CN105999260A - 氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 - Google Patents
氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 Download PDFInfo
- Publication number
- CN105999260A CN105999260A CN201610318724.XA CN201610318724A CN105999260A CN 105999260 A CN105999260 A CN 105999260A CN 201610318724 A CN201610318724 A CN 201610318724A CN 105999260 A CN105999260 A CN 105999260A
- Authority
- CN
- China
- Prior art keywords
- sodium chloride
- antigen
- adjuvant
- immunological adjuvant
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 title claims abstract description 178
- 239000011780 sodium chloride Substances 0.000 title claims abstract description 96
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 title claims abstract description 69
- 239000000568 immunological adjuvant Substances 0.000 title claims abstract description 65
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 239000002131 composite material Substances 0.000 title abstract description 22
- 239000000427 antigen Substances 0.000 claims abstract description 83
- 102000036639 antigens Human genes 0.000 claims abstract description 82
- 108091007433 antigens Proteins 0.000 claims abstract description 82
- 239000002671 adjuvant Substances 0.000 claims abstract description 56
- 229960005486 vaccine Drugs 0.000 claims abstract description 52
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 27
- 230000036039 immunity Effects 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 17
- 230000001900 immune effect Effects 0.000 claims abstract description 16
- 150000001875 compounds Chemical class 0.000 claims description 47
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 33
- 239000002245 particle Substances 0.000 claims description 11
- 208000006454 hepatitis Diseases 0.000 claims description 7
- 231100000283 hepatitis Toxicity 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 4
- 239000008215 water for injection Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- 239000012467 final product Substances 0.000 claims 1
- 230000035479 physiological effects, processes and functions Effects 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 12
- 210000004881 tumor cell Anatomy 0.000 abstract description 7
- 210000001744 T-lymphocyte Anatomy 0.000 abstract description 4
- 230000000259 anti-tumor effect Effects 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 4
- 229960002520 hepatitis vaccine Drugs 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 229940024545 aluminum hydroxide Drugs 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 229940024546 aluminum hydroxide gel Drugs 0.000 abstract 1
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 108010058846 Ovalbumin Proteins 0.000 description 37
- 229940092253 ovalbumin Drugs 0.000 description 37
- 241000699670 Mus sp. Species 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 21
- 108010074328 Interferon-gamma Proteins 0.000 description 19
- 102100037850 Interferon gamma Human genes 0.000 description 17
- 238000002649 immunization Methods 0.000 description 17
- 238000002474 experimental method Methods 0.000 description 16
- 230000003053 immunization Effects 0.000 description 16
- 210000004698 lymphocyte Anatomy 0.000 description 16
- 229910052782 aluminium Inorganic materials 0.000 description 15
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 15
- 230000000890 antigenic effect Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 210000000952 spleen Anatomy 0.000 description 10
- 229910001679 gibbsite Inorganic materials 0.000 description 9
- 238000002347 injection Methods 0.000 description 9
- 239000007924 injection Substances 0.000 description 9
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- XDIVEACYGYLGAW-UHFFFAOYSA-L [OH-].[Na+].[Cl-].[Al+3] Chemical compound [OH-].[Na+].[Cl-].[Al+3] XDIVEACYGYLGAW-UHFFFAOYSA-L 0.000 description 8
- 238000001514 detection method Methods 0.000 description 8
- 230000028327 secretion Effects 0.000 description 8
- 230000001413 cellular effect Effects 0.000 description 7
- 238000000926 separation method Methods 0.000 description 7
- 230000002265 prevention Effects 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 238000002965 ELISA Methods 0.000 description 5
- 238000008157 ELISA kit Methods 0.000 description 5
- 239000004677 Nylon Substances 0.000 description 5
- 239000004411 aluminium Substances 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 230000028993 immune response Effects 0.000 description 5
- 238000011081 inoculation Methods 0.000 description 5
- 229920001778 nylon Polymers 0.000 description 5
- 238000012216 screening Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 230000004614 tumor growth Effects 0.000 description 5
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000003449 preventive effect Effects 0.000 description 4
- 238000007920 subcutaneous administration Methods 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- HIGRAKVNKLCVCA-UHFFFAOYSA-N alumine Chemical compound C1=CC=[Al]C=C1 HIGRAKVNKLCVCA-UHFFFAOYSA-N 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- 239000012646 vaccine adjuvant Substances 0.000 description 3
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 2
- 101001005728 Homo sapiens Melanoma-associated antigen 1 Proteins 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 102100025050 Melanoma-associated antigen 1 Human genes 0.000 description 2
- 229940037003 alum Drugs 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000011449 brick Substances 0.000 description 2
- 230000007969 cellular immunity Effects 0.000 description 2
- 239000012228 culture supernatant Substances 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000005740 tumor formation Effects 0.000 description 2
- 229940124931 vaccine adjuvant Drugs 0.000 description 2
- -1 10mg/mL Substances 0.000 description 1
- 108700031361 Brachyury Proteins 0.000 description 1
- 238000011740 C57BL/6 mouse Methods 0.000 description 1
- 210000001239 CD8-positive, alpha-beta cytotoxic T lymphocyte Anatomy 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 229940124872 Hepatitis B virus vaccine Drugs 0.000 description 1
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 210000003489 abdominal muscle Anatomy 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- 159000000013 aluminium salts Chemical class 0.000 description 1
- 229910000329 aluminium sulfate Inorganic materials 0.000 description 1
- SVEIXENKLWYGIZ-UHFFFAOYSA-J aluminum;sodium;tetrahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[Na+].[Al+3] SVEIXENKLWYGIZ-UHFFFAOYSA-J 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000004567 concrete Substances 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000012202 endocytosis Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 description 1
- 229940124736 hepatitis-B vaccine Drugs 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940021747 therapeutic vaccine Drugs 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (23)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610318724.XA CN105999260B (zh) | 2016-05-13 | 2016-05-13 | 氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 |
PCT/CN2016/102131 WO2017193535A1 (zh) | 2016-05-13 | 2016-10-14 | 氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 |
JP2018559377A JP6796146B2 (ja) | 2016-05-13 | 2016-10-14 | 水酸化アルミニウムゲル−塩化ナトリウム複合免疫学的アジュバント、並びにその調製方法及びその使用 |
US16/300,295 US10869922B2 (en) | 2016-05-13 | 2016-10-14 | Alhydrogel-sodium chloride compound immunologic adjuvant, preparation method and use thereof |
EP16901490.9A EP3456350A4 (en) | 2016-05-13 | 2016-10-14 | COMPOSITE IMMUNOLOGICAL ADJUVANT ALUMINUM HYDROXIDE-SODIUM CHLORIDE GEL, METHOD FOR PREPARING SAME, AND APPLICATIONS THEREOF |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610318724.XA CN105999260B (zh) | 2016-05-13 | 2016-05-13 | 氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105999260A true CN105999260A (zh) | 2016-10-12 |
CN105999260B CN105999260B (zh) | 2019-12-10 |
Family
ID=57100420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610318724.XA Active CN105999260B (zh) | 2016-05-13 | 2016-05-13 | 氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 |
Country Status (5)
Country | Link |
---|---|
US (1) | US10869922B2 (zh) |
EP (1) | EP3456350A4 (zh) |
JP (1) | JP6796146B2 (zh) |
CN (1) | CN105999260B (zh) |
WO (1) | WO2017193535A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017193535A1 (zh) * | 2016-05-13 | 2017-11-16 | 四川大学 | 氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 |
CN113827710A (zh) * | 2020-06-23 | 2021-12-24 | 四川大学华西医院 | 一种基于乳酸的肿瘤全细胞疫苗 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111184860B (zh) * | 2020-02-21 | 2022-05-06 | 中牧实业股份有限公司 | 一种改进的氢氧化铝佐剂及其制备方法 |
CA3194869A1 (en) * | 2020-10-09 | 2022-04-14 | Zeria Pharmaceutical Co., Ltd. | Novel use of mycobacterium tuberculosis extract |
CN113797329A (zh) * | 2021-10-19 | 2021-12-17 | 启锰生物科技(江苏)有限公司 | 一种二价锰佐剂和CpG佐剂的疫苗佐剂组合物及其制作方法 |
CN114028559B (zh) * | 2021-12-28 | 2024-06-18 | 广东粤港澳大湾区国家纳米科技创新研究院 | 一种铝锰复合纳米晶及其制备方法和应用 |
CN115124060B (zh) * | 2022-06-30 | 2023-03-10 | 长春生物制品研究所有限责任公司 | 一种氢氧化铝佐剂及其制备方法和应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102349996A (zh) * | 2011-10-17 | 2012-02-15 | 沈阳三生制药有限责任公司 | 人乳头瘤病毒药物组合物及其应用 |
CN104840956A (zh) * | 2015-05-25 | 2015-08-19 | 四川大学 | λ-角叉菜胶在制备免疫佐剂中的用途及抗原-佐剂复合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005123120A1 (en) | 2004-06-16 | 2005-12-29 | Smart Drug Systems Inc. | Sustained release vaccine composition |
CN101513526B (zh) | 2008-12-15 | 2012-12-26 | 张积仁 | 联合疫苗在肿瘤治疗中的应用 |
CN102526724B (zh) | 2011-01-14 | 2015-07-22 | 四川大学 | 氢氧化铝凝胶-多糖复合免疫佐剂及其制备方法和用途 |
RU2610174C2 (ru) | 2011-06-24 | 2017-02-08 | Мерк Шарп И Доум Корп. | Вакцинные составы против вируса папилломы человека (hpv), содержащие алюминиевый адъювант, и способы их получения |
CN103316356B (zh) * | 2012-03-22 | 2016-08-17 | 北京三诺佳邑生物技术有限责任公司 | 一种重组慢病毒载体制剂 |
CN103705914B (zh) | 2013-12-09 | 2016-04-20 | 成都欧林生物科技股份有限公司 | 一种金黄色葡萄球菌疫苗及其制备方法 |
CN105999260B (zh) | 2016-05-13 | 2019-12-10 | 四川大学 | 氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 |
-
2016
- 2016-05-13 CN CN201610318724.XA patent/CN105999260B/zh active Active
- 2016-10-14 WO PCT/CN2016/102131 patent/WO2017193535A1/zh active Search and Examination
- 2016-10-14 EP EP16901490.9A patent/EP3456350A4/en active Pending
- 2016-10-14 US US16/300,295 patent/US10869922B2/en active Active
- 2016-10-14 JP JP2018559377A patent/JP6796146B2/ja active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102349996A (zh) * | 2011-10-17 | 2012-02-15 | 沈阳三生制药有限责任公司 | 人乳头瘤病毒药物组合物及其应用 |
CN104840956A (zh) * | 2015-05-25 | 2015-08-19 | 四川大学 | λ-角叉菜胶在制备免疫佐剂中的用途及抗原-佐剂复合物 |
Non-Patent Citations (2)
Title |
---|
WATKINSON A ET AL.: "Increasing the potency of alhydrogel-formulated anthrax vaccine by minimizing antigen adjuvant interactions", 《CLIN VACCINE IMMUNOL》 * |
王一平等: "氢氧化铝佐剂对肠道病毒71型灭活疫苗诱导小鼠细胞免疫应答的影响", 《中国生物制品学杂志》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017193535A1 (zh) * | 2016-05-13 | 2017-11-16 | 四川大学 | 氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 |
US10869922B2 (en) | 2016-05-13 | 2020-12-22 | Sichuan University | Alhydrogel-sodium chloride compound immunologic adjuvant, preparation method and use thereof |
CN113827710A (zh) * | 2020-06-23 | 2021-12-24 | 四川大学华西医院 | 一种基于乳酸的肿瘤全细胞疫苗 |
Also Published As
Publication number | Publication date |
---|---|
WO2017193535A1 (zh) | 2017-11-16 |
US10869922B2 (en) | 2020-12-22 |
JP6796146B2 (ja) | 2020-12-02 |
EP3456350A1 (en) | 2019-03-20 |
US20190134191A1 (en) | 2019-05-09 |
CN105999260B (zh) | 2019-12-10 |
JP2019515005A (ja) | 2019-06-06 |
EP3456350A4 (en) | 2020-01-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105999260A (zh) | 氢氧化铝凝胶-氯化钠复合免疫佐剂及其制备方法和用途 | |
Wu et al. | Overview of vaccine adjuvants | |
CN102949717A (zh) | 一种含poly I:C佐剂的新型乙肝疫苗制剂 | |
CN111603556B (zh) | 一种新型冠状病毒亚单位纳米疫苗的制备和应用 | |
CN110124018A (zh) | 一种模拟坏死肿瘤细胞的磷酸钙-脂质纳米疫苗及其应用 | |
JP2010502766A (ja) | アジュバントとしてのキチン微粒子 | |
WO2021077770A1 (zh) | 一种迷你联合佐剂纳米颗粒及其制备方法和应用 | |
CN112516297B (zh) | 一种基于鱼精蛋白为载体的抗原和佐剂共传递纳米疫苗的制备方法及其应用 | |
CN107488235A (zh) | 一种新的增强型抗原联合多肽诱导肝癌特异性ctl细胞的制备及应用 | |
CN108324938A (zh) | 一种颗粒型佐剂及其制备方法和应用 | |
CN104338126B (zh) | 一种具有治疗或预防hpv病毒的疫苗组合物及其应用 | |
CN109701010A (zh) | 疫苗复合佐剂系统及其在抗原中的应用 | |
CN104338132A (zh) | 一种病毒免疫治疗药物复合物及其用途 | |
CN114028559A (zh) | 一种铝锰复合纳米晶及其制备方法和应用 | |
WO2016119308A1 (zh) | 一种抗肿瘤制剂及其制备方法 | |
CN107530432B (zh) | 药物 | |
CN115120713A (zh) | 氢氧化铝-CpG寡核苷酸-多肽复合佐剂、疫苗及制备方法和用途 | |
TWI522112B (zh) | 疫苗佐劑、疫苗組合物與牛樟芝子實體之多醣體用於製備一疫苗佐劑的用途 | |
US20230149347A1 (en) | CXCR4/CXCR7 Blockade and Treatment of Human Papilloma Virus-Associated Disease | |
JP2019527191A (ja) | 免疫増強剤、口蹄疫不活化ワクチンおよびその製造方法 | |
US20180264050A1 (en) | (en) potentiated t-cell modulator able to modulate immune response, method for extracting, testing and counting a dialysable leucocyte extract from shark spleen to produce same, and therapeutic use thereof | |
CN102349996A (zh) | 人乳头瘤病毒药物组合物及其应用 | |
CN107286245A (zh) | Pd-l1和pd-l2重组蛋白及其用途 | |
RU2379055C1 (ru) | Способ лечения онкологических заболеваний | |
TW202034950A (zh) | 用於治療b型肝炎的藥物製劑及其製備方法和用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Wei Xiawei Inventor after: Luo Min Inventor after: Wei Yuquan Inventor before: Luo Min Inventor before: Wei Xiawei Inventor before: Wei Yuquan |
|
COR | Change of bibliographic data | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210617 Address after: 610000 Chengdu Tianfu international biological city, Chengdu, Sichuan Province (No. 552, Fenghuang Road, Shuangliu District) Patentee after: Chengdu weisk biomedical Co.,Ltd. Address before: 610041, No. 24, south section of first ring road, Chengdu, Sichuan, Wuhou District Patentee before: SICHUAN University |
|
TR01 | Transfer of patent right |