CN102228241A - Health-care food capable of tonifying brain, enhancing intelligence and enhancing memory and preparation method thereof - Google Patents

Abstract

The invention relates to health-care food capable of tonifying brain, enhancing intelligence and enhancing memory and preparation method thereof. The health-care food comprises main raw materials of linseed and silkworm chrysalis; a crude oil mixture containing omega-3 fatty acid generated through separating and extracting linseed seed and silkworm chrysalis; omega-3 fatty acid is prepared after purifying; and a further synthesis is performed for preparing omega-3 fatty acid ester. The method for preparing the health-care food capable of tonifying brain, enhancing intelligence and enhancing memory comprises processes of separating and extracting the crude oil mixture containing omega-3 in linseed and silkworm chrysalis, and synthesizing omega-3 fatty acid ester; as well as the invention also comprises the method for preparing health-care food capable of tonifying brain, enhancing intelligence and enhancing memory, which takes linseed and silkworm chrysalis as main raw materials.

Description

Brain tonic and intelligence development strengthens memory health food and preparation method thereof

Technical field:

The present invention relates generally to brain tonic and intelligence development and strengthens memory health food and preparation method thereof.

Background technology:

At present, brain tonic and intelligence development strengthens the existing relevant report of prescription of memory health food.But be to use the prescription of silkworm chrysalis oil and siritch combination not appear in the newspapers as yet.

Though it is a lot of that present brain tonic and intelligence development strengthens the memory Ricipe for health care food, exists following problem:

Most brain tonic and intelligence developments enhancing memory health food functional components and functional component content are indeterminate, product does not have the science index of clear and definite function factor content to guarantee the health care of product, service quality and the controlled standardization production of safety that can't assurance function sexual health food production.

Brain tonic and intelligence development enhancing memory health food prescription element is a lot of mostly, the component content complexity, and the effective efficiency component content is seldom, does not reach due health care purpose.Because the invalid components complexity is various, be difficult to guarantee the safety of health food, implying potential side effect.

And the brain tonic and intelligence development of single component strengthens the memory health food, and its function and action effect are limited, and the side effect of taking for a long time also remains to be observed.

Owing to do not consider the demand of human body to brain tonic and intelligence development enhancing memory health food function factor mostly, most product active constituent content deficiencies do not reach due nutrition health-care functions in the existing prescription.

Though some has the Western medicine of clear and definite health care in the market, as phosphatid ylcholine, PS, DMAE, pyroglutamic acid fat, pantothenic acid etc., be the unification compound of organic synthesis or highly organic purifying mostly, very difficult assurance does not produce injury to human body.

Summary of the invention:

The present invention has overcome the various defectives that above-mentioned brain tonic and intelligence development strengthens the memory health food, research and develop out and a kind ofly composes active ingredient in---intelligence development animals that the DHA precursor component is maximum---the mysterious insect silkworm chrysalis that contains " brain gold " on the plant of brain tonic " earth land " and the earth by being commonly called as, the novel brain tonic and intelligence development that processes through the modern high tech method science strengthens the health food of remembering.

Brain tonic and intelligence development of the present invention strengthens the memory health food and has natural prescription, choose have clear and definite health function and the pure natural of clear and definite health care composition, the selection advantage of pure green animal-plant material, have can the digitlization quality control quality assurance, process through modernized high-tech means science again.The rare uniqueness of its animal-plant material, function factor is clearly concrete, and the functional experiment data is fully reliable, the pharmacological evaluation scientific and precise, the advanced science of processing method, the health product quality safety is good, can the eater guarantee to take without any toxic and side effect for a long time.

The primary raw material selection that brain tonic and intelligence development of the present invention strengthens the memory health food is linseed and silkworm chrysalis, comprises mulberry silkworm chrysalis and tussah chrysalis.

Linseed is the most healthy in the world food, and there be more than 5,000 year in linseed (Linseed) in human history, and it belongs to the seed class, grows in all over the world, but is top grade with the side that ice box is produced.Linseed meal is with linseed grind into powder and then edible a kind of edible powder.In recent years, western developed country based on Canada, Australia, Britain and the U.S., linseed has been done a large amount of work as the research and development of functional food, is that the product of representative appears on the market for many years already with the linseed meal, in becoming, the elderly's standing health products.Recently, meet the high-purity of health giving quality requirement, the product of standardization lignan extract also goes on the market, and can be widely used in the additive of capsule, compressing tablet, breakfast cereal and fast food.Containing multiple products such as the super dense emulsion of trophic function of omega-fatty acid, solubility food fiber and lignan and full milk beverage constantly appears on the market.And China is blank in this respect so far substantially.

Extractive of flax seed Flaxseed Extract/Flaxseed Ligans/Flaxseed SDG is the extract of the seed of flax family (Linaceae) plant flax Linum usitatissimum L..Its nature and flavor: property is flat, and it is sweet to distinguish the flavor of.

Linseed (flaxseed or linseed) claim flaxseed again, and kind is more, but be broadly divided into 3 classes: oil seed flax, fiber flax and oily fine mean flax, its seed all can extract oil, and has become one of the world ten big oil crops.Oil seed flax mainly originates in Canada, China, Argentina, the U.S..China is the flex seed of taking back when B.C. 2nd century sening as an envoy to the Western Regions by Han dynasty special envoy Zhang Qian, begin plantation on Shaanxi, Shanxi and other places, initial linseed is mainly done medicinal, just extract oil up to 16th century with its seed, being one of main economic crops in China now, also is the main oil crops of China North China, the plantation of northwest extremely frigid zones.

The function of linseed cure mainly for: moisturize, dispel the wind.Be used for pruitus, leprosy, dizzy, constipation.Among the peoplely be considered to have pain relieving, convergence, analgesia, diuresis, skin moisten, reduce phlegm, suppurate and treat function such as wound, by people be used for the treatment of that furuncle, bronchitis, burn, cancer, carbuncle are swollen, diseases such as flu, conjunctivitis, corn, cough, diarrhoea, gonorrhoea, gout, inflammation, alcoholism, excessive fatigue, rheumatism, scald, sclerosis, ulcer, spasm and tumour.Flex seed is considered to have medical values such as skin moisten, analgesia, treatment tuberculosis, diuresis.The Related product of linseed also has certain medical effect.As: linseed tea can be treated flu, cough, disease in the urological system (can add honey and lemon juice when drinking).Linseed oil can be used as relaxant and limewash just can be made into very famous carron oil with the certain proportion mixing, and it can be used for the treatment burn and scalds.It is the good cosmetics of a kind of effect that linseed oil and honey mix, and can remove freckle on the face.Hartwell thinks that flax is in the disease such as long knurl that is widely used for treating on lung cancer, numb limb, cirrhosis, stomatitis, condyloma, myocardiosclerosis, cervix tumor, gastric ulcer, emerald green ball, uterus, splanchnopathy, celioma, throat, gland, intestines, neck, the parotid gland, uvula, the thyroid gland among the people.

The main therapeutic action of linseed: (1) strong refreshing brain tonic, strengthen notice and memory, can make meninx become soft.This because of saturated fats such as animal tallow can make the meninx hardening, thereby makes the cerebral nerve contact more difficult to adult study particular importance.(2) fall blood viscosity, reduce blood fat, prevention blood clotting and hypotensive, anti-headstroke and miocardial infarction etc.; (3) increase autoimmunity; (4) anti-curing cancers is eliminated tumour, the oedema that treatment cardiovascular disease, obesity, cancer etc. cause; (5) harmful substance in the cleaning blood is prevented and treated heart disease; Cure breast cancer, colon cancer, prostate cancer; (6) extenuate climacteric metancholia; Depression; Super aggressive psychology; (7) effective in cure to diabetes; (8) supplemental treatment multiple sclerosis; (9) supplemental treatment arthritis and various inflammation (gastritis, enteritis, neuritis, regional enteritis (clone is sick)); (10) skin tinea and wet disease (dry skin, furuncle, decortication, psoriasis, skin patch, lupus erythematosus, strange skin etc.); (11) gastro-intestinal syndromes such as prevention and treatment constipation, diarrhoea, gastric ulcer; (12) helpful to allergic constitution; (13) fat-reducing; Can consume the health superabundant fats, be the health slimming method.(14) asthma; Eat and just can obviously alleviate asthma attack after several days.(15) Raynaud's disease (Raynaud's disease).

The chemical composition of linseed: every 100g flex seed calorific value is 498 cards, contain 3.3-6.6% water, 18.0-20.3% protein, 34.0-37.1% fat, 33.6-37.2% carbohydrate, 4.8-8.8% fiber, 2.4-4.5% ash, 170-171mgCa, 370-462mg P, 2.7-43.8mgFe, 0-30 μ g beta carotene analog, 0.17mg vitamin B2 and 1.4mg niacin.Cane (ZMB) after flax is dried contains 7.8% protein, 3.3% fat, 81.7% carbohydrate, 46.2% cellulose, 7.2% ash 0.72%Ca and 0.1%P.Natural linseed oil contains 0.25% phosphatide and various aliphatic acid, it consists of: leukotrienes Linolenic 45～60%, linoleic acid Linoleic 18.7%, oleic acid Oleic17.5%, eicosenoic acid Eicosenoic 16.4%, palmitic acid Palmitic 6%, (suitable) sinapic acid Erucic 3.5%, stearic acid Stearic 2.8%, eicosadienoic acid Eicosadienoic 2%, arachidic acid Arachidic 1.8% glyceride such as grade; Other contains eicosyl ferulate (eicosylferulate), linamarin (linamarin) etc.Contain some waxes in the natural linseed oil, wherein, 18.7% stearic acid, 32.5% cerinic acid, 43.1% hexacosyl alcohol and 7.0% hydrogen compound.Essential amino acids content is: every 16gN contains 8.4g arginine, 1.5g tryptophan, 5.6g phenylalanine, 2.3g methionine, 5.1g threonine, 7.0g leucine, 4.g isoleucine and 7.0g valine.Contain 30.6%K in the linseed ash ₂O, 2.1%Na ₂O, 8.1%CaO, 14.3%MgO, 1.1%Fe ₂O ₃, 41.5%P ₂O ₅, 2.3%SO ₃₂-, 0.2%Cl-and 1.2%Si, contain 7.7% water in total kind skin, 3.2%N, 1.8% linseed oil and 3.0% ash.Linseed meal (97%DM) contains 30.5% protein, 6.6% fat, 43.2%NFE, 9.5%CF and 7.0% ash.Also contain the 0.57mg vitamin B1 in per 100 gram linseed meals, 0.33mg ribonucleic acid, 4.1mg thiamines acid (element), 1.2mg pantothenic acid and a spot of vitamin E, but the A that is deficient in vitamin, C and D, in addition, linseed meal also contain 0.37%Ca, 0.86%P, 1.24%K, 0.11%Na, 0.04%Cl, 0.38%S, 0.58%Mg, 0.017%Fe and 3.95mg/100gMn and 2.65mg/100gCu (CSIR, 1948-1976).Flex seed contains 15% viscose glue, wax, rosin, sugar, phosphate phosphoric acid phenol and acetate.Contain 0.69%HCN in prematurity flax.

Linseed is the source of outstanding ω-3 essential fatty acid.Flax is the highest plant of ω-3 essential fatty acid content.Also contain dietary fiber, manganese, folic acid, V6, magnesium, phosphorus and copper.In addition, linseed also is rich in nutrient for plants--lignan.

Flax lignan calls off the different larch phenol diglucoside of ring.This is the phytoestrogen quite similar with human body estrogen.Flax lignan mainly is present in the linseed, and its content depends on flax kind, weather and ecological condition, generally accounts for the 0.9%-1.5% of seed weight, and is higher 100～800 times than other known 66 kinds of food that contain lignan.

It is ω-3 fat that this special food of linseed brings our being far above.Linseed meals and linseed meal are the sources of extraordinary fiber, can reduce artery sclerosis and diabetes-induced cardiac cholesterol levels, reduce the blood sugar level of carcinogenic chemicals to infringement, alleviate constipation and the stable diabetic of colon cell.

Linseed is the abundant source of lignanoid (lignan), this lignanoid is a kind of phytoestrogen of gentleness, what is kept bone health and reduced the flush symptom of climacteric women and very effective because of the fungal infection of the puckery initiation of the vagina universe, also be used to treat syndrome before the warp that may cause by hormonal disorder.Also have simultaneously anticancer disease, antibacterium, anti-germ and speciality such as antiviral.Estrogen can promote tumor growth really when high concentration, but linseed can the interior this material of balance health.Countless research has proved the abundant diet of picked-up fiber content, can reduce the cancer incidence relevant with hormone, as breast cancer, carcinoma of endometrium and prostate cancer.Fiber in the food is divided into two classes, and a kind of is non-soluble fiber, can reduce the intestinal transport time, very useful to constipation, can make that ight soil is rapider to excrete.Another kind is a water-soluble fibre, can help to regulate blood sugar, reduces cholesterol concentration.Contain 2/3rds non-soluble fibers and 1/3rd water-soluble fibres in the linseed, so it has both effects simultaneously.

Linseed still is the source of magnesium, can be by keeping tracheae to loosen and open, reduce asthma seriousness, reduce atherosclerotic and diabetes-induced cardiac's blood pressure and reduce heart attack and apoplexy risk, stop and cause migrainous vasopasm, promote to loosen, recover ortho.

Edible fiber diet is confirmed in a research that is published on " Archives of Internal Medicine ", as linseed, and can prevention of cardiac.About 10,000 Americans have participated in this research that lasts 19 years.Eat the people of maximum fibers, restrain every days 21, and than the people of edible minimum fiber, what restrain trouble coronary heart disease every days 5 lacks 12%, few 11% of trouble angiocardiopathy.The risk of the people's of those edible soluble fibres trouble coronary heart disease has reduced by 15%, suffers from cardiovascular disease risk and has reduced by 10%.

Linseed stops the growth of prostate cancer.For the patients with prostate cancer of preparing to undergo surgery, take 30 every day and restrain the growth that the linseed that is rich in omega-fatty acid and lignan can suppress tumor of prostate.40 patients take linseed every day separately or take with low fat diet, and with 40 patients that implement low fat diets, and other 40 keep the patient of original dietary structures to do contrast.The patient who takes linseed and take linseed on the basis of low fat diet has obtained best effect.

Researcher's Wendy's of Duke Univ USA. base of a fruit mark-Wa Naifu Rider thinks that the omega-fatty acid in the linseed has changed the clustered pattern of cancer cell, or cancer cell adheres to the mode of other cell, and the anti-angiogenic rebirth in the linseed becomes the factor---lignan suppresses the blood supply of tumour cell, the cytoactive that auxiliary termination causes cancer cell to increase.

Because they are to the special protection effect of women's health, linseed dish and linseed meal have obtained a lot of concerns.The lignan content of linseed is high especially.Lignan changes two kinds hormonal material, enterodiol and enterolactone into by useful interior intestines flora.The hormonal material of these classes has been showed the effect of some inhibition breast cancer, has supported vegetarian diet to reduce the saying of breast cancer incidence.Studies show that lignan content in patient with breast cancer and omnivorous woman's the urine is far below the woman of vegetarian diet.The animal experiment study of estimating lignan usefulness shows that the animal of edible higher fatty acid supplements with linseed meal reduces the early-stage breast cancer sign and surpasses 55%.

One is published in studies show that of U.S.'s clinical nutriology magazine, the edible little muffin that contains 25 gram soybean proteins or 25 gram linseed meals woman's every day of menopause, or promptly not soybean protein-containing do not contain the little muffin of placebo of linseed meal yet, the time in 16 weeks, have only the woman's of the little muffin of edible linseed female hormone metabolism that the change of several important protectiveness takes place: the female phenolic ketone of 16alpha-hydroxyl, 2-hydroxyestrone, a kind of content that is considered to have the weak biological agent female hormone metabolin of anti-breast cancer effect significantly raises; The ratio of 2-hydroxyestrone and the female phenolic ketone of 16alpha-hydroxyl (a kind of possible carcinogenic female hormone metabolin) increases.This is important, because estradione participates in keeping bone mass (density).Briefly, edible 1 ounce of linseed can help postclimacteric woman to prevent breast cancer but can not influence their bone density every day.

In order to reduce the risk that the woman gets cancer, the lignan that contains in the linseed can promote normal ovulation, extends half leading circulation of progesterone.Effectiveness is many-sided.Conceived for thinking, wish stable ovulation, obviously improve the woman of the chance of becoming pregnant.To 35-55 year, preceding menopause symptom is arranged, as irregular menstrual period, galactocele, headache, dyscoimesis, close that urine, anxiety, irritability, anxious state of mind, body weight increase, sexual desire reduces, brains is fuzzy, the woman of fibroma, severe haemorrhage, a possible reason is exactly that female hormone is too much.Especially in 10 years before the middle-aged women menelipsis, serum estrogen level fluctuates, and the progesterone level continues to reduce.Linseed is leading hormone by promoting ovulation and prolonging the second round of menstruation at this cycle progesterone, helps hormone to keep balance.

Preliminary studies show that linseed can protect the women of menopause to avoid coronary heart disease.Nearest double blind random studies show that, linseed can on average reduce the postmenopausal women who does not take hormone replacement therapy T-CHOL 6%.

At last, the fiber that is rich in lignan can reduce the insulin resistance, and then reduces female hormone, reduce the risk of breast cancer.Because the insulin resistance is the early warning signal of diabetes B, illustrate that linseed can prevent diabetes.

Linseed can reduce hot flash nearly 60%.The researcher has recruited 29 postclimacteric woman, and these people bear the torment of 14 hot flash weekly at least, reach one month.Because worry can suffer from breast cancer, their female hormone all of no use.Take 40 gram linseed meals every day, after 6 weeks, the frequency of morbidity has reduced by 50%, and wherein the women's of 21 experiments of finishing hot flash sum has on average descended 57%.

Dry eye syndrome is tormenting and is surpassing 10,000,000 Americans.Artificial tears can only the respite problem.Expensive prescription medicine is promised to undertake effectively, but side effect is very big.The research that is published in U.S.'s clinical nutrition magazine relates to 40,000 health, and the women in 45-84 year has added this " WHS ", proves that linseed can prevent scheroma.

Flax is a kind of important economic oil crops in China.The Mei Suo that linseed edible can be traced back to the area, South-West Asia before 5000 is Da Miya (Mesopotamia) not.Greatly about B.C. 650 years, the father of ancient Greek's medicine---just put down in writing the medical usage of linseed at the bottom of the uncommon ripple carat.Over nearly 20 years, linseed is subjected to the attention of the world of medicine, found before this that it was rich in omega-3 polyunsaturated fatty acids, find that again it contains the lignan that health is had important health-care effect, it is that content is the highest in the known food, therefore, American National tumor research institute (NCI) linseed as one of 6 kinds of plants for anticancer research objects.At present, linseed has become the hot point resource of development function nutraceutical.

Flax is ancient bast fiber crop and oil crops.Flax originates from the Near East, Mediterranean bank.The Neolithic Age before more than 5000 years, the Switzerland lake perch people and ancient egypt people, linum usitatissimum is also with its fibrous woven dress material, and " mummy " of Egyptian various places also is to use the linen clad.Oil is called flax again with type flax.Flax has cultivation history in 1000 at least in China.Fibrous type flax is to introduce from Japan in 1906.China mainly is distributed in Heilungkiang and Jilin two provinces.Nice and cool, the moistening weather of flax happiness.

Nutritive value: the land is mended the food of brain most.Linseed does not contain cholesterol, contains extremely to enrich ω-3 essential fatty acid, helps prevention of cardiac and other chronic diseases.Omega-fatty acid belongs to polynary non-saturated fatty acid, is one of most important composition in the human body cell structure, also is the normally essential material of cell membrane running, therefore claims essential fatty acid again.

Modern's eating habit in recent years changes, and the hyperabsorption saturated fatty acid influences the cell normal operation, thereby causes three big degenerative disorders: cardiovascular disease, carninomatosis, diabetes.Scientist thinks that increase absorbing omega-fatty acid can reduce and suffer from these degenerative disorders.

The function of linseed: in recent years after deliberation and clinical trial, confirm that linseed has following function:

1, promote that brains are flexible: increase brain and transmit medium (Neurotransmitter), strengthen the brain activity function, make the brain running more effective, the learn to think ability is better.

2, energetic: balance and improve health blood sugar amount makes you that vigor is more arranged.Also can increase the endurance of muscle, more can make the faster post-equalization of the motion tired muscle in back.

3, lower cardiac load: can reduce hypertension, reduce lipids contents, improve the level of unrighted acid simultaneously, improve haemoconcentration, lower the stickiness of blood, keep the flowability of blood, prevention angiemphraxis and diseases related.In addition, also can stop blood clotting, prevention of stroke (heart and brain artery occlusion), heart disease (heart arter obstruction), lung arteries and veins embolism (lung's artery occlusion) and blood vessel surface illness (being the subcutaneous ulcer sore).

4, promote cell health: improve the moisture content and the elasticity of cell membrane, increase cellular respiration and nutrition function of exchange, and strengthen soma and repair and healing ability, make cell health, lower the carninomatosis chance.4, promote compressive resistance: can reduce the influence of the harmful biochemical material that is produced when health is stressed, set the mind at rest, keep tranquil phychology, reduce melancholia and insomnia.

5, alleviate allergic reaction: help and alleviate allergic reaction, but because whole health will reorganize, and allergy thoroughly be eliminated needs one period long period, more want comprehensive nutrition auxiliary.

6, improve the organ-tissue inflammation: inflammation has very great help to the prevention organ-tissue, comprising meningitis, tendonitis, tonsillitis, gastritis, ileitis, colitis, arteritis, phlebitis, prostate inflammation, kidney inflammation, spleen inflammation, hepatitis, pancreatitis, otitis etc., also have tinea and sore.

7, reduce cholesterol: can reduce high cholesterol 25% and triglyceride 65% in the blood, unnecessary low density cholesterol (LDL) is transformed into cholic acid excrete.

Additional linseed can resist following disease:

1, there is the body builder to claim that the linseed oil replenishers can strengthen endurance, and helps them to operate the faster recovery of physical efficiency afterwards.Linseed oil comprises some natural antioxidants, therefore can help the faster recovery of tired muscle.In addition, its anti-inflammatory efficacy can also help to alleviate DOMS.

2, the intestines child that the researcher's of University of Toronto (University of Toronto) report, linseed replenishers can improve health adult moves, reduces slightly the LDL cholesterol, and improves the polybasic unsaturated fatty acid in the blood.10 continuous 4 weeks of volunteer are edible bakes 50 gram linseed oil in the bread into, and the result increases by 30% glutinous the moving of intestines in a week.

3, reduce cholesterol: the research group of New Jersey Jordon's heart foundation (Jordan Heart Fund), assess 15 too high sufferers of cholesterol.The volunteer accepts the vitamin E of 800 units, 3 bread that contain linseed every day, and the linseed of 15 grams.3 months Shens in test are showing T-CHOL and LDL cholesterol in the reduction blood.But, HDL cholesterol (good cholesterol) does not change.The platelet aggregation that blood coagulation (thrombin) causes may cause thrombus, also reduces to some extent in experiment periods.

Studies show that what Australia A De Randt hospital of imperial family (Royal Adelaide Hospital) was carried out the diet that is rich in linseed oil can make the α-linolein acid concentration in triglyceride in the blood plasma, Phospholipids (phospholipid), cholesterol ester (cholersteryl ester) and the Neutrophils Phospholipids (neutrophil phospholipid) heighten.The concentration of EPA in blood plasma lipide and Neutrophils phosphatide has increased by 2.5 times.

4, angiocardiopathy preventing: the research group of Australia snow pear university allows 11 healthy males take 40 gram linseed oil or sunflower oil every day 23 days.Hematoblastic EPA increases more than 2 times in the linseed volunteer, and the sunflower oil group then remains unchanged.But, EPA rises in the linseed group to some extent to the ratio of arachidonic acid (arachidonic acid), this ratio value is that thromboxane A2 (thromboxan A2) generates index with the platelet aggregation potentiality (thromboxane can make vessel retraction, promote thrombosis, and then may cause heart disease to be burst or apoplexy).Same, the people of picked-up linseed oil, the agglutinating reaction that is caused by collagen in its body also can reduce.These data are further evidences, prove the oils that is rich in α-flax resin acid owing to can prevent platelet aggregation together, therefore, and more can angiocardiopathy preventing than the oils that is rich in linolenic acid.

5, regulate hormone, improve menopause symptom: lignanoid is hormonal content in the adjustable body also, and alleviate some symptoms that climacteric brings, for example: flush heating and because of the fungal infection of the puckery initiation of the vagina universe.Linseed oil also is used to control disease group before the warp that may be caused by hormonal disorder.The treatment prostate: sieve uncle relies on. Ji Le (Robert M.Giller) doctor suggestion, and the sufferer that the prostate problem arranged is the several months continuously, and treat with the freezing compression linseed oil of 1 to 2 soupspoon every day.

6, cancer: though estrogen is extremely important to women's growth and reproduction, too much estrogen may cause tumour.Because linseed contains gentle phytoestrogen, can antagonist in too much estrogen, have anticancer effect so it is generally acknowledged it.Discover that when the female patient of suffering from breast cancer is taken 13 weeks of linseed continuously, their recurrent mammary tumor obviously reduces 50 percent for one that is published in " cancer generation ".

A long time ago, people just find as medicine good cancer suppressing action is arranged with flax, and research confirms that further flax contains 3 '-demethyl podophyllin toxin, cancerocidal substances such as podophyllin toxin and p one paddy street alcohol.

Linseed is suitable for the crowd:

The working people of high strength mental labour; The infant, the pregnant woman that lack omega-fatty acid; Before wanting to replenish total health nutrition pregnant, pregnancy period, the new mother in pregnant back, and new baby; Especially hypertension, high cholesterol or high fat of blood personage; Dry skin, the personage of the easy inflammation of microgroove, pachylosis or skin, long eczema is arranged.

Linseed oil energy brain tonic and intelligence development strengthens mental---and the land is mended the food of brain most: the human brain main component is a lipid material, and wherein about 20% is omega-3 unsaturated fatty acid; And in the lipid material in the human retina, have 40% to be omega-3 unsaturated fatty acid approximately.The famine omega-3 unsaturated fatty acid will influence memory and thinking ability, influence the infant with intelligence development, might cause diseases such as encephalatrophy, amentia, senile dementia, cranial nerve depauperation, the lighter can cause degradation symptom under depression, brainfag, retina aging and study and the ability to work.Linseed oil contains abundant omega-3 unsaturated fatty acid, and content is one of the highest plant of present known land omega-3 unsaturated fatty acid content up to 57%.Thereby linseed oil is considered to the natural food that the land is mended brain most.Alpha-linolenic acid can be converted into DHA in human body, for brain provides sufficient nutrition, infant's intelligence development, teenager improved memory, person in middle and old age's brain tonic and prevention senile dementia have important effect.

Reduce total cholesterol level; the prevention cardiovascular and cerebrovascular disease: medical research shows; alpha-linolenic acid can reduce total cholesterol level; increase useful HDL (HDL) level; suppress cellular uptake and accumulate LDL-C (LDL); thereby help to protect cardiovascular system health, improve high fat of blood and hypertension.

Diseases prevention purifies the blood----prevents cardiovascular and cerebrovascular disease.Omega-3 unsaturated fatty acid is essential aliphatic acid, and human body can not synthesize, and can only absorb from food.Medical research shows that omega-3 unsaturated fatty acid has the effect that reduces T-CHOL and remove triglycerides, reduces the morbidity risk rate of hyperlipemia; Omega-3 unsaturated fatty acid can suppress atherosclerotic, and the protection ischemic myocardial reduces the necrotic area, keeps hematoblastic normal function; Human body edible a certain amount of omega-3 unsaturated fatty acid every day, just can impel the metabolism of physical function normal, reduce triglycerides and T-CHOL, reduce thrombus, the prevention platelet aggregation lowers blood viscosity, vasodilator, keep blood vessel elasticity, prevention coronarospasm and thrombosis reduce the generation of cardiovascular and cerebrovascular disease.

Omega-fatty acid belongs to polynary non-saturated fatty acid, is one of most important composition in the human body cell structure, also is the normally essential material of cell membrane running, therefore claims essential fatty acid again.The change of modern's eating habit, the hyperabsorption saturated fatty acid influences the cell normal operation, thereby causes three big degenerative disorders: cardiovascular disease, carninomatosis, diabetes.Scientist thinks that increase absorbing omega-fatty acid can reduce and suffer from these degenerative disorders.

Linseed contains and extremely enriches ω-3 essential fatty acid: a soupspoon linseed contains 3800 milligrams omega-fatty acid, is equivalent to 10 times of cod-liver oil, but does not have the fraud place of high cholesterol and saturated fatty acid.

But linseed oil balance and improve health blood sugar amount makes you that vigor is more arranged.Also can increase the endurance of muscle, more can make the faster post-equalization of the motion tired muscle in back.

Everybody speaks approvingly of the effect of linseed oil.Go up scientist, gasp in admiration the fine of it invariably down to natural therapy teacher to national cancer institute.Flax is the annual herb plant that comes from Mediterranean Region, and a long time ago, linseed is supreme delicacies, and people believe that also it is the miraculous cure of love.People treat the indisposition of respiratory tract with him, and the European generations treat constipation with it.

No matter be nutritionist or alternative medicine doctor, they recommend the use linseed to the utmost.

Xylan is a kind of chemicals of finding on plant cell wall, can combine with the testosterone in the body.And in numerous patients with prostate cancer bodies, testosterone impels the material of tumor growth just.Someone thinks that xylan has and helps suppress prostate tumor cells and duplicate on a large scale.

The researcher of American Society of Clinical Oncology has studied the concrete effect of linseed in human body.Moral mark's watt that Freed is said: " whether linseed impacts the biology and the tumour cell division speed of tumour." this problem can answer simply: it really can.Have 161 patients with prostate cancer and participated in this current research, wherein have the patient of half to be required the round soupspoon linseed of edible tri every day in several weeks approximately.Afterwards, they have been carried out tumor resection.Moral mark's watt that Freed notices that " split speed of cancer cell descends suddenly in patient's body to check discovery after operation." this may be the utilizable cause of enlivening the testosterone minimizing of cancer cell.

Scientist it be unclear that, and whether the edible in a large number linseed of healthy people can reduce the possibility of suffering from prostate cancer.Certainly, the crowd of edible linseed can be very not big in a large number.Yet new positive data constantly occurs, and early-stage Study shows that also linseed helps treating the tumour that other respond to hormone, as breast cancer.

In cancer treatment procedure, the diffusion that prevents cancer is very crucial, because most of patients is to cause death because be diffused into the cancer cell at other positions.Therefore, to reduce the discovery of cancer metastasis be quite challenging to relevant ω-3.Cancer cell wants to be diffused into other ones from former portions, just must adhere to and be penetrated into then in blood vessel and the organ basement membrane on every side, the contained omega-fatty acid of linseed oil has stoped the glutinous effect that connects molecule of cell surface, " grapple " that has lacked this necessity, cancer cell just are not easy to be attached on the basilar memebrane.Even if cancer cell will oneself stick on the basilar memebrane, omega-fatty acid also also has next step clever move.It can stop the generation of the necessary clostridiopetidase A of dissolving basilar memebrane, and cancer cell can't be permeated into.

At chemicotherapy or the edible for patients linseed oil of tumor disease is arranged, have the theory of curing that certain help purposes has all been given prominence to " nutrient health " for just.Wherein, contain a large amount of ω-3, plant hormone, fiber and albumen in the linseed in the linseed sliced bread, wherein omega-fatty acid can further synthesize another kind of aliphatic acid EPA and DHA as precursor component in human body.And EPA and group DHA be another kind of omega-fatty acid, they are sound necessary the materials of growing of human brain, and are particularly important to infant's brain growth.Often edible linseed based food has very big effect to cerebral function running and raising body immunity, also helps angiocardiopathy preventing simultaneously.It is edible to be suitable for children.

Be rich in a kind of fat in the Linseed oil and be called alpha-linolenic acid (ALA), it is the aliphatic acid that health is used for making a kind of necessity of energy.It also is to form the basic material of keeping stabilizing blood pressure, normal blood coagulation, heart rate, blood vessel expansion, immune response and fat-splitting compound in the human body.Simultaneously, aliphatic acid also is the essential material of forming brain and nerve fiber.

ALA is a member of fatty family, is called as omega-fatty acid.Linseed oil and fish oil all contain abundant omega-fatty acid.Canola oil and soybean oil also comprise some omega-fatty acids.Corn, safflower, cottonseed, sesame and sunflower oil all are rich in the fat of a kind of ω of being called as-6 aliphatic acid.This fat of two types all plays different important function to health.The absorption equilibrium that keeps ω-6 aliphatic acid and omega-fatty acid in diet is very important.The excessive absorption of any fat can cause health problem..

Common people's diet all is rich in ω-6 aliphatic acid and lacks omega-fatty acid.If absorb ω-6 aliphatic acid more than omega-fatty acid in diet, health just may be made some and can cause inflammation or be unfavorable for the material that health is made normal reaction to disease, even the easier heart disease of suffering from.When suffering from inflammation (for example arthritis and psoriasis) and infectious disease, immunity is reduced, if think that health is healthy more, just should increase the omega-fatty acid that contains in the diet.When absorbing a large amount of ω-6 aliphatic acid, this way is even more important.

Lignan

Flax lignan Flax Lignans calls off the different larch phenol diglucoside Secoisolariciresinol Diglycoside of ring again.This is the phytoestrogen quite similar with human body estrogen.Flax lignan mainly is present in the linseed, and its content depends on flax kind, weather and ecological condition, generally accounts for 0.9%～1.5% of seed weight.The product proterties is the yellowish-brown powder.Molecular formula: C32H46O16.

Research points out that the lignan (lignans) of isoflavones of soybean (isoflavones) and linseed is two kinds and helps the endocrine rare species nutrient of balance.Isoflavones (isoflavones) is the nutrient for plants of needed by human body, but can only draw in minority plant (as soybean).Linseed is that lignan (lignans) is the source of enriching, and the content of its other foods of lignan content comparison exceeds 75-800 doubly, and comes to life when digestion.American National cancer association selects 6 kinds of food especially and makes research object, in the middle of comprise linseed.This is because linseed has positive influences to the cancer patient.

Physiological mechanism:

Lignan SDG is an inert matter, and it just becomes active material behind generation enterodiol and the enterolactone under mammal enteron aisle action of microorganisms.Enterodiol is similar to the molecular structure of 17 beta estradiols with enterolactone, all has two aromatic rings, although A ring and B ring to be connected carbochain different, the hydroxyl the position of substitution that can cause estrogen active is all.

Because with the structural similarity of 17 beta estradiols, phytoestrogen can combine the faint estrogen effect of performance with mammal ERs (ER), also can combine (ER) and show the estrogen antagonism with estradiol competitiveness.Phytoestrogen has estrogen and antiestrogenic two-way function, and relation between the two shows as U type dose-effect relationship.During low dosage, phytoestrogen combines (ER) with estrogen is competitive, mainly shows as estrogenic antagonist; During dosage, produce certain estrogen active; During high dose, additional phytoestrogen can activate the ER that fails to activate because of the estrogenic agents quantity not sufficient, produces the estrogen enhancement effect.

Function:

Flax lignan has extraordinary prevention effect to estrogen-dependent diseases especially breast cancer, prostate cancer, menstrual period syndrome, osteoporosis.In addition, the clinical studies show flax lignan is to diabetes, stomach and intestine tumor, coronary heart disease, kidney trouble, the effect that non-oxidizability is all useful.

U.S. tumor research institute has determined six kinds of natural anti-cancer plants at present, flax is the first-selection of six kinds of plants, as the lignan that has the linseed flesh side is an anticancer candidate's new drug of very promising pure natural plant, and it has antitumor, antiviral and suppresses the biologically active of some enzyme.Lignan is mainly derived from cereal and is rich in the product of fiber with other in the human foods, and linseed is the abundantest source of humans and animals lignin precursor.Lignan content in cereal is 2mg/kg～7mg/kg, and the content in linseed is 2mg/g～20mg/g, is 1,000 times of content in the cereal.

The application of lignan:

In recent years, western developed country based on Canada, Australia, Britain and the U.S., linseed has been done a large amount of work as the research and development of functional food, is that the product of representative appears on the market for many years already with the linseed meal, in becoming, the elderly's standing health products.Recently, meet the high-purity of health giving quality requirement, the product of standardization lignan extract also goes on the market, and can be widely used in the additive of capsule, compressing tablet, breakfast cereal and fast food.Containing multiple products such as the super dense emulsion of trophic function of omega-fatty acid, solubility food fiber and lignan and full milk beverage in addition constantly appears on the market.The research of the present flax lignan of China is carried out and is carried out successively, and corresponding raw material midbody supplier has occurred a lot.

Lignan is a plant polyphenol, generates cinnamyl alcohol by phenylalanine, and the cinnamyl alcohol dimerization reaction generates lignan.In plant kingdom a variety of lignans are arranged, refer to the lignan structurally similar wherein few in number here to human body estrogen.

According to the experiment of human faecal mass flora in vitro culture and feeding animal, the clear and definite to a certain extent metabolic pathway of lignan.In intestines and stomach, the different larch phenol of open loop glucoside can form enterodiol and enterolactone.The metabolin of lignan accumulates in liver, kidney, intestinal tissue and uterus, discharges with urine with the glucoside acid conjugate.

Discover that lignan can suppress the synthetic of ovarioestrogen by the comprehensive function to 3 kinds of estradiol synzyme (3 beta-hydroxysteroid dehydrogenases, aromatase enzyme and 17 beta-hydroxysteroid I type oxidoreducing enzyme), reduce the onset risk of breast cancer.Women's the lignan drainage value of suffering from breast cancer is lower, when urogaster lactone drainage value is lower than 1.5 μ mol/24h, has higher breast cancer risk.Studies have shown that: patient with breast cancer's every day, edible 75mg purity reached the lignan more than 85%, and edible tri is individual month continuously, and 70% patient tumors area has reduced 80%, has the part patient to be almost recovered.

Research of Animal Model for Study shows that lignan all is useful to diabetes, stomach and intestine tumor and coronary heart disease.

Alpha-linolenic acid

Linseed is the at present known maximum food of ω-3 that contains, and its ω-3 accounts for 57% of linseed oil fatty acid, and this is ω-3 content that doubles fish oil! Leukotrienes still is the precursor substance that synthesizes EPA (eicosapentaenoic acid) and DHA (DHA) in the human body.EPA and DHA are two kinds of unrighted acids that constitute human body cell film and organelle film.Do not contain leukotrienes or content in the general food seldom, have only in the fat of deep-sea fish and in the linseed and contain leukotrienes (Crowley, 1999), and linseed than the low prices of abyssal fishes many.Also contain many natural polyphenoils in the linseed, and glucosinolate content is lower, makes the linseed chemical property stable.

The leukotrienes that linseed is rich in (ALA) is a kind of of omega-fatty acid, is the precursor that generates the omega-fatty acid EPA in the fish oil.Because ALA is self-existent in the linseed oil, so the ALA concentration of linseed oil is than linseed height.Except the exclusive useful effect of ALA, it can also be converted into EPA in vivo, therefore has the effect of EPA.

ω-3 and ω-6 unrighted acids can't synthesize voluntarily at human body, need to replenish by food supply, so the title of human body " essential fatty acid " is arranged.Peanut oil, soybean oil and sunflower seed wet goods vegetable oil edible in our daily life mainly contain ω-6 aliphatic acid, and only contain omega-fatty acid seldom.This dietary structure causes the interior ω-3 of human body seriously unbalance with ω-6 aliphatic acid.Scientific research confirms that omega-3 unsaturated fatty acid helps to eliminate thrombosis factor and inflammatory factor, repairs the damaged cells film; Omega 6 polyunsaturated fatty acid then has the effect of ' double-edged sword ' to human body: it can help to protect cardiovascular and cerebrovascular health on the one hand; but when excessive; then human body is produced infringement, bring out various disease conditions such as cardiovascular and cerebrovascular disease, diabetes, arthritis, allergy, dermatitis, disease of immune system.

[0090] therefore, suitably replenish the situation that linseed oil helps to improve ω-3 and omega 6 polyunsaturated fatty acid imbalance in the existing dietary structure, better maintaining tissue health.

Linolenic linseed oil is rich in employing, is catalyst hydrolysis with lipase at supercritical carbon dioxide in mutually, the method of separating in conjunction with rectifying column by supercritical extract realizes the separation of inhomogeneity aliphatic acid simultaneously, will obtain the alpha-linolenic acid product of environmental protection.

Because the percentage composition of the alpha-linolenic acid in the linseed oil fatty acid is higher, and coexist with other aliphatic acid with the form of triglycerides, this obtains highly purified alpha-linolenic acid to separation and has brought certain difficulty.By linseed oil being dissolved in saponification in the ethanol water, obtain fatty acid mixed, urea clathrate then, slowly lower the temperature and evaporation and concentration, obtain 90% alpha-linolenic acid, successively separate obtaining the alpha-linolenic acid fat that purity is 95-99.9% more successively with esterification, by saponification, molecular clock obtains the colourless alpha-linolenic acid that purity is 95-99.9% at last.

ω-3, omega 6 polyunsaturated fatty acid is an essential fatty acid, has the important physical function, the ratio of-6 two kinds of aliphatic acid of ω-3 and ω also has very significant effects to body's immunological function.Canada is that first proposes ω-3, the country of omega 6 polyunsaturated fatty acid ratio recommendation, the male sex 1: 6.25, women 1: 5.8, it is 1: 2.3 that U.S. expert recommends suitable proportion, FAO's recommendation ratio was 1 in 1994: 5-10, suitable with ratio in the human breast milk, it is 1 that suitable proportion is recommended by Chinese Soclety of Nutrition: 4-6.

It should be noted that the ω 3 of needed by human, when ω 6 content of polyunsaturated fatty acid are too high, be vulnerable to the attack of free radical, its carbochain oxicracking generates aldehyde, thereby ketone and epoxides cause cell membrane and lipoprotein to change, thereby different aliphatic acid has the ratio of adaptation.The most authoritative recommendation is 1: 1: 1 in the world at present, and the recommendation of ACC is 1: 1.5: 1, and American National cholesterol education group recommendation is 1: 1.5-2: 1, and the recommendation of Chinese Soclety of Nutrition is＜1: 1: 1.

In the total fat of China's resident's meals, animal fat accounts for 50% (WT), in the common animals oil, saturated and monounsaturated fatty acids content is all above 40% (WT) in the lard, and saturated aliphatic acid accounts for 40%-60% (WT) monounsaturated fatty acids content and accounts for 40%-50% (WT) animal fat pufa-containing hardly in the tallow oil.Thereby vegetable oil must provide whole polyunsaturated fatty acids in the meals, a small amount of monounsaturated fatty acids, and reduce saturated fatty acid content as far as possible, to safeguard that aliphatic acid forms＜1 in the TFA intake: 1: 1 ratio.

Omega-fatty acid belongs to polynary non-saturated fatty acid, is one of most important composition in the human body cell structure, also is the normally essential material of cell membrane running.

Modern's eating habit in recent years changes, and the hyperabsorption saturated fatty acid influences the cell normal operation, thereby causes three big degenerative disorders: cardiovascular disease, carninomatosis, diabetes.Scientist thinks that increase absorbing omega-fatty acid can reduce and suffer from these degenerative disorders.

Linseed contains and extremely enriches ω-3 essential fatty acid: a soupspoon linseed contains 3800 milligrams omega-fatty acid, is equivalent to 10 times of cod-liver oil, but does not have the fraud place of fishy smell, high cholesterol and saturated fatty acid.

Linseed is the people of edible, especially hypertension, high cholesterol or high fat of blood per capita generally; Before wanting to replenish total health nutrition pregnant, pregnancy period, the new mother in pregnant back, and new baby; Dry skin, the people of the easy inflammation of microgroove, pachylosis or skin, long eczema is arranged; Be specially adapted to lack the crowd such as infant, pregnant woman of omega-fatty acid.

Studies have shown that not eating fish and without the people of fish oil supplementation agent, linseed oil is good substitute.At suffering from chronic diseases the research that African American carries out: every days 3 the soupspoon linseed oil, after 12 weeks, the content of EPA has improved 60% in the blood.

Nearest MEDLINE shows many pieces of papers and relates to linolenic research, has investigated a large amount of physiology courses and health status.As:

Anti-inflammatory: ω-3 fat is used for making series 1 and serial 3 prostaglandins, similar hormonal anti-inflammatory molecular by health.Series 2 prostaglandins are to cause the inflammation molecule, are made by the fat of other kinds, and especially ω-6 fat is present in animal tallow, margarine, many vegetable oil in a large number, comprises corn oil, safflower oil, sunflower oil, palm oil, peanut wet goods.ω-3 fat can reduce inflammation.Inflammation is the key factor of asthma, osteoarthritis, rheumatic arthritis, antimigraine and osteoporosis.

The protection bone: be present in the leukotrienes in linseed and the walnut, ω-3 fat is promoted bone health by preventing that excessive bone from upgrading.The food that is rich in ω-3 can reduce the ratio of ω-6 fat and ω-3 fat.

Other studies show that edible fish of being rich in ω-3, and (DHA EPA) also can reduce the ratio of ω-6 fat and ω-3 fat, reduces bone and runs off.The researcher thinks that being likely that ω-6 fat changes into causes scorching prostaglandin, and ω-3 fat then metabolism is the anti-inflammatory prostaglandin.

This research, 23 experimenters eat three kinds of a kind of in putting somebody on a diet respectively, and the time was 6 weeks, and the scavenging period of changing before putting somebody on a diet was 3 weeks.Three kinds of fat contents of putting somebody on a diet are basic identical, and different is ω-6 fat and ω-3 ratio.Put somebody on a diet 1, total fat 34%, wherein ω-6 fat conforms to typical American diet with the quantity of ω-3 fat: more than 9% yuan of unsaturated fat, wherein 7.7% is ω-6 fat, and ω-3 fat only has 0.8%, and causing the inflammation ratio is 9.6: 1.Put somebody on a diet 2, total fat 37%, 16% is polynary unsaturated fat, and wherein 12% is ω-6 fat, and ω-3 fat is 3.6%, reasonable ratio, and causing the inflammation ratio is 3.3: 1.Put somebody on a diet 3, total fat 38% belongs to the diet that is rich in ω-3 fat, and 17% is polynary unsaturated fat, and wherein 10.5% is ω-6 fat, and ω-3 fat is 6.5%, and causing the inflammation ratio is 1.6: 1.

The N-end peptide of experimenter's blood is measured in the end of at every turn putting somebody on a diet, and indicates the index that bone bursts apart, and 3 the experimenter's of finding to put somebody on a diet index is far below other 2 groups.The N-end peptide index of experimenter's blood is also relevant with the markers of inflammation that is called TNF-alpha (TNF-alpha).Put somebody on a diet 1 and the index of TNF-alpha of 2 the experimenter of putting somebody on a diet be higher than 3 the experimenter of putting somebody on a diet far away.

Prevent that heart disease, cancer and diabetes: ω-3 fat is used for making the material that reduces blood clot, can reduce the risk of artery sclerosis or diabetic heart attack and apoplexy.ω-3 fat also is used for making flexible cell membrane.Cell membrane is the entrance guard of cell, allows nutrients to enter cell and the interior refuse of scavenger-cell.Flexible cell membrane is important to everyone, especially the diabetic.The cell membrane that plate is hard is often caused by the diet of high saturated fat, hydrogenated fat and trans fats.In colon, ω-3 fat protection colon cell reduces the injury of carcinogenic toxins and radical pair cell, reduces the risk of suffering from colon cancer.

Prevention and control hypertension: the data demonstration of " international macroscopic view and microcosmic nutrient and blood pressure research (INTERMAP) ", the blood pressure that contains the few people of those edible linseeds of human blood pressure ratio of linseed of a large amount of omega-3 unsaturated fatty acids in the diet is low.

INTERMAP is the research about the life style factor, comprises the influence to blood pressure of diet and diet, and research object is to live in the men and women in 4680 40-59 years of Japan, China, the U.S. and Britain.The questionnaire that the measurement of blood pressure and the person of putting somebody on a diet return divides 4 batches to finish by the participant.The data of putting somebody on a diet are analyzed according to the content that comprises ω-3 in fish, nut, seed and the plant wet goods food.

Taking in omega-fatty acid in average day is 2 grams.The participant's that day absorption omega-fatty acid ratio is high systolic pressure and the low participant of diastolic pressure ratio day absorption omega-fatty acid ratio hang down the 0.55/0.57mm Hg. reduction 2mmHg that studies show that in the past respectively can reduce by 6 percentage points of the average apoplexy death rates, 4 percentage points of reduction Incidence of CHD.

2238 high omega-3 fatty acid absorption persons do not use medicine, health products, do not adopt special systolic pressure and diastolic pressure at the sick diet of hypertension, heart disease and glycosuria [0002] to reduce 1.01/0.98 percentage point respectively.

Do not suffer from hypertensive participant for 2038 of this group, the systolic pressure of the absorption diet of high omega-3 fatty acid and diastolic pressure have reduced 0.91/0.92 percentage point respectively.

Hirotsugu doctor Ueshima of Shiga, Japan medical university notices that omega-fatty acid is more remarkable to the action effect of not suffering from hypertensive people.Doctor Ueshima says. discovers from the omega-fatty acid of nut, seed and vegetable oil the effect of step-down is equal to omega-fatty acid from fish." to blood pressure, each millimeter is all meaningful.Every kind of nutraceutical effect is seemingly little, but independently, so their acting in conjunction meeting has substantial influence to blood pressure.

The effect that linseed reduces cholesterol equals to statins: a research that relates to 40 high cholesterols (more than the 240mg/dL) patient, restrain linseed meals, control group statins every day edible 20.Two groups of patients' that tried after 60 days T-CHOL, low density cholesterol, triglycerides and T-CHOL all has tangible reduction with the ratio of high density cholesterol.The effect of linseed group and the effect of statins are good equally.The numerical value of body-mass index, T-CHOL, high density cholesterol, low density cholesterol and triglycerides obtains before test and after 60 days respectively.The ratio (33.5%) of T-CHOL (17.2%), low density cholesterol (3.9%), triglycerides (36.3%) and T-CHOL and high density cholesterol of comparing the patient of edible linseed with baseline all has reduction significantly.Approximate reduction appears at the statins group equally.Two groups effect is significantly difference not.

Linseed oil reduces the high cholesterol male sex's blood pressure: the researcher of Greece has carried out the research of an observation to systolic pressure and diastolic pressure effect, and the time is 3 months, 59 middle-aged males edible linseed oil or safflower oil in diet.

Human body can be with linseed oil ALA metabolism for having the long-chain omega-fatty acid of protective effect, DHA and EPA, and safflower oil enrichment ω-6 fat, linoleic acid (LA) to heart.The man of edible linseed oil takes in 8 gram ALA every day, takes in 11 gram LA the every day of edible safflower oil.The conclusion of 12 weeks research: the people's of edible linseed oil systolic pressure and diastolic pressure all have reduction significantly.

A kind of explanation is that the antiinflammatory action of ω-3 fat has caused the blood pressure reduction.ω-3 fat and ω-6 fat all are essential aliphatic acid, and two kinds of fat all are that human body needs, and need obtain from food.Yet if there is not enough ω-3 fat to come balance, ω-36 fat has the tendency that forms excessive inflammation.

Most of nutritionists think that wholesome ω-6 fat and the ratio of ω-3 fat should be greater than 4: 1, and wherein many experts think that the best must example be 2: 1.Typical U.S. diet provides about 10 times of ω to ω-3 fat-6 fat.Practical prompting: a large amount of protection heart ω-36 fat from reduce diet that studies show that are done with the ratio of ω-3 fat.The ratio that improves ω-6 fat and ω-3 fat need increase the food that is rich in ω-3 fat, as linseed oil, rapeseed oil, walnut and cold water fish, as salmon.Reduce the edible food that is rich in ω-6 fat, as safflower oil, corn oil, peanut oil, butter and animal tallow.

The doctor of medicine is conceived to essential fatty acid ω-3 (mainly being present in cold water fish and the linseed) and ω-6 (being present in red meat, safflower oil, sunflower oil, soya-bean oil and the corn oil) role than Leah Na Mile Milunovich researcher and her colleague.

The people of containing maximum omega-fatty acids in the diet suffers from the risk people low 17% minimum than edible this aliphatic acid of dry eye syndrome.

In contrast, the people of the edible high-load ω-6 aliphatic acid risk of suffering from dry eye syndrome significantly increases.The risk that edible high ω-6/ ω-3 suffers from dry eye syndrome than the woman of food is 2.5 times of normal equilibrium drink trencherman.

Researcher's special concern the effect of edible tuna, tuna is rich in omega-fatty acid.

Be less than a people's contrast (portion is 4 ounces) with edible tuna weekly: the women of the edible 2-4 part tuna risk of suffering from scheroma has reduced by 19% weekly; The risk that the women of edible weekly 5-6 part tuna suffers from scheroma has reduced by 68%.

" these discoveries think that increasing the intake of omega-fatty acid in the diet can reduce the risk of suffering from scheroma.Scheroma is common illness in eye." colleague that reins in Milunovich researcher and she than Leah Na says.

Except tuna, other fertile fish (salmon, mackerel, flatfish, sardine and catfish), linseed and linseed oil also are rich in omega-fatty acid.Consider the content of mercury in the tuna, in order to reduce the risk of suffering from scheroma, we advise edible various cold water fish and linseed, linseed oil.

Alpha-linolenic acid is to the effect of health:

China Preventive Medicial Science Institute thinks that the effect for reducing fat of alpha-linolenic acid is remarkable, its lipopenicillinase approach by prostaglandin be other any lipid lowerers can not compare.It has complete effect for reducing fat, and anti-thrombosis function is regulated blood fat, anti-arrhythmia and ventricular fibrillation effect and anti-inflammatory response effect.The metabolite of alpha-linolenic acid can hemangiectasis, strengthens blood vessel elasticity, thereby plays hypotensive effect.

US Congress's ICR finds that alpha-linolenic acid has strong antitumaous effect.The speed of growth of cancer cell is reduced greatly; Can suppress colon cancer, breast cancer, prostate cancer, the generation of central nerve neuroma capilary; Can promote the natural death of cancer cell; Can strengthen the effect of chemicotherapy; And can also reduce the toxicity of chemicotherapy greatly; Can improve the cachexia of tumor patient, the decline that loses weight, it is synthetic to improve the body internal protein.Alpha-linolenic acid can make cancer cell be not easy to be penetrated in blood vessel and the organ basilar memebrane on every side, thereby reduces the speed of cancer metastasis.

Alpha-linolenic acid energy life-saving; Alpha-linolenic acid energy vision protection; Alpha-linolenic acid can be subdued too active immune system, suppresses allergic reaction, stops the generation of inflammatory disease; Alpha-linolenic acid can strengthen the sensitiveness of cell to insulin, protects us to avoid the puzzlement of metabolism diseases such as diabetes; Alpha-linolenic acid is except lowering the chance of suffering from coronary heart disease and some cancer, and it also can improve skeletal growth.Particularly visual cell DHA is many especially in the retina, if lack, eyesight will descend, and the retinal reflex ability prolongs recovery time.And the metabolite-DHA of alpha-linolenic acid can improve and vision protection; Alpha-linolenic acid can improve human mood.Its metabolite DHA can obviously alleviate depression, ADD, schizophrenia; Alpha-linolenic acid is the fat-reducing good merchantable brand.But its appetite-suppressing prevents that fat from piling up in vivo.The time ratio that food is retained in stomach does not have fat or low fat food is long.Promote that intestinal secretion goes out a kind of hormone that is called cholecystokinin, can send the signal that stops to take food to brain.In all enough nutriments of people's energy, the alpha-linolenic acid in the linseed oil can stop hunger, makes the people that feeling of repletion be arranged.It can not piled up in vivo with the form of fat.

Britain's Royal School of Medicine is discovered: the content of alpha-linolenic acid and metabolin thereof is directly proportional in the height of people's IQ and the brain.The Japan scientist is startling to 320 academicians' in the whole world research: alpha-linolenic acid content is high 3 times than the normal person in these scientist's brains! In the literary composition that " cracks the mystery in " the very best township " " on April 24th, 2006 " healthy Times ", reporter Yang Rui report recovered college entrance examination so far from 1977, the Huining County that has 550,000 populations is admitted to doctor people more than 200 altogether, and the master is the people more than 1000, the scholar is the people more than 10,000, the people more than 30,000 of all kinds of universities.Nutritionists have probed into out the mystery that able men are coming forth in multitudes in the poor county, can peaceful people almost all eat the linseed oil that is rich in alpha-linolenic acid every day.Alpha-linolenic acid has and increases intelligence, and improves memory, and vision protection improves functions such as sleep, is acknowledged as significant in the brain growth process.

Urgent need is improved the seriously unbalance of linoleic acid and alpha-linolenic acid ratio in vivo: derive because ω-6 unrighted acid (linoleic acid) and omega-3 unsaturated fatty acid (alpha-linolenic acid) are striven a kind of enzymatic conversion altogether in human body, a kind of aliphatic acid Excessive Intake will weaken the conversion of another kind of aliphatic acid.Therefore the scientist of countries in the world points out that balance between the two is vital.The ratio of proposition ω-6: the ω-3 of the World Health Organization should be less than 6: 1, and Japanese ministry of Health and Welfare proposes should be less than 4: 1, and it should be 4-6 that Chinese Soclety of Nutrition proposes calendar year 2001: 1, and having scientist to propose optimal proportion should be 1-3: 1.Yet because the quick raising of living standard, aliphatic acid is taken in total amount to be increased, and the ratio that people's essential fatty acid is taken in the actual life is up to 20-30: 1, i.e. and linoleic acid severe overweight, the leukotrienes wretched insufficiency, ratio is seriously unbalance.Living standard that Here it is improves, the main cause that the multiple chronic disease incidence of disease rises on the contrary.

The shortage of alpha-linolenic acid causes the fault of cell membrane in the body: its function that each cell all has wall one---cell membrane---is not allow toxin, bacterium, virus and other harmful substance enter in the cell, and allows the needed various nutrition of cell to enter cell.The cell membrane that is out of order has lost the function that opposing bacterium, virus, toxin and other harmful substance enter cell and destruction cell.Fat and oil are the main materials that is used for making these cell membranes.If it is normal to have eaten good fat and eleocyte film function.If eaten bad grease.Function of plasma membrane is just undesired, and at this moment, any disease that we can imagine all might take place.The sick reason of many people all is by improper diet and cause the fault of construction of cell membrane to be caused.

When alpha-linolenic acid lacked, saturated fat, trans fats or hydrogenated fat that health is just used in the body were made cell membrane.The cell membrane that the shape of trans fats and hydrogenated fat can not be used for building.The cell membrane that is built into them is leaky, fragile.If your health a lot of cells up and down all are leaky and fragile, various diseases has just come.The diet of too much saturated grease can cause stiff cell membrane, lacks necessary elasticity.Make vascular sclerosis, break easily, MT etc. tear wound easily.The cell membrane of being built by hydrogenated oil and fat can hinder oxygen to enter cell, and the cell of anoxic then can become cancerous state.Thereby cause fat, hypertension, high fat of blood, cardiovascular and cerebrovascular disease, diabetes, cancer etc. " modern civilization disease ".

Look at the reaction of other countries: the World Health Organization and European and American countries suggestion replenish omega-3 unsaturated fatty acid in view of the huge effect of omega-3 unsaturated fatty acid for human health, and countries in the world are promoted omega-3 unsaturated fatty acid one after another.The nineties in last century, the U.S., Britain, France, Japanese law-making stipulation must be added omega-3 unsaturated fatty acid, otherwise will not sell in multiclass food.Countries such as Germany also patent applied for omega-3 unsaturated fatty acid as medicine or food additives, be used for preventing and treating angiocardiopathy.The World Health Organization and FAO (Food and Agriculture Organization of the United Nation) just seriously issued a statement to the world in 1993, and in view of the importance of omega-3 unsaturated fatty acid and the situation of human general insufficiency of intake, the special omega-3 unsaturated fatty acid that replenishes is wanted in suggestion.

Fat has important effect as one of human body seven big class nutrients to people's health.But because people's the prejudice and the relative shortage of nutrient knowledge, a lot of people begin to repel fat, even regard it the synonym of fat and modern disease as.Do actually the misfortune that fat is invited, or we not understand fat? in fact, fat also has the branch of quality, and it is sick that good fat not only can let us, and also the health to us has important effect, and bad fat is only the real murderer of modern civilization disease! Or low fat food is long.Promote that intestinal secretion goes out a kind of hormone that is called cholecystokinin, can send the signal that stops to take food to brain.In all enough nutriments of people's energy, the alpha-linolenic acid in the linseed oil can stop hunger, makes the people that feeling of repletion be arranged.It can not piled up in vivo with the form of fat.

[0130] Britain's Royal School of Medicine is discovered: the content of alpha-linolenic acid and metabolin thereof is directly proportional in the height of people's IQ and the brain.The Japan scientist is startling to 320 academicians' in the whole world research: alpha-linolenic acid content is high 3 times than the normal person in these scientist's brains! In the literary composition that " cracks the mystery in " the very best township " " on April 24th, 2006 " healthy Times ", reporter Yang Rui report recovered college entrance examination so far from 1977, the Huining County that has 550,000 populations is admitted to doctor people more than 200 altogether, and the master is the people more than 1000, the scholar is the people more than 10,000, the people more than 30,000 of all kinds of universities.Nutritionists have probed into out the mystery that able men are coming forth in multitudes in the poor county, can peaceful people almost all eat the linseed oil that is rich in alpha-linolenic acid every day.Alpha-linolenic acid has and increases intelligence, and improves memory, and vision protection improves functions such as sleep, is acknowledged as significant in the brain growth process.

[0131] is badly in need of improving the seriously unbalance of linoleic acid and alpha-linolenic acid ratio in vivo: owing to ω-6 unrighted acid (linoleic acid) and omega-3 unsaturated fatty acid (alpha-linolenic acid) are striven a kind of enzymatic conversion altogether and derived in human body, a kind of aliphatic acid Excessive Intake will weaken the conversion of another kind of aliphatic acid.Therefore the scientist of countries in the world points out that balance between the two is vital.The ratio of proposition ω-6: the ω-3 of the World Health Organization should be less than 6: 1, and Japanese ministry of Health and Welfare proposes should be less than 4: 1, and it should be 4-6 that Chinese Soclety of Nutrition proposes calendar year 2001: 1, and having scientist to propose optimal proportion should be 1-3: 1.Yet because the quick raising of living standard, aliphatic acid is taken in total amount to be increased, and the ratio that people's essential fatty acid is taken in the actual life is up to 20-30: 1, i.e. and linoleic acid severe overweight, the leukotrienes wretched insufficiency, ratio is seriously unbalance.Living standard that Here it is improves, the main cause that the multiple chronic disease incidence of disease rises on the contrary.

[0132] shortage of the interior alpha-linolenic acid of body causes the fault of cell membrane: its function that each cell all has wall one---cell membrane---is not allow toxin, bacterium, virus and other harmful substance enter in the cell, and allows the needed various nutrition of cell to enter cell.The cell membrane that is out of order has lost the function that opposing bacterium, virus, toxin and other harmful substance enter cell and destruction cell.Fat and oil are the main materials that is used for making these cell membranes.If it is normal to have eaten good fat and eleocyte film function.If eaten bad grease.Function of plasma membrane is just undesired, and at this moment, any disease that we can imagine all might take place.The sick reason of many people all is by improper diet and cause the fault of construction of cell membrane to be caused.

[0133] when alpha-linolenic acid lacks, saturated fat, trans fats or hydrogenated fat that health is just used in the body are made cell membrane.The cell membrane that the shape of trans fats and hydrogenated fat can not be used for building.The cell membrane that is built into them is leaky, fragile.If your health a lot of cells up and down all are leaky and fragile, various diseases has just come.The diet of too much saturated grease can cause stiff cell membrane, lacks necessary elasticity.Make vascular sclerosis, break easily, MT etc. tear wound easily.The cell membrane of being built by hydrogenated oil and fat can hinder oxygen to enter cell, and the cell of anoxic then can become cancerous state.Thereby cause fat, hypertension, high fat of blood, cardiovascular and cerebrovascular disease, diabetes, cancer etc. " modern civilization disease ".

[0134] look at the reaction of other countries: the World Health Organization and European and American countries suggestion replenish omega-3 unsaturated fatty acid in view of the huge effect of omega-3 unsaturated fatty acid for human health, and countries in the world are promoted omega-3 unsaturated fatty acid one after another.The nineties in last century, the U.S., Britain, France, Japanese law-making stipulation must be added omega-3 unsaturated fatty acid, otherwise will not sell in multiclass food.Countries such as Germany also patent applied for omega-3 unsaturated fatty acid as medicine or food additives, be used for preventing and treating angiocardiopathy.The World Health Organization and FAO (Food and Agriculture Organization of the United Nation) just seriously issued a statement to the world in 1993, and normal physiological function also needs fat to stimulate, and forms gall stone in order to avoid bile resides in gall-bladder for a long time.

Scientific research confirms that a lot of aliphatic acid people physical efficiencys self are synthetic, and two classes can't self be synthetic but have, and must resemble to absorb from food most of vitamin, so be called essential fatty acid.They are respectively linoleic acid (ω-6) and alpha-linolenic acid (ω-3).These two kinds of essential fatty acids all belong to polyunsaturated fatty acid, have only plant and marine algae to synthesize.Polyunsaturated fatty acid (as arachidonic acid, EPA, DHA) in the animal and plant body is transformed by them.Edible oil, can for we provide these must aliphatic acid, but because of edible oil raw material, technology difference, its contained necessary aliphatic acid kind and content also has sizable difference.If lack any necessary aliphatic acid in the long-term edible oil of eating all healthy crisis will appear.Scientific research confirms, though linoleic acid---and be can not be excessive; Alpha-linolenic acid---must and be badly in need of replenishing! National authority department spells out: the whole people replenish the alpha-linolenic acid engineering and replenish the calcium, enrich the iodine more important than the whole people!

Silkworm chrysalis (comprising mulberry silkworm chrysalis and tussah chrysalis)

Silkworm chrysalis (Silkworm Pupa) is the pupa of Bombycidae insect bombyx mori (Bombyx moil.), is a kind of cuisines of high nutrition, also is Chinese medicine simply.

Silkworm chrysalis is the abundantest stage of stored nutrient in the silkworm metamorphosis process, multiple natural active matter that is rich in the body and pheromones be support that silkworm moth sprouts wings, circles in the air, the energy of reproduction and embryonic development, have important nutritive value and health care.Silkworm is extremely enervated, in the growth course agricultural chemicals and all kinds of pollution is had strong repellency, cocoons even can not weave silk by small pollution, is changed to pupa.Silkworm chrysalis belongs to no ridge Vertebrate simultaneously, edible can the generation such as " rabid ox disease ", " bird flu " and infecting both domestic animals and human diseases such as " aftosas ".

Contain the fat about 30% in the fresh silkworm chrysalis, main component is the glyceride and the unrighted acid of unrighted acid.Its contained unrighted acid has oleic acid, linoleic acid, linolenic acid etc., and these unrighted acids all have drug effect preferably to treatment hypertension, vascular sclerosis, high cholesterol etc.Also contain phosphatide, polysaccharide, cholesterine, phytosterol, ergosterol, adrenaline, norepinephrine, adenine, hypoxanthine in the silkworm chrysalis body simultaneously, choline and multiple protein hormone, as thoratropic hormone, diapause hormone, and a large amount of vitamin As, vitamin B2, vitamin D, folic acid, Mg, Ca, Zn, Fe, trace elements such as Cu, Se with abundant are taken the course of its own its alimentary health-care function in each nutritious food.

Silkworm chrysalis oil contains multiple unrighted acid, and content is up to more than 80%, and wherein alpha-linolenic acid content accounts for more than 30%.What deserves to be mentioned is and also contain a certain amount of odd-carbon fatty acid such as carbon 15 in the silkworm chrysalis oil, odd-carbon fatty acid is extremely rare in terrestrial life.Also contain have an appointment 4% phosphatide and 0.21% gamma-Linolenic acid in the silkworm chrysalis grease, contain lysolecithin in the pupa phosphatide, lipid sphyngomyelin, phosphatidylinositols, lecithin etc.

Silkworm chrysalis is gone into food has long history in China.It is reported that the silkworm chrysalis boiling go into to fete the history in more than 1400 year is arranged.The silkworm chrysalis main component is a protein, and is good protein.Protein after the silkworm chrysalis degreasing can reach 79%, think that through automatic amino acid analyzer mensuration pupa albumen is a full price albumen, amino acid great variety of goods not only, and 8 kinds of necessary amino acid equilibriums of human nutrition, ratio is suitable, meet the requirement of FAO/WHO (FAO (Food and Agriculture Organization of the United Nation) and the World Health Organization), and essential amino acid accounts for total amino acid more than 40%.100 kilograms of bright pupas contain protein and are equivalent to 34 kilograms of thin porks, or 30 kilograms of eggs, or 40 kilograms of crucians.Silkworm chrysalis not instrument is delicious flavour, nutritious non-staple food, and the valuable raw material of number of chemical medicine is extracted in still extremely valuable animal protein source especially.

The discovery of rich zinc in the pupa albumen, make the nutrition of silkworm chrysalis more characteristic, when Chinese scholar Li Zheng in 1992 utilizes the ICP plasma emission spectrometer to measure 20 kinds of constants of degreasing pupa and trace element, at first record and find that zinc content reaches 19.025g/100g in the silkworm chrysalis, the zinc content that is much higher than more than 200 foods commonly used that China reports the nineties on Journal of Nutrition, this discovery causes participant's very big concern after reading out in the 19th the entomology conference.Because zinc is to lack more a kind of necessary trace element in China's food, in child nutrition, it is comparatively general to lack the zinc phenomenon, and apocleisis is one of specific manifestations that lacks the zinc children.

Crude protein content can reach 77% in the degreasing pupa.Pupa albumen is a kind of full price high-quality protein, and the amino acid great variety of goods wherein contains 18 seed amino acids, 8 seed amino acid total amounts of needed by human are 40.85%, surpass 36% standard of World Health Organization's defined, contain lysine 3.02mg in the bright silkworm chrysalis of every hectogram, threonine 2.34mg, leucine 3.51mg, isoleucine 3.09mg, methionine 1.30mg, phenylalanine 2.73mg, valine 3.22mg, tryptophan 1.22mg, being fit to very much the needs of human body, is a kind of insect protein of high-quality.The saying that an egg of seven silkworm chrysalises is arranged, be weak, after being ill, old man and the high-grade nutrient tonic in women postpartum.Silkworm chrysalis can play certain regulating action, silkworm chrysalis oil reducing blood lipid well, norcholesterol to body sugar and fat metabolism.To the supplemental treatment hypercholesterolemia with improve liver function remarkable effect is arranged.Silkworm chrysalis can produce the product with pharmacological activity.This activated product can effectively improve the leucocyte level in the human body, thereby improves the immunologic function of human body, and the effective senescence process of delaying human body function.

The silkworm chrysalis chitin mainly concentrates in the pupa skin.Contain pupa skin 8%～9% in the degreasing silkworm chrysalis, Main Ingredients and Appearance is chitin, albumen, inorganic salts and pigment etc.Also contain phosphatide, polysaccharide, cholesterine, phytosterol, ergosterol, adrenaline, norepinephrine, adenine, hypoxanthine in the silkworm chrysalis, choline and multiple protein hormone, as thoratropic hormone, diapause hormone, and a large amount of vitamin As, vitamin B2, vitamin D, folic acid and abundant Mg, Ca, Zn, Fe, trace elements such as Cu, Se.When Chinese scholar Li Zheng in 1992 utilizes the ICP plasma emission spectrometer to measure 20 kinds of constants of degreasing pupa and trace element, at first record and find that zinc content reaches 19.025mg/100g in the silkworm chrysalis, the zinc content that is much higher than more than 200 foods commonly used that China reports the nineties on Journal of Nutrition, this discovery after reading out in the 19th the entomology conference, causes participant's very big concern in this discovery.

Modern scientific research confirms that the silkworm chrysalis nutritive value is high.According to surveying and determination, contain crude fat 25%～30% in the dried silkworm chrysalis, crude protein 55%～60%, glycogen 2%～4%, chitin 2%～3%, ash content 3%～5%, and other multiple bioactivator, as trace element, vitamin, antibacterial peptide, hormone, lysozyme etc.

The silkworm chrysalis of living is the many and full biology of unique up to now energy abstraction function active material on the earth.Silkworm itself casts off a skin, weaves silk into cocoon, pupa, cocoon-break Cheng E from ovum to four, claps ovum to breath, and everything all occurs in short one month, and this is that the interior particular matter of its body determines this magical transformation.Discover, the oil that silkworm chrysalis extracts, unrighted acid (needed by human but the aliphatic acid that self can not synthesize) reaches more than 80% unexpectedly, and wherein the overwhelming majority is alpha-linolenic acid (ω-3 series), in tellurian, reach rare odd-carbon fatty acid in addition and (can claim interferon, anti-cancer and kill cancer action), contain tens kinds of vitamin and trace elements.

Silkworm chrysalis oil includes multiple bioactivator, and aliphatic acid is formed rationally.Be rich in many active lipids such as hormone and pheromones in the silkworm chrysalis oil, the growth of silkworm is played important adjusting and information transfering action.

Unsaturated fatty acid content is higher in the silkworm chrysalis grease, and its aliphatic acid is formed and is better than deep sea fish oil.And the ratio of saturated fatty acid, monounsaturated fatty acids and polyunsaturated fatty acid extremely levels off to the edible best fatty acid proportion standard of human body that current nutritionist recommends, be natural high-quality nutrient edible oil, for vegetable fat, animal fat and artificial synthetic ready-mixed oil can not be compared.

It is worth noting that exist the extremely rare odd-carbon fatty acid of nature in the silkworm chrysalis oil, wherein 17 carbonic acid are main.Kind of material reduces people in middle age gradually, and the people can not synthesize naturally, therefore, causes people's body machine immunity degradation, and anticancer and anti-disease activity descends, and is the root place of causing various obstinate diseases.But do not have in normal food and the animals and plants,, made scientist that the enrichment and the separation and Extraction of odd-carbon fatty acid in the silkworm chrysalis grease have been produced great interest because odd-carbon fatty acid has stronger active anticancer.The every gram of material of exploitation extraction odd-carbon fatty acid spends unexpectedly and has reached U.S. dollars up to ten thousand and caused development cost surprising in the international market.Extracting this type of material can only be to hope and halt as the business capital that do not have certain scale and technology.

More interesting is, silkworm is as plant-feed insect, the function of cholesterol is finished by phytosterol, and it is apparent different that this phenomenon has silkworm chrysalis oil and other terrestrial animal greases of high cholesterol count, thereby becomes the high-quality food or the animal fat resource of lower cholesterol content.The insect food that cholesterol level is extremely low.Long-term edible without any side effect.

Silkworm chrysalis oil

Silkworm chrysalis oil is the mixture that contains multiple higher fatty acids glyceride that extract from silkworm chrysalis, and outward appearance is the transparent oily liquids of yellow to red.Contain the unrighted acid that reaches more than 80% in the silkworm chrysalis grease, wherein main component is alpha-linolenic acid, oleic acid, linoleic acid etc.Function assessment both domestic and external and nutrition studies show that alpha-linolenic acid has important health care: brain tonic and intelligence development strengthens memory; Strengthen amphiblestroid albedo, the prevention vision degeneration; Reduce blood fat, cholesterol and blood pressure, angiocardiopathy preventing; Suppress platelet aggregation, prevent thrombosis and apoplexy etc.The silkworm chrysalis oil grease article can be used for improving memory and prevent diseases such as high fat of blood, hyperglycaemia, hypertension.Silkworm chrysalis oil can extract aliphatic acid, the multiple light industry industry of epoxy silkworm chrysalis wet goods and medical industry raw material.

The security of silkworm chrysalis is high, the Ministry of Public Health and Food Hygiene Surveillance check institute of the Ministry of Public Health are respectively with " defending prison sends out (1991) No. 45 ", " No. the 23rd, (88) food prison searching " and " defending prison sends out (1998) No. 9 " file, announced the list of totally 91 kinds " are food be again medicine ", silkworm chrysalis is listed in wherein as unique insect; In 2004 No. 17 bulletins of the Ministry of Public Health, again silkworm chrysalis is classified as the new resources bread and cheese, further confirmed the security of silkworm chrysalis.

Commentary about silkworm chrysalis nutrition and medical value:

Silkworm just has the title of " refreshing worm " from ancient times, and Compendium of Material Medica is carried " silkworm and imperial same gas ".

Silkworm is extremely enervated, in the growth course agricultural chemicals and all kinds of pollution is had strong repellency, cocoons even can not weave silk by small pollution, is changed to pupa.

Important Arts for the People's Welfare carry: drive with silkworm chrysalis and entertain guests at a banquet;

Compendium of Material Medica is carried: distinguish the flavor of salty suffering, property of silkworm chrysalis is flat, nontoxic, and people's food can be kept fit body-building, is used as medicine how sick can cure, can benefiting qi and nourishing blood, the strong kidney of strong waist, nourishing lung and clearing intestine;

" Japan hanako materia medica " claims that it can " control wind and labor is thin ";

Prescriptions Worth Thousand Gold for Emergencies carries: the salty temperature of silkworm chrysalis nature and flavor, main beneficial vital essence;

" medical center usurp will " claims that silkworm chrysalis can " and taste, curing rheumatism, long yang-energy ".

Modern this agrostology works is also all included silkworm chrysalis as " Chinese medicine voluminous dictionary ", " Chinese medicinal herbal ", " Chinese medicine sea ", " Chinese medicine Ci hai " etc. as Chinese medicine.

" Chinese medicine voluminous dictionary " carries: hypercholesterolemia, it is for oral administration to make pill with the purification product of silkworm pupal fat.

It is modern that " practical nourishing healthy handbook is introduced: silkworm chrysalis is gone into kidney channel, establishing-Yang.To the insufficiency of the kidney yang, impotence person can do the dietotherapy product.

Expert's evidence of the World Health Organization, the alpha-linolenic acid that is rich in the silkworm chrysalis is an essential fatty acid, produces EPA, DHA and prostacyclin etc. the human body metabolism.

Office checks and approves identification through the state food drug surveilance, and the world of medicine is that raw material has been developed the new drug with step-down, lipopenicillinase and liver-protecting function with the silkworm chrysalis.

In view of silkworm chrysalis important nutritive value and health care, health ministry assert that it is the new resources nutraceutical.。

The preclinical medicine effect of silkworm chrysalis oil:

The scientific research personnel reduces 10 preclinical medicine effects from the angle of medical science with silkworm chrysalis oil.

1, highly increase intelligence: silkworm chrysalis oil energy brain tonic and intelligence development strengthens memory.The metabolin of silkworm chrysalis oil alpha-linolenic acid is EPA and DHA, is commonly called as " brain gold ", can promote the synthetic of interior nucleic acid protein of brain and monoamine neurotransmitter, can strengthen brain worker's memory effectively.

The silkworm chrysalis oil alpha-linolenic acid is the precursor of synthetic brain gold (DHA) in the human body; The Britain Royal School of Medicine finds that alpha-linolenic acid and metabolite content are directly proportional in IQ height and the brain; Increase brain nutrition, slow down and prevent the generation of senile dementia, highly increase intelligence, therefore, prevention of silkworm chrysalis oil alpha-linolenic acid health care and supplemental treatment encephalopathic, the silkworm chrysalis oil alpha-linolenic acid is to repairing the damage of brain cell, and prevention and supplemental treatment encephalatrophy, senile dementia, apoplexy sequelae, brain paralysis, Parkinson's have the effect of prevention and supplemental treatment.

2, strengthen immunity, delay senility.The generation of many diseases, relevant with the immune function of human body imbalance, silkworm chrysalis can strengthen the pliability of immunocyte film, the vigor of immunocyte is increased, thereby make the healthy barrier of human body firmer, effectively prevents the generation of inferior health and disease.Can obviously improve the vigor of hepatocuprein, reduce the Radical Metabolism product, have good anti-aging effects.

Suppress aging, fat-reducing and beauty.Can promote fatty mitochondrial activity effectively, too much heat in the consumer, and without any side effects need not be gone on a diet, fasting; What simultaneously alpha-linolenic acid can participant soma cell membrane is synthetic, effectively prevents and alleviates modern female because of symptoms such as the wrinkle that multiple reason causes increases, the yellow black and agings in advance of pigment deposition, skin.

The mankind have welcome aging, but are difficult to for aging down definite definition.Most researchers think aging can be divided into the aging and physiological ageing of morbid state.In fact the two strictly separately also is difficult to.Alpha-linolenic acid not only can prolong the life-span of headstroke rat, also can prolong the life-span of common rat simultaneously.Along with the increase at age, EPA, the DHA in human blood platelets, the red blood cell lipid reduces, and arachidonic acid (AA) increases, and the generation of MDA simultaneously increases, and SOD is active to be increased, and points out it that anti-aging effects is arranged.The reason of silkworm chrysalis oil alpha-linolenic acid life-saving is not one probably.As foregoing inhibition thrombotic diseases, suppress cancer generation and transfer, keep normal arterial pressure, suppress cerebral hemorrhage morbidity etc., all can be regarded as life-saving aspect role.

3, reduce blood fat: can reduce triglyceride effectively, prevention and treatment fatty liver also have the better protect effect to liver after drinking, can improve environment in blood quality and the blood vessel, effectively softening blood vessel, bring high blood pressure down, prevent artery sclerosis and thrombosis.

During will testing, a lot of people draw the effect that silkworm chrysalis oil has reduction serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein, VLDL and rising serum high-density LP.

Give clinically and take the result that silkworm chrysalis oil observes with 204 routine hyperlipemic patients and show that after high serum levels of triglyceride patient took, the serum TG value descended significantly.Near normal value, be in the 10th week and continue reduction trend (P＜0.01) during the 5th week.High T-CHOL (TC) the blood also highly significant (P＜0.01) that descends.

Silkworm chrysalis oil reduces the mechanism of serum cholesterol, and except that increasing the cholesterol drainage, it is synthetic also very important to suppress endogenous cholesterol.HMG-GOA reductase and acyl CoA cholesterol fat transferase (ACAT) are the synthetic main rate-limiting enzymes of cholesterol.Tield etc. find to take in alpha-linolenic acid, and rabbit liver meat HMG-COA reductase activity is reduced, and make the active rising of ACAT simultaneously, and the hepatomicrosome inner cholesterol reduces; The HMG-COA reductase activity at little time end 2/3 position is also seen reduction.

Silkworm chrysalis oil reduces the mechanism of serum triglyceride, and is main by the triglycerides in the minimizing VLDL and the biosynthesis of apolipoprotein B.Aspect reduction serum low-density LP mechanism, silkworm chrysalis oil mainly suppresses the synthetic of low-density lipoprotein, and DHA is playing a major role aspect the increasing high density lipoprotein (HDL).In the HDL generative process, lipoprotein lipase and lecithin cholesterol base change enzyme (LCAT) and play an important role.It is active and promote that HDL's is synthetic that DHA can increase albumen lipase and LCAT.Simultaneously silkworm chrysalis oil can also suppress the activity of liver endothelial cell esterase (HEL) and suppress the degraded of HDL.Research also shows, the silkworm chrysalis oil HDL2 component in the blood that mainly raises, and HDL3 is then constant substantially.

Pupal fat Alpha-ethyl linolenate can raise liver mitochondrion and the activity of microsome with the relevant enzyme of fatty acid oxidation are quickened aliphatic acid by preferential beta-oxidation and are decomposed, and reduce the synthetic substrate of TG, suppress the synthetic of TG; Inhibited to TC synzyme HMG-CoA reductase, suppress the synthetic of TC and/or promote TC metabolism and discharge.When reducing serum TC, liver TC also reduces, and is showing the activity of raising serum LCA (LCAT), promotes generation and the TC antiport of ripe HDL-C.

4, reduce hypertension:

Silkworm chrysalis oil is given and Hypertensive Rats and common blood pressure rat.Observe its blood pressure.The result shows that silkworm chrysalis oil suppresses increased blood pressure, and its fall is about 10%.And the rat of common blood pressure, no matter whether identical aliphatic acid is in the food, almost not influence.Silkworm chrysalis oil should be very effective to boundary territory hypertension.Certainly, even blood pressure is higher, easily produce the phenomenon of hemorrhagic cerebral apoplexy, silkworm chrysalis oil still has the hypotensive activity about 40%.Its step-down mechanism is to descend because of silkworm chrysalis oil can make the neutral fat (cholesterol, triglycerides) in the blood plasma, and these are comprehensive to presenting the blood pressure drops effect together.

5, suppress thrombotic diseases, prevention miocardial infarction and cerebral infarction:

Because form thrombus, blood vessel blockage just can not be from passing on oxygen and nutrition here forward, cell sustains damage, and promptly is the infraction state.Easily form thrombus at heart coronary artery and cerebrovascular place, form miocardial infarction and cerebral infarction.Always think since in the blood vessel stacking energy of cholesterol etc. form thrombus, so the cholesterol in the food is considered as the enemy.In fact facilitating the even more important factor of thrombosis is the degree of platelet aggregation energy.By coming its degree of comparison for the rat silkworm chrysalis oil to the platelet aggregation energy.The result shows that silkworm chrysalis oil obviously suppresses the free energy (P＜0.05) that platelet aggregation energy (P＜0.02) has suppressed thrombocytin simultaneously.

6, antiinflammatory action:

Human body is taken in silkworm chrysalis oil and is included leucocyte in, is released again when leucocyte is upset, and changes the leucocyte flowability, makes leukocytic neutral chemotactic and is suppressed to the inner skin cell viscosity reaction.External evoked excitation experiment finds that arachidonic acid (AA) and EPA produce LTB4 and LTB5 respectively, and the short leukocyte recruitment organized enzyme of LTB5 only reaches LTB4 day 10%.The alloisomerism of LTB5 is non-activity then.The metabolite that produces through the lipoxygenase effect with the isomolar EPA of AA can make under the output of LTB and make a price reduction 68%, and its inhibitory action mechanism may be to suppress the LTB hydrolytic enzyme activities.In vivo studies also draws similar conclusion.Discoveries such as Payan, silkworm chrysalis oil can make the T lymphocyte reaction increase, Ziboh etc. think DHA may the words of the lowly carry little weight a kind of special ring add the cloudy disconnected agent of valve enzyme and suppress arachidonic acid and produce LT4

The pupal fat Alpha-ethyl linolenate is the precursor of ω 3 unrighted acids, generate a series of metabolins through desaturation and carbochain prolongation effect, has very strong physiologically active, inflammatory mediator, interleukins etc. is had regulating action, reduces the content of MDA (MDA) in the liver, reduce hepatocellular injury.

7, suppress allergic reaction:

In the past in the period of 30, pollen hypersensitivity, food allergy, specificity eczema, asthma etc. are increasing exponentially.Part investigation of giving birth to of Japan shows that per 3 philtrums of pupil just have 1 people to be diagnosed as specificity allergy.Child in the kindergarten surpasses 40%.The youth also is remarkable increase trend in recent years, thinks that its reason has 2 points, and the one, anaphylactogen increases; The 2nd, somatic reaction is hyperfunction.Mast cell, neutrocyte when producing allergy in the health play an important role.Anaphylactogen one enters human body, just combines with mast cell, stimulates just release out histamine and leukotriene (LT) so produce.In addition, by the neutrocyte platelet activating factor of releasing out.These have just caused irritated various symptoms, as expiratory dyspnea, secretion increase, rhinitis etc.

Experiment showed, releasing of platelet activating factor (PAF) about irritated inflammation, the silkworm chrysalis oil alpha-linolenic acid can produce to face upward to make and use.

8, insulin secretion accelerating prolongs hypoglycemic effect, suppresses complication.The effect that impels prostaglandin to keep balance is arranged in body, the prevention prostatic disorders, the function of raising pancreatic excreting insulin, the activity of the fatty acid desaturase of recovery diabetes patient cell has the obvious functions of blood sugar effect, and can not rebound.

The silkworm chrysalis oil alpha-linolenic acid can promote pancreatic excreting insulin and the stable effect in blood of protection insulin.Can reduce the opposing of target cell ginseng insulin.When suffering from diabetes, the lipolysis in the body is quickened, and the lipid metabolism rate disorderly causes that blood fat increases, and causes vascular sclerosis, complication such as hyperlipemia, fatty liver, hypertension.In addition, fatty excessive decomposition can produce ketoboidies, as surpassing the limit of utilizing of body, piles up in vivo in a large number, will produce DKA.The silkworm chrysalis oil alpha-linolenic acid can be regulated lipid metabolism in human body, suppress complication, reduces the probability of acid, ketoacidosis.The silkworm chrysalis oil alpha-linolenic acid is of great advantage to each organ of human body and neural protective effect humidification to the diabetes patient simultaneously.

The pupal fat Alpha-ethyl linolenate can effectively improve renal function, reduce UCaE, suppressing experimental mouse kidney calcium oxalate crystal forms, can be by acting on insulin PI3K/PKB signal transduction pathway, increase skeletal muscle to the sensitiveness of insulin, alleviate or avoid skeletal muscle insulin resistance and metabolism obstacles of blood glucose.

9, suppress fatty liver, it is normal to recover liver function

Liver is one does not have sensorineural internal organs, is called as " reticent organ ", even piled up a lot of fat in the liver, even inflammation occurs, can not feel pain yet.Just because of this, people are often off one's guard, ignored the existence of fatty liver, cause fatty liver at leisure to fibrillatable, even the sclerosis differentiation, lead to irremediable consequence at last.

After fatty liver developed into to a certain degree, sex change, necrosis can take place in liver cell.If fatty liver can not get treatment for a long time, might become fatty liver hepatitis and liver fibrosis with that, until developing into cirrhosis.According to authoritative statistics both domestic and external, the liver fibrosis incidence of fatty liver is 25%, and final the evolution, liver ascites, varication and hemorrhage of digestive tract will take place in the patient, and individual other patient also fat embolism can occur.Liver is the detoxifcation organ of body maximum, and after the liver sclerosis, obstacle promptly takes place the detoxification ability of liver, and a large amount of toxin will be trapped in the liver in the body, thereby causes canceration.Silkworm chrysalis oil can prevent fat accumulation, decomposes digestion to piling up fat, excretes, and removes the hepatomegaly phenomenon.Repair the liver damage cell simultaneously, enhanced activity is removed inflammatory cell, especially removes some harmful enzymes, recovers liver function.

10, suppress the generation and the transfer of cancer:

The generation of α, inhibition cancer:

At first, silkworm chrysalis oil can reduce the linoleic quantity that cancerous swelling is extracted from blood, makes cancerous swelling give up a kind of its in demand nutriment.Passivation in this way the linoleic effect that promotes cancer generation effect arranged.Alpha-linolenic acid in second silkworm chrysalis oil can produce needed enzyme in the metabolic process of cancerous swelling with the contention of Ω-6 series fatty acid.The 3rd, the silkworm chrysalis oil alpha linolenic acid is more unsaturated by the cell membrane of cancer cell, becomes to be easy to destroy.Recently research data shows that linoleic acid can help to prevent on the cancer cell band gene of natural death.And the silkworm chrysalis oil alpha-linolenic acid can promote the natural death of cancer cell, has increased the death rate of cancer cell, has therefore also just slowed down the speed of growth of cancerous swelling.

B, inhibition cancer metastasis:

Cancer makes the fearful place of people most, is its branch problem, though being restored to the original state, cancer is difficult to, if can suppress its transfer, also be a flying colours.In cancer treatment procedure, the diffusion that prevents cancer is very crucial, because Most patients is because being diffused into the cancer cell at other positions causes death, rather than dies from former cancer.Therefore, to reduce the discovery of cancer metastasis speed be very challenging to the silkworm chrysalis oil alpha-linolenic acid.Cancer cell wants to be diffused into other positions from former position, just must be penetrated in blood vessel and the organ basilar memebrane on every side.The silkworm chrysalis oil alpha-linolenic acid has stoped the glutinous effect that connects molecule of cell surface, and " grapple " cancer cell that has lacked this necessity just is not easy to be attached on the basilar memebrane.Even if cancer cell will oneself stick on the basilar memebrane, the silkworm chrysalis oil alpha-linolenic acid also also has next step way.It can stop the generation of the necessary clostridiopetidase A of dissolving basilar memebrane, and cancer cell can't be permeated into.

The research of the medicinal and health-care efficacy of silkworm chrysalis grease:

Silkworm chrysalis oil improves the mouse memory experimental study of effect: the Peng Xinli of food engineering institute of Jilin Agriculture University, Zheng Hongyan etc. studies have shown that silkworm chrysalis oil has the obvious memory effect that improves.

The silkworm chrysalis oil polyenoic fatty acid is to the influence of rat fat and serum EPA, DHA content: medical college of Shandong University fourth China, Zhang Xiumei, Wei Xinbing etc. feed rat with high lipid diet and set up hyperlipidemia model, discover that silkworm chrysalis oil can increase the generation of interior EPA of rat body and DHA, therefore having tangible intelligence development increases the intelligence effect.Simultaneously, have the blood fat of adjusting and lipoid peroxidization resistant.

Silkworm chrysalis oil is to the influence of rat fat level and platelet function: the Yang Xue of Tongji Medical College, Huazhong Science and Technology Univ. cutting edge of a knife or a sword, coptis treasure, Hu Jianping etc. discover that the silkworm pupal fat that is rich in alpha-linolenic acid can reduce the rat fat level, suppress platelet aggregation.

Silkworm chrysalis oil is to the influence of lipid metabolism in rats: the Yang Xue of Tongji Medical College, Huazhong Science and Technology Univ. cutting edge of a knife or a sword, coptis treasure, Hu Jianping etc. discover that the silkworm pupal fat that is rich in alpha-linolenic acid is more effective than safflower oil aspect lipopenicillinase.

The research of silkworm chrysalis oil anti-thrombosis function: Zheng of food engineering institute of Jilin Agriculture University swan goose, the prosperous friend's power of preclinical medicine institute of Jilin University etc. is studied the thrombotic influence in inside and outside with regard to silkworm chrysalis oil, proves that silkworm chrysalis oil has anti-thrombosis function.

The research of odd-carbon fatty acid active anticancer in the silkworm chrysalis oil: natural pond doctor Tian Guanghong is adopting aliphatic acid to carry out finding in the exploitation of cancer therapy drug, odd number carbonic acid active anticancer is higher, and this discovery makes people to the health care and the value of silkworm chrysalis grease new understanding arranged all.

Tussah pupal fat and unrighted acid are to the preventive and therapeutic effect of hyperlipemia: Wang Qian, Wang XueyingDeng report, with the wister male mice is experimental animal, the ingest unrighted acid goods of tussah pupal fat and purification, the result shows that tussah pupal fat and unrighted acid goods thereof all have blood fat regulating action preferably, is used for the treatment of that hyperlipemia has feasibility and exploitation is worth.

The relevant report of silkworm chrysalis grease pharmacological research:

The influence that silkworm chrysalis oil forms the rat NASH: 100 of SD rats, male and female half and half, be divided into 9 groups at random by body weight and with reference to blood lipid level: the blank group, high fat control group, the prevention low dose group, dosage group in the prevention, the prevention high dose group, treatment low dose group, dosage group in the treatment, the treatment high dose group, and positive controls (evening primrose oil), feed respectively and raise all feeds. put to death rat in the 11st week, detect the heavy exponential sum liver tg of the liver (triglyceride of liver, TG), T-CHOL (total cholesterol, TC), MDA (malondialdehyde, MDA) level. the result tested for 11 weekends, the prevention group, the heavy index of the liver of treatment group and positive controls rat, liver TG, TC and MDA level all are starkly lower than high fat control group (P＜0.05), and have dose dependent.Conclusion: silkworm chrysalis oil can have the effect that very significant prevention and treatment NASH form by adjusting lipid-metabolism, is better than evening primrose oil.

The silkworm pupal fat is to the influence of lipid metabolism in rats: 50 of male adult Wistar rats; be divided into 5 groups by blood lipid level: the normal control group; high fat control group; silkworm pupal fat group; silkworm pupal fat+VE group and safflower oil group; feed respectively raise respectively organize feed .6w after; survey blood lipid level and index of correlation. result: (1) experiment 3w end; silkworm pupal fat group rat blood serum T-CHOL (TC); triglycerides (TG); LDL-C (LDL-C) level all significantly is lower than high fat control group; and there was no significant difference meaning between the safflower oil group; and serum high-density LP cholesterol (HDL-C) level is significantly higher than the safflower oil group; AI (AI) significantly is lower than the safflower oil group; these variations continue to the experiment of 6w end always and finish. and (2) silkworm pupal fat group rat blood serum LCA (LCAT) activity is significantly higher than high fat control group and safflower oil group. (3) silkworm pupal fat group rat liver TG level; the liver index significantly is lower than high fat control group; and there was no significant difference meaning between the safflower oil group; and liver TC level significantly is lower than the safflower oil group. (4) silkworm pupal fat+VE group rat blood serum VE level significantly raises; lipid peroxide (MDA) level significantly reduces, and serum TC; the LDL-C level significantly is lower than silkworm pupal fat group.Conclusion: the silkworm pupal fat that is rich in alpha-linolenic acid is more effective than safflower oil aspect lipopenicillinase, can effectively suppress peroxidatic reaction of lipid after adding VE, and does not add VE person and have stronger reduction cholesterol effect.

The silkworm pupal fat is to the influence of rat fat level and platelet function: choose 40 of male adult Wistar rats, be divided into 4 groups by blood lipid level: the normal control group, high fat control group, silkworm pupal fat group and silkworm pupal fat+VE group, feed respectively raise respectively organize feed .6 week after, measuring blood lipid level and platelet function. the result shows, (1) compares with high fat control group, the silkworm pupal fat can significantly reduce rat blood serum T-CHOL (TC), triglycerides (TG), LDL-C (LDL-C) level and AI (AI), rising serum high-density LP cholesterol (HDL-C) level; Platelet aggregation rate, blood plasma thromboxane B2 (TXB2) level and TXB2/6-k-PGF1 α (T/P) ratio significantly reduce, and 6-ketone PGF1 (6-k-PGF1 α) level significantly rises; (2) silkworm pupal fat+VE group Serum TC, LDL-C level significantly are lower than silkworm pupal fat group, and platelet aggregation rate, T/P ratio also significantly reduce.Conclusion: the silkworm pupal fat that is rich in alpha-linolenic acid can reduce the rat fat level, suppresses platelet aggregation, and behind the adding VE, this effect is more obvious.

[022] the silkworm chrysalis oil polyenoic fatty acid is to rat fat and serum EPA, the influence of DHA content: feed rat with high lipid diet and set up hyperlipidemia model, observe silkworm chrysalis oil (being rich in alpha-linolenic acid) to triglycerides in the rat blood serum (TG), T-CHOL (TC), HDL-C (HDLC), HDL-C/TC, MDA (MDA) and superoxide dismutase (SOD), eicosapentaenoic acid (EPA), the influence of MDA content in DHA (DHA) and the liver. the result: silkworm chrysalis oil can reduce TC and MDA content in the rat blood serum, rising HDL-C/TC ratio, reduce MDA content in the hepatic tissue, and it is synthetic to increase in the rat body EPA and DHA.Conclusion: silkworm chrysalis oil can increase the generation of interior EPA of rat body and DHA, and has the blood fat of adjustment, lipoid peroxidization resistant.

Silkworm chrysalis oil is regulated the experimental study of blood fat: male SD rat is divided into 3 dosage silkworm chrysalis oil experimental group (0.2g/kg.bw, 0.6g/kg.bw, 1.2g/kg.bw) and high fat control group by blood lipid level, continuous irrigation stomach 30d, d 30 measures serum total cholesterol (TC), triglycerides (TG) and HDL-C (HDL-C).The result: silkworm chrysalis oil is rich in unrighted acid (accounting for 71.97%), wherein alpha-linolenic acid accounts for 34.33%, it is relatively preceding with experiment that oleic acid accounts for 31.11%., high fat control group TC and TG raise when experiment finished, difference has statistical significance (P＜0.05). and point out high fat animal model to set up successfully. 1.2g/kg.bw silkworm chrysalis oil group TG level significantly was lower than high fat control group (P＜0.05) when experiment finished, and 0.6g/kg.bw silkworm chrysalis oil group HDL-C level is significantly higher than high fat control group (P＜0.05).Conclusion: silkworm chrysalis oil has the auxiliary effect that reduces serum triglyceride.

The comprehensive pharmacological action of silkworm chrysalis oil:

Function test confirms that deep sea fish oil is to the function of human body, and silkworm chrysalis oil not only all has, and abundanter, more comprehensively.It pharmacological action that possesses is summarized as follows:

1, brain tonic and intelligence development strengthens memory.Increase the generation of interior EPA of body and DHA, the prevention senile dementia.

2, prevention cardiovascular and cerebrovascular disease, prevention miocardial infarction and cerebral infarction suppress cerebral hemorrhage.

3, improve various inflammation, prevent and treat reactions such as asthma, allergy, specificity eczema.

4, improve looks, delay the youth, increase skin elasticity, medicine for curing poliosis reaches stablizes effect of weight reducing.

5, alleviate the germ infiltration capability, effectively prevent the prostatitis effect.

6, regulate " three height " (reducing blood lipid, hypotensive, hypoglycemic).

7, recover the chemistry hepar damnification, effectively prevent progressive stage hepatitis.

8, resist AIDS virus＜HIV〉infection, function of tumor inhibition.

Use:

The silkworm chrysalis essential oil is because of being rich in especially alpha-linolenic acid of unrighted acid, except that direct edible, also being widely used in industries such as medicine, health food, nutraceutical and the cosmetics of super quality, is to produce to be medicine, health food, nutraceutical and cosmetics of super quality quality raw materials.

Silkworm chrysalis oil alpha-linolenic acid extraction process:

Adopt three kinds of processes such as acid-hydrolysis method, alkali hydrolysis method and saponification method, be the feedstock production silkworm chrysalis oil with the fresh silkworm chrysalis, and the gained silkworm chrysalis oil carried out constituent analysis with gas chromatograph.Three kinds of processes prepare that unsaturated fatty acid content is respectively 5.26%, 3.04% and 5.51% in the silkworm chrysalis oil as a result, show to contain abundant unrighted acid in the silkworm chrysalis oil; The content of linoleic acid, oleic acid, alpha-linolenic acid is respectively 37.53%, 4.94% and 30.24% in the silkworm chrysalis oil unrighted acid.Conclusion: it is higher that saponification method technology is extracted silkworm chrysalis oil unrighted acid yield.

Silkworm chrysalis oil ultrasonic wave auxiliary extraction and antioxidative stabilizer thereof:

The optimum process condition that draws ultrasonic wave auxiliary extraction silkworm chrysalis oil by the analysis of quadratic regression model response curved surface is: ultrasonic power 102W, ultrasonic time 20min; 40 ℃ of ultrasonic temperature, with this understanding, the mean value of silkworm chrysalis oil net yield is 28.9%, recovery rate is 96.3%; The unrighted acid relative amount is 74.2% in the silkworm chrysalis oil of ultrasonic wave auxiliary extraction, wherein the oleic acid relative amount is 38.3%, and the alpha-linolenic acid relative amount is 30.2%, and the linoleic acid relative amount is 4.3%, the palmitoleic acid relative amount is 1.0%, and the arachidic acid relative amount is 0.4%; Illumination, metal ion, temperature all can significantly be quickened the silkworm chrysalis oil oxidation, and Chinese tannin is the strongest to the silkworm chrysalis oil non-oxidizability in several natural polyphenol extracts.Experiment shows: the recovery rate height of silkworm chrysalis oil ultrasonic wave auxiliary extraction, extraction time weak point, oil quality is good, adds Chinese tannin and can be used as the good natural of silkworm chrysalis oil.

The supercritical CO of silkworm chrysalis oil in the silkworm chrysalis ₂Extraction:

Silkworm chrysalis oil is at CO ₂Under the flow 8kg/h, show by experiment of single factor and Orthogonal experiment results, extracting pressure to silkworm chrysalis oil yield influence significantly, extraction temperature and time influence be not obvious, the silkworm chrysalis oil supercritical CO ₂The extraction optimal conditions is: pressure 25Mpa, 45 ℃ of temperature, time 2.5h, and under these conditions, the silkworm chrysalis oil yield is 28.97%, effect of extracting and conventional solvent extraction phase are worked as, but the silkworm chrysalis oil quality is higher than solvent extraction gained silkworm chrysalis oil.

The urea clathrate of unrighted acid separates in the silkworm chrysalis oil, the conditions such as mass ratio, inclusion time, inclusion temperature, urea and solvent burden ratio of investigation urea/aliphatic acid show the influence experiment of unrighted acid separating effect: suitable urea clathrate condition is: urea/ethanol 1: 3.2 (W/V), the mass ratio of urea/aliphatic acid 1.5: 1,5 ℃ of inclusion temperature, inclusion time 2h, the unrighted acid yield is 70% under these conditions, and the content of unrighted acid brings up to 91.1% by 71.01%.Adopt silver nitrate complexing method that alpha-linolenic acid in the silkworm chrysalis oil has been carried out enrichment, the result shows: solvent polarity and complexing temperature are bigger to the purity influence of unrighted acid.Under AgNO_32mol/L, 40% methanol-water solution, 0 ℃ complexing condition, the ALA yield reaches 50%, and purity reaches 99%.

Silkworm chrysalis oil refining refinement technology:

Silkworm chrysalis after reeling off raw silk from cocoons is fatty more than 30%, also contains multiple human body essential amino acid and vitamin, and nutrition is very abundant.Take silkworm chrysalis, the brain cell of human body is had the effect of invigorating, so can improve thinking ability and operating efficiency; Can treat the deficiency disease that causes because of indigestion, particularly evident to children.The extract leukotrienes of silkworm chrysalis can be treated hypertension, vascular sclerosis and cerebral thrombus, and contained nucleotides, polyprotein are again to promote human body metabolism, constitutional material.

Silkworm chrysalis is a series of developing trend from the beverage to the medicine, are causing enterpriser's attention.The refinement of silkworm chrysalis oil, purification techniques technology are as follows:

1, silkworm chrysalis extraction: select the silkworm chrysalis of fresh odorless, send in the extractor, squeeze into extraction solvent (making extractant uses) with solvent pump, the amount of squeezing into is to flood pupa face degree of being.Arrive 44-45 ℃ with Steam Heating then, insulated and stirred is about 40 minutes again.If it is bigger to handle the silkworm chrysalis amount, can adopt the hoirzontally rotating extractor, the extracting operation temperature is about 50 ℃, speed 100 is changeed about part.

2, silkworm chrysalis drying: the wet silkworm chrysalis through extraction, though oil is extracted out, wherein also contain very high quantity of solvent, dried recovered in addition, otherwise factory will be difficult to silkworm chrysalis is carried out deep processing.The place that output is few can adopt evaporator that wet pupa is carried out drying, reclaims liquid and merges in the extract.

3, mix the pupal fat evaporation: the mixing pupal fat that extraction obtains, its oil concentration only is about 35%, about 70% are materials such as solvent, moisture, pigment, impurity.Therefore, be through pervaporation, concentrate, reclaim solvent naphtha, and improve the quality and the concentration of hair pupal fat.The evaporator operation temperature is that air pressure is suitable about 105 ℃.

4, oil and the separating of water:,, become solvent for extraction and moisture two parts material of liquid phase through the condensation of condenser by a wet pupa drier and the solvent vapo(u)r that hair pupal fat evaporimeter comes out.Utilize the difference on their proportion, oil water separator will make water and separated from solvent automatically.It is reusable to separate back gained solvent, and water is then in time bled off automatically.

5, the refining of hair pupal fat: contain more acid in the hair pupal fat, will determine its acid value earlier, determine to add alkali number according to acidity.Earlier with the alkali lye (soda ash or sodium bicarbonate) of clear water preparation 18-24 Baume degrees, add alkali lye before, earlier oil is poured in the pot, stir and be warming up to about 60 ℃, under stirring fast, slowly adding alkali lye.The acidity of crude oil is pH value about 7 (using the pH detection paper).Make into to stir at a slow speed after adding alkali, when treating oily temperature rise to the 75 ℃ left and right sides, add an amount of 70 ℃ common salt aqueous solution again, stir while adding, salt solution adds the back and stirred 10-15 minute under heating again, leaves standstill 10-12 hour, can put soap stock from pot bottom.With more than the oily temperature rise to 80 ℃, secondary adds common salt aqueous solution again, is washing under stirring at a slow speed.After stopping to stir, precipitate and emitted waste water in about 30 minutes, again the oil after the washing in the pot is heated to more than 100 ℃, carry out drying and dehydrating, and the maintenance certain hour.

Missible oil after dehydration is purer, treats its cooling back filtration, can obtain the yellowish-brown silkworm chrysalis oil finished product of transparent clear.

Brain tonic and intelligence development strengthens the memory production of health food:

1, select primary raw material: linseed and the qualified silkworm chrysalis of every sanitary index of choosing pure natural, pure green non-pollution are the product main material.

2, select less important raw material: the optional genseng of secondary material, pilose antler, wilsonii, glue thigh indigo plant, the Radix Astragali, saline cistanche, fructus alpiniae oxyphyllae, the fruit of Chinese magnoliavine, OVIDUCTUS RANNAE, American Ginseng, radix pseudostellariae, south (north) the root of straight ladybell, Radix Angelicae Sinensis, glutinous rehmannia, Radix Codonopsis, polygala root, grass-leaved sweetflag.

3, select other raw materials: EPA, DHA, deep sea fish oil.

4, select auxiliary material: the polyphenol of lecithin, vitamin E, vitamin C, butylated hydroxy anisole, dibutyl hydroxy toluene, n-propyl gallate, catechin or anthocyanidin, glutathione, lipoic acid.

5, crude drug processing technology: according to different selections, adopt microwave, ultrasonic wave ancillary technique respectively, adopt film separation, molecular clock, resin adsorption, column chromatography separation technology, supercritical extraction technique carries out active ingredient to be separated.

6, with primary raw material, less important raw material, other raw materials and auxiliary material by extract, separate, after the purifying exquisiteness, fully the modern preparation technique of utilization rationally is processed into soft capsule, hard shell capsules, dripping pill, micropill, liposome, transdermal agent, powder, obedient agent, granule, tablet, injection, spray, oral liquid.

The specific embodiment:

Brain tonic and intelligence development strengthens the prescription of memory capsule or soft capsule and forms:

Embodiment 1: a kind of brain tonic and intelligence development strengthens the memory soft capsule, comprises that following weight ratio becomes to be grouped into: linseed oil 450 weight portions, silkworm chrysalis oil 500 weight portions, vitamin E 5 weight portions, lecithin 10 weight portions.

Embodiment 2: a kind of brain tonic and intelligence development strengthens the memory soft capsule, comprises that following weight ratio becomes to be grouped into: linseed oil 100 weight portions, silkworm chrysalis oil 800 weight portions, vitamin E 10 weight portions, lecithin 5 weight portions.

Embodiment 3: a kind of brain tonic and intelligence development strengthens the memory soft capsule, comprises that following weight ratio becomes to be grouped into: linseed oil 800 weight portions, silkworm chrysalis oil 100 weight portions, vitamin E 1 weight portion, lecithin 50 weight portions.

Embodiment 4: a kind of brain tonic and intelligence development strengthens the memory soft capsule, comprises that following weight ratio becomes to be grouped into: linseed oil 450 weight portions, silkworm chrysalis oil 500 weight portions, vitamin E 5 weight portions, lecithin 10 weight portions.

Embodiment 5: a kind of brain tonic and intelligence development strengthens the memory capsule, comprises that following weight ratio becomes to be grouped into: linseed 450 weight portions, silkworm chrysalis 500 weight portions, vitamin E 1 weight portion, lecithin 10 weight portions.

Embodiment 6: a kind of brain tonic and intelligence development strengthens the memory soft capsule, comprise that following weight ratio becomes to be grouped into: thick oil mixture 450 weight portions of linseed oil omega-fatty acid, thick oil mixture 500 weight portions of silkworm chrysalis oil omega-fatty acid, vitamin E 5 weight portions, lecithin 10 weight portions.

Embodiment 7: a kind of brain tonic and intelligence development strengthens the memory soft capsule, comprise that following weight ratio becomes to be grouped into: thick oil mixture 450 weight portions of linseed oil omega-fatty acid, thick oil mixture 500 weight portions of silkworm chrysalis oil omega-fatty acid, vitamin E 5 weight portions, lecithin 10 weight portions.

Embodiment 8: a kind of brain tonic and intelligence development strengthens the memory soft capsule, comprises that following weight ratio becomes to be grouped into: linseed oil omega-fatty acid essential oil 400 weight portions, silkworm chrysalis oil omega-fatty acid essential oil 500 weight portions, vitamin E 15 weight portions, lecithin 30 weight portions.

Embodiment 9: a kind of brain tonic and intelligence development strengthens the memory capsule, comprises that following weight ratio becomes to be grouped into: linseed 250 weight portions, silkworm chrysalis 300 weight portions, genseng 200 weight portions, pilose antler 100 weight portions.

Embodiment 10: a kind of brain tonic and intelligence development strengthens the memory capsule, comprises that following weight ratio becomes to be grouped into: linseed 350 weight portions, silkworm chrysalis 250 weight portions, wilsonii 200 weight portions, the fruit of Chinese magnoliavine 100 weight portions.

Brain tonic and intelligence development strengthens memory capsule or preparation of soft capsule method:

Embodiment 11: the preparation technology of ultrasonic wave auxiliary extraction silkworm chrysalis oil: at ultrasonic power 102W, and ultrasonic time 30min; 35 ℃ of ultrasonic temperature, under the condition, the mean value of silkworm chrysalis oil net yield is 31.2%, recovery rate is 97.2%; The unrighted acid relative amount is 80.2% in the silkworm chrysalis oil of ultrasonic wave auxiliary extraction, wherein the oleic acid relative amount is 31.5%, and the alpha-linolenic acid relative amount is 32.1%, and the linoleic acid relative amount is 5.2%, the palmitoleic acid relative amount is 1.5%, and the arachidic acid relative amount is 0.6%.

Embodiment 12: the preparation technology of silkworm chrysalis oil in the supercritical CO 2 extraction silkworm chrysalis: under the condition of CO2 flow 8kg/h, pressure 25Mpa, 45 ℃ of temperature, time 2.5h, the silkworm chrysalis oil yield is 30.2%, and the silkworm chrysalis oil quality is apparently higher than solvent extraction gained silkworm chrysalis oil.

Embodiment 13: silkworm chrysalis oil refining refinement technology: select the silkworm chrysalis of fresh odorless, send in the extractor, squeeze into extraction solvent with solvent pump, with Steam Heating to 50 ℃, insulated and stirred is about 50 minutes more then.Obtain mixing pupal fat after the extraction,, improve the quality and the concentration of hair pupal fat through pervaporation, concentrated, recovery solvent naphtha.Automatically make water and separated from solvent with oil water separator.After pouring into oil in the pot, stirring is warming up to about 60 ℃, slowly adds the alkali lye with the 18-24 Baume degrees of clear water preparation under stirring fast.Make into to stir at a slow speed after adding alkali, when treating oily temperature rise to the 75 ℃ left and right sides, add an amount of 70 ℃ common salt aqueous solution again, stir while adding, salt solution adds the back and stirred 20 minutes under heating again, leaves standstill 12 hours, can put soap stock from pot bottom.With more than the oily temperature rise to 80 ℃, secondary adds common salt aqueous solution again, is washing under stirring at a slow speed.After stopping to stir, precipitate and emitted waste water in about 30 minutes, again the oil after the washing in the pot is heated to more than 100 ℃, carry out drying and dehydrating, and the maintenance certain hour.Missible oil after dehydration is purer, treats its cooling back filtration, can obtain the yellowish-brown silkworm chrysalis oil finished product of transparent clear.

Embodiment 14: the technology of the thick oil preparation of a kind of linseed linseed oil ethyl ester: at first after being heated to about 80 ℃ through mechanical expression or organic solvent extraction crude oil, ratio in 0.2% adds the phosphoric acid of concentration 85%, adding about 80 ℃ hot water in 5% ratio again stirred 30 minutes, standing separation is come unstuck, the back feed liquid of will coming unstuck is negative pressure 0.1MPa in vacuum, temperature is 90 ℃ and carries out vacuum dehydration, with the feed liquid after the dehydration by feed liquid: absolute ethyl alcohol: sulfuric acid (concentration 98%) is 1: 1: 0.02 weight ratio adding ethanol, sulfuric acid mixture liquid, in temperature is 65-75 ℃, add hot reflux 5-6 hour and carry out ester exchange, again: in the hot wash of about 80 ℃ of feed liquid quality 80% ratio addings,, the feed liquid after glycerine that flush away is residual and sulfuric acid will wash at last pumps into freezing equipment, treat that temperature reaches subzero after, saturated fatty acid is removed in press filtration, feed liquid after the washing is distilled, intercept 120-140 ℃, pressure promptly gets and makes with extra care the linseed oil ethyl ester at the distillate of 1-5Pa.

Embodiment 15: a kind of brain tonic and intelligence development strengthens memory preparation of soft capsule method: produce linseed oil and the silkworm chrysalis oil of producing by supercritical technology by supercritical technology, get linseed oil 500 weight portions after refining, silkworm chrysalis oil 450 weight portions, vitaminize E 5 weight portions, lecithin 10 weight portions fully mix back preparation brain tonic and intelligence development and strengthen memory health food soft capsule.

Claims (10)

1. brain tonic and intelligence development strengthens memory health food and preparation method thereof, comprising:

(1) contains primary raw material linseed and silkworm chrysalis; And

(2) separate with silkworm chrysalis by linseed and extract produced contain the thick oil mixture of omega-fatty acid; Thereby

(3) omega-fatty acid that makes behind the purifying; And

(4) the further synthetic omega-fatty acid ester that makes; And

(5) this brain tonic and intelligence development strengthens the preparation method of memory health food.

2. health food according to claim 1, silkworm chrysalis wherein comprises mulberry silkworm chrysalis and tussah chrysalis.

3. health food according to claim 1 wherein can comprise less important raw material genseng, pilose antler, wilsonii, glue thigh indigo plant, the Radix Astragali, saline cistanche, fructus alpiniae oxyphyllae, the fruit of Chinese magnoliavine, OVIDUCTUS RANNAE, American Ginseng, radix pseudostellariae, south (north) the root of straight ladybell, Radix Angelicae Sinensis, glutinous rehmannia, Radix Codonopsis, polygala root, grass-leaved sweetflag.

4. health food according to claim 1 wherein can comprise other raw materials EPA, DHA, deep sea fish oil.

5. health food according to claim 1 wherein can comprise polyphenol, glutathione, the lipoic acid of auxiliary material lecithin, vitamin E, vitamin C, butylated hydroxy anisole, dibutyl hydroxy toluene, n-propyl gallate, catechin or anthocyanidin.

6. health food according to claim 1, this food have the health care that brain tonic and intelligence development strengthens memory.

7. health food according to claim 1, the content of linseed is 1-99% (WT) in this food, the content of silkworm chrysalis is 1-99% (WT); Omega-fatty acid content is 1-99% (WT).

8. the preparation method of health food according to claim 1 comprises the separating of linseed oil and silkworm chrysalis oil, extraction and purifying and refining.

9. the preparation method of health food according to claim 1 comprises thick oil mixture separation and Extraction of omega-fatty acid and purifying in linseed and the silkworm chrysalis, and the omega-fatty acid ester is synthetic.

10. the preparation method of health food according to claim 1, comprise that with linseed and silkworm chrysalis be the method that primary raw material is prepared into health food, the health food formulation of this method preparation includes but not limited to soft capsule, hard shell capsules, dripping pill, micropill, liposome, transdermal agent, powder, obedient agent, granule, tablet, injection, spray, oral liquid.