CN106071173A - A kind of feed additive for milch cow postpartum recovery and preparation method thereof - Google Patents
A kind of feed additive for milch cow postpartum recovery and preparation method thereof Download PDFInfo
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- CN106071173A CN106071173A CN201610701552.4A CN201610701552A CN106071173A CN 106071173 A CN106071173 A CN 106071173A CN 201610701552 A CN201610701552 A CN 201610701552A CN 106071173 A CN106071173 A CN 106071173A
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- clostridium butyricum
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Abstract
Patent of the present invention discloses a kind of feed additive for milch cow postpartum recovery, it is characterized in that this feed additive is grouped into by the one-tenth of following percentage by weight: the Clostridium butyricum 10%～50% of bacterium >=5.0 × 108cfu/ml alive, calcium gluconate 5%～30%, propylene glycol 5%～30%, remaining is water；The present invention discloses the preparation method of a kind of feed additive for milch cow postpartum recovery, including weighing raw material, dissolve, blend step, this feed additive can be taken in cow feeding feedstuff when simultaneously, containing clostridium butyricum active bacteria composition, health promotion effect can be played for a long time after entering milch cow gastrointestinal tract field planting, consumption is less, it is applied to milch cow Health restoration in puerperal, can comprehensively tackle the generation of milch cow multiple disease in puerperal, particularly milch cow postpartum paralysis and the generation of ketoacidosis, promote the Health restoration in milch cow puerperal.
Description
Technical field
Patent of the present invention relates to a kind of domestic animal feed additive field, a kind of feedstuff for milch cow postpartum recovery
Additive.
Background technology
Milch cow is in raising dairy cattle management very important period puerperal, and within this period, milch cow can occur appetite to subtract
Move back, body constitution is weak, resistance is poor situation, various obstetrics and metabolism class disease, wherein postpartum paralysis, ketoacidosis, abomasum displacement occur
It is common disease in milch cow puerperal etc. disease, and occurs the most simultaneously.Often cause the decline of milk production of cow and extra
Economic loss.So it is particularly significant to carry out the work of milch cow Health restoration in puerperal.There is a lot of postpartum disease of cow on the market at present
Curative drug, such as treatment milch cow postpartum paralysis commonly use the medicines such as intravenous injection calcium diborogluconate., magnesium sulfate, dexamethasone
Thing, this therapeutic modality drug dose is wayward, is easily generated side effect.And puerperal disease prophylactic formulation mostly is Chinese drug-treated group
Side, nutritional supplementation agent composition etc., generally exist and use inconvenience, the shortcomings such as consumption is big, and such as CN201310296239.3 is public
A kind of milch cow opened gavages supplementary and using method thereof puerperal, its mainly comprise raw material be yeast culture, calcium propionate,
Solid propylene glycol, calcium chloride etc., use the mode of cud liquid filling to use, the most inconvenient, and large usage quantity.
Clostridium butyricum is probiotic bacteria, is used for preventing and treating the intestinal tract disease of humans and animals the most already.At home, Clostridium butyricum
It is widely used in terms for the treatment of human body intestinal canal disease as people's medicine, in regulation human body microecological balance, treatment human body intestinal canal disease
Sick aspect all achieves good curative effect；But, Clostridium butyricum application on animal feed is less.
Summary of the invention
For the problems of the prior art, the invention aims to provide a kind of feedstuff for milch cow postpartum recovery to add
Add agent and preparation method thereof, contain clostridium butyricum active bacteria composition by the feed additive obtained of this preparation method and other become
Point, it is possible to the generation of the multiple disease in prevention milch cow puerperal, particularly milch cow postpartum paralysis and the generation of ketoacidosis.
In order to achieve the above object, the technical scheme is that
A kind of feed additive for milch cow postpartum recovery, it is characterised in that this feed additive is by following weight percent
The one-tenth of ratio is grouped into: the Clostridium butyricum 10%～50% of bacterium >=5.0 × 108cfu/ml alive, calcium gluconate 5%～30%, and third
Glycol 5%～30%, remaining is water.
As preferably, this feed additive is grouped into by the one-tenth of following percentage by weight: bacterium >=5.0 × 108cfu/ alive
The Clostridium butyricum 20%～30% of ml, calcium gluconate 10%～20%, propylene glycol 15%～25%, remaining is water.
As preferably, this feed additive is grouped into by the one-tenth of following percentage by weight: bacterium >=5.0 × 108cfu/ alive
The Clostridium butyricum 23% of ml, calcium gluconate 15%, propylene glycol 20%, remaining is water.
Further, the water in this feed additive is purified water.
The present invention discloses the preparation method of a kind of feed additive being previously discussed for milch cow postpartum recovery, its
Be characterised by that the method comprises the steps: a, weighs raw material, according to percentage by weight weigh a certain amount of calcium gluconate and
Propylene glycol, standby；B, dissolving, be added to the water calcium gluconate and propylene glycol successively, and the post-heating that stirs boils to normal pressure
Boiling state, and keep 30 minutes, make additive fully dissolve, then use recirculated water cooling method to allow to cool to room temperature；C, mixed
Close, add the Clostridium butyricum of bacterium >=5.0 × 108cfu/ml alive of certain weight ratio, stir.
As preferably, the water used in this preparation method is purified water.
Preferably Clostridium butyricum uses the Clostridium butyricum fermentation liquid that lilium auratum lindle biotech inc, Henan produces, its
Middle sporeformer is lived and is required >=5.0 × 108cfu/ml.
Compared with prior art, the feed additive for milch cow postpartum recovery that the present invention provides and preparation method thereof
Technological means novelty is unique, and beneficial effect is good, and this feed additive can be taken in, the most just cow feeding feedstuff when simultaneously
Just.And containing clostridium butyricum active bacteria composition, after entering milch cow gastrointestinal tract field planting, health promotion effect, consumption can be played for a long time
Less.It is applied to milch cow Health restoration in puerperal, it is possible to the comprehensive generation tackling milch cow multiple disease in puerperal, particularly milch cow puerperal
Paralysis and the generation of ketoacidosis, promote the Health restoration in milch cow puerperal.
Clostridium butyricum is the Gram-positive bacillus cereus of a kind of anaerobism, and stability is strong, it is possible to tolerance gastric juice, bile acid,
Digestive system, has intestinal regulation effect, it is possible to prevents pathogen and the putrefaction bacteria abnormality proliferation in intestinal and promotes that intestinal has
Benefit bacterium propagation, the dual function grown.The research such as Chen Qiuhong shows that Clostridium butyricum is to pathogenic entero becteria escherichia coli, Salmonella
With shigella, there is stronger inhibitory action, remarkably promote the growth of intestinal beneficial bacterium simultaneously.It addition, Clostridium butyricum can increase
Strong Immune Function In Animals, promotes the growth of animal, and easily China etc. study and show that oral Clostridium butyricum significantly increases IgA in serum
With IgM content.And in intestinal, produce the materials such as vitamin B group, vitamin K, vitamin E, body is had health-care effect.?
After, Clostridium butyricum has the strongest drug resistance, can use with some antibiotic simultaneously.Milch cow belongs to easy stadium puerperal, is substituting
In the case of antibiotic therapy, application Clostridium butyricum carries out conditioning and recovers, and plays the beneficial effect of this additive, meets food peace
Full requirement, the use of this additive can reduce the abuse of antibiotic product in present feed, reduce residual in milk of medicine
Stay, ensure milk quality.And this additive can safeguard the microecological environment in milch cow gastrointestinal tract, promote cud, abomasum, intestinal
Probiotics fermention is movable, reduces the generation of food stagnation；Use milch cow fast quick-recovery in puerperal feed intake after this additive, improve healthy shape
State, improves milk yield；Effectively maintain blood calcium, energy level, effectively reduce sending out of the metabolic diseases such as milking cow postpartum paralysis, ketoacidosis
Raw.
The calcium gluconate added is a kind of outstanding organic calcium, relative to calcium carbonate conventional in feed additive, phosphorus
The inorganic calcium dissolubilities such as acid hydrogen calcium, calcium chloride are more preferable, easily absorb, and pH is close to neutral, and taste is preferable.
The propylene glycol added is a kind of high-energy feed additive, and the research of Wang Yanhui etc. shows, it is to Ketosis, Asia
Ketoacidosis has good prevention and therapeutic effect, and its Main Function mechanism is: be converted into glucose by glyconeogenesis approach,
There is provided energy for milch cow, reduce body fat and decompose, reduce the generation of ketoboidies.Additionally propylene glycol can also increase milk crop and carry
The advantages such as high fertility rate.But propylene glycol palatability is poor, need to be used together together with the feed additive of other local flavor, and butanoic acid
Clostridial fermentation liquid mouthfeel acid perfume (or spice) good palatability, use in conjunction can eliminate the propylene glycol impact on feed taste, and improve feedstuff
Palatability, increases milch cow feed intake in puerperal；And Clostridium butyricum can regulate function of rumen of cow, promote that the fermentation of propylene glycol is inhaled
Receive, play the effect of Synergistic.
Detailed description of the invention
Below by specific embodiment, technical scheme is described in detail.
Embodiment 1:
Present embodiments providing a kind of feed additive for milch cow postpartum recovery and preparation method thereof, this feedstuff adds
Agent is grouped into by the one-tenth of following percentage by weight: the Clostridium butyricum 23% of bacterium >=5.0 × 108cfu/ml alive, calcium gluconate
15%, propylene glycol 20%, remaining is purified water.
The preparation method of this feed additive being used for milch cow postpartum recovery comprises the steps: a, weighs raw material, according to
Percentage by weight weighs calcium gluconate and 20% propylene glycol of 15%, standby；B, dissolving, the gluconic acid after weighing successively
Calcium and propylene glycol are added to the water, and the post-heating that stirs is to normal pressure boil condition, and keeps 30 minutes, makes additive the most molten
Solve, then use recirculated water cooling method to allow to cool to room temperature；C, mixing, add the bacterium alive >=5.0 that percentage by weight is 23%
The Clostridium butyricum of × 108cfu/ml, stirs.
The using method of above-mentioned feed additive is: a 1L, and one day 1 time, the mode that can make spice or drinking-water is taken in, even
Continuous use 2-3 days.
Embodiment 2:
Present embodiments providing a kind of feed additive for milch cow postpartum recovery and preparation method thereof, this feedstuff adds
Agent is grouped into by the one-tenth of following percentage by weight: the Clostridium butyricum 15% of bacterium >=5.0 × 108cfu/ml alive, calcium gluconate
25%, propylene glycol 18%, remaining is purified water.
The preparation method of this feed additive being used for milch cow postpartum recovery comprises the steps: a, weighs raw material, according to
Percentage by weight weighs calcium gluconate and 18% propylene glycol of 25%, standby；B, dissolving, the gluconic acid after weighing successively
Calcium and propylene glycol are added to the water, and the post-heating that stirs is to normal pressure boil condition, and keeps 30 minutes, makes additive the most molten
Solve, then use recirculated water cooling method to allow to cool to room temperature；C, mixing, add the bacterium alive >=5.0 that percentage by weight is 15%
The Clostridium butyricum of × 108cfu/ml, stirs.
The using method of above-mentioned feed additive is: a 1L, and one day 1 time, the mode that can make spice or drinking-water is taken in, even
Continuous use 2-3 days.
Embodiment 3:
Present embodiments providing a kind of feed additive for milch cow postpartum recovery and preparation method thereof, this feedstuff adds
Agent is grouped into by the one-tenth of following percentage by weight: the Clostridium butyricum 10% of bacterium >=5.0 × 108cfu/ml alive, calcium gluconate
25%, propylene glycol 10%, remaining is purified water.
The preparation method of this feed additive being used for milch cow postpartum recovery comprises the steps: a, weighs raw material, according to
Percentage by weight weighs calcium gluconate and 10% propylene glycol of 25%, standby；B, dissolving, the gluconic acid after weighing successively
Calcium and propylene glycol are added to the water, and the post-heating that stirs is to normal pressure boil condition, and keeps 30 minutes, makes additive the most molten
Solve, then use recirculated water cooling method to allow to cool to room temperature；C, mixing, add the bacterium alive >=5.0 that percentage by weight is 10%
The Clostridium butyricum of × 108cfu/ml, stirs.
The using method of above-mentioned feed additive is: a 1L, and one day 1 time, the mode that can make spice or drinking-water is taken in, even
Continuous use 2-3 days.
Embodiment 4:
Present embodiments providing a kind of feed additive for milch cow postpartum recovery and preparation method thereof, this feedstuff adds
Agent is grouped into by the one-tenth of following percentage by weight: the Clostridium butyricum 50% of bacterium >=5.0 × 108cfu/ml alive, calcium gluconate
5%, propylene glycol 30%, remaining is purified water.
The preparation method of this feed additive being used for milch cow postpartum recovery comprises the steps: a, weighs raw material, according to
Percentage by weight weighs calcium gluconate and 30% propylene glycol of 5%, standby；B, dissolving, the gluconic acid after weighing successively
Calcium and propylene glycol are added to the water, and the post-heating that stirs is to normal pressure boil condition, and keeps 30 minutes, makes additive the most molten
Solve, then use recirculated water cooling method to allow to cool to room temperature；C, mixing, add the bacterium alive >=5.0 that percentage by weight is 50%
The Clostridium butyricum of × 108cfu/ml, stirs.
The using method of above-mentioned feed additive is: a 1L, and one day 1 time, the mode that can make spice or drinking-water is taken in, even
Continuous use 2-3 days.
In order to prove the effect above of this additive, carry out following experiment:
Experiment purpose: the feed additive for milch cow Health restoration in puerperal that the checking present invention provides is to Postpartum Cows paralysis
Paralysis, the preventive effect of ketoacidosis and the impact of feed intake.
Experiment feed additive: the feedstuff for milch cow Health restoration in puerperal provided in the embodiment of the present invention adds
Agent；
Laboratory animal: 44 experiment milch cows are selected from Henan Province people and Nai Ye Science and Technology Ltd. in spring, and parity is close.
Experimental technique: 44 cow heads are randomly divided into 2 groups, respectively experimental group and matched group, often organizes each 22.Respectively organize base
Plinth daily ration component is identical, experimental group from childbirth start day basal diet increase feed additive of the present invention, essence, roughage by than
Example is added, altogether 1L/ every day head, uses 3 days continuously.Free choice feeding, drinking-water.Timing blood sampling every day detection blood calcium, blood ketone are dense
Spend and record feed intake.Statistics day data in puerperal 10, calculates meansigma methods.
Blood calcium concentration meansigma methods such as following table:
Note: below 8.5mg/dl is low blood calcium milch cow, and 8.5-11.0mg/dl is normal milch cow.
Blood ketone mean concentration such as following table:
Note: below 1.2mmol/L for healthy cow, 1.2～2.0mmol/L for subclinical ketosis, 2.0mmol/L with
On for clinical ketoacidosis.
Feed intake meansigma methods such as following table:
By above experimental example it is apparent that the feedstuff for milch cow Health restoration in puerperal that the present invention provides adds
Agent has prevention milch cow postpartum paralysis, the pathogenetic effect of ketone, reduces disease rates, and can increase cow feeding amount, promotees
Enter milch cow Health restoration in puerperal.
It is understood that above with respect to the specific descriptions of the present invention, be merely to illustrate the present invention and be not limited to this
Technical scheme described by inventive embodiments, it will be understood by those within the art that, still can carry out the present invention
Amendment or equivalent, to reach identical technique effect；As long as meet use needs, all protection scope of the present invention it
In.
Claims (6)
1. the feed additive for milch cow postpartum recovery, it is characterised in that this feed additive is by following percentage by weight
One-tenth be grouped into: bacterium lives the Clostridium butyricum 10%～50% of >=5.0 × 108cfu/ml, calcium gluconate 5%～30%, the third two
Alcohol 5%～30%, remaining is water.
A kind of feed additive for milch cow postpartum recovery the most according to claim 1, it is characterised in that: this feedstuff adds
Add agent to be grouped into by the one-tenth of following percentage by weight: the Clostridium butyricum 20%～30% of bacterium >=5.0 × 108cfu/ml alive, Fructus Vitis viniferae
Calciofon 10%～20%, propylene glycol 15%～25%, remaining is water.
A kind of feed additive for milch cow postpartum recovery the most according to claim 1, it is characterised in that: this feedstuff adds
Add agent to be grouped into by the one-tenth of following percentage by weight: the Clostridium butyricum 23% of bacterium >=5.0 × 108cfu/ml alive, calcium gluconate
15%, propylene glycol 20%, remaining is water.
4., according to a kind of feed additive for milch cow postpartum recovery according to any one of claims 1 to 3, its feature exists
In: the water in this feed additive is purified water.
5. the preparation method of the feed additive for milch cow postpartum recovery as according to any one of claims 1 to 3, it is special
Levy and be that the method comprises the steps: a, weighs raw material, weigh a certain amount of calcium gluconate and third according to percentage by weight
Glycol, standby；B, dissolving, be added to the water calcium gluconate and propylene glycol successively, and the post-heating that stirs boils to normal pressure
State, and keep 30 minutes, make additive fully dissolve, then use recirculated water cooling method to allow to cool to room temperature；C, mixing,
Add the Clostridium butyricum of bacterium >=5.0 × 108cfu/ml alive of certain weight ratio, stir.
6., according to the preparation method of the feed additive for milch cow postpartum recovery according to any one of claim 5, it is special
Levying the water being in this preparation method to use is purified water.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107927359A (en) * | 2017-11-15 | 2018-04-20 | 陕西省生物农业研究所 | A kind of feed addictive and feeding device for increasing milk cow disease resistance |
| CN108671219A (en) * | 2018-07-27 | 2018-10-19 | 河北新世纪药业有限公司 | It is a kind of to be used for postpartum disease of cow prevention, strengthen immunity, the pharmaceutical composition to keep fit and healthy |
| CN108740399A (en) * | 2018-08-22 | 2018-11-06 | 天津市畜牧兽医研究所 | It is a kind of to be used for the compound premixed feed and its application that milk cow postpartum gavages |
| CN112458030A (en) * | 2020-12-22 | 2021-03-09 | 广东溢多利生物科技股份有限公司 | Preparation method of clostridium butyricum preparation special for ruminants |
| CN112544800A (en) * | 2020-11-17 | 2021-03-26 | 郑州百瑞动物药业有限公司 | Liquid feed additive for ruminants and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107927359A (en) * | 2017-11-15 | 2018-04-20 | 陕西省生物农业研究所 | A kind of feed addictive and feeding device for increasing milk cow disease resistance |
| CN108671219A (en) * | 2018-07-27 | 2018-10-19 | 河北新世纪药业有限公司 | It is a kind of to be used for postpartum disease of cow prevention, strengthen immunity, the pharmaceutical composition to keep fit and healthy |
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| CN112458030A (en) * | 2020-12-22 | 2021-03-09 | 广东溢多利生物科技股份有限公司 | Preparation method of clostridium butyricum preparation special for ruminants |
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Application publication date: 20161109 |
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