CN106146584A - 新型胞苷衍生物二聚体及其应用 - Google Patents
新型胞苷衍生物二聚体及其应用 Download PDFInfo
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- CN106146584A CN106146584A CN201510167580.8A CN201510167580A CN106146584A CN 106146584 A CN106146584 A CN 106146584A CN 201510167580 A CN201510167580 A CN 201510167580A CN 106146584 A CN106146584 A CN 106146584A
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- cytidine derivatives
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- hydroxyl
- nitro
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- -1 nitro, amino, hydroxyl Chemical group 0.000 claims description 38
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Classifications
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
溶剂 | 批号 | 厂商 |
无水乙醇 | 10009218 | 国药集团化学试剂有限公司 |
Cremophor EL | 27963 | Sigma |
0.9%生理盐水 | 13083004 | 华裕制药有限公司 |
Claims (8)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710858124.7A CN107513089B (zh) | 2014-11-17 | 2015-04-09 | 一种新型胞苷衍生物二聚体及其应用 |
CA2966709A CA2966709C (en) | 2014-11-17 | 2015-06-10 | Cytidine derivative dimers and applications thereof |
RU2017120032A RU2687252C2 (ru) | 2014-11-17 | 2015-06-10 | Новые димеры производных цитидина и их применения |
PCT/CN2015/081138 WO2016078399A1 (zh) | 2014-11-17 | 2015-06-10 | 新型胞苷衍生物二聚体及其应用 |
AU2015349306A AU2015349306B2 (en) | 2014-11-17 | 2015-06-10 | New type of cytidine derivative dimer and application thereof |
EP15860643.4A EP3216799A4 (en) | 2014-11-17 | 2015-06-10 | New type of cytidine derivative dimer and application thereof |
JP2017526072A JP6271091B2 (ja) | 2014-11-17 | 2015-06-10 | 新規シチジン誘導体二量体およびその応用 |
DE202015009594.1U DE202015009594U1 (de) | 2014-11-17 | 2015-06-10 | Neue Dimere von Cytidin-Derivaten |
KR1020177015267A KR101872264B1 (ko) | 2014-11-17 | 2015-06-10 | 신규한 유형의 시티딘 유도체 이량체 및 그의 용도 |
EP18165697.6A EP3369740B1 (en) | 2014-11-17 | 2015-06-10 | New cytidine derivative dimers and applications thereof |
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CN2014106527244 | 2014-11-17 | ||
CN201410652724 | 2014-11-17 |
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CN201710858124.7A Division CN107513089B (zh) | 2014-11-17 | 2015-04-09 | 一种新型胞苷衍生物二聚体及其应用 |
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CN106146584A true CN106146584A (zh) | 2016-11-23 |
CN106146584B CN106146584B (zh) | 2019-03-01 |
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CN201710858124.7A Active CN107513089B (zh) | 2014-11-17 | 2015-04-09 | 一种新型胞苷衍生物二聚体及其应用 |
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CN201710858124.7A Active CN107513089B (zh) | 2014-11-17 | 2015-04-09 | 一种新型胞苷衍生物二聚体及其应用 |
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US (2) | US9862741B2 (zh) |
EP (2) | EP3216799A4 (zh) |
JP (1) | JP6271091B2 (zh) |
KR (1) | KR101872264B1 (zh) |
CN (2) | CN106146584B (zh) |
AU (1) | AU2015349306B2 (zh) |
CA (1) | CA2966709C (zh) |
DE (1) | DE202015009594U1 (zh) |
RU (1) | RU2687252C2 (zh) |
WO (1) | WO2016078163A1 (zh) |
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CN110229110B (zh) * | 2019-06-26 | 2022-07-08 | 中国医学科学院生物医学工程研究所 | 一种小分子杂环二聚体和用途 |
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CN101044150A (zh) * | 2004-09-24 | 2007-09-26 | 安吉奥金尼药品有限公司 | 生物还原活化的前药 |
CN102775458A (zh) * | 2011-05-09 | 2012-11-14 | 中国人民解放军军事医学科学院毒物药物研究所 | β-D-(2’R)-2’-脱氧—2’-氟-2’-C-甲基胞苷衍生物的制备及用途 |
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US20100068786A1 (en) * | 2008-09-16 | 2010-03-18 | Chmielewski Jean A | Methods and compositions for reversing p-glycoprotein medicated drug resistance |
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WO2016078163A1 (zh) * | 2014-11-17 | 2016-05-26 | 常州方圆制药有限公司 | 新型胞苷衍生物二聚体及其应用 |
WO2016188943A1 (en) * | 2015-05-27 | 2016-12-01 | Idenix Pharmaceuticals Llc | Nucleotides for the treatment of cancer |
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CN101044150A (zh) * | 2004-09-24 | 2007-09-26 | 安吉奥金尼药品有限公司 | 生物还原活化的前药 |
CN102775458A (zh) * | 2011-05-09 | 2012-11-14 | 中国人民解放军军事医学科学院毒物药物研究所 | β-D-(2’R)-2’-脱氧—2’-氟-2’-C-甲基胞苷衍生物的制备及用途 |
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CN106146584B (zh) | 2019-03-01 |
US10351586B2 (en) | 2019-07-16 |
JP6271091B2 (ja) | 2018-01-31 |
AU2015349306B2 (en) | 2019-02-28 |
US9862741B2 (en) | 2018-01-09 |
EP3369740A1 (en) | 2018-09-05 |
JP2017533940A (ja) | 2017-11-16 |
RU2017120032A3 (zh) | 2018-12-19 |
DE202015009594U1 (de) | 2018-06-25 |
EP3369740B1 (en) | 2020-11-25 |
US20180105550A1 (en) | 2018-04-19 |
RU2017120032A (ru) | 2018-12-19 |
CA2966709C (en) | 2018-04-10 |
CN107513089B (zh) | 2021-04-02 |
CN107513089A (zh) | 2017-12-26 |
CA2966709A1 (en) | 2016-05-26 |
US20160137684A1 (en) | 2016-05-19 |
RU2687252C2 (ru) | 2019-05-08 |
KR20170073699A (ko) | 2017-06-28 |
KR101872264B1 (ko) | 2018-06-29 |
EP3216799A1 (en) | 2017-09-13 |
WO2016078163A1 (zh) | 2016-05-26 |
EP3216799A4 (en) | 2018-06-13 |
AU2015349306A1 (en) | 2017-05-18 |
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