Multi-reagent needle biochemistry analyzer
Technical field
The present invention relates to a kind of multi-reagent needle biochemistry analyzer, in particular, relate in particular to a kind of multi-reagent needle biochemistry analyzer that is provided with accurate reagent pump and coupled array reagent needles.
Background technology
Biochemical Analyzer is a kind of hospital clinical conventional analysis instrument, is mainly used in measuring the various biochemical indicators in human body fluid, comprises the routine biochemistry indexs such as routine blood test, myocardial enzymes, blood pressure and blood lipoid, liver function, immunoglobulin (Ig).At present, existing automatic biochemistry analyzer mainly partly is comprised of sample device, reagent device, sampler, reaction tank, warmer, detecting device, microprocessor, printer, Function detection device etc.But existing automatic clinical chemistry analyzer exists more shortcoming, the one, and, existing Biochemical Analyzer is in operational process, reaction tray is rotated a week, can only add a kind of reagent and sample, so just makes its test speed not high, especially when data to be detected are more, can't meet the demands; The 2nd,, cuvette on existing Biochemical Analyzer recycles, when recycling, totally easily do not cause cross pollution owing to cleaning, and cuvette can cause wearing and tearing to a certain degree in the long-term process of using, this just makes its light transmission relatively poor, and cross pollution and wearing and tearing all can cause measured experimental data and the data of reality that larger difference is arranged.
Summary of the invention
The present invention is in order to overcome the shortcoming of above-mentioned technical matters, and a kind of multi-reagent needle biochemistry analyzer that is provided with accurate reagent pump and coupled array reagent needles is provided.
Multi-reagent needle biochemistry analyzer of the present invention, comprise sample storage dish, reaction tray, be used for adding sample sampling mechanical arm, be arranged at the some cuvettes in reaction tray, described sample storage dish, reaction tray and mechanical arm are connected with respectively sample disc drive unit, reaction tray drive unit and mechanical arm driving device; Also comprise the reagent add-on system for reagent adding in cuvette, its special feature is: described reagent add-on system comprises plural reagent bottle, plural accurate reagent pump and array reagent needles, and described array reagent needles is by plural reagent needles cell formation; Described single reagent bottle is connected with the input end of single accurate reagent pump, and described single accurate reagent delivery side of pump is connected with single reagent needles unit.The sample storage dish is used for placing sample to be detected, sampling mechanical arm is used for the sample that is placed in the sample storage dish is filled into cuvette, mechanical arm driving device is used for driving sampling mechanical arm, can realize the lifting of mechanical arm and the rotation of special angle, and then realize adding sample and clean the sample pin; Reaction tray is used for carrying cuvette, the reaction tray drive unit is used for driving the rotation of reaction tray, but the reaction tray drive unit is driving the special angle rotation of reaction tray and realization response dish, is coordinating the motion of array reagent needles and sampling mechanical arm to realize respectively reagent adding and the action that adds sample; Add the reagent needles employing array reagent needles that reagent is used in the reagent add-on system, changed the form of single reagent needles interpolation reagent in the past, improved the interpolation speed of reagent, the array reagent needles is by several reagent needles cell formations, each reagent needles unit all is connected with the output port of accurate reagent pump, the input end of each accurate reagent pump is because single reagent bottle is connected, different reagent bottles is to deposit different reagent, accurate reagent pump can carry out work simultaneously, the reagent of namely annotating in the cuvette unit simultaneously.
Multi-reagent needle biochemistry analyzer of the present invention comprises standby cuvette system, and described standby cuvette system comprises that being arranged at the reaction tray top is used for depositing the cuvette storehouse of cuvette to be replaced and carries out the cuvette changing device more of changing the cuvette action; Described cuvette more changing device comprises clamp system and lift rotating device, and described clamp system comprises the first clamping plate and the second clamping plate, and described the second clamping plate is arc and is fixed with carriage release lever; Described the first clamping plate comprises curved portions and the horizontal support section that is fixedly connected with curved portions, and described the second clamping plate parallels with the curved portions of the first clamping plate; Be fixed with the clamping stepper motor on described support portion, the output shaft of described clamping stepper motor is connected with the form of carriage release lever by rack-and-pinion; The lower surface of described support portion is fixedly connected with the hoisting rotation axle that is connected with lift rotating device.Cuvette in the past is recycling form, and it is of long duration that cuvette uses, and will affect the accuracy of measured experimental data, adopts disposable cuvette to make experimental data more accurate.The cuvette storehouse is used for holding untapped cuvette, the cuvette more clamp system of changing device is mainly used to realize the clamping of contrast colors cup, the clamping of clamp system contrast colors cup and unclamp by clamping stepper motor and realize, lift rotating device is arranged at the bottom of clamp system, can realize upper and lower displacement and the rotation of clamp system by the driving of lift rotating device, and then realize used cuvette in reaction tray is removed and the cuvette in the cuvette storehouse is placed in reaction tray.
Multi-reagent needle biochemistry analyzer of the present invention, be provided with two on described clamp system for the guiding mechanism that leads to the second clamping plate, described guiding mechanism comprises the guide pole that is fixed on the second clamping plate and is fixed in orienting lug on the support portion, is provided with the circular hole that matches with guide pole on described orienting lug.Orienting lug is fixed on the support portion, guide pole be fixed on the second clamping plate and by circular hole through orienting lug, the curved portions that can guarantee the second clamping plate and the first clamping plate by two guiding mechanisms are set remains the parallel shape body, the whole position contrast colors cup that so just can guarantee the second clamping plate and curved portions carries out clamping, has guaranteed the stability of clamping.
Multi-reagent needle biochemistry analyzer of the present invention, described accurate reagent pump is accurate peristaltic pump, and described array reagent needles is arranged on the top of reaction tray and is connected with elevating lever, and this elevating lever is connected with the reagent needles drive unit.Adopt accurate peristaltic pump can well control the amount of adding reagent, the array reagent needles is arranged on the top of reaction tray and can moves up and down, and realizes adding the action of reagent in reagent bottle.
Multi-reagent needle biochemistry analyzer of the present invention, described cuvette camber and by by plural cuvette cell formation, described array reagent needles becomes the arc identical with cuvette; The number of the cuvette unit on the number of the reagent needles unit on described each array reagent needles and each cuvette equates.Cuvette equates with curvature and the arc length of array reagent needles place arc, is the convenience of adding reagent in the cuvette for the array reagent needles; The number of the cuvette unit on the number that guarantees the reagent needles unit on the array reagent needles and cuvette equates, is also in order to add the convenience of reagent.
Multi-reagent needle biochemistry analyzer of the present invention, the radian number of described array reagent needles and cuvette place arc are 36 degree.If the radian number of cuvette place arc is 36 degree, the number of the cuvette of placing on reaction tray so is 10.
Multi-reagent needle biochemistry analyzer of the present invention, on the number of described reagent bottle, the number of accurate reagent pump and array reagent needles, the number of reagent unit is 5 to 20.About the number of reagent unit on the number of the number of reagent bottle, accurate reagent pump and array reagent needles can be chosen setting as required, the project to be detected of their quantity and blood is relevant with the kind of required reagent.
Multi-reagent needle biochemistry analyzer of the present invention, the arranged outside of described reaction tray has ultrasonic stirrer.In the cross pollution that the arranged outside ultrasound wave stirring apparatus of reaction tray can effectively avoid mechanical stirring apparatus in the past to bring, can improve the accuracy of data that Biochemical Analyzer of the present invention detects.
Multi-reagent needle biochemistry analyzer of the present invention, described reagent needles unit is made of the connecting portion that is used for being connected with accurate reagent delivery side of pump and the needle section that is used for reagent is injected in cuvette.Connecting portion not only is connected with accurate reagent delivery side of pump, but also is used for realizing the connection between the reagent needles unit; In the process of using, needle section can extend in the cavity of reagent bottle unit, and the reagent of annotating in the reagent bottle.
The invention has the beneficial effects as follows: reagent needles in reagent add-on system of the present invention adopts and comprises two above reagent needles cellular array reagent needles, has increased the speed of filling reagent in the cuvette, has improved the detection efficiency of whole analyser; As further improvement, standby cuvette system also can be set, recycling of cuvette become once use, effectively avoided the inaccurate of experimental data that the long-term use due to cuvette brings, make testing result more accurate.
Description of drawings
Fig. 1 is plan structure schematic diagram of the present invention;
Fig. 2 is the structural representation in A-A of the present invention cross section;
Fig. 3 is the syndeton schematic diagram of reagent bottle of the present invention, accurate reagent pump and array reagent needles;
Fig. 4 is the structural representation of array reagent needles of the present invention;
Fig. 5 is the structural representation of cuvette of the present invention;
Fig. 6 is the more structural representation of the clamp system in changing device of cuvette of the present invention.
in figure: 1 sample storage dish, 2 sampling mechanical arms, 3 ultrasonic stirrers, 4 cuvettes are changing device more, cuvette bakie on 5, 6 Reagent Tube passages, 7 array reagent needles, 8 accurate reagent pumps, 9 agent bins, 10 reaction tray, 11 cuvette storehouses, 12 spring push-rods, 13 rinse baths, 14 upper mounted plates, 15 bottom plates, 16 reaction tray drive units, 17 times cuvette bakies, 18 trash receptacles, 19 pulleys, 20 sample disc drive units, 21 mechanical arm driving devices, 22 reagent needles drive units, 23 reagent bottles, 24 first Reagent Tubes, 25 second Reagent Tubes, 26 connecting portions, 27 needle section, 28 cuvettes, 29 cuvette unit, 30 cuvette openings, 31 first clamping plates, 32 second clamping plates, 33 carriage release levers, 34 clamp stepper motor, 35 hoisting rotation axles, 36 curved portions, 37 support portions, 38 guide poles, 39 orienting lugs.
Embodiment
The invention will be further described below in conjunction with accompanying drawing and embodiment.
Fig. 1 and Fig. 2 have provided respectively the structural representation in plan structure schematic diagram of the present invention and A-A cross section, and shown multi-reagent needle biochemistry analyzer of the present invention comprises sample storage dish 1, sampling mechanical arm 2, ultrasonic stirrer 3, cuvette more changing device 4, upper cuvette bakie 5, Reagent Tube passage 6, array reagent needles 7, accurate reagent pump 8, agent bin 9, reaction tray 10, cuvette storehouse 11, rinse bath 13, cuvette 28, upper mounted plate 14, bottom plate 15; Comprise that also the contrast colors cup heats up and the attemperating unit that is incubated and the colorimetric analysis device that is used for gathering experimental data.Upper mounted plate 14 and main the rising of bottom plate 15 are fixed and supporting role.The structural representation of cuvette 28 as shown in Figure 5, cuvette 28 is made of some cuvette cell cubes 29, on each cuvette 28, the number of cuvette cell cube 29 is 4,8 or 20, certainly also can select other numerical value of 5 to 20, but preferably equate with the number of reagent needles unit on array reagent needles 7.
Described rinse bath 13, ultrasonic stirrer 3, reaction tray 10 all are fixedly installed on upper mounted plate 14, and sample storage dish 1 is fixed on upper mounted plate 14 and by the supporting construction that is connected with bottom plate 15 and supports.wherein ultrasonic stirrer 3 is arranged at the outside of reaction tray 10, sampling mechanical arm 2 is rotating to be fixed on upper mounted plate 14 and between sample storage dish 1 and reaction tray 10, be provided with the sample pin of drawing sample on sampling mechanical arm 2, in the process that sampling mechanical arm 2 rotates, the sample pin can extend in sample bottle in the sample storage dish, in cuvette in reaction tray and in rinse bath 13, the rotation of sampling mechanical arm and lifting are completed by mechanical arm driving device 21, mechanical arm driving device 21 is fixed on bottom plate 15, sampling mechanical arm 2 and mechanical arm driving device 21 actings in conjunction can realize getting reagent in sample bottle from the sample storage dish, add sample and clean the sample pins by rinse bath 13 in cuvette unit 29 in the reaction tray.Reaction tray 10 is fixed on upper mounted plate 14 and by the mechanism that is connected with bottom plate 15 and supports, be provided with on reaction tray 10 for the groove of placing cuvette 28, the lower end of reaction tray 10 is connected with reaction tray drive unit 16, is provided with stepper motor in reaction tray drive unit 16; By being arranged on the driving of the stepper motor in reaction tray drive unit 16, but realization response dish 10 decide angular turn.The number of the cuvette of placing in the groove on reaction tray 10 is 5 to 20, and the quantity of the cuvette 28 that can place is relevant with the radian number of single cuvette place arc, can arrange as required.Cuvette 28 on being placed into reaction tray 10 after, need to guarantee that cuvette 28 is higher than reaction tray 10, namely guarantee the height of cuvette 28 higher than the degree of depth of the groove on reaction tray 10, in order to guarantee to be provided with the Biochemical Analyzer of standby cuvette system, can be clamping and shift out with the cuvette 28 of mistake.
Also be fixedly installed array reagent needles 7 on upper mounted plate 14, array reagent needles 7 movably is fixed on upper mounted plate 14 by array reagent needles clamping device.The structural drawing of array reagent needles 7 as shown in Figure 4, shown array reagent needles 7 comprises several reagent needles unit, the reagent needles unit comprises connecting portion 26 and needle section 27, and connecting portion 26 is used for being connected with the output port of accurate reagent pump 8, and needle section 27 is for the reagent of annotating to cuvette 28.The installation site of array reagent needles 7 should guarantee that it is in the process that moves up and down, array reagent needles 7 is positioned at the top of the cuvette 28 that is placed on reaction tray 10 all the time, only use like this, 22 driving array reagent needles of reagent needles drive unit move up and down and get final product, and reagent needles drive unit 22 is fixed on bottom plate 15.In each array reagent needles 7, the number of reagent needles unit is 4,8 or 20, certainly also can select other numerical value of 5 to 20.28 one-tenth curvature of array reagent needles 7 and cuvette and arc equal in length, like this, array reagent needles 7 is once added the reagent cuvette 28 of just having annotated.
Also be fixedly installed accurate reagent pump 8 and agent bin 9 on bottom plate 15, agent bin 9 is used for containing reagent bottle 23, the quantity of accurate reagent pump 8 and reagent bottle 23 preferably equates with the quantity of reagent needles unit on array reagent needles 7, certainly, the quantity of reagent bottle 23 and the accurate reagent pump 8 also number of the reagent needles unit that comprises of comparable array reagent needles 7 is many, so that standby.Accurate reagent pump 8 adopts accurate peristaltic pump, in order to control the injection rate IR of reagent.The annexation of reagent bottle 23, accurate peristaltic pump 8 and array reagent needles 7 as shown in Figure 3, shown array reagent bottle 23 is arranged in agent bin 9, reagent bottle 23 is connected with the input end of accurate reagent pump 8 by the first Reagent Tube 24, is used for realizing the reagent of accurate reagent pump 8 is extracted out; The output terminal of accurate reagent pump 8 is connected by the reagent needles unit on the second Reagent Tube 25 and array reagent needles 7, reagent bottle 23, accurate reagent pump 8 are connected connection with the reagent needles unit be man-to-man form, namely a reagent bottle 23 is connected with an accurate reagent pump 8, accurate reagent pump 8 is connected with a reagent needles unit, so just saved the complete a kind of reagent of every interpolation in the past cleaning step afterwards, simplify operation steps, improved work efficiency.
Multi-reagent needle biochemistry analyzer of the present invention, its step of adding reagent comprises: be at first that stepper motor by reagent needles drive unit 22 inside drives reaction tray 10 and turns to the angle that sets in advance; Then driving array reagent needles 7 by reagent needles drive unit 22 descends, when the needle section 27 on the reagent needles unit stretched in the internal cavities of cuvette unit by cuvette opening 30 by the time, array reagent needles 7 stopped descending and annotates reagent in the cuvette unit 29; By the time annotated after reagent, then driven array reagent needles 7 by reagent needles drive unit 22 and rise, stopped after rising to default position; Then, reaction tray 10 begins to rotate, and enters into the step of adding sample.
for fear of the cuvette that recycles, experiment is detected and impact, multi-reagent needle biochemistry analyzer of the present invention also is provided with standby cuvette system, this standby cuvette system comprises the cuvette storehouse 11 that is arranged at reaction tray 10 tops, be used for to realize change more changing device 4 of cuvette that cuvette changes action, be placed in the trash receptacle 18 of bottom plate 15 belows, have cuvette bakie 5 and lower cuvette bakie 17 in position corresponding with trash receptacle 18 on upper mounted plate 14 and bottom plate 15, the cuvette of finishing using can enter into trash receptacle 18 by upper cuvette bakie 5 and lower cuvette bakie 17.Cuvette storehouse 11 is the flat barrel-like structure of an end opening and is fixedly installed on upper mounted plate 14, cuvette storehouse 11 is across above reaction tray 10,11 inside is placed with the stand-by cuvette 28 of some quantity in the cuvette storehouse, in cuvette storehouse 11, the height of outermost cuvette is higher than the height of inferior outermost cuvette, the realization of this structure can realize by the inclined-plane of certain slope, and purpose is for the ease of the more clamping of changing device 4 of cuvette; Be arranged on spring push-rod in cuvette storehouse 11 and can realize the displacement of cuvette, can remain the openend that is in all the time the cuvette storehouse among a cuvette to be replaced.
Cuvette more changing device 4 comprises clamp system and lift rotating device, and lift rotating device wherein is used for realizing rising and the rotation of clamp system, and clamp system is mainly used in realizing the clamping cuvette.The structural representation of clamp system as shown in Figure 6, shown clamp system comprises the first clamping plate 31, the second clamping plate 32, carriage release lever 33, clamps stepper motor 34, hoisting rotation axle 35, guide pole 38, orienting lug 39.The first clamping plate 31 has comprised the support portion 37 and the curved portions 36 that is connected with support portion 37 of supporting with the carrying effect, the curvature that the curved portions 36 of the second clamping plate 31 and the first clamping plate is arc and place arc equates with the curvature of cuvette 28 place arcs, is parallel to each other between the curved portions 36 of the second clamping plate 31 and the first clamping plate.Clamp on the upper surface of support portion 37 that stepper motor 34 is fixed on the first clamping plate, carriage release lever 33 and the second clamping plate 32 fix, one end of carriage release lever 33 is the tooth bar shape, and carriage release lever 33 matches with gear on clamping stepper motor 34 output shafts by the tooth bar above it; Two guide poles 38 all fix with the second clamping plate 32, orienting lug 39 is fixed on the first clamping plate 31 and has the circular hole that matches with guide pole on it, be provided with guide pole 38 and orienting lug 39 can guarantee can to remain itself and the first clamping plate 31 in the process of the second clamping plate 32 motion curved portions 36 and be in all the time parastate, and then realize the good clamping of contrast colors cup.The support portion 37 of the upper end of hoisting rotation axle 35 and the first clamping plate fixes, the lower end is connected with the output shaft of the lift rotating device that drives clamp system lifting and rotation, by the driving of lift rotating device, can realize the more work of changing device 4 of whole cuvette.
The work of standby cuvette system comprises the placement with new cuvette of removing with the cuvette of crossing, removing of the cuvette of wherein using comprises the following steps: at first, adjust the position of clamp system by lift rotating device, make clamp system just be in the top of certain cuvette; Then, then driving clamp system by lift rotating device and descend, when the top that drops to cuvette was between the curved portions 36 of the second clamping plate 32 and the first clamping plate, clamp system stopped descending; Then by clamping the driving of stepper motor 34, realize the movement of the second clamping plate 32, and then realize the clamping of contrast colors cup; Last by the further rising of lift rotating device and the driving of rotation formula, realize removing with the cuvette of crossing; Coordinate again reaction tray to drive the driving of moving device 16, repeating the removable whole cuvettes of using of above-mentioned steps.
The placement step of stand-by cuvette comprises: be at first the driving by lift rotating device, the top that makes an outermost cuvette in the cuvette storehouse is just between the curved portions 36 of the second clamping plate 32 and the first clamping plate the time, and clamp system stops descending; Then by clamping the driving of stepper motor 34, realize the movement of the second clamping plate 32, and then realize the clamping of contrast colors cup; At last by the driving of further rising, rotation and the decline form of lift rotating device, realize the placement of stand-by cuvette; Coordinating again reaction tray to drive the driving of moving device 16, repeating above-mentioned steps and can place all cuvettes to be placed.