)
Priority Applications (1)
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Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1796540A (zh) * | 2004-12-29 | 2006-07-05 | 王敖喜 | 具有抗肠道致病菌和抗氧化特性的双歧杆菌及其用途 |
CN101611738A (zh) * | 2008-06-26 | 2009-12-30 | 遵义市乳制品有限公司 | 双歧多益生菌多功能酸奶 |
CN102851259A (zh) * | 2011-06-28 | 2013-01-02 | 花王株式会社 | 抗氧化剂的制造方法 |
CN103555707A (zh) * | 2013-10-28 | 2014-02-05 | 青岛蔚蓝生物集团有限公司 | 一种制备复合菌剂的方法 |
CN104509864A (zh) * | 2015-01-20 | 2015-04-15 | 北京东方兴企食品工业技术有限公司 | 一种具有改善胃肠功能的营养保健食品及其制备方法 |
CN104543679A (zh) * | 2015-01-23 | 2015-04-29 | 绍兴上虞宏晟技术转让服务有限公司 | 一种含益生菌的保健食品及其制备方法 |
CN104623122A (zh) * | 2015-01-12 | 2015-05-20 | 江瀚生物科技(上海)有限公司 | 一种具有抗疲劳功能的生物制剂及其制作方法 |
CN104781390A (zh) * | 2012-08-16 | 2015-07-15 | 庆熙大学校产学协力团 | 具有对衰老及痴呆的预防和/或治疗活性的乳酸菌 |
CN104894005A (zh) * | 2015-04-30 | 2015-09-09 | 江苏紫石微康生物科技有限公司 | 一种高产胞外多糖的乳酸菌bl21及制备方法和应用 |
CN104928208A (zh) * | 2015-04-30 | 2015-09-23 | 江苏紫石微康生物科技有限公司 | 一种植物乳杆菌Lp90及其筛选方法和应用 |
-
2016
- 2016-09-08 CN CN201610809684.9A patent/CN106399163B/zh active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1796540A (zh) * | 2004-12-29 | 2006-07-05 | 王敖喜 | 具有抗肠道致病菌和抗氧化特性的双歧杆菌及其用途 |
CN101611738A (zh) * | 2008-06-26 | 2009-12-30 | 遵义市乳制品有限公司 | 双歧多益生菌多功能酸奶 |
CN102851259A (zh) * | 2011-06-28 | 2013-01-02 | 花王株式会社 | 抗氧化剂的制造方法 |
CN104781390A (zh) * | 2012-08-16 | 2015-07-15 | 庆熙大学校产学协力团 | 具有对衰老及痴呆的预防和/或治疗活性的乳酸菌 |
CN103555707A (zh) * | 2013-10-28 | 2014-02-05 | 青岛蔚蓝生物集团有限公司 | 一种制备复合菌剂的方法 |
CN104623122A (zh) * | 2015-01-12 | 2015-05-20 | 江瀚生物科技(上海)有限公司 | 一种具有抗疲劳功能的生物制剂及其制作方法 |
CN104509864A (zh) * | 2015-01-20 | 2015-04-15 | 北京东方兴企食品工业技术有限公司 | 一种具有改善胃肠功能的营养保健食品及其制备方法 |
CN104543679A (zh) * | 2015-01-23 | 2015-04-29 | 绍兴上虞宏晟技术转让服务有限公司 | 一种含益生菌的保健食品及其制备方法 |
CN104894005A (zh) * | 2015-04-30 | 2015-09-09 | 江苏紫石微康生物科技有限公司 | 一种高产胞外多糖的乳酸菌bl21及制备方法和应用 |
CN104928208A (zh) * | 2015-04-30 | 2015-09-23 | 江苏紫石微康生物科技有限公司 | 一种植物乳杆菌Lp90及其筛选方法和应用 |
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