CN106389172A - Cosmetic containing herba cistanche and oviductus ranae - Google Patents
Cosmetic containing herba cistanche and oviductus ranae Download PDFInfo
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- CN106389172A CN106389172A CN201610300263.3A CN201610300263A CN106389172A CN 106389172 A CN106389172 A CN 106389172A CN 201610300263 A CN201610300263 A CN 201610300263A CN 106389172 A CN106389172 A CN 106389172A
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- Prior art keywords
- saline cistanche
- cistanche
- oviductus rannae
- oviductus
- cosmetics containing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention relates to the field of cosmetics, in particular to a cosmetic containing herba cistanche and oviductus ranae. The cosmetic containing the herba cistanche and the oviductus ranae provided by the invention takes the herba cistanche and the oviductus ranae as active skin care matters. Specifically, on the basis of a modern technology, an extract or a fermented material of the herba cistanche extract is subjected to supercritical carbon dioxide extraction, so that a high-content active ingredient is obtained. According to the cosmetic provided by the invention, through a synergistic effect of the compatibility of the herba cistanche and the oviductus ranae, more obvious effects of resisting aging and resisting oxidation are developed when the herba cistanche and the oviductus ranae are applied to the cosmetic as the active skin care matters; by inhibiting elastinase and/or stimulating the generation of collagen, skin condition is significantly improved, and an outstanding anti-aging effect is achieved; and with the application of the process provided by the invention, the effects of the herba cistanche and the elastinase can be fully developed and utilized, and the waste of traditional Chinese medicinal materials and active ingredients thereof can be avoided.
Description
Technical field
The present invention relates to cosmetic field is and in particular to a kind of cosmetics containing saline cistanche OVIDUCTUS RANNAE.
Background technology
Saline cistanche is loaded in《Sheng Nong's herbal classic》, it is classified as top grade, the effects such as there is kidney-replenishing, benefiting essence-blood, relax bowel.《Chinese Pharmacopoeia》Record
Saline cistanche is the fleshy stem of orobanchaceae plant cistanche and Cistanche tubulosa dry zone scale leaf.Saline cistanche mainly contain benzyl carbinol glycosides, iridoid glycoside,
The chemical composition such as lignanoid and sterol, wherein phenylethanoid glycosides are the main active in saline cistanche, have establishing-Yang, anti-oxidant, anti-aging, carry
The several functions such as high immunity, enhancing memory.
OVIDUCTUS RANNAE (Ranae Oviductus) is the fallopian tubal of ranid Rana temporaria chensinensis (Rana temporaria chensinensis David) the female frog,
Obtain through gathering and processing dry.OVIDUCTUS RANNAE is also called oviductus ranae, oviductus ranae, Oviductus Ranae, Oviductus Ranae, clam ant oil, snow frog oil or wood frog's fallopian tube cream.Black Longjiang,
Jilin, Liaoning are the main place of production, wherein based on Jilin.OVIDUCTUS RANNAE is sweet, salty, mild-natured, have tonifying kidney and benefiting sperm, invigorating spleen and reinforcing stomach, enriching yin and nourishing kidney,
The effects such as moistening lung is promoted the production of body fluid.OVIDUCTUS RANNAE is strengthened the body resistance to consolidate the constitution medicine as one kind, to the curative effect such as general deficiency of qi, energy consume, the not good, neurasthenia of memory relatively
Good, it is rich in the good reputation of nourishing " soft gold ", the Qing Dynasty was once listed in royal offerings, was also China's specialties of the Northeast, famous and precious dietotherapy Chinese medicine well-known at home and abroad.
Gao Yanling in 1996 reports OVIDUCTUS RANNAE and has obvious antifatigue effect；Chen Xiaoping also reports OVIDUCTUS RANNAE and can adjust human endocrine, has anti-tired
Work is used；According to another the report such as Liu Yulan in 1997, OVIDUCTUS RANAE can extend mouse pole-climbing, roller and swimming time, normal healthy animal be had
Certain antifatigue effect.
Prior art is many to be combined saline cistanche, OVIDUCTUS RANNAE and other active components, for different medical usages.Such as CN201110123123
Disclose a kind of Chinese medicine for treating ephritis, wherein in addition to containing saline cistanche, OVIDUCTUS RANNAE, also unknown essence, Long Stephania Herb, red stilbene, long-noded pit viper
Tens kinds of Chinese medicines such as grass, Chinese cassia tree, goldenrod, various acute and chronic nephritis can quickly and efficiently be treated by this Chinese medicine.CN201210199964
The snow disclosing a kind of kidney tonifying premodial qi, resisting cancer and beautifying faces breathes out food and preparation method thereof, using snow Kazakhstan be equipped with glossy ganoderma, Chinese yam, ginseng, pilose antler, cultivated land,
Matrimony vine, the fruit of medicinal cornel, desert cistanche, Semen sesami nigrum, mushroom, nutrition is more comprehensively it is easier to absorb, thus the effect of reach kidney tonifying premodial qi, resisting cancer and beautifying faces.
CN201510108792 discloses a kind of Chinese medicine preparation having and eliminating motility limbs fatigue effect, is to be made up of the bulk drug of following weight portion：
30～40 parts of the Radix Astragali, 30～40 parts of saline cistanche, 20～30 parts of matrimony vine, 20～30 parts of motherwort, 20～30 parts of radix achyranthis bidentatae, the bark of eucommia 10～20
Part, 10～20 parts of Chinese yam, 10～20 parts of the tuber of dwarf lilyturf, 5～15 parts of paniculate swallowwort, 5～15 parts of OVIDUCTUS RANNAE, 20～30 parts of Radix Glycyrrhizae；Have antifatigue
Effect, can eliminate/alleviate athletic limbs fatigue, strengthen athletic physical efficiency, make post exercise body fast quick-recovery physical efficiency, and fortune can be increased
Mobilize heart reservation ability, suitable sportsman drinks.Master's thesis that Wang Gaoxue (Xibei Univ. of Agricultural ＆ Forest Science ＆ Technology) delivers and《Chinese patent drug》Upper
The article of table is pointed out, OVIDUCTUS RANNAE has that composition is single, the not congruent weak point of effect, then with OVIDUCTUS RANNAE as primary raw material, is aided with it by theory of traditional Chinese medical science
His kinds of traditional Chinese medicines, carries out the screening of antifatigue effect；Although having investigated the effect of OVIDUCTUS RANNAE independent compatibility saline cistanche, the effect obtaining in research process
Really not good enough, finally the formula of preferably OVIDUCTUS RANNAE antifatigue compound is：OVIDUCTUS RANNAE 500mg, rhodiola root 220mg, saline cistanche 100mg, strand
Blue 80mg, ginseng 200mg.In other prior arts, CN99113085 discloses a kind of nourishing health granule, its be with OVIDUCTUS RANNAE,
Saline cistanche is raw material, and size-reduced Cheng Fenzai makes graininess electuary, and proposes that the two is compatible, and its effect can be complementary, strengthens its tonic
Effect.
Extracellular matrix (ECM) particular importance in aging course of skin.ECM provide not only Skin Cell attachment and being properly oriented within of skin
The three-dimensional rack needing, and the ECM also transmission pipeline as the signal to Skin Cell plays a role, and described signal stimulus Skin Cell is implemented
Key function, such as tissue repair.When destroying ECM by environmental exposure or usual aging process, skin has just developed undesired aging
Outward appearance, such as wrinkle.For reducing the destruction of already present fibrous proteins in skin, generation this proteinoid more are stimulated to be cosmetics neck
The expectation in domain.For example, HLE be by activate leucocyte release serine protease, can be exposed to UV light or its
In skin under its excitant stimulus, cause the extensive destruction of multiple ECM protein matter components.Therefore, there is the inhibitory action to this protease,
Thus protecting the cosmetics of ECM damage to be favourable.
CN201510650282 discloses saline cistanche, and particularly the biologic ferment of the extract of saline cistanche and/or saline cistanche is used for cosmetic composition
To improve skin condition and/or anti-aging effects are provided.
Prior art does not also have to be reported saline cistanche and OVIDUCTUS RANNAE compatibility as skin care active thing used in cosmetics.
Content of the invention
Research finds, using saline cistanche and OVIDUCTUS RANNAE compatibility as skin care active thing uses in cosmetics when, can work in coordination with and play anti-aging, antioxygen
The effect changed, significantly improves skin by suppressing elastoser and/or stimulate collagen to produce, has the anti-aging effects of brilliance.
The present invention provides a kind of cosmetics containing saline cistanche OVIDUCTUS RANNAE, and it is using saline cistanche and OVIDUCTUS RANNAE as skin care active thing.
Further, the present invention utilizes modern crafts, cistanche extracts or fermentate is carried out supercritical carbon dioxide extracting, is obtained in that height contains
The active ingredient of amount.
Further, after described herba cistanches extract or ferment, carry out supercritical carbon dioxide extracting, the saline cistanche extract of acquisition is mixed with OVIDUCTUS RANNAE
Close, prepare the cosmetics containing saline cistanche OVIDUCTUS RANNAE.
Further, saline cistanche or its extract 1-98 weight portion, OVIDUCTUS RANNAE 2-99 weight portion are contained in the described cosmetics containing saline cistanche OVIDUCTUS RANNAE.
Further, in the described cosmetics containing saline cistanche OVIDUCTUS RANNAE, active component should be safe and effective dose, and preferred saline cistanche or
The content of its extract is between 1-98%, further preferred 5-85%, still more preferably 15-55%；Or in 1-98 arbitrary integer hundred
Fraction.The content of preferably OVIDUCTUS RANNAE is between 2-99%, further preferred 5-85%, still more preferably 15-55%；Or appoint in 2-99
The percentage of meaning integer.
Further, the described cosmetics containing saline cistanche OVIDUCTUS RANNAE are selected from emulsifiable paste, creme, gel, lotion, spray agent, emulsion, suspension
Or the form such as liquid preparation.
Further, cod-liver oil, vitamin E and/or other arbitrarily auxiliary material are also contained in the described cosmetics containing saline cistanche OVIDUCTUS RANNAE.Further,
It can be the additive that any one or more cosmetic field uses that described auxiliary material is selected from.CTFA Cosmetic Ingredient Dictionary
(CTFA Cosmetic Ingredient Handbook) describes a large amount of those skilled in the art conventional use of nonlimiting cosmetic composition, it
Be suitable in the cosmetic composition of the present invention use.The example of this kind of component type includes：Grinding agent, emulsifying agent, absorbent, gelling agent,
Antifoaming agent, buffer, colouring agent, filmogen, pH adjusting agent, wetting agent, thickener and pigment.It is also to be recognized that be based on being intended to by group
The whole structure wanted that compound produces, the cosmetic composition of the present invention can also be using other cosmetic active ingredients, such as：Anti-acne is lived
Property thing is (for example：Salicylic acid or benzoyl peroxide), antiwrinkle active thing is (for example：Retinoids or β-hydroxy acid), antioxidant is (for example：Anti- bad
Hematic acid and its derivative, or tea extract), chelating agent is (for example：Furil-dioxime), antiinflammatory is (for example：Corticosteroid), anoretic
(for example：Caffeine), skin lightening agent is (for example：Fructus Mori extract or kojic acid), or sun-screening agent is (for example：The commercially available product of entitled PARSOL
Product).
Further, the described cosmetics containing saline cistanche OVIDUCTUS RANNAE can be processed in conventional manner by those skilled in the art, and is suitable for used for cosmetic
On the way.Especially, composition is preferably suitable for use in wrinkly, striated, coarse, being dried, and/or UV-
The skin damaging, thus improving outward appearance and the sense of touch of skin, and the skin for health, thus the degeneration of prevention or delaying skin.
The general cosmetics containing saline cistanche OVIDUCTUS RANNAE preparing the present invention by the conventional method preparing cosmetic composition known in the art.This
Class method relates generally to blending constituent in one or more steps, becomes relatively uniform state, is wherein with or without heating, cooling, uses very
Sky etc..The described cosmetics containing saline cistanche OVIDUCTUS RANNAE can be any conventional form, for example emulsifiable paste, creme, gel, lotion, spray agent,
Emulsion, suspension or liquid preparation.
Further, described saline cistanche refers to fresh saline cistanche, the saline cistanche being dried or the desertliving cistanche sheet processing through various concocting methods, institute
State saline cistanche and be selected from saline cistanche, Cistanche tubulosa, halophilous herbage, husky desert cistanche and/or broomrape.Wherein fresh saline cistanche is cut into suitable after cleaning
Preferably the sheet of size, strip or granular for extracting or fermentation process, be polished into slurries for extract or fermentation process.For be dried saline cistanche or
Desertliving cistanche sheet can soaking after be prepared into the sheet of suitable size, strip or granular for extracting or fermentation process, or be polished into slurries and be used for extracting
Or fermentation process, or not soaking directly claying into power extracted or fermentation process.
Further, described extraction is to carry out refluxing extraction or Ultrasonic Heating extraction using ethanol.Further, described ethanol solution concentration is 20-70
%.Further, described ethanol solution and the weight of described saline cistanche are than for 6-12: 1；Preferably 8-10: 1.
Further, described extraction comprises the following steps：Saline cistanche grinding and sieving or be polished into slurries, using ethanol solution refluxing extraction 1-4h,
Filter, filter residue uses ethanol solution refluxing extraction 1-3 time, merging extract again, by supernatant reduced pressure concentration, drying after centrifugation, obtains final product saline cistanche and carries
Take thing.
Further, described fermentation is liquid fermentation method or solid fermentation.Described fermented bacterium includes but is not limited to saccharomycete, lactic acid bacteria, acidophilus
Lactobacillus, lactobacillus bulgaricus, Lactobacillus plantarum, bacillus subtilis, Bifidobacterium Bifidum, aspergillus oryzae, halimasch, Cordyceps Militaris, Ganoderma Lucidum,
Bright red bacterium etc. can be used in the bacterial classification of food or pharmaceutical fermentation for one or more.Preferably, the addition of described bacterial classification is fermentation substrate 3-12%
, or 5-10% (w/w) or 8% (w/w) (w/w).Preferably, the addition of saline cistanche raw material is the 0.5-5% of culture medium in described fermentation
Or 0.5-5% (v/v) (w/v).
Further, described fermentation includes solid slope culture, Shaking culture and/or seed tank culture.The culture medium of described fermentation includes carbohydrate, nitrogen
Source and inorganic salts.Further, described carbohydrate be selected from white sugar, brown sugar, sucrose, glucose, fructose, glycitols, rock sugar, in honey one
Plant or several.Preferably, the addition of described carbohydrate is the 0-10% of raw material gross weight.Described nitrogen source be selected from dusty yeast, peptone, analysis for soybean powder,
One or more of corn steep liquor, fish meal, pupa powder, wheat bran.Preferably, the addition of described nitrogen source is the 0-12% of raw material gross weight.Described
Inorganic salts are selected from one or more of ammonium sulfate, manganese chloride, magnesium sulfate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate.Preferably, described inorganic salts
Addition be raw material gross weight 0-5%.
Further, the culture medium composition of described solid slope culture includes glucose 2-4%, peptone 2-3%, bean powder 1-4%, agar 3-8
%, magnesium sulfate 0.05-0.08%, potassium dihydrogen phosphate 0.2-0.3%, sodium chloride 0.1-0.3%.Further, the culture medium of described Shaking culture includes
Glucose 2-4%, peptone 2-3%, bean powder 1-4%, wheat bran 0.5-2%, magnesium sulfate 0.01-0.1%, potassium dihydrogen phosphate 0.1-0.4%, phosphoric acid
Hydrogen dipotassium 0.1-0.2%.Preferably, the rotating speed of described shaking flask is 200 turns/min.Further, the culture medium of described seed tank culture is beef
Cream 1-2%, peptone 2-3%, corn steep liquor 0.5-1%, potassium dihydrogen phosphate 0.03-0.05%, zinc sulfate 0.02-0.07%, magnesium chloride 0.04-0.08
%, remaining is water.
Further, described fermentation temperature is 20-37 DEG C, and described fermentation time is 7-40 days.
Further, the pressure of described supercritical carbon dioxide extracting is 20-40MPa.Further, described pressure be 20-35MPa or
28-32MPa or 30MPa.
Further, the temperature of described supercritical carbon dioxide extracting is 15-50 DEG C.Further, described temperature be 20 DEG C, 25 DEG C, 30 DEG C,
35 DEG C, 40 DEG C or 45 DEG C；Or other arbitrary integer temperature in 20 DEG C -50 DEG C or non-integer temperature.
Further, the time of described supercritical carbon dioxide extracting is 0.5-5h.Further, the described time be 1.5h or 2.0h or 2.5h,
Or 3.0h or 3.5h or 4.0h or 4.5h.
Further, the flow of the carbon dioxide of described supercritical carbon dioxide extracting is 5-30L/h.Further, described flow be 10L/h,
Or 15L/h or 20L/h or 25L/h.
Further, the entrainer of described supercritical carbon dioxide extracting is ethanol.
The explanation of technical term
Unless otherwise noted, all percentage used herein and ratio are all the weight accounting for total composition.Unless otherwise noted, all temperature are all
It is degree Celsius.
Term " safety and effective dose " used herein refers to enough to induce the forward direction compound of benefit described herein or the amount of composition, but
Judgement according to technical staff as little as be enough to avoid serious side effect.
Used herein, improve skin and include eliminating, minimize and/or prevent the flaw of skin, described flaw can be visually or by touching
Feel detects, for example not whole (irregularity), including but not limited to wrinkle, uneven or coarse, lose skin elasticity, sagging, decomposition of collagen,
Lose the skin restoring force (rccoil) from modification, and dark yellow.
The present invention has such advantages as with respect to prior art and effect：
(1) present invention utilizes saline cistanche to act synergistically with OVIDUCTUS RANNAE compatibility, when using in cosmetics as skin care active thing, plays
More significantly anti-aging, oxidation resistant effect, significantly improve skin by suppressing elastoser and/or stimulate collagen to produce, tool
There are the anti-aging effects of brilliance；
(2) technique adopting the present invention, can fully excavate and utilize effect of saline cistanche, OVIDUCTUS RANNAE, it is to avoid Chinese medicine and its active ingredient
Waste.
Specific embodiment
Described below is only the preferred embodiments of the present invention, is not limited to the present invention, although carrying out to the present invention with reference to following embodiments
Detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in each embodiment, or to it
Middle some technical characteristics carry out equivalent.All any modification, equivalent substitution and improvement within the spirit and principles in the present invention, made etc., all
Should be included within protection scope of the present invention.
Embodiment 1 cistanche extracts
Fresh saline cistanche is polished into slurries after cleaning, adds 50% ethanol solution of 10 times of weight portions, refluxing extraction 2h, filter, filter residue
Again with 60% ethanol solution refluxing extraction 3 times, merge extract, by supernatant reduced pressure concentration, drying after centrifugation, obtain final product cistanche extracts.
Embodiment 2 saline cistanche fermentate
(1) dry saline cistanche is taken to thinly slice, pulverize, cold sterilization is processed；
(2) prepare fermentation substrate：In Solid agar culture, add step (1) gained saline cistanche raw material, described saline cistanche raw material plus
Enter 1% (w/w) that amount is culture medium；
(3) bacterial classification is implanted and is fermented：Selection bacillus subtilis is fermented bacterium, after solid slope culture, Shaking culture, seed tank culture,
Implant in described fermentation substrate and fermented；The culture medium composition of described solid slope culture include glucose 2%, peptone 2%, bean powder 2%,
Agar 5%, magnesium sulfate 0.06%, potassium dihydrogen phosphate 0.2%, sodium chloride 0.1%；The culture medium of described Shaking culture includes glucose 2%, egg
White peptone 2%, bean powder 2%, wheat bran 1%, magnesium sulfate 0.04%, potassium dihydrogen phosphate 0.3%, dipotassium hydrogen phosphate 0.1%；Described seed tank culture
Culture medium is beef extract 1%, peptone 2%, corn steep liquor 1%, potassium dihydrogen phosphate 0.05%, zinc sulfate 0.02%, magnesium chloride 0.08%, remaining
For water.The implantation amount of described bacillus subtilis is fermentation substrate 6% (w/w).Described fermentation is to ferment 21 days in 28 DEG C under aeration condition,
Ventilated body is filtrated air, and throughput is 5.0L/min.
(4) extract the liquid after fermentation, obtain saline cistanche fermentate after filtering.
Embodiment 3 saline cistanche supercritical carbon dioxide extracting thing
The cistanche extracts of Example 1 preparation or the saline cistanche fermentate of embodiment 2 preparation, through supercritical carbon dioxide extracting after being dried, with
Ethanol is entrainer, and extracting pressure is 30MPa, and extraction temperature is 30 DEG C, and extraction time is 2h, and the flow of carbon dioxide is 15L/h, is obtained
Saline cistanche supercritical carbon dioxide extracting thing.
The cosmetic emulsifiable paste containing saline cistanche OVIDUCTUS RANNAE for the embodiment 4
| Composition | Phase | Content (w/w%) |
| Embodiment 3 saline cistanche extract | A | 12.5 |
| OVIDUCTUS RANNAE | A | 8.5 |
| Stearic acid | A | 20.0 |
| Myrj 59 | A | 5 |
| Span 60 | A | 5 |
| Propylparaben | A | 0.5 |
| BHT | A | 0.1 |
| Dimethicone | A | 0.5 |
| Water | B | * appropriate |
| EDTA | B | 0.2 |
| Methyl p-hydroxybenzoate | B | 0.1 |
* appropriate=to add to 100%
Prepare the cosmetic emulsifiable paste containing saline cistanche OVIDUCTUS RANNAE in such a way：All A phase constituents are mixed and heated to 65 DEG C；In another container
By all B phase constituent Hybrid Heating to 65 DEG C；Stop heating afterwards, under stirring, be slowly mixed together A, B two-phase；Gained mixture is cooled to room temperature,
Then packaging obtains final product.
The cosmetic cream containing saline cistanche OVIDUCTUS RANNAE for the embodiment 5
| Composition | Phase | Content (w/w%) |
| Embodiment 3 saline cistanche extract | A | 12.5 |
| OVIDUCTUS RANNAE | A | 22 |
| Polyglycereol -2 dimerization hydroxy stearic acid ester | B | 10 |
| Polyglyceryl-3 diisostearate | B | 15 |
| Vitamin E | B | 1 |
| Propane diols | C | 5 |
| Glycerine | C | 20 |
| Water | C | * appropriate |
| EDTA | C | 0.2 |
| Methyl p-hydroxybenzoate | C | 0.1 |
* appropriate=to add to 100%
Prepare the cosmetic cream containing saline cistanche OVIDUCTUS RANNAE in such a way：All B, C phases are separately heated to 70 DEG C；First A phase suction is emulsified
Pot, then by B phase slowly suction emulsification pot, homogeneous 20 minutes, 70 DEG C of constant temperature stirs 30 minutes；A is added to emulsification pot, stirs；
Gained mixture is cooled to room temperature, then packaging obtains final product.
The cosmetic gel containing saline cistanche OVIDUCTUS RANNAE for the embodiment 6
| Composition | Phase | Content (w/w%) |
| Embodiment 3 saline cistanche extract | A | 10.5 |
| OVIDUCTUS RANNAE | B | 32 |
| EDETATE SODIUM | A | 0.5 |
| Butanediol | A | 3 |
| Cetanol | B | 5 |
| Caprylic/capric triglyceride | B | 15 |
| Spices | B | 0.1 |
| Butylated hydroxytoluene | B | 0.3 |
| Water | A | * appropriate |
* appropriate=to add to 100%
Prepare the cosmetic gel containing saline cistanche OVIDUCTUS RANNAE in such a way：All A, B phases are separately heated to 60 DEG C；60 DEG C of constant temperature stir afterwards
Mix down and be slowly mixed together A, B two-phase；Continue stirring up to sticky, gained mixture is cooled to room temperature, then packaging obtains final product.
The cosmetic emulsion containing saline cistanche OVIDUCTUS RANNAE for the embodiment 7
| Composition | Content (w/w%) |
| Embodiment 3 saline cistanche extract | 23 |
| OVIDUCTUS RANNAE | 9.5 |
| Cod-liver oil | 5 |
| EDETATE SODIUM | 0.5 |
| PEG 400 | 10 |
| Propane diols | 5 |
| Mineral oil | 3 |
| Water | * appropriate |
* appropriate=to add to 100%
Usual manner using this area prepares the cosmetic emulsion containing saline cistanche OVIDUCTUS RANNAE.
The cosmetic suspension containing saline cistanche OVIDUCTUS RANNAE for the embodiment 8
| Composition | Content (w/w%) |
| Saline cistanche | 8 |
| OVIDUCTUS RANNAE | 5 |
| Vitamin E | 1 |
| PEG 1500 | 5 |
| Hyaluronic acid | 2 |
| Avicel 951 | 3 |
| Water | * appropriate |
* appropriate=to add to 100%
Usual manner using this area prepares the cosmetic suspension containing saline cistanche OVIDUCTUS RANNAE.
Comparative example 1 contains only the cosmetic emulsifiable paste of saline cistanche
| Composition | Phase | Content (w/w%) |
| Embodiment 3 saline cistanche extract | A | 20 |
| Stearic acid | A | 20.0 |
| Myrj 59 | A | 5 |
| Span 60 | A | 5 |
| Propylparaben | A | 0.5 |
| BHT | A | 0.1 |
| Dimethicone | A | 0.5 |
| Water | B | * appropriate |
| EDTA | B | 0.2 |
| Methyl p-hydroxybenzoate | B | 0.1 |
* appropriate=to add to 100%
Preparation method is with embodiment 4.
Comparative example 2 contains only the cosmetic suspension of saline cistanche
| Composition | Content (w/w%) |
| Saline cistanche | 15 |
| Vitamin E | 1 |
| PEG 1500 | 5 |
| Hyaluronic acid | 2 |
| Avicel 951 | 3 |
| Water | * appropriate |
* appropriate=to add to 100%
Usual manner using this area prepares the cosmetic suspension containing saline cistanche OVIDUCTUS RANNAE.
The anti-oxidant test of test example 1
Using ABTS TAC test (ABTS Total Antioxidant Capacity Test) detection embodiment 4, embodiment 8 and right
Ratio 1-2, the test sample that described test measures specified rate removes excessive ABTS (2,2 '-azine, two-(3- ethyl benzo thiazole phenanthroline -6- sulfonic acid))
The degree of radical cation.Before testing, remove any insoluble substance from sample by filtering (0.2 μm of aperture) and/or centrifugation.?
After completing test, calculated and the standard anti-oxidant Trolox (water-soluble analogues of alpha-tocopherol) with equivalent amount is being represented described ability.
This detection is to determine the standard method of " TAC " of test sample.
By the tester of decile is pressed variable concentrations and the ABTS containing fixed amount0+Reactant mixture mixing, carry out examinations.At 20 minutes
At the end of the reaction phase, by measuring ABTS0+In the light absorption value of 734nm, determine the remaining ABTS not removed0+.Each detection is wrapped
Include Trolox as sample, as the standard of the oxidation resistance in order to represent test sample with " Trolox equivalent ".Especially, every kind of unknown
The oxidation resistance of sample is represented with the concentration (%v/v) of equal value with 20 μM of Trolox.Following table shows that the Trolox of each sample is of equal value.
| Sample | Equivalent concentration (%v/v) |
| Embodiment 4 | 1.04±0.05** |
| Embodiment 8 | 1.21±0.04** |
| Comparative example 1 | 1.98±0.07 |
| Comparative example 2 | 2.15±0.10 |
From the above results, respectively compared with comparative example 1-2, embodiment 4,8 poles significantly improve antioxidation activity (* * P ＜ 0.01).
Test example 2：Anti-aging is tested
Elastin laminin enzyme level and the stimulation of collagen generation.Using Whatman 1 urn filter filtered sample, and utilize 0.8 and 0.2 Mm filter
Clarify further.
Positive active in test confirms the activity of fighting against senium of tester, according to HLE to the rate of cutting of chromogenic peptide substrate reality
Testing tries, with the IC of each sample50Value represents, it represents that suppression HLE reaches the concentration of 50% test sample, relatively low
IC50Value represents there is higher Elastase Inhibitory.
Grow fibroblasts of adult human dermis in porous plate, then stimulated with different tester interventions, after incubation 3 days, measured by ELISA
It is secreted into the amount of the type i collagen in growth medium, represent every kind of test with the percentage with respect to detection in the culture medium not stimulating cell
Under the conditions of exist collagen amount.
According to above-mentioned method of testing, the Elastase Inhibitory of much filtrate and collagen stimulation act on following two tables.
| Sample | IC50Value |
| Embodiment 4 | 1.1±0.1** |
| Embodiment 8 | 1.0±0.1** |
| Comparative example 1 | 3.1±0.4 |
| Comparative example 2 | 2.8±0.6 |
From the above results, respectively compared with comparative example 1-2, embodiment 4,8 poles significantly improve activity of fighting against senium (* * P ＜ 0.01), this body
The inhibitory activity of elastoser and collagen stimulation activity clearly change now.
Claims (10)
1. a kind of cosmetics containing saline cistanche OVIDUCTUS RANNAE are it is characterised in that using saline cistanche and OVIDUCTUS RANNAE as skin care active thing.
2. the cosmetics containing saline cistanche OVIDUCTUS RANNAE according to claim 1 are it is characterised in that after the extraction of described herba cistanches or fermentation, enter
Row supercritical carbon dioxide extracting, the saline cistanche extract of acquisition is mixed with OVIDUCTUS RANNAE, prepares the cosmetics containing saline cistanche OVIDUCTUS RANNAE.
3. the cosmetics containing saline cistanche OVIDUCTUS RANNAE according to claim 1 are it is characterised in that the described cosmetics containing saline cistanche OVIDUCTUS RANNAE
In contain saline cistanche or its extract 1-98 weight portion, OVIDUCTUS RANNAE 2-99 weight portion, the content of described saline cistanche or its extract is between 1-98%,
The content of described OVIDUCTUS RANNAE is between 2-99%.
4. the cosmetics containing saline cistanche OVIDUCTUS RANNAE according to claim 1 are it is characterised in that described cosmetics are selected from emulsifiable paste, creme, coagulate
One of glue, lotion, spray agent, emulsion, suspension or liquid preparation.
5. the cosmetics containing saline cistanche OVIDUCTUS RANNAE according to claim 1 are it is characterised in that the described cosmetics containing saline cistanche OVIDUCTUS RANNAE
In also contain cod-liver oil, vitamin E and/or other arbitrarily auxiliary material.
6. the cosmetics containing saline cistanche OVIDUCTUS RANNAE according to claim 1-5 any one it is characterised in that described saline cistanche refer to fresh
Saline cistanche, be dried saline cistanche or through various concocting methods process desertliving cistanche sheet, described saline cistanche be selected from saline cistanche, Cistanche tubulosa,
Halophilous herbage, husky desert cistanche and/or broomrape.
7. the cosmetics containing saline cistanche OVIDUCTUS RANNAE according to claim 1-5 any one are it is characterised in that described extraction is to adopt ethanol
Carry out refluxing extraction or Ultrasonic Heating extracts, described ethanol solution concentration is 20-70%, described ethanol solution with the weight ratio of described saline cistanche is
6-12∶1.
8. the cosmetics containing saline cistanche OVIDUCTUS RANNAE according to claim 1-5 any one are it is characterised in that described fermentation is liquid fermentation
Method or solid fermentation, the addition of described fermented bacterium is fermentation substrate 3-12% (w/w), and in described fermentation, the addition of saline cistanche raw material is training
The 0.5-5% (w/v) of foster base, described fermentation temperature is 20-37 DEG C, and described fermentation time is 7-40 days.
9. the cosmetics containing saline cistanche OVIDUCTUS RANNAE according to claim 1-5 any one are it is characterised in that described supercritical carbon dioxide
The pressure of extraction is 20-40MPa, and temperature is 15-50 DEG C, and the time is 0.5-5h, and the flow of carbon dioxide is 5-30L/h.
10. the cosmetics containing saline cistanche OVIDUCTUS RANNAE according to claim 1-5 any one are it is characterised in that described overcritical titanium dioxide
The entrainer of carbon extraction is ethanol.
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| CN201610300263.3A CN106389172A (en) | 2016-04-30 | 2016-04-30 | Cosmetic containing herba cistanche and oviductus ranae |
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