CN106093016A - A kind of chemical luminescent detecting method - Google Patents
A kind of chemical luminescent detecting method Download PDFInfo
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- CN106093016A CN106093016A CN201610727708.6A CN201610727708A CN106093016A CN 106093016 A CN106093016 A CN 106093016A CN 201610727708 A CN201610727708 A CN 201610727708A CN 106093016 A CN106093016 A CN 106093016A
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- 238000000034 method Methods 0.000 title claims abstract description 38
- 239000000126 substance Substances 0.000 title claims abstract description 33
- 238000006243 chemical reaction Methods 0.000 claims abstract description 109
- 239000007788 liquid Substances 0.000 claims abstract description 90
- 238000002156 mixing Methods 0.000 claims abstract description 43
- 238000001514 detection method Methods 0.000 claims abstract description 31
- 238000004140 cleaning Methods 0.000 claims abstract description 16
- 230000000694 effects Effects 0.000 claims abstract description 9
- 230000007246 mechanism Effects 0.000 claims description 109
- 238000002347 injection Methods 0.000 claims description 84
- 239000007924 injection Substances 0.000 claims description 84
- 239000012530 fluid Substances 0.000 claims description 56
- 230000003068 static effect Effects 0.000 claims description 19
- 230000033001 locomotion Effects 0.000 claims description 14
- 230000012447 hatching Effects 0.000 claims description 10
- 239000011521 glass Substances 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 230000004044 response Effects 0.000 claims description 8
- 230000004888 barrier function Effects 0.000 claims description 7
- 230000003028 elevating effect Effects 0.000 claims description 6
- 230000005622 photoelectricity Effects 0.000 claims description 6
- 238000011049 filling Methods 0.000 claims description 5
- 238000009413 insulation Methods 0.000 claims description 5
- 239000002699 waste material Substances 0.000 claims description 4
- 230000003044 adaptive effect Effects 0.000 claims description 3
- 239000011324 bead Substances 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 238000011534 incubation Methods 0.000 claims description 3
- 230000001360 synchronised effect Effects 0.000 claims description 3
- 238000013519 translation Methods 0.000 claims description 3
- 230000008450 motivation Effects 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 9
- 238000013461 design Methods 0.000 abstract description 3
- 230000005540 biological transmission Effects 0.000 description 10
- 239000000376 reactant Substances 0.000 description 6
- 230000008901 benefit Effects 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000007422 luminescence assay Methods 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000000904 thermoluminescence Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
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- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention discloses a kind of chemical luminescent detecting method, rotation platform is being put cup position, is being taken liquid level, liquid blending position, hatch position, cleaning position, reading position and lose cup position and be respectively arranged with the first Hall element, the position of each station is arrived for sensing reaction cup, Magnet is followed rotary turnplate and is circled under the effect of motor, when turntable rotation is to relevant position, Magnet senses with Hall element, and rotating disk stops, and will detect operation accordingly in this position.The detection of this chemical luminescent detecting method is accurately, it is easy to implement.Corresponding mensuration systemic-function is enriched, and each several part runs smooth and easy, can mutually interact, and structure is compact to design and reasonable, jointly cooperates, and can complete the mensuration flow process of complexity, and automaticity is high.
Description
Technical field
The present invention relates to a kind of chemical luminescent detecting method.
Background technology
Existing chemical luminescent detecting method, although detection automatically can be realized, but there are problems, such as detect not
Enough accurately corresponding mensuration system structure is the compactest, takes up room big, and existing method easily causes reactant by dirt
Dye, therefore, it is necessary to a kind of chemical luminescent detecting method of design.
Summary of the invention
The technical problem to be solved is to provide a kind of chemical luminescent detecting method, this chemical luminescent detecting method
Detection is accurately, it is easy to implement.
The technical solution of invention is as follows:
A kind of chemical luminescent detecting method, it is characterised in that comprise the following steps:
Step 1: placing response cup；
The rotating disk of rotation platform is in initial position, i.e. zero-bit (A), the fixture now reaction cup being placed on arc
On；
Step 2: take liquid step；
Turntable rotation makes reaction cup arrive and takes liquid level (B), Qu Ye mechanism inject liquid into reaction cup；Described liquid
Including reagent and sample；
Step 3: mixing step for the first time；
Turntable rotation makes reaction cup arrive mixing position (C), and the rabbling mechanism of fluid injection/evenly mixing device is to the liquid in reaction cup
Body is stirred；
Step 4: incubation step
Turntable rotation makes reaction cup arrive and hatches position (D), incubating device heat the liquid in reaction cup and incubate
Educate operation；
Step 5: cleaning step；
Turntable rotation makes reaction cup arrive cleaning position (E), uses wiper mechanism to clean the magnetic bead in reaction cup；
Step 6: second time mixing step；
Turntable rotation makes reaction cup arrive mixing position, and the rabbling mechanism of fluid injection/evenly mixing device injects and triggers agent A liquid also
Liquid in reaction cup is stirred；
Step 7: reading step；
Turntable rotation makes reaction cup arrive reading position (F), injects and triggers agent B liquid, and reading plotter reads reaction result；
Waste liquid is taken away after reading；
Step 8: lose a glass step；
Turntable rotation makes reaction cup arrive to lose cup position (G), pushed away by reaction cup (to hopper and receive by losing cup device
Collection)；
Complete the determination step once for reaction cup medicinal liquid.
After step 8, rotating disk continues to be rotated back to zero-bit, and chemical luminescent detecting method resets.
Chemical luminescent detecting system is used to realize determination step；Chemical luminescent detecting system includes base, rotation platform, takes
Liquid device, clean device, fluid injection/evenly mixing device, incubating device, reading plotter and lose cup device；
Rotation platform is arranged on the central authorities of base, liquid taking device, cleaning device, fluid injection/evenly mixing device, incubating device, reading
Counting apparatus and lose cup device and be all arranged on base around rotation platform；
Rotation platform: rotation platform includes support, rotating disk, arc carrier and drives motor and the gear of rotating disk；
Rotating disk is arranged on support, and rotating disk is endless member, and the internal ring side of rotating disk is provided with for adaptive with described gear
Double wedge；Gear is arranged in the rotating shaft of motor；
Arc carrier is fixed on rotating disk by arc carrier vertical columns, can be with rotating disk synchronous axial system；On arc carrier
It is provided with the fixture for accommodating reaction cup；
Arc carrier is provided with the Magnet fixed block with Magnet；Being fixed with the first Hall element on support, first suddenly
Your sensor is concordant with the height of Magnet.
Support is provided with for detecting the reaction cup detection sensor whether reaction cup exists.
Described Hall element is multiple, being arranged circumferentially on support along rotating disk.
Described support includes support ring and for supporting many support columns of support ring.
Firm banking it is provided with bottom support column.
Reaction cup rotating mechanism is also called rotation platform, is used for driving reaction cup to switch in each module, and this platform has
Internal-gear type rotary turnplate mechanism, the arc carrier of placing response cup；
The arc carrier of described placing response cup is fixed on rotating disk, and fixture is used for clamping reaction cup, instrument (i.e. chemistry
Luminescence assays system) when running, manually reaction cup is placed on arc carrier, clamp reaction cup, it is ensured that doing circumference fortune
Time dynamic, reaction cup is not rocked；
Described Hall element arrives the position of each station for detecting reaction cup；Described reaction cup detection sensing
Device is used for detecting whether arc carrier responds cup.
This rotation platform is being put cup position, is being taken liquid level, liquid blending position, hatch position, cleaning position, reading position and lose cup position respectively
Being provided with Hall element, arrive the position of each station for sensing reaction cup, Magnet follows the rotary turnplate work at motor
Circling under with, when turntable rotation to relevant position, Magnet senses with Hall element, and rotating disk stops, will be at this
Position detects operation accordingly.
Fluid injection/evenly mixing device: include the second riser, cam flat pushing mechanism and for the mechanism for filling liquid for reaction cup fluid injection；
Cam flat pushing mechanism include the second cam, the second actuated by cams motor for driving cam to rotate, pushing block, second
Guide post, the second back-moving spring；
Described mechanism for filling liquid includes liquid injection pipe fixed plate and the liquid injection pipe being vertically fixed in liquid injection pipe fixed plate；
Riser is provided with pilot hole, and guide post is inserted in pilot hole；Liquid injection pipe fixed plate and pushing block are separately positioned on leads
To leading section and the rearward end of bar；Back-moving spring is sleeved on guide post；
Second cam contacts with pushing block；When second cam rotates, the second cam can drive liquid injection pipe fixed plate and liquid injection pipe
Travel forward.
The second described guide post is 2, and described pilot hole is 2.Fluid injection/evenly mixing device also includes the testing machine that puts in place
Structure, described to include that static inducting parts being arranged on riser and being arranged on push away on cup mechanism to position detecting mechanism movable
Trigger unit.Movable trigger unit and static inducting parts are respectively magnetic sheet and the second Hall element, or, described work
Dynamic formula trigger unit and static inducting parts are respectively light barrier and photoelectricity correlation detection module.
Being additionally provided with baffle plate on second riser, baffle plate is positioned at the lower section of liquid injection pipe fixed plate, and baffle plate is provided with for for fluid injection
The bar shaped guide hole of pipe guided in translation；
Fluid injection/evenly mixing device includes that rabbling mechanism, rabbling mechanism include rabbling mechanism fixed plate, stirring motor and for overlapping
Live the sleeve of reaction cup.
Described rabbling mechanism is driven by Z axis drive mechanism.
Incubating device: incubating device include vertical plate and be arranged on vertical plate hatch block；The outer wall hatching block is provided with
Thermal insulation board；It is provided with heater in hatching block；
Described block of hatching is connected with vertical plate by Z axis straight-line motion mechanism.
Z axis straight-line motion mechanism is lead screw transmission mechanism, including the 3rd motor, screw mandrel, screw mandrel contiguous block be vertically directed
Bar；
The top of vertical plate and bottom are respectively equipped with upper plate and lower shoe, the described top and bottom being vertically directed bar
It is separately fixed on upper plate and lower shoe；Screw mandrel contiguous block is arranged on and is vertically directed on bar, drives motor to be fixed on upper plate
On；The upper end of screw mandrel connects the 3rd motor, the lower end connection wire rod contiguous block of leading screw；Hatch block to be fixed on screw mandrel contiguous block；
When 3rd motor rotates, drive and hatch block along being vertically directed bar elevating movement.Being vertically directed bar is 2.
Reading plotter:
Reading plotter includes bearing, lift drive mechanism, fluid injection/discharge opeing needle assembly, darkroom and PMT reading module；
Described bearing is provided with the guide rail of vertical direction；Lift drive mechanism includes the 4th motor, drive mechanism and leads
Rail contiguous block (95)；Guide rail contiguous block is arranged on guide rail, and PMT reading module is fixed on guide rail contiguous block, and darkroom is read with PMT
Digital-to-analogue block is connected；Motor drives PMT reading module and darkroom to make elevating movement along guide rail by drive mechanism and guide rail contiguous block；
Fluid injection/discharge opeing needle assembly is arranged on bearing, and darkroom is positioned at the underface of fluid injection/discharge opeing needle assembly；During detection, treat
The reaction cup of detection is positioned in darkroom.
Drive mechanism is lead screw transmission mechanism.The 4th described motor is motor.Bearing is provided with Z-axis transmission machine
Structure, fluid injection/discharge opeing needle assembly is arranged on bearing by Z-axis transmission mechanism.
Lose cup device: lose cup device and include the first riser, cam mechanism and push away cup mechanism；
Cam mechanism includes the first cam and for the first actuated by cams motor driving cam to rotate；
The described cup mechanism that pushes away includes push pedal, the first guide post, the first back-moving spring and wedge shape pushing block；
Riser is provided with for for pushing away the pilot hole that cup mechanism guides, and the first guide post is inserted in pilot hole；Wedge shape pushes away
Block and push pedal are separately positioned on leading section and the rearward end of the first guide post；Back-moving spring is sleeved on the first guide post；
First cam contacts with push pedal；When first cam rotates, the first cam can drive and push away cup mechanism and travel forward, wedge shape
When pushing block advances, the fixture of clamping reaction cup can be pushed open so that reaction cup departs from fixture.
The first described guide post is 2, and described pilot hole is 2.
Lose cup device and also include that Diu Bei testing agency, described Diu Bei testing agency include the static sense being arranged on riser
Answer parts and be arranged on the movable trigger unit pushing away on cup mechanism；Movable trigger unit and static inducting parts are respectively magnetic
Sheet and Hall element, or, described movable trigger unit and static inducting parts are respectively light barrier and photoelectricity correlation
Detection module.
Triggering agent A and triggering agent B and be also called trgA and trgB, its composition is respectively sodium hydroxide and hydrogen peroxide, plays and urges
Change effect.
PMT is photomultiplier tube, is a staple product in photon technology device, and it is that one has high sensitivity
Light-detecting device with ultrafast time response.Can be widely applied to photon counting, atomic weak light detection, chemiluminescence, biology
Light research, the detection of extremely low energy-ray, spectrophotometer, polariscope, colorimeter, illumination meter, aeroscope, scopometer, optical density
In the instrument and equipment such as meter, thermoluminescence amount instrument, radio heat meter, scanning electron microscope, biochemistry analyzer.
Beneficial effect:
The chemical luminescent detecting method of the present invention, is arranged on middle part by rotation platform, and other mechanisms set around rotation platform
Put, reasonable structural arrangement；
And, system corresponding to this method is provided with liquid taking device, cleans device, fluid injection/mixing (stirring) device, reading
Device (determinator) and lose cup device, can realize the whole flow process of luminescence assays, only need artificial by reaction cup as rotation
On platform, can be achieved with the testing process of complexity, export measurement result, automaticity is high.
The advantage place of each crucial submodule of following division:
(1) automatically lose cup device, use the first cam mechanism to push away cup mechanism and realize losing cup operation, compact conformation, knot
Structure is ingenious, runs smooth and easy, can be with rotation platform slitless connection, and closely cooperate action.
(2) drive mechanism, testing agency's (whether detection reaction cup exists), detent mechanism are integrated by reaction cup rotating mechanism
Become an entirety, compact conformation, use Hall element to coordinate Magnet to carry out position detection, the advantage with accurate positioning, adopt
With gear and headgear, by step motor drive, have and run advantage smoothly.
(3) fluid injection/evenly mixing device uses cam mechanism to promote mechanism for filling liquid to implement fluid injection, and fluid injection immediately exits from note after completing
Liquid level, it is to avoid reactant is contaminated；In a word, mechanism compact conformation, run smooth and easy, can be with detection equipment slitless connection.
(4) incubating device uses lead-screw drive mechanism and guiding mechanism based on upright guide rail, can ensure that incubating device is transported
Row is steady and smooth and easy, hatches and arranges thermal insulation board on block, can effectively prevent heat to scatter and disappear, be provided with multiple hole, energy it addition, hatch in block
Sample in multiple reaction cup is hatched operation simultaneously, and efficiency is high.
(5) interpretation device (i.e. reading plotter) uses darkroom to be in the light, and ensures the accuracy of reading, uses based on stepping
The elevating mechanism of motor, lead screw transmission mechanism and guide rail, can ensure fluid injection/smooth and easy operation of discharge opeing needle assembly, uses two set transmissions
Mechanism controls PMT module and fluid injection/discharge opeing needle assembly lifting respectively, can control fluid injection, discharge opeing and detection neatly, therefore, and this
Plant interpretation device and there is compact conformation, perfect in shape and function, reading accuracy advantages of higher.
In sum, the chemical luminescent detecting method coupling system of the present invention, can ensure that each several part runs smooth and easy, can be mutually
Collaborative work, system structure design is compact and reasonable, can complete the mensuration flow process of complexity, and automaticity is high.
Accompanying drawing explanation
Fig. 1 is the overall layout chart of chemical luminescent detecting system；
Fig. 2 is the axonometric chart of chemical luminescent detecting system；
Fig. 3 is luminescence assays flow chart；
Fig. 4 is the structural representation (axonometric chart) automatically losing cup device；
Fig. 5 is the enlarged drawing of A1 part in Fig. 1；
Fig. 6 is the structural representation (top view) automatically losing cup device.
Fig. 7 is the population structure schematic diagram (axonometric chart) of rotation platform；
Fig. 8 is the population structure schematic diagram (top view) of rotation platform；
Fig. 9 is the population structure schematic diagram (side view) of rotation platform.
Figure 10 is the structural representation (axonometric chart) of incubating device；
Figure 11 is the structural representation (top view) of incubating device；
Figure 12 is reading plotter structural representation.
Label declaration:
46-firm banking, 47-arc carrier vertical columns, 48-rotating disk, 49-support ring, 50-arc carrier, 521-
One Hall element, 531-reaction cup detection sensor, 541-support column, 551-Magnet fixed block, 561-gear, 571-stepping
Motor, 581-motor fixed rack.51-the first riser, 52-the first actuated by cams motor, 53-the first cam, 54-push pedal, 55-
First back-moving spring, 56-wedge shape pushing block, 57-fixture, 58-the first guide post, 59-hopper, 60-light barrier, 61-photoelectricity correlation
Detection module.
62-the 3rd motor, 63-upper plate, 64-vertical plate, 65-screw mandrel contiguous block, 66-is vertically directed bar, and 67-goes to the bottom
Plate, 68-screw mandrel, 69-hatches block, 70-thermal insulation board.
71-the second riser, 72-baffle plate, 73-liquid injection pipe fixed plate, 74-liquid injection pipe, 75-magnetic sheet, 76-the second hall sensing
Device, 77-the second back-moving spring, 78-the second cam, 79-the second actuated by cams motor, 80-the second guide post, 81-stirring motor,
82-sleeve, 83-rabbling mechanism fixed plate.
89-the 4th motor, 90-motor contiguous block；91-is in the light column, 92-darkroom, 93-PMT module, 94-guide rail, 95-
Guide rail contiguous block, 105-fluid injection/discharge opeing needle assembly.
A-zero-bit, B-takes liquid level, and C-mixes position, and D-hatches position, E-cleaning position, F-reading position, and G-loses cup position.
Detailed description of the invention
Below with reference to the drawings and specific embodiments, the present invention is described in further details:
Embodiment 1:
Such as Fig. 1-12, a kind of chemical luminescent detecting method, comprise the following steps:
Step 1: placing response cup；
The rotating disk of rotation platform is in initial position, i.e. zero-bit (A), the fixture now reaction cup being placed on arc
On；
Step 2: take liquid step；
Turntable rotation makes reaction cup arrive and takes liquid level (B), Qu Ye mechanism inject liquid into reaction cup；Described liquid
Including reagent and sample；
Step 3: mixing step for the first time；
Turntable rotation makes reaction cup arrive mixing position (C), and the rabbling mechanism of fluid injection/evenly mixing device is to the liquid in reaction cup
Body is stirred；
Step 4: incubation step
Turntable rotation makes reaction cup arrive and hatches position (D), incubating device heat the liquid in reaction cup and incubate
Educate operation；
Step 5: cleaning step；
Turntable rotation makes reaction cup arrive cleaning position (E), uses wiper mechanism to clean the magnetic bead in reaction cup；
Step 6: second time mixing step；
Turntable rotation makes reaction cup arrive mixing position, and the rabbling mechanism of fluid injection/evenly mixing device injects and triggers agent A liquid also
Liquid in reaction cup is stirred；
Step 7: reading step；
Turntable rotation makes reaction cup arrive reading position (F), injects and triggers agent B liquid, and reading plotter reads reaction result；
Waste liquid is taken away after reading；
Step 8: lose a glass step；
Turntable rotation makes reaction cup arrive to lose cup position (G), pushed away by reaction cup (to hopper and receive by losing cup device
Collection)；
Complete the determination step once for reaction cup medicinal liquid.
After step 8, rotating disk continues to be rotated back to zero-bit, and chemical luminescent detecting method resets.
The system of its correspondence includes base, rotation platform, liquid taking device, cleaning device, fluid injection/evenly mixing device, hatches dress
Put, reading plotter and lose cup device；
Rotation platform is arranged on the central authorities of base, liquid taking device, cleaning device, fluid injection/evenly mixing device, incubating device, reading
Counting apparatus and lose cup device and be all arranged on base around rotation platform；
Rotation platform is being put cup position, is being taken liquid level, liquid blending position, hatch position, cleaning position, reading position and lose cup position and set respectively
Being equipped with Hall element, arrive the position of each station for sensing reaction cup, Magnet follows the rotary turnplate effect at motor
Under circle, when turntable rotation to relevant position, Magnet senses with Hall element, rotating disk stop, will be in this position
Put and detect operation accordingly.
Lose cup device include first riser the 51, first cam mechanism and push away cup mechanism；
First cam mechanism includes the first cam 53 and for the first actuated by cams motor 52 driving the first cam to rotate；
The described cup mechanism that pushes away includes push pedal the 54, first guide post the 58, first back-moving spring 55 and wedge shape pushing block 56；
First riser is provided with for for pushing away the pilot hole that cup mechanism guides, and the first guide post is inserted in pilot hole；Wedge
Shape pushing block and push pedal are separately positioned on leading section and the rearward end of the first guide post；First back-moving spring is sleeved on the first guide post
On；
First cam contacts with push pedal；When first cam rotates, the first cam can drive and push away cup mechanism and travel forward, wedge shape
When pushing block advances, the fixture 57 of clamping reaction cup can be pushed open so that reaction cup departs from fixture, it is achieved lose cup.
The first described guide post is 2, and described pilot hole is 2.
Automatically lose cup device and also include that Diu Bei testing agency, described Diu Bei testing agency include being arranged on the first riser
Static inducting parts and be arranged on the movable trigger unit pushing away on cup mechanism.
Movable trigger unit and static inducting parts are respectively magnetic sheet and Hall element, or, described is movable
Trigger unit and static inducting parts are respectively light barrier 60 and photoelectricity correlation detection module 61.
Automatically losing cup device and also include the rotation platform for installing fixture, described fixture is multiple, is arranged on rotation
On platform.
Losing a glass process: before a glass process of losing starts, lose cup device and be in original state, now wedge shape pushing block is at the first reset bullet
Retraction position, the initial position of retraction position, position wedge shape pushing block it is under the effect of spring；
Lose a glass process to comprise the following steps:
Step 1: alignment procedures: the wedge shape pushing block pushing away cup mechanism is directed at the fixture being clamped with reaction cup；
Step 2: push away a glass step: start the first actuated by cams motor, the first actuated by cams motor drives the first cam to rotate,
First cam promotes push pedal to advance, and wedge shape pushing block links with push pedal, and wedge shape pushing block is pushed fixture arrival open and pushed away cup position so that reaction cup
Depart from the clamping of fixture, complete to lose cup；
Step 3: reset process: it is the first cam return action that the first actuated by cams motor shaft rotates the rear half-turn of a circle,
Wedge shape pushing block returns to initial position under the effect of the first back-moving spring, and the sensing chip being now fixed on pushing block passes with optocoupler
Sensor senses, motor stalls；Lose cup to terminate；Initiate to push away a glass step Deng Wait Order next time；
Use the position of Diu Bei testing agency detection wedge shape pushing block；
When wedge shape pushing block is in initial position, the static inducting parts being arranged on the first riser can sense and be arranged on
Push away the movable trigger unit on cup mechanism；
When wedge shape pushing block is in and pushes away glass position, described static inducting parts can not sense movable trigger unit.
Movable trigger unit and static inducting parts are respectively magnetic sheet and Hall element, or, described is movable
Trigger unit and static inducting parts are respectively light barrier 60 and photoelectricity correlation detection module 61.
Fixture is multiple, is arranged on rotation platform and along rotation platform circumferentially, by controlling rotary flat
The anglec of rotation of platform makes wedge shape pushing block and grip alignment.
The lower section of wedge shape pushing block is additionally provided with hopper 59, guides collecting box for the reaction cup that will abandon.
Rotation platform includes support, rotating disk 48, arc carrier 50 and drives motor 571 and the gear 561 of rotating disk；
Rotating disk is arranged on support, and rotating disk is endless member, and the internal ring side of rotating disk is provided with for adaptive with described gear
Double wedge；Gear is arranged in the rotating shaft of motor；
Arc carrier is fixed on rotating disk by arc carrier vertical columns, can be with rotating disk synchronous axial system；On arc carrier
It is provided with the fixture 57 for accommodating reaction cup；
Arc carrier is provided with the Magnet fixed block 551 with Magnet；The first Hall element 521 it is fixed with on support,
Hall element is concordant with the height of Magnet.
Support is provided with for detecting the reaction cup detection sensor 531 whether reaction cup exists.
Described Hall element is multiple, being arranged circumferentially on support along rotating disk.
Described support includes support ring and for supporting many support columns 541 of support ring.
Firm banking 46 it is provided with bottom support column.
Reaction cup rotating mechanism is also called rotation platform, is used for driving reaction cup to switch in each module, and this platform has
Internal-gear type rotary turnplate mechanism, the arc carrier of placing response cup；
The arc carrier of described placing response cup is fixed on rotating disk, and fixture is used for clamping reaction cup, when instrument runs,
Manually reaction cup is placed on arc carrier, clamp reaction cup, it is ensured that reaction cup is not rocked when moving in a circle；
Described Hall element arrives the position of each station for detecting reaction cup；Described reaction cup detection sensing
Device is used for detecting whether arc carrier responds cup.
Fluid injection/evenly mixing device (evenly mixing device is also known as agitating device) include the second riser 71, cam flat pushing mechanism and for
Fluid injection/evenly mixing device for reaction cup fluid injection；
Cam flat pushing mechanism include the second cam 78, the second actuated by cams motor 79 for driving cam to rotate, pushing block,
Second guide post the 80, second back-moving spring 77；
Described fluid injection/evenly mixing device includes liquid injection pipe fixed plate 73 and the fluid injection being vertically fixed in liquid injection pipe fixed plate
Pipe 74；
Second riser is provided with pilot hole, and guide post is inserted in pilot hole；Liquid injection pipe fixed plate and pushing block are respectively provided with
Leading section and rearward end at the second guide post；Back-moving spring is sleeved on the second guide post；
Second cam contacts with pushing block；When second cam rotates, the second cam can drive liquid injection pipe fixed plate and liquid injection pipe
Travelling forward, when arriving foremost, start fluid injection, after fluid injection completes, liquid injection pipe fixed plate and liquid injection pipe return reset.
The second described guide post is 2, and described pilot hole is 2.
Described fluid injection/evenly mixing device also includes position detecting mechanism, described include being arranged on to position detecting mechanism vertical
Static inducting parts on plate and be arranged on the movable trigger unit pushing away on cup mechanism.
Movable trigger unit and static inducting parts are respectively magnetic sheet 75 and the second Hall element 76, or, described
Movable trigger unit and static inducting parts be respectively light barrier and photoelectricity correlation detection module.
Being additionally provided with baffle plate 72 on riser, baffle plate is positioned at the lower section of liquid injection pipe fixed plate, and baffle plate is provided with for for liquid injection pipe
The bar shaped guide hole of guided in translation.
Fluid injection/evenly mixing device also includes the rabbling mechanism being positioned at below baffle plate, and rabbling mechanism includes rabbling mechanism fixed plate
83, stirring motor 81 and for entangling the sleeve 82 of reaction cup.
Described rabbling mechanism is driven by Z axis drive mechanism.
The reaction cup rear stirrer structure that puts in place moves upward, and reaction cup is pressed into stirring sleeve under the stop of baffle plate, now needs
Will be to reaction cup fluid injection, the second actuated by cams motor action, drive fluid injection/evenly mixing device to advance, after putting in place, note for reaction cup
Liquid.After fluid injection completes, the second actuated by cams motor does not reoperates, and under the effect of back-moving spring, fluid injection/evenly mixing device resets.
After liquid liquid enters, stirring motor starts drive stirring sleeve and carries out high-speed motion, to reach the effect of liquid blending.
Incubating device include vertical plate 64 and be arranged on vertical plate hatch block 69；The outer wall hatching block is provided with thermal insulation board
70；It is provided with heater in hatching block.
Described block of hatching is connected with vertical plate by Z axis straight-line motion mechanism.
Z axis straight-line motion mechanism is lead screw transmission mechanism, including the 3rd motor 62, screw mandrel 68, screw mandrel contiguous block 65 and perpendicular
Straight guide post 66；
The top of vertical plate and bottom are respectively equipped with upper plate 63 and lower shoe 67, and being vertically directed bar is 2 so that hatch
Block runs more steady.
The top and bottom being vertically directed bar are separately fixed on upper plate and lower shoe；Screw mandrel contiguous block is arranged on vertically
On guide post, the 3rd motor is fixed on upper plate；The upper end of screw mandrel connects driving motor, and the lower end connection wire rod of leading screw connects
Block；Hatch block to be fixed on screw mandrel contiguous block；When 3rd motor rotates, drive and hatch block along being vertically directed bar elevating movement.
The when of needing the sample in reaction cup is hatched, hatching block liter, after having hatched, block will be hatched
Lower and step down.Hatch block top and be provided with multiple hole for accommodating reaction cup.
Reading plotter includes bearing, lift drive mechanism, fluid injection/discharge opeing needle assembly 105, darkroom 92 and PMT reading module
93；
Described bearing is provided with the guide rail 94 of vertical direction；Lift drive mechanism includes the 4th motor 89, drive mechanism
With guide rail contiguous block 95；Guide rail contiguous block is arranged on guide rail, and PMT reading module is fixed on guide rail contiguous block, darkroom and PMT
Reading module is connected；4th motor drives PMT reading module and darkroom to rise along guide rail by drive mechanism and guide rail contiguous block
Fall motion；
Fluid injection/discharge opeing needle assembly is arranged on bearing, and darkroom is positioned at the underface of fluid injection/discharge opeing needle assembly；During detection, treat
The reaction cup of detection is positioned in darkroom, and the column 91 that is in the light is for being in the light；
Being provided with Z-axis transmission mechanism on bearing, fluid injection/discharge opeing needle assembly is arranged on bearing by Z-axis transmission mechanism.
Drive mechanism is lead screw transmission mechanism.
The 4th described motor is motor.Motor contiguous block 90 is for coordinating with leading screw.During detection, reaction cup is placed in
In darkroom, the liquid in reaction cup is detected and reading by PMT module.Reaction cup is added after declining by fluid injection/discharge opeing needle assembly
Liquid and discharge opeing operation.PMT module is docked with darkroom, and both are positioned at sustained height (being i.e. positioned at same level position).
When reactant arrives this system, fluid injection/discharge opeing needle assembly declines injection substrate in reaction cup and produces signal, PMT
Reading module rises to close up again and carries out signal detection and export data, and in the process, light-baffling device (darkroom) is that system provides
Dark room conditions.
Darkroom module is fixed in PMT reading module, and PMT reading module is for carrying out reading detection, darkroom to reactant
The ambient of module isolation reactant ensures the accuracy of reading；Fluid injection/discharge opeing needle assembly includes liquid injection pipe fixed plate, fluid injection
Pipe, discharging tube, influidic pipe fixed block, this assembly produces signal for reactant is injected substrate, and discharging tube is after to reading
Reaction cup carries out waste liquid eliminating；Fluid injection realizes accurate liquid feeding by plunger displacement pump, and plunger displacement pump is a kind of energy liquid with precise control sample-adding
The device of amount；This assembly is existing mature modules.
Claims (10)
1. a chemical luminescent detecting method, it is characterised in that comprise the following steps:
Step 1: placing response cup；
The rotating disk of rotation platform is in initial position, and i.e. zero-bit (A), is now placed on reaction cup on the fixture on arc；
Step 2: take liquid step；
Turntable rotation makes reaction cup arrive and takes liquid level (B), Qu Ye mechanism inject liquid into reaction cup；Described liquid includes
Reagent and sample；
Step 3: mixing step for the first time；
Turntable rotation makes reaction cup arrive mixing position (C), and the liquid in reaction cup is entered by the rabbling mechanism of fluid injection/evenly mixing device
Row stirring；
Step 4: incubation step
Turntable rotation makes reaction cup arrive and hatches position (D), incubating device heat the liquid in reaction cup and hatch behaviour
Make；
Step 5: cleaning step；
Turntable rotation makes reaction cup arrive cleaning position (E), uses wiper mechanism to clean the magnetic bead in reaction cup；
Step 6: second time mixing step；
Turntable rotation makes reaction cup arrive mixing position, and the rabbling mechanism of fluid injection/evenly mixing device injects and triggers agent A liquid and to instead
The liquid in cup is answered to be stirred；
Step 7: reading step；
Turntable rotation makes reaction cup arrive reading position (F), injects and triggers agent B liquid, and reading plotter reads reaction result；Reading
After take waste liquid away；
Step 8: lose a glass step；
Turntable rotation makes reaction cup arrive to lose cup position (G), by losing cup device, reaction cup pushes away (to hopper and collect)；
Complete the determination step once for reaction cup medicinal liquid.
Chemical luminescent detecting method the most according to claim 1, it is characterised in that after step 8, rotating disk continues to rotate back to
To zero-bit, chemical luminescent detecting method resets.
Chemical luminescent detecting method the most according to claim 2, it is characterised in that use chemical luminescent detecting system to realize
Determination step；Chemical luminescent detecting system includes base, rotation platform, liquid taking device, cleaning device, fluid injection/evenly mixing device, incubates
Educate device, reading plotter and lose cup device；
Rotation platform is arranged on the central authorities of base, liquid taking device, cleaning device, fluid injection/evenly mixing device, incubating device, reading dress
Put and lose cup device and be all arranged on base around rotation platform；
Rotation platform includes support, rotating disk (48), arc carrier (50) and drives motor (571) and the gear of rotating disk
(561)；
Rotating disk is arranged on support, and rotating disk is endless member, and the internal ring side of rotating disk is provided with for the double wedge adaptive with described gear；
Gear is arranged in the rotating shaft of motor；
Arc carrier is fixed on rotating disk by arc carrier vertical columns, can be with rotating disk synchronous axial system；Arc carrier is provided with
For accommodating the fixture (57) of reaction cup；
Arc carrier is provided with the Magnet fixed block (551) with Magnet；The first Hall element (521) it is fixed with on support,
First Hall element is concordant with the height of Magnet；
The first described Hall element is multiple, being arranged circumferentially on support along rotating disk；
The first described Hall element arrives the position of each station for detecting reaction cup；
This rotation platform is being put cup position, is being taken liquid level, liquid blending position, hatch position, cleaning position, reading position and lose cup position and be respectively provided with
Having the first Hall element, arrive the position of each station for sensing reaction cup, Magnet follows the rotary turnplate work at motor
Circling under with, when turntable rotation to relevant position, Magnet senses with Hall element, and rotating disk stops, will be at this
Position detects operation accordingly.
Chemical luminescent detecting method the most according to claim 3, it is characterised in that:
Chemical luminescent detecting system includes the second riser (71), cam flat pushing mechanism and is used for the filling machine for reaction cup fluid injection
Structure；
Cam flat pushing mechanism include the second cam (78), for drive cam to rotate the second actuated by cams motor (79), pushing block,
Second guide post (80), the second back-moving spring (77)；
Described mechanism for filling liquid includes liquid injection pipe fixed plate (73) and the liquid injection pipe (74) being vertically fixed in liquid injection pipe fixed plate；
Riser is provided with pilot hole, and guide post is inserted in pilot hole；Liquid injection pipe fixed plate and pushing block are separately positioned on guide post
Leading section and rearward end；Back-moving spring is sleeved on guide post；
Second cam contacts with pushing block；When second cam rotates, the second cam can drive liquid injection pipe fixed plate and liquid injection pipe forward
Motion.
Chemical luminescent detecting method the most according to claim 4, it is characterised in that be additionally provided with baffle plate on the second riser
(72), baffle plate is positioned at the lower section of liquid injection pipe fixed plate, and baffle plate is provided with for the bar shaped guide hole for liquid injection pipe guided in translation；
Fluid injection/evenly mixing device includes that rabbling mechanism, rabbling mechanism include rabbling mechanism fixed plate (83), stirring motor (81) and use
In the sleeve (82) entangling reaction cup.
Chemical luminescent detecting method the most according to claim 5, it is characterised in that incubating device include vertical plate (64) and
Be arranged on vertical plate hatches block (69)；The outer wall hatching block is provided with thermal insulation board (70)；It is provided with heater in hatching block；
Described block of hatching is connected with vertical plate by Z axis straight-line motion mechanism.
Chemical luminescent detecting method the most according to claim 6, it is characterised in that Z axis straight-line motion mechanism is that screw mandrel passes
Motivation structure, including the 3rd motor (62), screw mandrel (68), screw mandrel contiguous block (65) be vertically directed bar (66)；
The top of vertical plate and bottom are respectively equipped with upper plate (63) and lower shoe (67), the described upper end being vertically directed bar and
Lower end is separately fixed on upper plate and lower shoe；Screw mandrel contiguous block is arranged on and is vertically directed on bar, drives motor to be fixed on
On base plate；The upper end of screw mandrel connects the 3rd motor, the lower end connection wire rod contiguous block of leading screw；Hatch block and be fixed on screw mandrel contiguous block
On；When 3rd motor rotates, drive and hatch block along being vertically directed bar elevating movement.Being vertically directed bar is 2.
Chemical luminescent detecting method the most according to claim 3, it is characterised in that
Reading plotter includes bearing, lift drive mechanism, fluid injection/discharge opeing needle assembly (105), darkroom (92) and PMT reading module；
Described bearing is provided with the guide rail of vertical direction；Lift drive mechanism includes the 4th motor (89), drive mechanism and leads
Rail contiguous block (95)；Guide rail contiguous block is arranged on guide rail, and PMT reading module is fixed on guide rail contiguous block, and darkroom is read with PMT
Digital-to-analogue block is connected；Motor drives PMT reading module and darkroom to make elevating movement along guide rail by drive mechanism and guide rail contiguous block；
Fluid injection/discharge opeing needle assembly is arranged on bearing, and darkroom is positioned at the underface of fluid injection/discharge opeing needle assembly；During detection, to be detected
Reaction cup be positioned in darkroom.
Chemical luminescent detecting method the most according to claim 3, it is characterised in that lose cup device and include the first riser
(51), cam mechanism and push away cup mechanism；
Cam mechanism includes the first cam (53) and for the first actuated by cams motor (52) driving the first cam to rotate；
The described cup mechanism that pushes away includes push pedal (54), the first guide post (58), the first back-moving spring (55) and wedge shape pushing block (56)；
First riser is provided with for for pushing away the pilot hole that cup mechanism guides, and the first guide post is inserted in pilot hole；Wedge shape pushes away
Block and push pedal are separately positioned on leading section and the rearward end of the first guide post；Back-moving spring is sleeved on the first guide post；
First cam contacts with push pedal；When first cam rotates, the first cam can drive and push away cup mechanism and travel forward, wedge shape pushing block
During advance, the fixture (57) of clamping reaction cup can be pushed open so that reaction cup departs from fixture.
Chemical luminescent detecting method the most according to claim 9, it is characterised in that lose cup device and also include losing cup detection
Mechanism, described Diu Bei testing agency includes the static inducting parts being arranged on riser and is arranged on the activity pushing away on cup mechanism
Formula trigger unit；Movable trigger unit and static inducting parts are respectively magnetic sheet and Hall element, or, described activity
Formula trigger unit and static inducting parts are respectively light barrier (60) and photoelectricity correlation detection module (61).
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|---|---|---|---|
| CN201610727708.6A CN106093016B (en) | 2016-08-26 | 2016-08-26 | A kind of chemical luminescent detecting method |
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| CN201610727708.6A CN106093016B (en) | 2016-08-26 | 2016-08-26 | A kind of chemical luminescent detecting method |
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| CN106554914A (en) * | 2017-02-09 | 2017-04-05 | 上海亿康医学检验所有限公司 | A kind of automatic nucleic acid extraction system |
| CN108169139A (en) * | 2018-02-08 | 2018-06-15 | 宁波水表股份有限公司 | Turbidity transducer automatic pollution removing calibrating installation |
| WO2019000707A1 (en) * | 2017-06-28 | 2019-01-03 | 苏州长光华医生物医学工程有限公司 | Chemiluminescence immunoassay analyser |
| CN109211782A (en) * | 2017-06-29 | 2019-01-15 | 宁夏软件工程院有限公司 | A kind of efficient detection device for manganese ion concentration |
| CN109580591A (en) * | 2017-09-28 | 2019-04-05 | 深圳市新产业生物医学工程股份有限公司 | Measuring chamber and chemiluminescence detector |
| CN112156747A (en) * | 2020-10-28 | 2021-01-01 | 苏州宇测生物科技有限公司 | Reaction cup and reaction cup mixing device |
| CN114618850A (en) * | 2020-12-11 | 2022-06-14 | 深圳市帝迈生物技术有限公司 | Method for cleaning magnetic separation reaction cup, sample analyzer and readable storage medium |
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| CN114618850A (en) * | 2020-12-11 | 2022-06-14 | 深圳市帝迈生物技术有限公司 | Method for cleaning magnetic separation reaction cup, sample analyzer and readable storage medium |
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