CN106232125B - 用于调节pkk表达的组合物和方法 - Google Patents

用于调节pkk表达的组合物和方法 Download PDF

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CN106232125B
CN106232125B CN201580020831.8A CN201580020831A CN106232125B CN 106232125 B CN106232125 B CN 106232125B CN 201580020831 A CN201580020831 A CN 201580020831A CN 106232125 B CN106232125 B CN 106232125B
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certain embodiments
compound
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antisense
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CN106232125A (zh
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撒扎·P·普拉卡什
普内特·P·塞思
埃里克·E·斯威兹
苏珊·M·弗赖尔
H·布维
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Ionis Pharmaceuticals Inc
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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CN201580020831.8A 2014-05-01 2015-05-01 用于调节pkk表达的组合物和方法 Active CN106232125B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461987478P 2014-05-01 2014-05-01
US61/987,478 2014-05-01
US201462058629P 2014-10-01 2014-10-01
US62/058,629 2014-10-01
US201462088459P 2014-12-05 2014-12-05
US62/088,459 2014-12-05
PCT/US2015/028765 WO2015168532A2 (en) 2014-05-01 2015-05-01 Compositions and methods for modulating pkk expression

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CN106232125A CN106232125A (zh) 2016-12-14
CN106232125B true CN106232125B (zh) 2020-10-16

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US (4) US10294477B2 (enExample)
EP (3) EP4534092A3 (enExample)
JP (4) JP6665111B2 (enExample)
KR (1) KR102366078B1 (enExample)
CN (1) CN106232125B (enExample)
AU (2) AU2015252917B2 (enExample)
BR (1) BR112016022855B1 (enExample)
CA (1) CA2943705A1 (enExample)
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WO (1) WO2015168532A2 (enExample)

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KR20250145702A (ko) * 2017-04-11 2025-10-13 아뷰터스 바이오파마 코포레이션 표적화 조성물
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WO2019105418A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
KR102834361B1 (ko) 2017-12-01 2025-07-17 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 핵산, 이를 포함하는 조성물과 컨쥬게이트, 및 그의 제조 방법과 용도
JP7365052B2 (ja) 2017-12-01 2023-10-19 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
US11414661B2 (en) 2017-12-01 2022-08-16 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof
CA3087106A1 (en) 2017-12-29 2019-07-04 Suzhou Ribo Life Science Co., Ltd. Conjugates and preparation and use thereof
JP2021533800A (ja) 2018-08-21 2021-12-09 スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. 核酸、当該核酸を含む薬物組成物及び複合体ならびにその使用
CN111655297A (zh) 2018-09-30 2020-09-11 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
CN113891939B (zh) * 2019-05-24 2024-04-02 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN115362256A (zh) * 2020-02-07 2022-11-18 因特利亚治疗公司 用于激肽释放酶（klkb1）基因编辑的组合物和方法
EP4118208A4 (en) * 2020-03-13 2025-03-12 Ionis Pharmaceuticals, Inc. Compositions and methods for treating and preventing prekallikrein-associated diseases
CN116669746B (zh) * 2020-12-29 2025-09-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途
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CN116917477B (zh) * 2022-01-30 2024-04-09 大睿生物医药科技(上海)有限公司 含有n-乙酰半乳糖胺的靶向配体
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