CN106361593A - Natural anti-senescence component and preparation method thereof - Google Patents
Natural anti-senescence component and preparation method thereof Download PDFInfo
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- CN106361593A CN106361593A CN201610840191.1A CN201610840191A CN106361593A CN 106361593 A CN106361593 A CN 106361593A CN 201610840191 A CN201610840191 A CN 201610840191A CN 106361593 A CN106361593 A CN 106361593A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
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Abstract
The invention discloses a natural anti-senescence component and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparation. The medicinal ingredients-polysaccharides are extracted by taking natural Chinese herbs including herba scutellariae barbatae, herba epimedii, herba portulacae, rhizoma gastrodiae and Chinese magnoliavine fruit as cores through an ultrasonic extraction method. The technology is simple, the cost is reduced, the extraction amount is greatly increased, and by means of scientific and reasonable proportioning, the polysaccharides of the five traditional Chinese medicines complement and cooperate with one another to achieve the synergistic effect. The polysaccharide ingredients in the formula come from natural plants, have no chemical synthesis ingredient or side effect of hormones and have the high medicinal functions of resisting oxidization and senescence, improving the immunity and the like.
Description
Technical field
The present invention relates to technical field of Chinese medicines is and in particular to a kind of natural anti-aging and preparation method thereof.
Background technology
In recent years, with the change of social environment and natural environment, human diseasess spectrum there occurs huge change.Body declines
Old property or body own metabolism and the not normal complexity multifactor property disease for main spectrum group of regulation and control.Under this trend, Zhong Duochuan
The chemical synthetic drug of system increasingly can not meet the needs of mankind's preventing and treating diseases.Therefore, from enhancing body non-oxidizability
Set out with autoimmunity, the Integrate adjustment ability using the distinctive multicomponent of Chinese herb medicine, many effects resists to flight against senium of human body
Oxidation and immune system are improved, thus reaching the purpose improving human health level, it has also become medical treatment or health care trend.Existing
Show for medical research achievement, a lot of Chinese herbal medicine contain polysaccharide, organic acid, alkaloidss, glycoside and volatile oil etc., this
A little materials pass through to promote the oxidation resistance of body in human body, strengthen immune cell function, improve cytokine secretion etc. and make
With can achieve the consolidation to each organ dysfunction of body and lifting, the preventing and treating to disease has great significance.
Content of the invention
The technical problem to be solved is to provide a kind of natural anti-aging and preparation method thereof.
For realizing the purpose of the present invention, the technical solution adopted in the present invention is:
A kind of natural anti-aging, by Scutellaria Barbata D. Don Polysaccharides, epimedium brevicornum polysaccharide, Polysaccharide from Portulaca oleracea, gastrodia elata polysaccharide, Fructus Schisandrae Polysaccharide
Composition, the weight of wherein each component ratio is for 1:1:1:1:1.
Preparation method comprises the following steps:
Step one, the preparation of Scutellaria Barbata D. Don Polysaccharides
Choose the Herba Scutellariae Barbatae of drying and crushing, additional proportion is the 50-60 DEG C of distilled water of 1:12-14, ultrasonic extraction 3-4 time, often
Secondary 5-7min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that Scutellaria Barbata D. Don Polysaccharides is precipitated, high speed centrifugation toward in concentrated solution
15-18min is precipitated, and with washing with acetone 5-6 time, lyophilization at low temperature, obtains Scutellaria Barbata D. Don Polysaccharides；
Step 2, the preparation of epimedium brevicornum polysaccharide
Choose the Herba Epimedii of drying and crushing, additional proportion is the 50-60 DEG C of distilled water of 1:14-16, ultrasonic extraction 3-4 time, often
Secondary 6-8min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that epimedium brevicornum polysaccharide is precipitated, high speed centrifugation toward in concentrated solution
15-18min is precipitated, and with washing with acetone 2-3 time, lyophilization at low temperature, obtains epimedium brevicornum polysaccharide；
Step 3, the preparation of Polysaccharide from Portulaca oleracea
Choose the Herba Portulacae of drying and crushing, additional proportion is the 50-60 DEG C of distilled water of 1:10-13, ultrasonic extraction 2-3 time, often
Secondary 5-7min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that Polysaccharide from Portulaca oleracea is precipitated, high speed centrifugation toward in concentrated solution
10-12min is precipitated, and with washing with acetone 5-6 time, lyophilization at low temperature, obtains Polysaccharide from Portulaca oleracea；
Step 4, the preparation of gastrodia elata polysaccharide
Choose the Rhizoma Gastrodiae of drying and crushing, additional proportion is the 80-100 DEG C of distilled water of 1:40-45, ultrasonic extraction 2-3 time, every time
8-15min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that gastrodia elata polysaccharide is precipitated, high speed centrifugation 10- toward in concentrated solution
12min is precipitated, and with washing with acetone 5-6 time, lyophilization at low temperature, obtains gastrodia elata polysaccharide；
Step 5, the preparation of Fructus Schisandrae Polysaccharide
Choose the Rhizoma Gastrodiae of drying and crushing, additional proportion is the 60-80 DEG C of distilled water of 1:20-25, ultrasonic extraction 2-3 time, every time
5-7min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that gastrodia elata polysaccharide is precipitated, high speed centrifugation 10- toward in concentrated solution
12min is precipitated, and with washing with acetone 5-6 time, lyophilization at low temperature, obtains gastrodia elata polysaccharide；
Step 6, preparation
By above-mentioned prepared Scutellaria Barbata D. Don Polysaccharides, epimedium brevicornum polysaccharide, Polysaccharide from Portulaca oleracea, gastrodia elata polysaccharide, Fructus Schisandrae Polysaccharide in proportion 1:
The uniform mixing of 1:1:1:1 can get natural anti-aging.
Preferably, the concentration of alcohol in five in described step is 95-97%.
Preferably, the low temperature state in five in described step is -50 to -55 DEG C.
Record according to traditional medical book, Herba Scutellariae Barbatae, and Herba Epimedii has invigorating the spleen and replenishing QI, blood circulation promoting and blood stasis dispelling, effect of heat-clearing and toxic substances removing, such as closes
Reason uses cooperatively, and can play an important role in terms of antioxidation, defying age and immune lifting.By modern science document report, half
Branch lotus polysaccharide can promote the mouse boosting cell lymphocyte transformations of cona induction in vitro, and its optimum concentration is 400 μ g/ml.
Subcutaneous administrations one Zhou Houke significantly improves the percentage rate of esterase positive cell in Mouse Peripheral Blood Lymphocyte, and abdominal cavity is given
Promote the mice delayed allergy of dncb induction after medicine.Herba Scutellariae Barbatae water extraction polysaccharide has stronger scavenging action to h2o2,
And be in dose-effect relationship.Show through mouse experiment, the effect of its oxidation-resisting and caducity is by raising sod vigor with to negative oxygen-derived free radicals
Scavenging action and lipoid peroxidization resistant old and feeble extend the life-span to resist.Herba Epimedii is to heavy dose of hydrocortisone and hydroxyl
Caused by urea, the phagocytic function of immunologic hypofunction model mice macrophage is remarkably reinforced effect.Epimedium brevicornum polysaccharide is bitten carefully to huge
Intracrine il-1 and tumor necrosis factor have dual regulation, and promote proliferation and differentiation and the nature of t/b lymphocyte
Killer cell activity, improves Immune Function.
Polysaccharide from Portulaca oleracea has the antioxidation more higher than vitamin c, and research shows, Polysaccharide from Portulaca oleracea can effectively be removed
The effect of various active oxygens, reduces the generation of lipid peroxidation product mda, has reached antioxidation, the effect of defying age.
Gastrodia elata polysaccharide is remarkably improved mouse aging serum, liver, brain, superoxide dismutase (sod) and mistake in heart tissue
Hydrogen oxide enzyme (cat) activity, substantially suppression mouse aging serum, liver, brain, in heart tissue malonaldehyde (mda) formation, significantly carry
The activity of high mouse aging serum Glutathione Peroxidase (gsh-px), gastrodia elata polysaccharide has preferable body of removing and gives birth to
The excessive free radicals becoming, reduce the content of mda, play the effect of delaying cell aging.
Scientific research result shows, Fructus Schisandrae Polysaccharide can significantly inhibit mouse liver even slurry lipid peroxidation hence it is evident that dropping
Low senile rat Serum LPO Levels (lpo) content, improves superoxide dismutase (sod) activity, has stronger
Scavenging activated oxygen ability.Multitest as shown by data Fructus Schisandrae Polysaccharide can make the thymus of mouse aging atrophy significantly increase
Thickening, thymus cortex cell number and splenocyte number showed increased, splenic nodule increases, and makes the neurocyte of mouse aging regression
Cell space increases, and points out Fructus Schisandrae Polysaccharide not only can improve the immunologic function of mouse aging, and mouse aging nerve can be promoted thin
The growth of born of the same parents.
In sum, five kinds of Chinese medicines all show extremely strong antioxidant activity and the potentiality of enhancing human body immunity function, its
Chief active position is polysaccharide, and five kinds of vegetable polysaccharidess are compounded the natural plant composition making defying age, can achieve a kind of effective
Natural anti-aging.
A kind of natural anti-aging and preparation method thereof that the present invention provides, primary raw material is with natural Chinese medicinal herb half
Lotus, Herba Epimedii Herba Portulacae, Rhizoma Gastrodiae and Fructus Schisandrae Chinensis are core, using supersonic extracting method, its active ingredient Polyose extraction are carried out
Extract, its process is simple, cost-effective, extracted amount substantially increases, make five kinds of taste of Chinese medicine sources through scientific and reasonable proportioning
Complementary the working in coordination with of medicine polysaccharide plays potentiation.Polysaccharide component in formula derive from natural plants, no chemosynthesis composition, no
The side effect such as hormone, have the pharmacodynamic features such as stronger antioxidation, defying age and immunity lifting.
Specific embodiment
The following enforcement to the present invention is further described, so that those skilled in the art can be better understood from simultaneously
Implement.
Embodiment 1
A kind of natural anti-aging, by Scutellaria Barbata D. Don Polysaccharides, epimedium brevicornum polysaccharide, Polysaccharide from Portulaca oleracea, gastrodia elata polysaccharide, Fructus Schisandrae Polysaccharide
Composition, the weight of wherein each component ratio is for 1:1:1:1:1.
Preparation method comprises the following steps:
Step one, the preparation of Scutellaria Barbata D. Don Polysaccharides
Choose the Herba Scutellariae Barbatae of drying and crushing, additional proportion is 50 DEG C of distilled water of 1:12, ultrasonic extraction 3 times, each 5min closes
And each extracting solution, concentrating under reduced pressure, add 95% ethanol so that Scutellaria Barbata D. Don Polysaccharides is precipitated toward in concentrated solution, high speed centrifugation 15min obtains
Precipitation, with washing with acetone 5 times, lyophilization at -50 DEG C of low temperature, obtain Scutellaria Barbata D. Don Polysaccharides；
Step 2, the preparation of epimedium brevicornum polysaccharide
Choose the Herba Epimedii of drying and crushing, additional proportion is 60 DEG C of distilled water of 1:16, ultrasonic extraction 4 times, each 8min,
Merge each extracting solution, concentrating under reduced pressure, add 96% ethanol so that epimedium brevicornum polysaccharide is precipitated toward in concentrated solution, high speed centrifugation 18min obtains
To precipitation, with washing with acetone 3 times, lyophilization at -52 DEG C of low temperature, obtain epimedium brevicornum polysaccharide；
Step 3, the preparation of Polysaccharide from Portulaca oleracea
Choose the Herba Portulacae of drying and crushing, additional proportion is 55 DEG C of distilled water of 1:12, ultrasonic extraction 3 times, each 6min,
Merge each extracting solution, concentrating under reduced pressure, add 95% ethanol so that Polysaccharide from Portulaca oleracea is precipitated toward in concentrated solution, high speed centrifugation 11min obtains
To precipitation, with washing with acetone 5 times, lyophilization at -50 DEG C of low temperature, obtain Polysaccharide from Portulaca oleracea；
Step 4, the preparation of gastrodia elata polysaccharide
Choose the Rhizoma Gastrodiae of drying and crushing, additional proportion is 95 DEG C of distilled water of 1:40, ultrasonic extraction 3 times, each 15min closes
And each extracting solution, concentrating under reduced pressure, add 97% ethanol so that gastrodia elata polysaccharide is precipitated toward in concentrated solution, high speed centrifugation 12min is sunk
Form sediment, with washing with acetone 6 times, lyophilization at -55 DEG C of low temperature, obtain gastrodia elata polysaccharide；
Step 5, the preparation of Fructus Schisandrae Polysaccharide
Choose the Rhizoma Gastrodiae of drying and crushing, additional proportion is 70 DEG C of distilled water of 1:20, ultrasonic extraction 2 times, each 7min merges
Each extracting solution, concentrating under reduced pressure, add 97% ethanol so that gastrodia elata polysaccharide is precipitated toward in concentrated solution, high speed centrifugation 12min is sunk
Form sediment, with washing with acetone 6 times, lyophilization at -55 DEG C of low temperature, obtain gastrodia elata polysaccharide；
Step 6, preparation
By above-mentioned prepared Scutellaria Barbata D. Don Polysaccharides, epimedium brevicornum polysaccharide, Polysaccharide from Portulaca oleracea, gastrodia elata polysaccharide, Fructus Schisandrae Polysaccharide in proportion 1:
The uniform mixing of 1:1:1:1 can get natural anti-aging.
Claims (4)
1. a kind of natural anti-aging is it is characterised in that described natural anti-aging is many by Scutellaria Barbata D. Don Polysaccharides, Herba Epimedii
Sugar, Polysaccharide from Portulaca oleracea, gastrodia elata polysaccharide, Fructus Schisandrae Polysaccharide composition, the weight of wherein each component ratio is for 1:1:1:1:1.
2. as described in claim 1 a kind of preparation method of natural anti-aging it is characterised in that including following walking
Rapid:
Step one, the preparation of Scutellaria Barbata D. Don Polysaccharides
Choose the Herba Scutellariae Barbatae of drying and crushing, additional proportion is the 50-60 DEG C of distilled water of 1:12-14, ultrasonic extraction 3-4 time, often
Secondary 5-7min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that Scutellaria Barbata D. Don Polysaccharides is precipitated, high speed centrifugation toward in concentrated solution
15-18min is precipitated, and with washing with acetone 5-6 time, lyophilization at low temperature, obtains Scutellaria Barbata D. Don Polysaccharides；
Step 2, the preparation of epimedium brevicornum polysaccharide
Choose the Herba Epimedii of drying and crushing, additional proportion is the 50-60 DEG C of distilled water of 1:14-16, ultrasonic extraction 3-4 time, often
Secondary 6-8min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that epimedium brevicornum polysaccharide is precipitated, high speed centrifugation toward in concentrated solution
15-18min is precipitated, and with washing with acetone 2-3 time, lyophilization at low temperature, obtains epimedium brevicornum polysaccharide；
Step 3, the preparation of Polysaccharide from Portulaca oleracea
Choose the Herba Portulacae of drying and crushing, additional proportion is the 50-60 DEG C of distilled water of 1:10-13, ultrasonic extraction 2-3 time, often
Secondary 5-7min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that Polysaccharide from Portulaca oleracea is precipitated, high speed centrifugation toward in concentrated solution
10-12min is precipitated, and with washing with acetone 5-6 time, lyophilization at low temperature, obtains Polysaccharide from Portulaca oleracea；
Step 4, the preparation of gastrodia elata polysaccharide
Choose the Rhizoma Gastrodiae of drying and crushing, additional proportion is the 80-100 DEG C of distilled water of 1:40-45, ultrasonic extraction 2-3 time, every time
8-15min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that gastrodia elata polysaccharide is precipitated, high speed centrifugation 10- toward in concentrated solution
12min is precipitated, and with washing with acetone 5-6 time, lyophilization at low temperature, obtains gastrodia elata polysaccharide；
Step 5, the preparation of Fructus Schisandrae Polysaccharide
Choose the Rhizoma Gastrodiae of drying and crushing, additional proportion is the 60-80 DEG C of distilled water of 1:20-25, ultrasonic extraction 2-3 time, every time
5-7min, merges each extracting solution, concentrating under reduced pressure, adds ethanol so that gastrodia elata polysaccharide is precipitated, high speed centrifugation 10- toward in concentrated solution
12min is precipitated, and with washing with acetone 5-6 time, lyophilization at low temperature, obtains gastrodia elata polysaccharide；
Step 6, preparation
By above-mentioned prepared Scutellaria Barbata D. Don Polysaccharides, epimedium brevicornum polysaccharide, Polysaccharide from Portulaca oleracea, gastrodia elata polysaccharide, Fructus Schisandrae Polysaccharide in proportion 1:
The uniform mixing of 1:1:1:1 can get natural anti-aging.
3. as described in claim 2 a kind of preparation method of natural anti-aging it is characterised in that one in described step
Concentration of alcohol in five is 95-97%.
4. as described in claim 2 a kind of preparation method of natural anti-aging it is characterised in that in described step
Low temperature state in one to five is -50 to -55 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111803400A (en) * | 2020-08-18 | 2020-10-23 | 黑龙江中医药大学 | Traditional Chinese medicine polysaccharide moisturizing and freckle removing mask and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156106A (en) * | 2013-02-04 | 2013-06-19 | 北华大学 | Lipid lowering and liver protecting drug or health food prepared by active ingredients of fructus schisandrae chinensis and preparation method |
| CN103864943A (en) * | 2012-12-18 | 2014-06-18 | 青岛中仁药业有限公司 | Portulace polysaccharide ultrasonic-auxiliary extraction method |
| CN104292353A (en) * | 2014-09-30 | 2015-01-21 | 河南科技大学 | Anti-oxidation natural plant polysaccharide and preparation method thereof |
| CN105859899A (en) * | 2016-04-10 | 2016-08-17 | 黄河水利职业技术学院 | Rhizoma gastrodiae polysaccharide extraction method |
-
2016
- 2016-09-22 CN CN201610840191.1A patent/CN106361593A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103864943A (en) * | 2012-12-18 | 2014-06-18 | 青岛中仁药业有限公司 | Portulace polysaccharide ultrasonic-auxiliary extraction method |
| CN103156106A (en) * | 2013-02-04 | 2013-06-19 | 北华大学 | Lipid lowering and liver protecting drug or health food prepared by active ingredients of fructus schisandrae chinensis and preparation method |
| CN104292353A (en) * | 2014-09-30 | 2015-01-21 | 河南科技大学 | Anti-oxidation natural plant polysaccharide and preparation method thereof |
| CN105859899A (en) * | 2016-04-10 | 2016-08-17 | 黄河水利职业技术学院 | Rhizoma gastrodiae polysaccharide extraction method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111803400A (en) * | 2020-08-18 | 2020-10-23 | 黑龙江中医药大学 | Traditional Chinese medicine polysaccharide moisturizing and freckle removing mask and preparation method thereof |
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