CN110367522A - A kind of herbal cuisine composition and preparation method thereof for strengthen immunity - Google Patents
A kind of herbal cuisine composition and preparation method thereof for strengthen immunity Download PDFInfo
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- CN110367522A CN110367522A CN201910650114.3A CN201910650114A CN110367522A CN 110367522 A CN110367522 A CN 110367522A CN 201910650114 A CN201910650114 A CN 201910650114A CN 110367522 A CN110367522 A CN 110367522A
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The present invention provides a kind of herbal cuisine composition for strengthen immunity, material composition includes 60~75 parts of selenium-rich grifola frondosus, 35~45 parts of rich-selenium Agaricus blazei, 30~40 parts of selenium-rich Radix Astragali, 2~10 parts of gynosaponin, 2~10 parts of glutathione according to parts by weight；Wherein, the selenium-rich grifola frondosus, rich-selenium Agaricus blazei, the Se content in selenium-rich Radix Astragali are greater than 400ppm；The present invention also provides the preparation method of the herbal cuisine composition, mentioned using water and method that low temperature extracts repeatedly.Each component rationally compounds in the present invention, and prescription is exquisite, has effects that adjust human body gas, blood, the balance of yin, yang and enhancing matrix immunity.The preparation method is extracted repeatedly using low temperature, can extract as far as possible more effective component under the premise of guaranteeing that effective component is active.
Description
Technical field
The present invention relates to Chinese medicine and field of health care food more particularly to a kind of herbal cuisine composition for strengthen immunity and
Preparation method.
Background technique
Immunity is the defense mechanism of human body itself, is that human bioequivalence and any foreign matter of the external intrusion of elimination are (viral, thin
Bacterium etc.)；It handles aging, damage, death, the own cells of denaturation and identification and processing vivo mutations cell and virus infection is thin
The ability of born of the same parents.Immunity not only protects people's health in the daily routines of people, and can help when disease occurs
We resist the disease, and get well.
Health and disease be the problem of whole society all pays special attention to, it be related to everyone, each family it is personal
Interests.Although people extremely pay close attention to health problem, many moderns are busy with living under the pressure of life stress, are busy with cause, often
Ignore the health of oneself.In addition worldwide environmental quality decline, the body of most people often holds all in the state of inferior health
The easy sick or symptoms such as appearance, apathetic, fatigue and weak, loss of appetite, sleep disturbance, if things go on like this seriously affect people
Health and quality of life, or even induce more serious disease.Guarantee health be not instead of it is ill go to control, focus on nothing
Disease first prevents that we need to tackle the problem at its root, and reduce the generation of disease.
Summary of the invention
The herbal cuisine composition and preparation method thereof that the purpose of the present invention is to provide a kind of for strengthen immunity, the herbal cuisine
Composition prescription is exquisite, has effects that adjust human body gas, blood, the balance of yin, yang and enhancing matrix immunity；The preparation method
It is extracted repeatedly using low temperature, more effective component can be extracted as far as possible under the premise of guaranteeing that effective component is active.
The present invention solves its technical problem and adopts the following technical solutions to realize:
The present invention provides a kind of herbal cuisine composition for strengthen immunity, and material composition includes richness according to parts by weight
60~75 parts of selenium grifola frondosus, 35~45 parts of rich-selenium Agaricus blazei, 30~40 parts of selenium-rich Radix Astragali, 2~10 parts of gynosaponin, gluathione
2~10 parts of peptide；Wherein, the selenium-rich grifola frondosus, rich-selenium Agaricus blazei, the Se content in selenium-rich Radix Astragali are greater than 400ppm.
The present invention also provides the preparation methods of the herbal cuisine composition for strengthen immunity described in one kind, including walk as follows
It is rapid:
Step 1, pretreatment: weighing 60~75 parts of selenium-rich grifola frondosus in parts by weight, and 35~45 parts of rich-selenium Agaricus blazei, selenium-rich
It 30~40 parts of Radix Astragali, cleans and is soaked in water respectively；
Step 2, defibrination: wearing into slurry for pretreated selenium-rich grifola frondosus, rich-selenium Agaricus blazei, selenium-rich Radix Astragali respectively, and
It is mixed to get mixed slurry；
Step 3 is crushed: after the mixed slurry is heated to 44~46 DEG C, ultrasonication obtains broken solution；
Step 4 is extracted: broken solution being heated to 70~80 DEG C, is cooled to 15~25 after maintaining 20~40min
℃；70~80 DEG C are again heated to, is cooled to 15~25 DEG C after maintaining 20~40min；So repeat heating cooling totally 3~6 times, mistake
Residue is filtered out, is cooled to 20~28 DEG C, obtains raw material extracting solution；
Step 5, mixing: 2~10 parts of gynosaponin and 2~10 parts of resulting raw materials of addition step 4 of glutathione are mentioned
It takes and makes it dissolve and mix in liquid, obtain material liquid mixture；
Step 6 is concentrated and dried: after the concentration of step 5 gained material liquid mixture, being dried to powder to get to for enhancing
The herbal cuisine composition of immunity.
Activity is as follows the effect of each primary raw material medicine in the present invention:
1, grifola frondosus: it is commonly called as " dance mushroom ", is food, medicine dual-purpose gill fungus bacterium, contains grifolan in grifola frondosus, is from ash tree
A kind of fungi polysaccharide being separated in beggar's entity, research shows that grifolan, based on beta glucan (glucan), wherein
Anticancer activity is strong, and β-(1,3)-glucan of 6 branches of band accounts for sizable specific gravity, has cancer-resisting effect: activating phagocytic
The immunocytes such as cell, constant killer cell, nocuity T cell induce leukin, interferon-γ, tumor necrosis factor-alpha
Etc. cell factors secretion；Cancer cell specific induction of apoptosis；It is closed with traditional chemotherapeutic agent (mitomycin, Ka Mosiding etc.)
With not only increasing drug effect, but also mitigate the toxic side effect in chemotherapy process；Work is cooperateed with immunotherapy medicaments (interferon-' alpha ' 2b)
With；Slow down the pain of patient with advanced cancer, increases appetite, improve the quality of life of patient.It additionally can be reduced insulin resistance,
Enhance human body to the susceptibility of insulin, helps to control blood glucose.Inhibit fat cell accumulation.It reduces blood pressure.Strengthen immunity.
For selenium-rich grifola frondosus of the invention from bestowing favour, Se content is greater than 400PPM.
2, Agricus blazei: also known as Brazilian mushroom, it lives in hot, humid and airy environment, has almond flavor, mouthfeel is crisp
It is tender.Edible part contains crude protein, soluble saccharide, crude fibre, fat, ash content；It include 18 kinds of amino acid, people in protein composition
8 kinds of essential amino acids of body are complete, also contain multivitamin and ergosterol.Mannan contained therein is (outstanding to tumour is inhibited
It is ascites carcinoma), medical hemorrhoid complicated by anal fistula, enhancing energy, anti-angiocardiopathy etc. it is all effective in cure.The antineoplastic component of Agricus blazei mainly has
Nucleic acid, lectin, sterol and fatty acid and polysaccharide.Furthermore Agricus blazei contains active polysaccharide body, has strengthening healthy qi, enhancing
Body immunity and other effects.For rich-selenium Agaricus blazei of the invention from bestowing favour, Se content is greater than 400PPM.
3, Radix Astragali, sweet in flavor warm-natured, return lung, the spleen channel, comprising: (1) invigorating qi for consolidating superficies: the sweeter temperature of Radix Astragali enters the spleen channel, is help
The key medicine of temper can treat deficiency-weakness of spleen-QI, fatigue and weakness and anorexia and loose stool；(2) arrest sweating admittedly take off；(3) inducing diuresis to remove edema；(4) torr sore
Apocenosis: Radix Astragali keeps healthy tendency vigorous with the function of its benefiting qi and nourishing blood, can treat acne, carbuncle furuncle etc. with pus draining and toxin expelling, myogenic sore；
(5) adjust blood pressure: its antihypertensive compositions are γ-aminobutyric acid and astragalus saponin 1, have dual regulation, Neng Gouming to blood pressure
The aobvious resistance for reducing the cerebrovascular, peripheral blood vessel, coronary artery, mesenteric artery；(5) increase body's immunity: can be significant
Increase the sum of leucocyte in blood, promote the phagocytic function and sterilizing function of neutrophil leucocyte and macrophage, enhancing human body is exempted from
Epidemic disease ability；(5) liver protection function；(6) heart tonifying function: can be such that systaltic amplitude increases, and output quantity increases, in
The effect of poison either heart failure becomes apparent.And astragalus polyose is effective against Acute myocardial caused by pituitrin
Ischemic.The ingredients such as Radix Astragali I containing astragalin, II, III, IV, daucosterol and soyasaponins；Radix Astragali also contains Flavonoid substances, such as awns
Handle xanthin, calycosin and a variety of flavones ingredients；In Radix Astragali it is separated go out 3 kinds of polysaccharide, as astragalus polyose I, II,
III, IV also isolate two kinds of glucans AG-1, AG-2 and two kinds of heteroglycan AH-1, AH-2.AG-1 and AH-1 has immune promote
Into effect；Radix Astragali contains glucuronic acid, lymphatic temperament, bitter principle, 0- sitosterol, sucrose, glycine betaine, kumatakenin, palmitinic acid, Asia
Oleic acid, linolenic acid, choline, folic acid, amylase, Ingredients Such As Coumarin.It is noted that Radix Astragali contains 21 kinds of amino acid, wherein 7
Kind content is higher, including asparagine, canavanine, proline, y- aminobutyric acid etc., and contains 14 kinds of microelements, content
Higher is iron, manganese, zinc, rubidium, and there is also selenium, copper etc..From bestowing favour, Se content is greater than selenium-rich Radix Astragali of the invention
400PPM。
4, gynosaponin: also known as seven leaf gallbladders, Herb Gynostemmae Pentaphylli, Herba Gynostemmatis, public arched bottom, belong to cucurbitaceous plant.(1) gynostemma pentaphylla
Saponin improves significantly to the tool of big white mouse acute liver damage caused by carbon tetrachloride, can promote liver cell regeneration.Strand
Blue Total saponin has significant antibody Monoclonal and effect of anti hepatic fibrosis, significantly reduces rat blood serum glutamic-pyruvic transaminase, hepatic tissue hydroxyl dried meat
Propylhomoserin (Hyp) content；(2) gynosaponin has antifatigue, anti anoxia, resistant to high temperatures, low-temperature resistance, extends biological cell and fruit
The service life of fly, mouse can significantly improve SOD activity, reduce the content of the heart, brain, liver cell lipofuscin.(3) gynosaponin
With immunoregulation effect.Gynosaponin can significantly improve the index and spleen index and thymus index of mouse, while can also be significant
The content for improving Ig G and Ig A in mice serum, also has certain facilitation to the generation of IL-2 in mice serum.Strand
Blue polysaccharide can alleviate cyclophosphamide to the depression effect of mouse spleen immune function.
5, glutathione: being a kind of small-molecular peptides being made of three amino acid, it is as antioxidant important in vivo
And free radical scavenger, such as in conjunction with free radical, heavy metal, so that poisonous substance harmful in body is converted into harmless object
Matter excretes external.Glutathione can not only eliminate human free radical, can also improve the immunity of the human body.
The invention has the following advantages:
1, a kind of herbal cuisine composition for strengthen immunity provided by the invention, prescription is exquisite, have adjust human body gas,
Blood, the balance of yin, yang and enhancing matrix immunity inhibit the effect of virus and tumour；Wherein grifola frondosus and Agricus blazei collaboration are matched
Closing has anticancer, inhibits tumour；Gynosaponin, selenium-rich Radix Astragali and glutathione coordinated have the function of liver protecting；
5 kinds of selenium-rich grifola frondosus, rich-selenium Agaricus blazei, selenium-rich Radix Astragali, gynosaponin, glutathione ingredient coordinateds have extremely strong exempt from
Epidemic disease adjustment effect.
2, a kind of herbal cuisine composition for strengthen immunity provided by the invention, can overcome mutually side effect, while energy
Improve mutual pharmacological action: gynosaponin has digestive system side effect in use；And Agricus blazei contains largely
Dietary fiber and other beneficiating ingredients, have significant protective effect to alimentary canal, i.e. Agricus blazei can overcome gynosaponin
Bring digestive system side effect.
3, a kind of herbal cuisine composition for strengthen immunity provided by the invention, from the point of view of Chinese medicine channel tropism, Chinese medicine thinks
Selenium-rich grifola frondosus converge to the spleen channel, rich-selenium Agaricus blazei return kidney, stomach meridian；Selenium-rich Radix Astragali return lung, Pi warp；Gynostemma pentaphylla return lung, Liver Channel, this 4 kinds
The glutathione of component and liver protecting, each component rationally compound, and adjust liver, spleen, stomach, kidney together, are in body function most
Good state.
4, extracting method in the prior art takes a long time and Extracting temperature is higher；It is provided by the invention a kind of for enhancing
The preparation method of the herbal cuisine composition of immunity, (1) are extracted repeatedly using low temperature, can guarantee the active premise of effective component
Under, more effective component is extracted as far as possible, not only increases recovery rate, and avoids the destruction of effective component as far as possible；(2) phase
For other extracting modes, this is lower for water deduction, safer；(3) after fresh material being broken into slurry, then clasmatosis is carried out, had
Help reduce cost, guarantees effective component activity, improve recovery rate.
Specific embodiment
Embodiment 1
1, a kind of herbal cuisine composition for strengthen immunity, material composition include selenium-rich grifola frondosus according to parts by weight
68 parts, 40 parts of rich-selenium Agaricus blazei, 35 parts of selenium-rich Radix Astragali, 6 parts of gynosaponin, 6 parts of glutathione；Wherein, the selenium-rich ash tree
Flower, rich-selenium Agaricus blazei, the Se content in selenium-rich Radix Astragali are greater than 400ppm.
2, the preparation method of the herbal cuisine composition for strengthen immunity, includes the following steps:
Step 1, pretreatment: weighing 68 parts of selenium-rich grifola frondosus in parts by weight, and 40 parts of rich-selenium Agaricus blazei, selenium-rich Radix Astragali 35
Part, it cleans respectively and impregnates 2.5h with 50 DEG C of water；
Step 2, defibrination: wearing into slurry for pretreated selenium-rich grifola frondosus, rich-selenium Agaricus blazei, selenium-rich Radix Astragali respectively, and
It is mixed to get mixed slurry；The solid-liquid ratio of the mixed slurry is 1:22；
It is step 3, broken: by the mixed slurry be heated to 45 DEG C (heating time 7min, 45 DEG C hold time for
After 35min), ultrasonication (SL-1200 type ultrasonic cell disruption instrument, ultrasonic time 10min, ultrasonic power 750W),
Obtain broken solution；
Step 4 is extracted: broken solution being heated to 75 DEG C (time 15min of heat temperature raising), after maintaining 30min
It is cooled to 20 DEG C rapidly by the way of clean ice bag is added；It quickly heats up to 75 DEG C after cooling again, maintains after 30min rapidly
It is cooled to 20 DEG C；Heating cooling totally 5 times is so repeated, residue is filtered to remove using 70 mesh gauzes, is cooled to 25 DEG C, obtains raw material
Extracting solution；
Step 5, mixing: will add in 6 parts of gynosaponin and 6 parts of resulting raw material extracting solutions of addition step 4 of glutathione
Heat elevates the temperature to 52 DEG C, after maintaining 25min to make it dissolve, is placed in the blender that revolving speed is 15r/min and mixes, expected
Liquid mixture；
Step 6 is concentrated and dried: by the concentration of step 5 gained material liquid mixture, (feed liquid concentration ratio is 18 times, temperature control
At 120 DEG C hereinafter, vacuum degree is in 0.85mPa) after, it is spray dried to powder and is combined to get to the herbal cuisine for strengthen immunity
Object.
Embodiment 2
1, a kind of herbal cuisine composition for strengthen immunity, material composition include selenium-rich grifola frondosus according to parts by weight
60 parts, 45 parts of rich-selenium Agaricus blazei, 30 parts of selenium-rich Radix Astragali, 2 parts of gynosaponin, 2 parts of glutathione；Wherein, the selenium-rich ash tree
Flower, rich-selenium Agaricus blazei, the Se content in selenium-rich Radix Astragali are greater than 400ppm.
2, the preparation method of the herbal cuisine composition for strengthen immunity, includes the following steps:
Step 1, pretreatment: weighing 60 parts of selenium-rich grifola frondosus in parts by weight, and 45 parts of rich-selenium Agaricus blazei, selenium-rich Radix Astragali 30
Part, it cleans respectively and impregnates 3h with 40 DEG C of water；
Step 2, defibrination: wearing into slurry for pretreated selenium-rich grifola frondosus, rich-selenium Agaricus blazei, selenium-rich Radix Astragali respectively, and
It is mixed to get mixed slurry；The solid-liquid ratio of the mixed slurry is 1:15；
It is step 3, broken: by the mixed slurry be heated to 44 DEG C (heating time 10min, 44 DEG C hold time for
After 40min), ultrasonication (SL-1200 type ultrasonic cell disruption instrument, ultrasonic time 5min, ultrasonic power 700W) is obtained
To broken solution；
Step 4 is extracted: broken solution being heated to 70 DEG C (time 10min of heat temperature raising), after maintaining 20min
It is cooled to 15 DEG C rapidly by the way of clean ice bag is added；70 DEG C are again heated to, is cooled to 15 rapidly after maintaining 20min
℃；Heating cooling totally 6 times is so repeated, residue is filtered to remove using 60 mesh gauzes, is cooled to 20 DEG C, obtains raw material extracting solution；
Step 5, mixing: will add in 2 parts of gynosaponin and 2 parts of resulting raw material extracting solutions of addition step 4 of glutathione
Heat elevates the temperature to 45 DEG C, after maintaining 20min to make it dissolve, is placed in the blender that revolving speed is 10r/min and mixes, expected
Liquid mixture；
Step 6 is concentrated and dried: by the concentration of step 5 gained material liquid mixture, (feed liquid concentration ratio is 15 times, temperature control
At 120 DEG C hereinafter, vacuum degree is in 0.8mPa) after, it is spray dried to powder and is combined to get to the herbal cuisine for strengthen immunity
Object.
Embodiment 3
1, a kind of herbal cuisine composition for strengthen immunity, material composition include selenium-rich grifola frondosus according to parts by weight
75 parts, 35 parts of rich-selenium Agaricus blazei, 40 parts of selenium-rich Radix Astragali, 10 parts of gynosaponin, 10 parts of glutathione；Wherein, the selenium-rich ash
Flower, rich-selenium Agaricus blazei, the Se content in selenium-rich Radix Astragali are set greater than 400ppm.
2, the preparation method of the herbal cuisine composition for strengthen immunity, includes the following steps:
Step 1, pretreatment: weighing 75 parts of selenium-rich grifola frondosus in parts by weight, and 35 parts of rich-selenium Agaricus blazei, selenium-rich Radix Astragali 40
Part, it cleans respectively and impregnates 2h with 60 DEG C of water；
Step 2, defibrination: wearing into slurry for pretreated selenium-rich grifola frondosus, rich-selenium Agaricus blazei, selenium-rich Radix Astragali respectively, and
It is mixed to get mixed slurry；The solid-liquid ratio of the mixed slurry is 1:30；
It is step 3, broken: by the mixed slurry be heated to 46 DEG C (heating time 5min, 46 DEG C hold time for
After 30min), ultrasonication (SL-1200 type ultrasonic cell disruption instrument, ultrasonic time 15min, ultrasonic power 800W),
Obtain broken solution；
Step 4 is extracted: broken solution being heated to 80 DEG C (time 20min of heat temperature raising), after maintaining 40min
It is cooled to 25 DEG C rapidly by the way of clean ice bag is added；80 DEG C are again heated to, is cooled to 25 rapidly after maintaining 40min
℃；Heating cooling totally 3 times is so repeated, residue is filtered to remove using 80 mesh gauzes, is cooled to 28 DEG C, obtains raw material extracting solution；
Step 5, mixing: will be in 10 parts of gynosaponin and 10 parts of resulting raw material extracting solutions of addition step 4 of glutathione
Heating elevates the temperature to 60 DEG C, after maintaining 30min to make it dissolve, is placed in the blender that revolving speed is 20r/min and mixes, obtain
Material liquid mixture；
Step 6 is concentrated and dried: by the concentration of step 5 gained material liquid mixture, (feed liquid concentration ratio is 20 times, temperature control
At 120 DEG C hereinafter, vacuum degree is in 0.9mPa) after, it is spray dried to powder and is combined to get to the herbal cuisine for strengthen immunity
Object.
Embodiment 4
1, a kind of herbal cuisine composition for strengthen immunity, material composition include selenium-rich grifola frondosus according to parts by weight
70 parts, 41.5 parts of rich-selenium Agaricus blazei, 37 parts of selenium-rich Radix Astragali, 8 parts of gynosaponin, 8 parts of glutathione；Wherein, the selenium-rich ash
Flower, rich-selenium Agaricus blazei, the Se content in selenium-rich Radix Astragali are set greater than 400ppm.
2, the preparation method of the herbal cuisine composition for strengthen immunity, includes the following steps:
Step 1, pretreatment: weighing 70 parts of selenium-rich grifola frondosus in parts by weight, and 41.5 parts of rich-selenium Agaricus blazei, selenium-rich Radix Astragali 37
Part, it cleans respectively and impregnates 2h with 60 DEG C of water；
Step 2, defibrination: wearing into slurry for pretreated selenium-rich grifola frondosus, rich-selenium Agaricus blazei, selenium-rich Radix Astragali respectively, and
It is mixed to get mixed slurry；The solid-liquid ratio of the mixed slurry is 1:30；
It is step 3, broken: by the mixed slurry be heated to 46 DEG C (heating time 5min, 46 DEG C hold time for
After 30min), ultrasonication (SL-1200 type ultrasonic cell disruption instrument, ultrasonic time 15min, ultrasonic power 800W),
Obtain broken solution；
Step 4 is extracted: broken solution being heated to 80 DEG C (time 20min of heat temperature raising), after maintaining 40min
It is cooled to 25 DEG C rapidly by the way of clean ice bag is added；80 DEG C are again heated to, is cooled to 25 rapidly after maintaining 40min
℃；Heating cooling totally 3 times is so repeated, residue is filtered to remove using 80 mesh gauzes, is cooled to 28 DEG C, obtains raw material extracting solution；
Step 5, mixing: 8 parts of gynosaponin are heated in 8 parts of resulting raw material extracting solutions of addition step 4 of glutathione
It elevates the temperature to 60 DEG C, after maintaining 30min to make it dissolve, is placed in the blender that revolving speed is 20r/min and mixes, obtain feed liquid
Mixture；
Step 6 is concentrated and dried: by the concentration of step 5 gained material liquid mixture, (feed liquid concentration ratio is 20 times, temperature control
At 120 DEG C hereinafter, vacuum degree is in 0.9mPa) after, it is spray dried to powder and is combined to get to the herbal cuisine for strengthen immunity
Object.
Embodiment 5
1, a kind of herbal cuisine composition for strengthen immunity, material composition include selenium-rich grifola frondosus according to parts by weight
65 parts, 38.5 parts of rich-selenium Agaricus blazei, 33 parts of selenium-rich Radix Astragali, 4 parts of gynosaponin, 4 parts of glutathione；Wherein, the selenium-rich ash
Flower, rich-selenium Agaricus blazei, the Se content in selenium-rich Radix Astragali are set greater than 400ppm.
2, the preparation method of the herbal cuisine composition for strengthen immunity, includes the following steps:
Step 1, pretreatment: weighing 65 parts of selenium-rich grifola frondosus in parts by weight, and 38.5 parts of rich-selenium Agaricus blazei, selenium-rich Radix Astragali 33
Part, it cleans respectively and impregnates 2h with 60 DEG C of water；
Step 2, defibrination: wearing into slurry for pretreated selenium-rich grifola frondosus, rich-selenium Agaricus blazei, selenium-rich Radix Astragali respectively, and
It is mixed to get mixed slurry；The solid-liquid ratio of the mixed slurry is 1:30；
It is step 3, broken: by the mixed slurry be heated to 46 DEG C (heating time 5min, 46 DEG C hold time for
After 30min), ultrasonication (SL-1200 type ultrasonic cell disruption instrument, ultrasonic time 15min, ultrasonic power 800W),
Obtain broken solution；
Step 4 is extracted: broken solution being heated to 80 DEG C (time 20min of heat temperature raising), after maintaining 40min
It is cooled to 25 DEG C rapidly by the way of clean ice bag is added；80 DEG C are again heated to, is cooled to 25 rapidly after maintaining 40min
℃；Heating cooling totally 3 times is so repeated, residue is filtered to remove using 80 mesh gauzes, is cooled to 28 DEG C, obtains raw material extracting solution；
Step 5, mixing: 4 parts of gynosaponin are heated in 4 parts of resulting raw material extracting solutions of addition step 4 of glutathione
It elevates the temperature to 60 DEG C, after maintaining 30min to make it dissolve, is placed in the blender that revolving speed is 20r/min and mixes, obtain feed liquid
Mixture；
Step 6 is concentrated and dried: by the concentration of step 5 gained material liquid mixture, (feed liquid concentration ratio is 20 times, temperature control
At 120 DEG C hereinafter, vacuum degree is in 0.9mPa) after, it is spray dried to powder and is combined to get to the herbal cuisine for strengthen immunity
Object.
Comparative example 1
In the comparative example except step 4 is changed to " broken solution is heated to 75 DEG C (time 15min of heat temperature raising),
It maintains after 30min using being cooled to 20 DEG C rapidly by the way of the clean ice bag of addition, in 20 DEG C of maintenance 30min-150min ",
His step and formula composition are the same as embodiment 1.
Comparative example 2
(step 3), remaining step and formula group are directly carried out after step 1 in addition to without step 2 in the comparative example
Cheng Juntong embodiment 1.
1 zoopery of experimental example
1, experimental animal
Purebred health adult male rabbit, weight 2.0kg or so, 80.
2, grouping and administration
The rabbit that weight is 5-8kg is grouped at random, is divided into blank control group, (embodiment 1 is formulated low experimental group
Dosage group 0.25g/kg), 3 groups of experiment 2 groups (embodiments 1 be formulated middle dose group 0.5g/kg) and experiment (formula of embodiment 1
High dose group 0.75g/kg), every group 20.
It is converted according to equivalent dose between animals and human beings, the rabbit of experimental group 1~3 takes orally 0.5g/kg daily.And it is above-mentioned each
Group is divided equally 2 morning, stomach-fillings in afternoon, and continuous gavage 1 month.Blank control group takes orally the distilled water of same volume.
3, observation index
Then internal organs/gravity test, delayed allergy measurement, the survey of lymphocyte transformation value are surveyed in continuous feeding 30 days
Fixed and NK cytoactive detection.
4, result and analysis
Inspection result are as follows:
1, weight, thymus gland/weight ratio, spleen/weight ratio: to the weight of animal, thymus gland/weight ratio and spleen/
Weight ratio, which has no, to be significantly affected.
2, the mouse spleen lymphocyte conversion test (mtt assay) of ConA induction: the rabbit lymphocyte of experimental group 1~3 turns
Change ability is apparently higher than blank control group, and difference has conspicuousness (P < 0.05), shows that experimental group 1~3 all has enhancing
The effect of mouse cell immune function.
Table 1
| Group | Number of animals (only) | Lymphopoiesis ability (X ± SD) |
| Experimental group 1 | 20 | 0.076±0.08 |
| Experimental group 2 | 20 | 0.106±0.07a |
| Experimental group 3 | 20 | 0.112±0.09a |
| Blank control group | 20 | 0.062±0.09 |
Note: subscript a indicates there is significant difference, i.e. P < 0.05 compared with blank control group, similarly hereinafter.
3, mouse Tardive allergy (vola pedis thickens method): the rabbit toes swelling of experimental group 1~3 is apparently higher than sky
White control group, and difference has conspicuousness (P < 0.05), shows that experimental group 1~3 all has enhancing mouse cell immune function
Effect.
Table 2
| Group | Number of animals (only) | Toes swelling for 24 hours after injection |
| Experimental group 1 | 20 | 0.279±0.08 |
| Experimental group 2 | 20 | 0.356±0.12a |
| Experimental group 3 | 20 | 0.358±0.11a |
| Blank control group | 20 | 0.262±0.06 |
In conclusion a kind of herbal cuisine composition and preparation method thereof for strengthen immunity provided by the invention, the medicine
Meals composition prescription is exquisite, has effects that adjust human body gas, blood, the balance of yin, yang and enhancing matrix immunity；It cooperates with together
Liver, spleen, stomach, kidney are adjusted, body function is made to be in optimum state.
Experimental example 2
Measure and Statistics Implementation example 1, comparative example 1, in comparative example 2 after step 4 extraction gained raw material extracting solution it is effective
Constituents extraction efficiency, as shown in table 3.
Table 3
| Group | Extraction efficiency |
| Embodiment 1 | 81.5% |
| Comparative example 1 | 46.7% |
| Comparative example 2 | 53.3% |
As shown in Table 3, compared with comparative example 1-2, the extraction efficiency of embodiment 1 is greatly improved；Show provided by the invention
A kind of preparation method of the herbal cuisine composition for strengthen immunity, (1) are extracted repeatedly using low temperature, can guarantee effectively at
Under the premise of point active, more effective component is extracted as far as possible, not only increases recovery rate, and avoid effective component as far as possible
Destruction；(2) relative to other extracting modes, this is lower for water deduction, safer；(3) it after fresh material being broken into slurry, then carries out
Clasmatosis helps to reduce cost, guarantees effective component activity, improves recovery rate.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of herbal cuisine composition for strengthen immunity, which is characterized in that its material composition includes richness according to parts by weight
60~75 parts of selenium grifola frondosus, 35~45 parts of rich-selenium Agaricus blazei, 30~40 parts of selenium-rich Radix Astragali, 2~10 parts of gynosaponin, gluathione
2~10 parts of peptide；Wherein, the selenium-rich grifola frondosus, rich-selenium Agaricus blazei, the Se content in selenium-rich Radix Astragali are greater than 400ppm.
2. being used for the herbal cuisine composition of strengthen immunity as described in claim 1, which is characterized in that its material composition is by weight
Number meter includes 65~70 parts of selenium-rich grifola frondosus, and 38.5~41.5 parts of rich-selenium Agaricus blazei, 33~37 parts of selenium-rich Radix Astragali, gynostemma pentaphylla soap
4~8 parts of glucoside, 4~8 parts of glutathione.
3. being used for the herbal cuisine composition of strengthen immunity as described in claim 1, which is characterized in that its material composition is by weight
Number meter includes 68 parts of selenium-rich grifola frondosus, and 40 parts of rich-selenium Agaricus blazei, 35 parts of selenium-rich Radix Astragali, 6 parts of gynosaponin, glutathione 6
Part.
4. a kind of preparation method of the herbal cuisine composition for strengthen immunity as described in claims 1 to 3 is any, feature
It is, includes the following steps:
Step 1, pretreatment: weighing 60~75 parts of selenium-rich grifola frondosus in parts by weight, and 35~45 parts of rich-selenium Agaricus blazei, selenium-rich Radix Astragali
It 30~40 parts, cleans and is soaked in water respectively；
Step 2, defibrination: pretreated selenium-rich grifola frondosus, rich-selenium Agaricus blazei, selenium-rich Radix Astragali are worn into slurry, and mixed respectively
Obtain mixed slurry；
Step 3 is crushed: after the mixed slurry is heated to 44~46 DEG C, ultrasonication obtains broken solution；
Step 4 is extracted: broken solution being heated to 70~80 DEG C, is cooled to 15~25 DEG C after maintaining 20~40min；Again
70~80 DEG C are heated to, is cooled to 15~25 DEG C after maintaining 20~40min；Heating cooling totally 3~6 times is so repeated, crosses and filters out
Residue is removed, is cooled to 20~28 DEG C, obtains raw material extracting solution；
Step 5, mixing: by 2~10 parts of gynosaponin and 2~10 parts of resulting raw material extracting solutions of addition step 4 of glutathione
In make it dissolve and mix, obtain material liquid mixture；
Step 6 is concentrated and dried: after the concentration of step 5 gained material liquid mixture, being dried to powder to get to immune for enhancing
The herbal cuisine composition of power.
5. the preparation method for the herbal cuisine composition of strengthen immunity as claimed in claim 4, which is characterized in that the step
In rapid 1,2~3h is impregnated using 40~60 DEG C of water.
6. the preparation method for the herbal cuisine composition of strengthen immunity as claimed in claim 4, which is characterized in that the step
In rapid 2, the solid-liquid ratio of the mixed slurry is 1:15-30.
7. the preparation method for the herbal cuisine composition of strengthen immunity as claimed in claim 4, which is characterized in that the step
In rapid 3, the heating time for being heated to 44~46 DEG C is 5~10min, and 44~46 DEG C are held time as 30~40min；The ultrasound
Time is 5~15min, and ultrasonic power is 700~800W.
8. the preparation method for the herbal cuisine composition of strengthen immunity as claimed in claim 4, which is characterized in that the step
It is described to be cooled to ice bag clean using addition at 15~25 DEG C in rapid 4；The filtering uses 60~80 mesh gauzes.
9. the preparation method for the herbal cuisine composition of strengthen immunity as claimed in claim 4, which is characterized in that the step
It in rapid 5, dissolves and mixes specific steps are as follows: heating elevates the temperature to 45~60 DEG C, after maintaining 20~30min, is placed in revolving speed
To be mixed in the blender of 10~20r/min.
10. the preparation method for the herbal cuisine composition of strengthen immunity as claimed in claim 4, which is characterized in that described
In step 6, the parameter of the concentration are as follows: feed liquid concentration ratio is 15~20 times, and temperature control is at 120 DEG C hereinafter, vacuum degree exists
0.8~0.9mPa.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329968A (en) * | 2020-03-27 | 2020-06-26 | 潍坊峰林功能食品技术研究院有限公司 | Selenium-enriched agaricus blazei murill and ash tree flower tablet and preparation method thereof |
| CN111567713A (en) * | 2020-05-21 | 2020-08-25 | 蔡文球 | Composition for improving immunity and preparation method thereof |
| CN115364138A (en) * | 2022-09-19 | 2022-11-22 | 博斯创想(上海)医疗科技有限公司 | Compound bacterial liquid for improving chemotherapy side effects and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940313A (en) * | 2010-03-25 | 2011-01-12 | 无锡市天赐康生物科技有限公司 | Health food capable of enhancing immunity of human body and preparation method thereof |
| CN104013764A (en) * | 2014-05-13 | 2014-09-03 | 湖北金鹰生物科技有限公司 | Traditional Chinese medicine with immunity enhancing function and preparation method thereof |
| CN106860506A (en) * | 2017-02-17 | 2017-06-20 | 甘肃省中医学校 | A kind of selenium-rich Astragalus Root P.E, extracting method and application |
-
2019
- 2019-07-18 CN CN201910650114.3A patent/CN110367522A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940313A (en) * | 2010-03-25 | 2011-01-12 | 无锡市天赐康生物科技有限公司 | Health food capable of enhancing immunity of human body and preparation method thereof |
| CN104013764A (en) * | 2014-05-13 | 2014-09-03 | 湖北金鹰生物科技有限公司 | Traditional Chinese medicine with immunity enhancing function and preparation method thereof |
| CN106860506A (en) * | 2017-02-17 | 2017-06-20 | 甘肃省中医学校 | A kind of selenium-rich Astragalus Root P.E, extracting method and application |
Non-Patent Citations (2)
| Title |
|---|
| 张维等: "超声破碎法及匀浆法提取鹿茸多肽的比较研究", 《吉林中医药》 * |
| 韩枫等: "磨浆-超声法提取薯蓣皂素工艺过程研究", 《化学工程》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329968A (en) * | 2020-03-27 | 2020-06-26 | 潍坊峰林功能食品技术研究院有限公司 | Selenium-enriched agaricus blazei murill and ash tree flower tablet and preparation method thereof |
| CN111567713A (en) * | 2020-05-21 | 2020-08-25 | 蔡文球 | Composition for improving immunity and preparation method thereof |
| CN115364138A (en) * | 2022-09-19 | 2022-11-22 | 博斯创想(上海)医疗科技有限公司 | Compound bacterial liquid for improving chemotherapy side effects and preparation method thereof |
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Application publication date: 20191025 |