CN100482104C - Process for preparing lactic acid bacteria oral liquor - Google Patents
Process for preparing lactic acid bacteria oral liquor Download PDFInfo
- Publication number
- CN100482104C CN100482104C CNB2006100452911A CN200610045291A CN100482104C CN 100482104 C CN100482104 C CN 100482104C CN B2006100452911 A CNB2006100452911 A CN B2006100452911A CN 200610045291 A CN200610045291 A CN 200610045291A CN 100482104 C CN100482104 C CN 100482104C
- Authority
- CN
- China
- Prior art keywords
- lactic acid
- acid bacteria
- lactobacillus
- oral liquor
- bacteria oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims abstract description 86
- 241000894006 Bacteria Species 0.000 title claims abstract description 63
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 43
- 239000004310 lactic acid Substances 0.000 title claims abstract description 43
- 238000004519 manufacturing process Methods 0.000 title description 2
- 238000002360 preparation method Methods 0.000 claims abstract description 20
- 244000199866 Lactobacillus casei Species 0.000 claims abstract description 17
- 235000013958 Lactobacillus casei Nutrition 0.000 claims abstract description 17
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims abstract description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 16
- 240000001046 Lactobacillus acidophilus Species 0.000 claims abstract description 14
- 240000006024 Lactobacillus plantarum Species 0.000 claims abstract description 14
- 229940017800 lactobacillus casei Drugs 0.000 claims abstract description 14
- 241000193749 Bacillus coagulans Species 0.000 claims abstract description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 11
- 239000008103 glucose Substances 0.000 claims abstract description 11
- 235000000346 sugar Nutrition 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000001888 Peptone Substances 0.000 claims abstract description 8
- 108010080698 Peptones Proteins 0.000 claims abstract description 8
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims abstract description 8
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims abstract description 8
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- 239000011702 manganese sulphate Substances 0.000 claims abstract description 8
- 235000007079 manganese sulphate Nutrition 0.000 claims abstract description 8
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims abstract description 8
- 235000019319 peptone Nutrition 0.000 claims abstract description 8
- 239000011780 sodium chloride Substances 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims abstract description 6
- 235000013351 cheese Nutrition 0.000 claims description 12
- 230000001580 bacterial effect Effects 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
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- 239000001963 growth medium Substances 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 2
- 239000002054 inoculum Substances 0.000 claims description 2
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- 230000001954 sterilising effect Effects 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 abstract description 11
- 235000013965 Lactobacillus plantarum Nutrition 0.000 abstract description 11
- 229940039695 lactobacillus acidophilus Drugs 0.000 abstract description 11
- 229940072205 lactobacillus plantarum Drugs 0.000 abstract description 11
- 229940054340 bacillus coagulans Drugs 0.000 abstract description 10
- 239000007788 liquid Substances 0.000 abstract description 10
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 5
- 238000012258 culturing Methods 0.000 abstract 1
- 235000001727 glucose Nutrition 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 235000013402 health food Nutrition 0.000 abstract 1
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- 238000000855 fermentation Methods 0.000 description 13
- 230000004151 fermentation Effects 0.000 description 13
- 239000002253 acid Substances 0.000 description 12
- 206010012735 Diarrhoea Diseases 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
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- 230000036039 immunity Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 239000002994 raw material Substances 0.000 description 4
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 3
- 229930182566 Gentamicin Natural products 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 229910000014 Bismuth subcarbonate Inorganic materials 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 description 2
- 229940036358 bismuth subcarbonate Drugs 0.000 description 2
- 230000013872 defecation Effects 0.000 description 2
- 229960002518 gentamicin Drugs 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 235000011497 sour milk drink Nutrition 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 235000013960 Lactobacillus bulgaricus Nutrition 0.000 description 1
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229940004208 lactobacillus bulgaricus Drugs 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
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- 230000035790 physiological processes and functions Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 235000021262 sour milk Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
Images
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100452911A CN100482104C (en) | 2006-07-07 | 2006-07-07 | Process for preparing lactic acid bacteria oral liquor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100452911A CN100482104C (en) | 2006-07-07 | 2006-07-07 | Process for preparing lactic acid bacteria oral liquor |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1899314A CN1899314A (en) | 2007-01-24 |
CN100482104C true CN100482104C (en) | 2009-04-29 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2006100452911A Expired - Fee Related CN100482104C (en) | 2006-07-07 | 2006-07-07 | Process for preparing lactic acid bacteria oral liquor |
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CN (1) | CN100482104C (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5487379B2 (en) | 2008-03-19 | 2014-05-07 | 森下仁丹株式会社 | Blood phosphorus level increase inhibitor |
CN101700061B (en) * | 2009-10-28 | 2012-06-27 | 山东康智多生物科技有限公司 | High-activity fermented milk beverage and preparation method thereof |
CN103622026A (en) * | 2013-12-18 | 2014-03-12 | 青岛根源生物技术集团有限公司 | Nutritional oral solution containing probiotics and preparation method thereof |
CN105831534B (en) * | 2016-03-28 | 2019-03-26 | 济南康多宝生物技术有限公司 | A kind of compound lactobacillus beverage and preparation method thereof |
CN106858596A (en) * | 2017-02-10 | 2017-06-20 | 天津金匮堂生物科技有限公司 | A kind of probiotic acid jujube oral liquid and preparation method thereof |
CN110463892A (en) * | 2019-02-25 | 2019-11-19 | 山东中微众康生物科技有限公司 | A kind of lactic acid bacteria solid beverage and preparation method thereof improving human body intestinal canal health |
CN110464741A (en) * | 2019-02-25 | 2019-11-19 | 山东中微众康生物科技有限公司 | A kind of lactic acid bacteria oral liquor and preparation method thereof improving human body intestinal canal health |
CN109700033B (en) * | 2019-03-04 | 2021-06-04 | 山东环亿生物科技有限公司 | Probiotic composition for regulating intestinal tract and preventing constipation and preparation method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1105544A (en) * | 1994-09-09 | 1995-07-26 | 扬州大学农学院 | Method for preparing active lactic acid bacteria oral liquor |
-
2006
- 2006-07-07 CN CNB2006100452911A patent/CN100482104C/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1105544A (en) * | 1994-09-09 | 1995-07-26 | 扬州大学农学院 | Method for preparing active lactic acid bacteria oral liquor |
Non-Patent Citations (1)
Title |
---|
新型符合乳酸菌制剂的初步研究. 万荣峰.硕士学位论文. 2005 * |
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CN1899314A (en) | 2007-01-24 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shandong Kangzhiduo Biotechnology Co.,Ltd. Assignor: High tech research center of Shandong Academy of Agricultural Sciences Contract record no.: 2011370000076 Denomination of invention: Process for preparing lactic acid bacteria oral liquor Granted publication date: 20090429 License type: Exclusive License Open date: 20070124 Record date: 20110408 |
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ASS | Succession or assignment of patent right |
Owner name: SHANDONG KANGZHIDUO BIOTECHNOLOGY CO., LTD. |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20110803 Address after: Mulberry road Licheng District 250100 in Shandong city of Ji'nan province No. 11 Co-patentee after: Shandong Konsdom Biological Technology Co.,Ltd. Patentee after: High tech research center of Shandong Academy of Agricultural Sciences Address before: Mulberry road Licheng District 250100 in Shandong city of Ji'nan province No. 11 Patentee before: High tech research center of Shandong Academy of Agricultural Sciences |
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ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: SHANDONG KANGZHIDUO BIOTECHNOLOGY CO., LTD. Effective date: 20141102 |
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C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: BIOTECHNOLOGY RESEARCH CENTER, SHANDONG ACADEMY OF Free format text: FORMER NAME: HIGH AND NEW TECHNOLOGY RESEARCH CENTER, SHANDONG PROV. ACADEMY OF AGRICULTURE S |
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CP03 | Change of name, title or address |
Address after: Industrial Road Licheng District, Ji'nan city of Shandong Province, No. 202 250100 Patentee after: Biotechnology Research Center, Shandong Academy of Agricultural Sciences Patentee after: Shandong Konsdom Biological Technology Co.,Ltd. Address before: Mulberry road Licheng District 250100 in Shandong city of Ji'nan province No. 11 Patentee before: High tech research center of Shandong Academy of Agricultural Sciences Patentee before: Shandong Konsdom Biological Technology Co.,Ltd. |
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TR01 | Transfer of patent right |
Effective date of registration: 20141102 Address after: Industrial Road Licheng District, Ji'nan city of Shandong Province, No. 202 250100 Patentee after: Biotechnology Research Center, Shandong Academy of Agricultural Sciences Address before: Industrial Road Licheng District, Ji'nan city of Shandong Province, No. 202 250100 Patentee before: Biotechnology Research Center, Shandong Academy of Agricultural Sciences Patentee before: Shandong Konsdom Biological Technology Co.,Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090429 |