CN109580591A - Measuring chamber and chemiluminescence detector - Google Patents
Measuring chamber and chemiluminescence detector Download PDFInfo
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- CN109580591A CN109580591A CN201710897776.1A CN201710897776A CN109580591A CN 109580591 A CN109580591 A CN 109580591A CN 201710897776 A CN201710897776 A CN 201710897776A CN 109580591 A CN109580591 A CN 109580591A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/064—Stray light conditioning
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Abstract
The present invention relates to a kind of measuring chamber and chemiluminescence detectors, above-mentioned measuring chamber includes bottom plate, inner casing, shell, upper cover, reaction cup turntable, substrate spray head and photomultiplier tube detection components, the bottom plate, shell and upper cover surround an accommodating space, the reaction cup turntable is arranged in the accommodating space, the inner casing is arranged in the accommodating space, it is set between the inner casing and the shell along the radial direction of the reaction cup turntable reaction cup turntable, along the axial direction of the reaction cup turntable reaction cup turntable between upper cover and the bottom plate, the top of the shell and the junction of the reaction cup turntable form the first labyrinth structure, and/or the top of the inner casing and the junction of the reaction cup turntable form the second labyrinth structure.Above-mentioned measuring chamber uses folding face formula labyrinth structure, so that extraneous natural light is unable to reach the darkroom of measuring chamber, improves measurement accuracy.At the same time, above-mentioned folding face formula labyrinth structure has dynamic sealing effect, so that will not mutually light interference between multiple reaction cups of concurrent job on each reaction cup processing station.
Description
Technical field
The present invention relates to the technical fields of medical instrument, more particularly to a kind of chemiluminescence detector.
Background technique
Biochemiluminescence immunodetection is built upon in the theoretical basis of radioimmunoassay detection technology, with labelling method light
Machine is a kind of non-radioactive Labeled immunoassay method for setting up of tracer signal, has that high sensitivity, restricted driving range be wide, easy behaviour
The advantages that making, be easy to automate.Currently, realizing biochemiluminescence detection with the high speed development of biological medicine equipment
The full-automation of instrument has certain condition, and the biochemiluminescence detector based on biochemiluminescence immunodetection is
It is increasingly becoming the medical diagnostic equipment of mainstream,
Measuring chamber is the critical component for influencing chemiluminescence detector measurement result accuracy and measuring speed, is especially surveyed
The leakproofness of amount room determines measurement result accuracy and measuring speed.As Chinese patent literature CN205449807U is revealed
Measuring chamber can only work in series, that is to say, that a reaction cup can only be put into measuring chamber every time and close flip lid and surveyed
Amount opens flip lid again to take out reaction cup after being measured, in the reaction cup processing station work of measuring chamber, other are anti-
Answer cup processing station be in idle condition, therefore cannot simultaneously parallel processing reaction cup disengaging, be pumped into excitation substrate, photon survey
The operation such as amount, liquid waste processing, seriously reduces the measuring speed of instrument.
Summary of the invention
Based on this, it is necessary to which in view of the above technical problems, providing one kind can be improved the accurate measuring chamber of measurement and chemistry
Luminometer.
The present invention provides a kind of measuring chamber, including bottom plate, inner casing, shell, upper cover, reaction cup turntable, substrate spray head and light
Electric multiplier tube detection components, the bottom plate, shell and upper cover surround an accommodating space, and the reaction cup turntable is arranged described
In accommodating space, the inner casing is arranged in the accommodating space, along the radial direction of the reaction cup turntable reaction cup turntable
It is set between the inner casing and the shell, is located at upper cover and institute along the axial direction of the reaction cup turntable reaction cup turntable
State between bottom plate, the junction of the top of the shell and the reaction cup turntable formed the first labyrinth structure and/or it is described in
The top of shell and the junction of the reaction cup turntable form the second labyrinth structure.
The present invention provides a kind of chemiluminescence detector, including measuring chamber, measuring chamber include: bottom plate, inner casing, shell, on
Lid, reaction cup turntable, substrate spray head and photomultiplier tube detection components, it is empty that the bottom plate, shell and upper cover surround a receiving
Between, the reaction cup turntable is arranged in the accommodating space, and the inner casing is arranged in the accommodating space, along the reaction
The radial direction reaction cup turntable of cup turntable is set between the inner casing and the shell, along the axial direction of the reaction cup turntable
The reaction cup turntable is between upper cover and the bottom plate, the junction shape at the top of the shell and the reaction cup turntable
The second labyrinth structure is formed at the top of the first labyrinth structure and/or the inner casing and the junction of the reaction cup turntable.
Above-mentioned measuring chamber and chemiluminescence detector use folding face formula labyrinth structure, so that extraneous natural light is unable to reach survey
The darkroom of room is measured, measurement accuracy is improved；
At the same time, measuring chamber and chemiluminescence detector use folding face formula labyrinth structure, have dynamic sealing effect, make
Obtaining will not mutually interfere light between multiple reaction cups of concurrent job on each reaction cup processing station, so that above-mentioned measuring chamber
More reaction cup processing stations can substantially increase the measuring speed of instrument with concurrent working.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
The attached drawing of other embodiments is obtained according to these attached drawings.
Fig. 1 is the structural schematic diagram of measuring chamber in an embodiment；
Fig. 2 is the sectional view of measuring chamber shown in Fig. 1；
Fig. 3 is the structural schematic diagram of the bottom plate of measuring chamber shown in Fig. 2；
Fig. 4 is the structural schematic diagram of the inner casing of measuring chamber shown in Fig. 2；
Fig. 5 is the structural schematic diagram of the shell of measuring chamber shown in Fig. 2；
Fig. 6 is the structural schematic diagram of the upper cover of measuring chamber shown in Fig. 2；
Fig. 7 is the structural schematic diagram in one direction of reaction cup turntable of measuring chamber shown in Fig. 2；
Fig. 8 is the structural schematic diagram of the reaction cup turntable other direction of measuring chamber shown in Fig. 2.
Fig. 9 is bottom plate, inner casing and the shell integrated formed structure schematic diagram of measuring chamber in another embodiment.
Specific embodiment
To facilitate the understanding of the present invention, station is handled to measuring chamber, the more reaction cups of measuring chamber below with reference to relevant drawings
Concurrent working method, chemical luminescent detecting method and chemiluminescence detector are described more fully.Survey is given in attached drawing
Measure the head of room, the more reaction cup processing station concurrent working methods of measuring chamber, chemical luminescent detecting method and chemiluminescence detector
Select embodiment.But the more reaction cup processing station concurrent working methods of measuring chamber, measuring chamber, chemical luminescent detecting method and change
Learning luminometer can realize in many different forms, however it is not limited to embodiment described herein.On the contrary, providing
The purpose of these embodiments is made to measuring chamber, measuring chamber more reaction cup processing station concurrent working methods, chemical luminescent detecting
Method and the disclosure of chemiluminescence detector are more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Herein the more reaction cups processing station concurrent working methods of measuring chamber, measuring chamber,
The term used in the description of chemical luminescent detecting method and chemiluminescence detector is intended merely to describe specifically to implement
The purpose of example, it is not intended that in the limitation present invention.Term " and or " used herein includes one or more relevant listed
Any and all combinations of project.
Combined with Figure 1 and Figure 2, the measuring chamber 1000 in an embodiment include bottom plate 1110, inner casing 1120, shell 1130,
Upper cover 1140, reaction cup turntable 1700, driving mechanism 1200, the first substrate spray head 1300, the second substrate spray head 1900, photoelectricity times
Increase pipe detection components 1400 and waste suction liquid needle assemblies 1500.Bottom plate 1110, shell 1130 and upper cover 1140 surround measuring chamber 1000
Accommodating space (being not marked in figure), reaction cup turntable 1700, inner casing 1120 be located in accommodating space, bottom plate 1110, shell
1130, inner casing 1120, upper cover 1140 and reaction cup turntable 1700 constitute a darkroom (being not marked in figure).Measuring chamber 1000 includes four
It is a mutually to handle station every the reaction cup of light sealing:
First reaction cup handles station (reaction cup enters station), and reaction cup is placed at the first reaction cup processing station
Or it takes out in the measuring chamber 1000；
Second reaction cup handles station (excitation I station of substrate is added), and the first substrate spray head 1300 is set to described second
Reaction cup is handled at station so that excitation substrate I is added to reaction cup；
Third reaction cup handles station (reaction cup measurement station), and the second substrate spray head 1900 is set to the third reaction
Excitation substrate II is added to the reaction cup at cup processing station, photomultiplier tube detection components 1400 are set to the third
Reaction cup is handled at station；
4th reaction cup handles station (taking out waste liquid station), and waste suction liquid needle assemblies 1500 are set at the 4th reaction cup
The waste liquid of the reaction cup is extracted at science and engineering position.
First reaction cup handles station, the second reaction cup processing station, third reaction cup processing station and the 4th reaction cup
Processing station is arranged successively along 1700 sense of rotation of reaction cup turntable and mutually seals every light, and the first reaction cup handles station and the
Three reaction cups processing station is diagonally arranged, and the second reaction cup processing station and the 4th reaction cup processing station are diagonally arranged.
In conjunction with Fig. 3, in one embodiment, bottom plate 1110 offers first through hole 1112, and bottom plate 1110 is along first through hole
1112 radially-inwardly sequentially form fourth annular boss 1116 and the 5th annular convex platform 1114.Fourth annular boss 1116 is the bottom of by
1110 outer rim of plate protrudes upward to be formed, the 5th annular convex platform 1114, fourth annular boss 1116, first through hole 1112 and reaction cup
The central axis of turntable 1700 is identical, and the internal diameter of the 5th annular convex platform 1114 is less than fourth annular boss 1116.Fourth annular is convex
The first container 1115, the 5th annular convex platform 1114 and first through hole 1112 are formed between platform 1116 and the 5th annular convex platform 1114
Between form the second container 1117.An opening 1118 is additionally provided on bottom plate 1110, opening 1118 is for installing waste suction liquid needle group
Part 1500.
In conjunction with Fig. 4, in one embodiment, inner casing 1120 is cylindrical, and the top outer rim of inner casing 1120 opens up annular groove 1121,
To form the second annular convex platform 1122 at the top of inner casing 1120, (that is the second annular convex platform 1122 is located at inner casing 1120
Close to one end of the reaction cup turntable 1700), inner casing 1120 offers the second through-hole 1124.1120 inner wall of inner casing corresponding second
Through-hole 1124 is equipped with a light source.Second through-hole 1124 is used for the light emitted by light source.
In conjunction with Fig. 5, in one embodiment, shell 1130 is cylindrical, and the bottom outer-edge of shell 1130 offers Fourth Ring
Connected in star 1132, to form first neck 1131 and the first shoulder 1133 in the bottom of shell.The top outer rim of shell 1130
Third annular groove 1134 is offered, to form third neck 1137 and third shoulder 1135, shell at the top of shell
1130 inner cavity is stepped hole 1136, which includes the first hole 11361 and the second hole 11362,11361 He of the first hole
Second hole 11362 is located at the top and bottom end of shell 1130, and the diameter in the first hole 11361 is greater than the straight of the second hole 11362
Diameter, to form first annular groove 11363 in the junction in the first hole 11361 and the second hole 11362.
Further, in one embodiment, 1130 side wall of shell offers third through-hole 1138, referring also to Fig. 1, shell
1130 corresponding third through-holes 1138 are equipped with photomultiplier tube detection components 1400.Photomultiplier tube detection components 1400 pass through the
Three through-holes 1138 detect the photon numbers that the chemiluminescence immunoassay reaction carried out in darkroom (being not marked in figure) generates.Shell 1130
On be also provided with fourth hole 1139 for installing optocoupler 1600.Optocoupler 1600 is for detecting in darkroom (being not marked in figure) the
Whether there is reaction cup at two reaction cups processing station.
In conjunction with Fig. 6, in one embodiment, upper cover 1140 includes circular cover board 1141 and third annular convex platform 1142, lid
The outer rim of plate 1141 protrudes out to form third annular convex platform 1142 downwards, and third annular convex platform 1142 encircles the central axis of cover board 1141
Line, cover board 1141 include the first surface (the namely bottom surface of cover board) being oppositely arranged and second surface (the namely top of cover board
Face), first surface is located at bottom, and second surface is located at top.The center of the first surface of cover board 1141 offers the first blind hole
1143, successively downward projection forms the first rotary table 1145 and the second rotary table 1146, the first circle in the bottom surface center of the first blind hole 1143
Platform 1145 is close to the bottom surface of the first blind hole 1143, bottom surface of second rotary table 1146 far from the first blind hole 1143, the first rotary table 1145
Diameter be greater than the second rotary table 1146 diameter, the first rotary table 1145, the second rotary table 1146, the first blind hole 1143 and cover board 1141
Central axis be same axis.The first surface of cover board 1141 open up along circumferential symmetrical four first of cover board 1141 every
Optical assembly container 1147, first every the radially extending and be connected to the first blind hole along first surface of optical assembly container 1147
Between 1143 and third annular convex platform 1142, this four first every 1147 container of optical assembly relative to third annular convex platform 1142
Central axis it is symmetrical, so that cover board 1141 is divided into four regions.Further, in one embodiment, upper cover
Reaction cup inlet and outlet 1144 are also provided on 1140.
In conjunction with Fig. 7 and Fig. 8, in one embodiment, the radial reaction cup turntable 1700 along reaction cup turntable 1700 is set to
Between inner casing 1120 and shell 1130, the Axial response cup turntable 1700 along reaction cup turntable 1700 is located at upper cover 1140 and bottom plate
Between 1110.Reaction cup turntable 1700 include top plate 1720, peripheral wall 1740 and shaft 1760, top plate 1720 in it is disk-shaped and including
The first surface and second surface being oppositely arranged, first surface are located at bottom, and second surface is located at top, second surface and upper cover
1140 clearance fits.
Further, in one embodiment, peripheral wall 1740 is overall cylindrical, from the first surface of top plate 1720 vertically to
Under extend, peripheral wall 1740 is around forming the inner cavity of reaction cup turntable 1700.The diameter of top plate 1720 is greater than peripheral wall 1740
Outer diameter, so that top plate 1720 radially protrudes out to form first annular boss 1730 relative to peripheral wall 1740.Peripheral wall 1740 wraps
Include first end and second end, first surface of the first end close to top plate 1720, first surface of the second end far from top plate 1720, week
The inside (bottom surface of peripheral wall) of the second end of wall 1740 opens up the 5th annular groove 1790, and the 5th annular groove 1790 is around reaction
The center of rotation axis of cup turntable.
Further, in one embodiment, shaft 1760 extended downwardly by the first surface center upright of top plate 1720 and
At.Shaft 1760 includes first end and second end, and first end is close to the first surface of top plate 1720, and second end is far from top plate 1720
First surface.The second end of shaft 1760 opens up a short slot 1762, which penetrates through the shaft 1760 in the horizontal direction
Second end, and form two convex blocks 1764 being oppositely arranged, which is symmetrically arranged at the short slot 1762
Two sides, 1762 top surface of short slot offers the second blind hole 1766, the central axis of the second blind hole 1766 and the center of shaft 1760
Axis it is identical.
Further, in one embodiment, the first surface of top plate 1720 is downwardly extending along the inner edge of peripheral wall 1740
First land 1780, the height of the first land 1780 are less than the height of peripheral wall 1740, and the first land 1780 is around reaction cup turntable
1700 central axis.First land 1780 includes the first end and second end being oppositely arranged, and first end is close to top plate 1720
First surface, first surface of the second end far from top plate 1720, second end (bottom surface of the first land) edge of the first land 1780
The circumferential direction of first land 1780 opens up second annular groove 1770, to the first land 1780 be divided for be spaced apart from each other first
Divide 1782 and second part 1784, first part 1782 and second part 1784 are respectively circular and turn respectively around reaction cup
The center of rotation axis of disk 1700, second part 1784 are located at the radial outside of first part 1782.
Further, in one embodiment, the second surface center of top plate 1720 opens up stepped hole 1722, stepped hole 1722
Including macropore and aperture, macropore is located at the top of aperture, and macropore and aperture junction form a step surface, step surface be annular and
Around the center of rotation axis of reaction cup turntable 1700.Second surface protrudes upward to form the second land 1724 in big hole peripheral,
Second land 1724 is in circular ring shape and around the center of rotation axis of reaction cup turntable 1700.Second surface reacts there are four opening up
Cup accommodating cavity 1726, for accommodating reaction cup, 1740 outer surface of peripheral wall of reaction cup turntable 1700 opens up four measurement windows 1742,
Four measurement windows 1742 are corresponded and are connected to four reaction cup accommodating cavities 1726, the peripheral wall of reaction cup turntable 1700
1740 inner surfaces offer loophole 1744, and loophole 1744 is connected to measurement window 1742, and loophole 1744 is connected to reaction cup and turns
The inner cavity of disk 1700 and measurement window 1742.When the head of reaction cup is hung on reaction cup accommodating cavity 1726, the cup body of reaction cup is stretched
Enter measurement window 1742, so as to observe the cup body of reaction cup.Second surface opens up four second every optical assembly container
1728, second every optical assembly container 1728 along top plate 1720 the outer rim for radially extending and being connected to macropore and top plate 1720 it
Between, this four second are symmetrical relative to the center of rotation axis of reaction cup turntable 1700 every optical assembly container 1728, from
And top plate 1720 is divided into four reaction cup accommodating areas, correspondingly reaction cup turntable 1700 is divided into four reaction cup accommodatings
Area, each reaction cup accommodating area are correspondingly arranged a reaction cup accommodating cavity 1726.Four second every optical assembly container 1728, four
A first every optical assembly container 1147, four every optical assembly, four reaction cups processing stations, four reaction cup accommodating areas number
Amount corresponds.The rotation of reaction cup turntable 1700 handles station so that four reaction cup accommodating areas are turned to corresponding reaction cup
When, four second correspond every optical assembly container 1728 and four first every optical assembly container 1147, every one first every
Optical assembly container 1147 collectively forms accommodating every the space of optical assembly every optical assembly container 1728 with corresponding second.
In conjunction with Fig. 2-4, in one embodiment, the accommodating space (being not marked in figure) of the measuring chamber is arranged in inner casing 1120
In, inner casing 1120 is fixedly mounted in the second container 1117 of bottom plate 1110, and the of 1120 outer wall of inner casing and bottom plate 1110
The side of the close first through hole 1112 of five annular convex platform 1114 abuts.Inner casing 1120 is located at the inner cavity of reaction cup turntable 1700
In, inner casing 1120 is axially located between the first surface and bottom plate 1110 of the top plate 1720 of reaction cup turntable 1700.
Referring also to Fig. 8, the second annular convex platform 1122 are located at inner casing 1120 close to one end of reaction cup turntable 1700, reaction
The first surface projection of the top plate of cup turntable 1700 forms the first land 1780, and first land 1780 circumferentially opens up
Form the second annular groove 1770, the second annular of the second annular convex platform 1122 and reaction cup turntable 1700 of inner casing 1120
Groove 1770 cooperates, and the second annular convex platform 1122 is embedded into second annular groove 1770, forms the second labyrinth structure, when
When reaction cup turntable rotates, the second annular convex platform 1122 can opposite sliding with second annular groove 1770.Inner casing 1120 is installed
It is deposited in the inner cavity of reaction cup turntable 1700, and between the inner wall of the peripheral wall 1740 of 1120 outer wall of inner casing and reaction cup turntable 1700
In certain gap, which can satisfy the rotation in darkroom (being not marked in figure) of reaction cup turntable 1700.At other
In embodiment, the second annular convex platform 1122 can be annular groove, and the second annular matched with the second annular convex platform 1122 is recessed
Slot 1770 can be annular convex platform, as long as the second annular convex platform 1122 and second annular groove 1770 can form labyrinth zig zag plane
?.
In conjunction with Fig. 3 and Fig. 5, in one embodiment, shell 1130 is fixedly mounted on the first container 1115 of bottom plate 1110
On, the fourth annular groove 1132 of shell 1130 is located at the shell 1130 close to one end of the bottom plate 1110, fourth annular
Groove 1132 is matched with the fourth annular boss 1116 of bottom plate 1110, and the first neck 1131 and fourth annular of shell 1130 are convex
Platform 1116 is abutted against close to the side of the first container 1115, and the first shoulder 1133 rides upon 1116 top surface of fourth annular boss,
Form the 4th labyrinth structure.In other embodiments, fourth annular boss 1116 can be annular groove, with fourth annular boss
The 1116 fourth annular grooves 1132 matched can be annular convex platform, as long as fourth annular boss 1116 and fourth annular groove
1132 can form labyrinth zig zag plane.Furthermore, on the third through-hole 1138 on shell 1130 and inner casing 1120
Second through-hole 1124 is corresponding, and third through-hole 1138 is identical with the central axis of the second through-hole 1124, when reaction cup turntable 1700
When reaction cup is transported to third reaction cup processing station, third through-hole 1138, the second through-hole 1124 and reaction cup turntable 1700
On loophole 1744 and measurement window 1742 be interconnected.
In conjunction with Fig. 5 and Fig. 6, in one embodiment, upper cover 1140 is fixedly mounted on shell 1130, third annular convex platform
1142 abut against close to the side of 1140 central axis of upper cover with 1130 third neck 1137 of shell, third annular convex platform 1142
Bottom surface rides upon on third shoulder 1135, so that third annular convex platform 1142 be made to match with third ring groove 1134, is formed
Third labyrinth structure.That is, the outer rim of cover board 1141 protrudes out to form the third annular convex platform 1142, the third is ring-like
Groove 1134 is located at the shell 1130 close to one end of the upper cover 1140, the third annular convex platform 1142 and the third
Annular groove 1134 matches abutting, forms third labyrinth structure.In other embodiments, third annular convex platform 1142 can be
Annular groove, the third annular groove 1134 matched with third annular convex platform 1142 can be annular convex platform, as long as third ring
Shape boss 1142 and third annular groove 1134 can form labyrinth zig zag plane.
In conjunction with Fig. 2, Fig. 5 and Fig. 7, in one embodiment, the first annular boss 1730 and shell of reaction cup turntable 1700
1130 first annular groove 11363 matches, and forms the first labyrinth structure, the side and the first hole of first annular boss 1730
There are certain gap between 11361 hole wall, which can satisfy reaction cup turntable 1700 in the accommodating space of measuring chamber
Rotation, the bottom surface of first annular boss 1730 and the bottom surface of first annular groove 11363 abut against in (being not marked in figure),
When reaction cup turntable 1700 rotates, first annular boss 1730 can opposite sliding with first annular groove 11363.Namely
It says, the top plate 1720 of the reaction cup turntable 1700 radially protrudes out to form the first annular boss 1730, described outer
First hole of shell 1130 and the junction in the second hole form first annular groove 11363, and the first annular boss 1730 is embedded in
The first annular groove 11363 opposite can simultaneously be slided, to form the first labyrinth structure.In other embodiments, the first ring
Shape boss 1730 can be annular groove, and the first annular groove 11363 matched with first annular boss 1730 can be ring
Shape boss, as long as first annular boss 1730 and first annular groove 11363 can form labyrinth folding face.Reaction cup turntable
1700 peripheral wall 1740 is arranged in the space that bottom plate 1110, inner casing 1120 and shell 1130 surround, the second end of peripheral wall 1740
There are certain gap between bottom plate 1110, which can satisfy reaction cup turntable 1700 in the accommodating space of measuring chamber
Rotation in (being not marked in figure).
In conjunction with Fig. 4 and Fig. 8, in one embodiment, on the 5th annular groove 1790 and bottom plate 1110 on peripheral wall 1740
5th annular convex platform 1114 matches, and forms the 5th labyrinth structure, when reaction cup turntable 1700 rotates, the 5th annular groove
1790 and the 5th annular convex platform 1114 can opposite sliding.In other embodiments, the 5th annular convex platform 1114 can be annular
Groove, the 5th annular groove 1790 matched with the 5th annular convex platform 1114 can be annular convex platform, as long as the 5th convex annular
Platform 1114 and the 5th annular groove 1790 can form labyrinth folding face.
In conjunction with Fig. 2, Fig. 6 and Fig. 7, in one embodiment, the second land 1724 of reaction cup turntable 1700 is sheathed on upper cover
In the first blind hole on 1140, side of second land 1724 far from 1700 central axis of reaction cup turntable and the first blind hole 1143
Hole wall abuts against, and the top surface of the second land 1724 and the bottom surface of the first blind hole 1143 abut against.Stepped hole 1722 is used for installation axle
1800 are held, bearing 1800 is arranged in the macropore of stepped hole 1722, is undertaken on the step surface of macropore and keyhole formation.Upper cover
1140 the second rotary table 1146 protrudes into stepped hole 1722, is set in bearing 1800,1145 He of the first rotary table of upper cover 1140
Second rotary table, 1146 junction forms limited step, for limiting to bearing 1800.In other words, bearing 1800 is along axial direction
It is limited between the limited step and the step surface.
Further, in one embodiment, every optical assembly (being omitted in figure) include elastic element and light insulation pad.Elastic element
Second is fixedly connected on every on optical assembly container 1728 by screw, and light insulation pad is placed on elastic element.When reaction cup turns
The rotation of disk 1700 is weighed every the position of optical assembly container 1147 and second every the position of optical assembly container 1728 completely to first
When conjunction, elastic element is in and bounces state, and light insulation pad is resisted against first every in optical assembly container 1147, every light by elastic element
Component (being omitted in figure) be in first every optical assembly container 1147 with corresponding second every optical assembly container 1728 composition every
In optical assembly accommodating chamber, so that upper cover 1140 and reaction cup turntable 1700 seal, the reaction cup on reaction cup turntable 1700 is located at
When reaction cup handles station, reaction cup can be carried out and correspondingly handled.When reaction cup turntable 1700 is rotated to second every optical assembly
When the position of optical assembly container 1147 is staggered, elastic element is in compressive state for the position of container 1728 and first, on
Light insulation pad (omitting in figure) is pressed onto second every in optical assembly container 1728, so that upper cover 1140 and reaction cup turntable by lid 1140
1700 can relatively rotate.
In conjunction with Fig. 2, in one embodiment, the first through hole that driving mechanism 1200 passes through on bottom plate 1110 is fixedly mounted on bottom
On plate 1110, driving mechanism 1200 includes link block 1220, rotating platform 1240 and motor 1260.Link block 1220 and rotary flat
Platform 1240 is fixedly connected, such as is fixedly connected by screw.Motor 1260 is fixedly connected on rotating platform 1240, motor 1260
Rotating platform 1240 is driven to rotate.Link block 1220 engages with the short slot 1762 of reaction cup turntable 1700.When rotating platform 1240
When rotation, drives the link block 1220 being fixedly connected with rotating platform 1240 to move, be connected to drive with link block 1220
Reaction cup turntable 1700 move, realize 1200 drive response cup turntable 1700 of driving mechanism rotated in darkroom.
Specifically, in one embodiment, photomultiplier tube detection components 1400 are mounted on shell 1130 and are set to institute
It states at third reaction cup processing station, and is oppositely arranged with reaction cup inlet and outlet 1144, for detecting darkroom (being not marked in figure)
The photon numbers that the chemiluminescence immunoassay reaction of middle progress generates.Setting is there are two substrate spray head in upper cover 1140, for to
It surveys in reaction cup and excitation substrate is added, the corresponding optocoupler 1600 of the first substrate spray head 1300 is mounted in upper cover 1140 and is located at second
Reaction cup handles station, and the corresponding photomultiplier tube detection components 1400 of the second substrate spray head 1900 are mounted in upper cover 1140 and position
Station is handled in third reaction cup, the first substrate spray head 1300 and the second substrate spray head 1900 are at right angles arranged in upper cover 1140
On.Measuring chamber 1000 can also include waste suction liquid needle assemblies 1500 and optocoupler 1600, and waste suction liquid needle assemblies 1500 are mounted on bottom plate
On 1110 and it is located at the 4th reaction cup processing station, for taking the waste liquid in the reaction cup detected away.Optocoupler 1600 is installed
On the shell 1300 of darkroom (being not marked in figure), it whether there is reaction for detecting the second reaction cup processing station in darkroom
Cup.
Further, measuring chamber of the invention further includes that a grounding assembly made of metal (is not marked in figure
Show), grounding assembly is mounted in the second container 1117 of bottom plate 1110 and is located in the inner cavity of reaction cup turntable 1700, ground connection
The top of component and upper cover 1140 are spaced apart, the top of grounding assembly setting one can elastic bending downwards elastic slice, bullet
Piece is pressed in advance between the top plate 1720 of reaction cup turntable 1700 and grounding assembly.It can be generated in 1700 rotation process of reaction cup turntable
Electrostatic, grounding assembly have an impact to release electrostatic to avoid working to measuring chamber 1000.
In another embodiment, as shown in figure 9, the bottom plate 1110 of measuring chamber 1000, shell 1130, the one of inner casing 1120 at
Type.Upper cover 1140 is fixed on shell 1130, and the top of shell 1130 and the junction of reaction cup turntable 1700 form the first fan
Palace structure, the top of inner casing 1120 and the junction of reaction cup turntable 1700 form the second labyrinth structure.Preferably, shell 1130
Third labyrinth structure is formed with the junction of upper cover 1140.Measuring chamber, the first labyrinth structure, the second labyrinth structure and third labyrinth
Structure is as described above, it will not be described here.
Specifically, in one embodiment, more reaction cups processing station concurrent working method of measuring chamber 1000 includes as follows
Step:
1) sample to be tested will be equipped with by handling station in the first reaction cup by the reaction cup inlet and outlet 1144 of upper cover 1140
First reaction cup is put into the first reaction cup accommodating cavity 1726 of reaction cup turntable 1700；
2) 1200 drive response cup turntable 1700 of driving mechanism is rotated by 90 °, and the first reaction cup accommodating cavity 1726 moves to
Two reaction cups handle station, and the second reaction cup accommodating cavity 1726 moves to the first reaction cup processing station, then it is synchronous execute with
Lower step:
(1) optocoupler 1600, which detects, reaction cup on reaction cup turntable 1700, the first substrate spray head 1300 is described second
Excitation substrate I is added into the first reaction cup for reaction cup processing station
(2) the second reaction cup is put into the second reaction cup accommodating cavity in first reaction cup processing station
1726；
3) 1200 drive response cup turntable 1700 of driving mechanism is rotated by 90 °, and the first reaction cup accommodating cavity 1726 moves to
Three reaction cups handle station, and the second reaction cup accommodating cavity 1726 moves to the second reaction cup processing station, the accommodating of third reaction cup
Chamber 1726 moves to the first reaction cup processing station, then synchronous to execute following steps:
Excitation substrate II is added into the first reaction cup for (1) second substrate spray head 1900, under the action of exciting substrate II,
Specificity substance in sample to be tested shines, and photomultiplier tube detection components 1400 receive and record photon numbers and detected；
(2) the excitation substrate I is added to second reaction cup in the first substrate spray head 1300；
(3) third reaction cup is put into the third reaction cup accommodating cavity in first reaction cup processing station
1726；
4) 1200 drive response cup turntable 1700 of driving mechanism is rotated by 90 °, and the first reaction cup accommodating cavity 1726 moves to
Four reaction cups handle station, and the second reaction cup accommodating cavity 1726 moves to third reaction cup processing station, the accommodating of third reaction cup
Chamber 1726 moves to the second reaction cup processing station, and the 4th reaction cup accommodating cavity 1726 moves to the first reaction cup processing work
Position, then synchronous to execute following steps:
(1) waste liquid that waste suction liquid needle assemblies 1500 will test in the first reaction cup of completion is taken away；
(2) the excitation substrate II is added to second reaction cup in the second substrate spray head 1900, in excitation substrate
Under the action of II, the specificity substance in sample to be tested shines, and photomultiplier tube detection components 1400 receive and record number of photons
Amount is detected；
(3) the excitation substrate I is added to the third reaction cup in the first substrate spray head 1300；
(4) the 4th reaction cup is put into the 4th reaction cup accommodating cavity in first reaction cup processing station
1726；
5) 1200 drive response cup turntable 1700 of driving mechanism is rotated by 90 °, and the first reaction cup accommodating cavity 1726 moves to
One reaction cup handles station, and the second reaction cup accommodating cavity 1726 moves to the 4th reaction cup processing station, the accommodating of third reaction cup
Chamber 1726 moves to third reaction cup processing station, and the 4th reaction cup accommodating cavity 1726 moves to the second reaction cup processing station,
Then synchronous to execute following steps:
(1) first reaction cup is removed and placed in the 5th reaction cup in first reaction cup processing station；
(2) the waste suction liquid needle assemblies 1500 take the waste liquid of second reaction cup away；
(3) the excitation substrate II is added to the third reaction cup in the second substrate spray head 1900, in excitation substrate
Under the action of II, the specificity substance in sample to be tested shines, and photomultiplier tube detection components 1400 receive and record number of photons
Amount is detected；
(4) the excitation substrate I is added to the 4th reaction cup in the first substrate spray head 1300.
Specifically, in another embodiment, more reaction cups processing station concurrent working method of measuring chamber 1000 includes such as
Lower step:
S1: entering station in reaction cup, and the first reaction cup equipped with sample to be tested is put into the measuring chamber 1000；
S2: station is measured in reaction cup, photomultiplier tube detection components 1400 measure the photon numbers of the second reaction cup.
Preferably, further include the steps that following synchronous execution: taking out waste liquid station, waste suction liquid needle assemblies 1500 take photon away
The waste liquid for the third reaction cup that takeoff finishes.
Preferably, further include the steps that following synchronous execution: exciting I station of substrate, the first substrate spray head 1300 being added
The excitation substrate I is added to the 4th reaction cup of photon numbers to be measured.
Preferably, in S2 step, further includes: the second substrate spray head 1900 is first added to second reaction cup described sharp
Send out substrate II.
Preferably, in S1 step, further includes: first enter the 5th reaction cup for having exhausted waste liquid in the reaction cup
Station takes out measuring chamber 1000.
Specifically, in one embodiment, the chemical luminescent detecting method of measuring chamber 1000 includes the following steps:
1) the first reaction cup equipped with sample to be tested is put into reaction cup turntable 1700 on the first reaction cup processing station
The first reaction cup accommodating cavity in；
2) rotation of reaction cup turntable 1700 is to move to the processing of the second reaction cup for the first reaction cup accommodating cavity
Station, the first substrate spray head 1300 handle station in second reaction cup and excitation substrate I are added to first reaction cup；
3) rotation of reaction cup turntable 1700 is to move to the processing of third reaction cup for the first reaction cup accommodating cavity
Station, excitation substrate II is added to first reaction cup in the second substrate spray head 1900, to be measured under the action of exciting substrate II
Specificity substance in sample shines, and photomultiplier tube detection components 1400 receive and record photon numbers and detected；
4) rotation of reaction cup turntable 1700 is to move to the processing of the 4th reaction cup for the first reaction cup accommodating cavity
Station, the waste suction liquid needle assemblies 1500 take the waste liquid of first reaction cup away；
5) rotation of reaction cup turntable 1700 is to move to the processing of the first reaction cup for the first reaction cup accommodating cavity
First reaction cup is removed and placed in new reaction cup in first reaction cup processing station by station.
The present invention also provides the chemiluminescence detector in an embodiment, chemiluminescence detector includes above-mentioned Fig. 1
To measuring chamber 1000 shown in Fig. 8.
Measuring chamber 1000 of the invention forms multiple above-mentioned folding face formula labyrinth structures, such as: bottom plate 1110 and shell 1130
The 4th labyrinth structure that is formed of junction, the 5th labyrinth that the junction of bottom plate 1110 and reaction cup turntable 1700 is formed is tied
The third labyrinth structure that structure, shell 1130 and 1140 junction of upper cover are formed, the connection of shell 1130 and reaction cup turntable 1700
Locate the first labyrinth structure formed, the second labyrinth structure of the junction formation of inner casing 1120 and reaction cup turntable 1700, when outer
It is close to disappear by the reflection of multiple folding faces when boundary's natural lighting is mapped to measuring chamber 1000 and transmits to darkroom (being not marked in figure)
Except natural light strength reduction, to eliminate influence of the natural light to detection, the accuracy of testing result is improved.
In addition, above-mentioned folding face formula labyrinth structure of the invention also has dynamic sealing effect, solve at more reaction cups
The luminous interference problem of remnants existing for more reaction cups parallel processing simultaneously in the measuring chamber 1000 of science and engineering parallel-by-bit processing.Work as drive
When 1200 drive response cup turntable 1700 of motivation structure rotates in darkroom (being not marked in figure), in multiple reaction cup accommodating cavities 1726
The reaction cup movement in darkroom (being not marked in figure) with reaction cup turntable 1700 simultaneously, when reaction cup is transported to corresponding place
After managing reaction cup processing station, multiple and different processing reaction cup processing stations can handle station to corresponding reaction cup is transported to
Reaction cup simultaneously carry out parallel processing so that above-mentioned measuring chamber realize reaction cup disengaging, plus excitation substrate, photon survey
Amount, liquid waste processing are worked at the same time in different reaction cup processing stations, substantially increase the measuring speed of instrument.
At the same time, it is of the invention it is multiple be set between reaction cup turntable 1700 and upper cover 1140 every optical assembly, it is multiple
It can be rotated with reaction cup turntable 1700 relative to the upper cover 1140 every optical assembly, the reaction cup turntable 1700 is divided
For mutually every light sealing multiple reaction cup accommodating areas, the mutual light isolation effect in this multiple reaction cup accommodating area compared with
Good, this to make parallel on each reaction cup processing station in the more reaction cup processing station concurrent working engineerings of measuring chamber
It will not mutually be interfered light between multiple reaction cups of industry, specifically ensure that third reaction cup processing station (reaction cup measurement station)
Reaction cup is not handled the interference of light caused by the reaction cup of station by other reaction cups in measurement process.This is not only improved
The accuracy of testing result also solves remnants existing for the same indoor more reaction cups of the measurement parallel processing simultaneously and sends out
Light interference problem, so that above-mentioned measuring chamber realizes the disengaging of reaction cup plus excites substrate, photon survey, liquid waste processing not
Same reaction cup processing station works at the same time, and substantially increases the measuring speed of instrument.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (19)
1. a kind of measuring chamber, including bottom plate, inner casing, shell, upper cover, reaction cup turntable, substrate spray head and photomultiplier tube detection
Component, the bottom plate, shell and upper cover surround an accommodating space, and the reaction cup turntable is arranged in the accommodating space,
It is characterized in that, the inner casing is arranged in the accommodating space, along the radial direction of the reaction cup turntable reaction cup turntable
It is set between the inner casing and the shell, is located at upper cover and institute along the axial direction of the reaction cup turntable reaction cup turntable
State between bottom plate, the junction of the top of the shell and the reaction cup turntable formed the first labyrinth structure and/or it is described in
The top of shell and the junction of the reaction cup turntable form the second labyrinth structure.
2. measuring chamber according to claim 1, which is characterized in that first labyrinth structure include first annular boss and
The first annular boss and the first annular groove one of both, institute are formed on first annular groove, the top of the shell
It states reaction cup turntable and forms the another of both the first annular boss and described first annular groove.
3. measuring chamber according to claim 2, which is characterized in that the shell is cylindrical, the reaction cup turntable
Top plate, which prolongs, radially outward to be protruded out to form the first annular boss, and the inner cavity of the shell is stepped hole, the ladder of the shell
Hole includes the first hole and the second hole, and the junction in first hole and second hole forms first annular groove, and described first
Annular convex platform is embedded in the first annular groove and can opposite sliding.
4. measuring chamber according to claim 1, which is characterized in that second labyrinth structure include the second annular convex platform and
Second annular groove, the reaction cup turntable form second annular convex platform and the second annular groove one of both, institute
The another of both second annular convex platform and described second annular groove is formed on the top for stating inner casing.
5. measuring chamber according to claim 4, which is characterized in that the inner casing is cylindrical, the reaction cup turntable packet
Disk-shaped top plate and peripheral wall are included, the top plate includes the first surface and second surface being oppositely arranged, and the peripheral wall is by described
The outer rim of top plate extends straight down, and the peripheral wall surround the central axis of the reaction cup turntable to form the reaction
The inner cavity of cup turntable, the inner casing are located in the inner cavity of the reaction cup turntable, and the inner casing is axially located in described anti-
It answers between the first surface and the bottom plate of the top plate of glass turntable, second annular convex platform is located at the inner casing and leans on
The first surface projection of one end of the nearly reaction cup turntable, the top plate of the reaction cup turntable forms the first land, institute
It states the first land circumferentially to open up to form the second annular groove, second annular convex platform is embedded in the second annular groove
And it can opposite sliding.
6. measuring chamber according to claim 1, which is characterized in that the upper cover is fixed on the housing, the shell
Third labyrinth structure is formed with the junction of the upper cover, the third labyrinth structure includes that third annular convex platform and third are ring-like
Groove, the upper cover form the third annular convex platform and the third ring groove one of both, and the shell forms described
Both third annular convex platform and the third ring groove it is another.
7. measuring chamber according to claim 6, which is characterized in that the shell is cylindrical, and the upper cover includes circle
Cover board and third annular convex platform, the outer rim of the cover board protrudes out to form the third annular convex platform, the third ring groove
Positioned at the shell close to one end of the upper cover, the third annular convex platform is matched with the third annular groove and is abutted.
8. measuring chamber according to claim 1, which is characterized in that the junction of the bottom plate and the shell forms the 4th
Labyrinth structure, the 4th labyrinth structure include fourth annular boss and fourth annular groove, and the bottom plate forms the described 4th
Annular convex platform and the fourth annular groove one of both, the shell form the fourth annular boss and the fourth annular
Both grooves it is another.
9. measuring chamber according to claim 8, which is characterized in that the shell is cylindrical, and the bottom plate outer rim protrudes out
Forming the fourth annular boss, the fourth annular groove is located at the shell close to one end of the bottom plate, and the described 4th
Annular convex platform is matched with the fourth annular groove and is abutted.
10. measuring chamber according to claim 1, which is characterized in that the junction of the bottom plate and the reaction cup turntable
The 5th labyrinth structure is formed, the 5th labyrinth structure includes the 5th annular convex platform and the 5th annular groove, and the bottom plate is formed
5th annular convex platform and the 5th annular groove one of both, the reaction cup turntable form the 5th annular convex platform
It is another with both the 5th annular grooves.
11. measuring chamber according to claim 10, which is characterized in that the 5th annular convex platform is located on the bottom plate,
The bottom plate outer rim protrudes out to form fourth annular boss, and the internal diameter of the 5th annular convex platform is less than the fourth annular boss,
5th annular convex platform is identical as the central axis of the fourth annular boss, and the 5th annular groove is located at the reaction
Close to one end of the bottom plate, the 5th annular convex platform is embedded in the 5th annular groove and can opposite sliding cup turntable.
12. measuring chamber according to claim 11, which is characterized in that the shell is cylindrical, the bottom plate with it is described
The junction of shell forms the 4th labyrinth structure, and the 4th labyrinth structure includes that the fourth annular boss and fourth annular are recessed
Slot, the fourth annular groove are located at the shell close to one end of the bottom plate, the fourth annular boss and the described 4th
Annular groove matches abutting.
13. measuring chamber according to claim 1, which is characterized in that it further include driving mechanism, the shell, the inner casing
And the bottom plate is integrally formed, the bottom plate opens up first through hole, and the inner casing is surround around the first through hole, the shell
The inner casing, the shell and the inner casing interval are arranged, and the driving mechanism passes through the first through hole and the reaction cup
Turntable is connected to drive the reaction cup turntable rotation.
14. measuring chamber according to claim 1, which is characterized in that further include driving mechanism, it is logical that the bottom plate opens up first
Hole, the bottom plate radially-inwardly sequentially form fourth annular boss and the 5th annular convex platform along the first through hole, and described
Four annular convex platform are protruded upward by the bottom plate outer rim and are formed, the 5th annular convex platform, fourth annular boss and described first
The central axis of through-hole is identical, and the internal diameter of the 5th annular convex platform is less than the fourth annular boss, and the fourth annular is convex
The first container is formed between platform and the 5th annular convex platform, is formed between the 5th annular convex platform and the first through hole
The bottom of second container, the shell and the reaction cup turntable is located in first container, the bottom of the inner casing
In second container, the driving mechanism passes through the first through hole and connect with the reaction cup turntable to drive
State reaction cup turntable rotation.
15. measuring chamber according to claim 1, which is characterized in that the bottom plate, the shell, the inner casing and described
Upper cover constitutes darkroom, and the reaction cup turntable includes top plate and peripheral wall, and the upper cover is located at the top of the top plate, the top plate
Including the first surface and second surface being oppositely arranged, the peripheral wall is located at the first surface, and the peripheral wall is around described anti-
The central axis of glass turntable is answered to form reaction cup turntable inner cavity, the second surface is towards the upper cover, and described second
Surface and the upper cover clearance fit, the inner casing are located in reaction cup turntable inner cavity.
16. measuring chamber according to claim 15, which is characterized in that the bottom surface center of the cover board of the upper cover offers
One blind hole, successively downward projection forms the first rotary table and the second rotary table, first rotary table in the bottom surface center of first blind hole
Diameter be greater than the diameter of second rotary table, the junction of first rotary table and second rotary table forms limited step,
The second surface center of the reaction cup turntable offers stepped hole, and the stepped hole includes macropore and aperture, described big
Hole is located at the top of the aperture, and the macropore and the aperture junction form a step surface, an axis are arranged in the macropore
It holds, second rotary table is set in the bearing, and the bearing is along axial limiting in the limited step and described
Between terrace.
17. measuring chamber according to claim 16, which is characterized in that described the of the top plate of the reaction cup turntable
Two surfaces protrude out to form the second land in the big hole peripheral, and second land is sheathed in first blind hole.
18. measuring chamber according to claim 1, which is characterized in that the bottom plate is equipped with a grounding assembly, the ground connection
Component is located in the inner cavity of the reaction cup turntable, the top of grounding assembly setting one can elastic bending downwards elastic slice,
The elastic slice is pressed in advance between the top plate and grounding assembly of reaction cup turntable.
19. a kind of chemiluminescence detector, which is characterized in that including the described in any item measuring chambers of such as claim 1 to 18.
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